Calcium receptor-active compounds

ABSTRACT

A novel calcium receptor active compound having the formula is provided:  
     Ar 1 —[CR 1 R 2 ] p —X—[CR 3 R 4 ] q —[CR 5 R 6 ]—NR 7 —[CR 8 R 9 ]—Ar 2    
     wherein:  
     Ar 1  is selected from the group consisting of aryl, heteroaryl, bis(arylmethyl)amino, bis(heteroarylmethyl)amino and arylmethyl(heteroarylmethyl)amino;  
     X is selected from the group consisting of oxygen, sulfur, sulfinyl, sulfonyl, carbonyl and amino;  
     R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8  and R 9  are, for example, hydrogen or alkyl;  
     Ar 2  is selected from the group consisting of aryl and heteroaryl;  
     p is an integer of from 0 to 6, inclusive; and,  
     q is an integer of from 0 to 14, inclusive.

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This application is a divisional of co-pending U.S. applicationSer. No. 10/053,133, filed Jan. 17, 2002, which is a continuation of aco-pending U.S. application Ser. No. 09/214,552, filed Jan. 6, 1999,which claims priority to an International Application No. PCT/JP97/02358filed on Jul. 8, 1997, which claims priority to Japanese ApplicationNos. 9/107778, filed Ap. 24, 1997; 8/350393, filed Dec. 27, 1996 and8/178315, filed Jul. 8, 1996, all which are incorporated by referenceherein.

FIELD OF THE INVENTION

[0002] This invention relates to the design, development, compositionand use of novel molecules able to modulate the activity of inorganicion receptor.

BACKGROUND OF THE INVENTION

[0003] Certain cells in the body respond not only to chemical signals,but also to ions such as extracellular calcium ions (Ca²⁺). Changes inthe concentration of extracellular Ca²⁺ (referred to herein as “[Ca²⁺]”)alter the functional responses of these cells. One such specialized cellis the parathyroid cell which secretes parathyroid hormone (PTH). PTH isthe principal endocrine factor relating Ca²⁺ homeostasis in the bloodand extracellular fluids.

[0004] PTH, by acting on bone and kidney cells, increases the level ofCa²⁺ in the blood. This increase in [Ca²⁺] then acts as a negativefeedback signal, depressing PTH secretion. The reciprocal relationshipbetween [Ca²⁺] and PTH secretion forms the essential mechanismmaintaining bodily Ca²⁺ homeostasis.

[0005] Extracellular Ca²⁺ acts directly on parathyroid cells to regulatePTH secretion. The existence of a parathyroid cell surface protein whichdetects changes in [Ca²⁺] has been confirmed. Brown et al., 366 Nature574, 1993. In parathyroid cells, this protein acts as a receptor forextracellular Ca²⁺ (“the calcium receptor”), and detects changes in[Ca²⁺] and to initiate a functional cellular response, PTH secretion.

[0006] Extracellular Ca²⁺ can exert effects on different cell functions,reviewed in Nemeth, et al., 11 Cell Calcium 319, 1990. The role ofextracellular Ca²⁺ in parafolicular (C cells) and parathyroid cells isdiscussed in Nemeth, 11 Cell Calcium 323, 1990. These cells have beenshown to express similar Ca²⁺ receptor. Brown et al., 366 Nature 574,1993; Mithal et al., 9 Suppl. 1 J. Bone and Mineral Res. s282, 1994;Rogers et al., 9 Suppl. 1 J. Bone and Mineral Res. s409 1994; Garrett etal., 9 Suppl. 1 J. Bone and Mineral Res. s409, 1994. The role ofextracellular Ca²⁺ on bone osteoclasts is discussed by Zaidi, 10Bioscience Reports 493, 1990. in addition keratinocytes, juxtaglomerularcells, trophoblasts, pancreatic beta cells and fat/adipose cells allrespond to increases in extracellular calcium which likely reflectsactivation of calcium receptors of these cells.

[0007] The ability of various compounds to mimic extracellular Ca²⁺ invitro is discussed by Nemeth et al., (spermine and spermidine) in“Calcium-Binding Proteins in Health and Disease”, 1987, Academic Press,Inc., pp.33-35; Brown et al., (e.g., neomycin) 128 Endocrinology 3047,1991; Chen et al., (diltiazem and its analog, TA-3090) 5 J. Bone andMineral Res. 581,1990; and Zaidi et al., (verapamil) 167 Biochem.Biophys. Res. Commun. 807, 1990. Nemeth et al., PCT/US93/01642,International Publication Number WO 94/18959, Nemeth et al.,PCT/US92/07175, International Publication Number WO 93/04373, Nemeth etal., PCT/US94/12117, International Publication Number WO 95/11221 andNemeth et al., PCT/US95/13704, International Publication Number WO96/12697 describe various compounds which can modulate the effect of aninorganic ion on a cell having an inorganic ion receptor, preferablymodulate the effects of calcium on a calcium receptor.

[0008] The object of the present invention is to provide a novelinorganic ion receptor active compound having the structure differentfrom the compounds described above.

DISCLOSURE OF THE INVENTION

[0009] The present invention features molecules which can modulate oneor more activities of an inorganic ion receptor. Preferably, themolecule can mimic or block the effect of extracellular Ca²⁺ on acalcium receptor. The preferred use of such molecules is to treatdiseases or disorders by altering inorganic ion receptor activity,preferably calcium receptor activity.

[0010] The present invention provides a novel calcium receptor activecompound of the formula:

Ar₁—[CR¹R²]_(p)—X—[CR³R⁴]_(q)—[CR⁵R⁶]—NR⁷—[CR⁸R⁹]—Ar₂  (1)

[0011] wherein:

[0012] Ar₁ is selected from the group consisting of aryl, heteroaryl,bis(arylmethyl)amino, bis(heteroarylmethyl)amino andarylmethyl(heteroarylmethyl)amino;

[0013] X is selected from the group consisting of oxygen, sulfur,sulfinyl, sulfonyl, carbonyl and amino;

[0014] R¹, R², R³, R⁴, R⁵, R⁶, R⁸ and R⁹ are independently selected fromthe group consisting of hydrogen, alkyl, cycloalkyl, alkenyl,,alkynyl,trihalomethyl, aryl, heteroaryl, heteroalicyclic, halogen, hydroxy,alkoxy, thioalkoxy, aryloxy, thioaryloxy, carbonyl, thiocarbonyl,C-carboxyl, O-carboxyl, C-amido, N-amido, O-carbamyl, N-carbamyl,O-thiocarbamyl, N-thiocarbamyl, cyano, nitro, amino and NR¹⁰R¹¹;wherein,

[0015] R¹⁰ and R¹¹ are independently selected from the group consistingof hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, carbonyl,trihaloacetyl, sulfonyl, trihalomethanesulfonyl and, combined, a five-or six-member heteroalicyclic ring containing at least one nitrogen;

[0016] any two adjacent “R” groups may be combined to form five- orsix-member fused cycloalkyl groups;

[0017] R⁷ is selected from the group consisting of hydrogen, alkyl,cycloalkyl, alkenyl, alkynyl, aryl, halogen, cyano, hydroxy, alkoxy,O-carboxyl, trihaloacetyl and trihalomethanesulfonyl;

[0018] Ar₂ is selected from the group consisting of aryl and heteroaryl;

[0019] p is an integer of from 0 to 6, inclusive; and,

[0020] q is an integer of from 0 to 14, inclusive;

[0021] or a pharmaceutically acceptable salt or hydrate of saidcompound.

[0022] As used herein, the term “aryl” refers to an all-carbonmonocyclic or fused ring polycyclic (i.e., rings which share adjacentpairs of carbon atoms) groups in which one or more of the rings has acompletely conjugated pi-electron system. Examples, without limitation,of aryl groups, are phenyl, naphthyl, anthracenyi, phenanthrenyl,fluorenyl, and indanyl. The aryl group may be substituted orunsubstituted. When substituted, the substituted group(s) is preferablyone or more selected from halogen, trihalomethyl, alkyl, alkenyl,alkynyl, hydroxy, alkoxy, aryloxy, thiohydroxy, thioalkoxy, thioaryloxy,cyano, nitro, carbonyl, thiocarbonyl, C-carboxy, O-carboxy, O-carbamyl,N-carbamyl, O-thiocarbamyl, N-thiocarbamyl, C-amido, N-amido, sulfinyl,sulfonyl, S-sulfonamido, N-sulfonamido, trihalomethane-sulfonamido,amino and NR¹⁰R¹¹ wherein:

[0023] R¹⁰ and R¹¹ are independently selected from the group consistingof hydrogen, alkyl, cycloalkyl, aryl, carbonyl, sulfonyl,trihalomethanesulfonyl, and, combined, a five- or six-memberheteroalicyclic ring which heteroalicyclic ring may be unsubstituted orsubstituted with one or more halogens.

[0024] A “heteroaryl” group refers to a monocyclic or fused ring (i.e.,rings which share an adjacent pair of atoms) group having in the ring(s)one or more atoms selected from the group consisting of nitrogen, oxygenand sulfur and, in addition, at least one of the rings has a completelyconjugated pi-electron system. Examples, without limitation, ofheteroaryl groups are pyrrole, furan, dibenzofuran, carbazole, acridine,thiophene, imidazole, benzimidazole, oxazole, thiazole, phenothiazine,triazole, thiadiazole, pyrazole, benzoxazole, benzthiazole, indole,benzofuran, indazole, pyridine, pyrimidine, quinoline, isoquinoline,quinazoline, purine, phthalazine and flavone. The heteroaryl group maybe substituted or unsubstituted. When substituted, the substitutedgroup(s) is preferably one or more selected from alkyl, cycloalkyl,halogen, trihalomethyl, hydroxy, alkoxy, aryloxy, thiohydroxy,thioalkoxy, thioaryloxy, cyano, nitro, carbonyl, thiocarbonyl,sulfonamido, C-carboxy, O-carboxy, sulfinyl, sulfonyl, C-carbamyl,N-carbamyl, O-thiocarbamyl, N-thiocarbamyl, C-amido, N-amido,S-sulfonamido, N-sulfonamido, trihalomethanesulfonamido, amino andNR¹⁰R¹¹ where R¹⁰ and R¹¹ are previously defined herein.

[0025] As used herein, the term “alkyl” refers to a saturated aliphatichydrocarbon including straight chain and branched chain groups.Preferably, the alkyl group has 1 to 20 carbon atoms. More preferably,it is a medium size alkyl having 1 to 10 carbon atoms. Most preferably,it is a lower alkyl having 1 to 4 carbon atoms. The alkyl group may besubstituted or unsubstituted. When substituted, the substituent group(s)is preferably one or more individually selected from cycloalkyl, aryl,heteroaryl, heteroalicyclic, hydroxy, alkoxy, aryloxy, thiohydroxy,thioalkoxy, thioaryloxy, cyano, halogen, carbonyl, thiocarbonyl,O-carbamyl, N-carbamyl, O-thiocarbamyl, N-thiocarbamyl, C-amido,N-amido, C-carboxy, O-carboxy, nitro, sulfonamido,trihalomethane-sulfonamido, amino and NR¹⁰R¹¹ where R¹⁰ and R¹¹ arepreviously defined herein. More preferably, the alkyl group is a mediumor lower alkyl which is optionally substituted with one or more groupsindependently selected from halogen, hydroxy, nitro, cyano andunsubstituted lower alkoxy, lower alkoxy substituted with one or morehalogens; an unsubstituted lower alkyl; and a lower alkyl substitutedwith one or more halogens.

[0026] A “cycloalkyl” group refers to an all-carbon monocyclic or fusedring (i.e., rings which share an adjacent pair of carbon atoms) groupwherein none of the rings has a completely conjugated pi-electronsystem. Examples, without limitation, of cycloalkyl groups arecyclopropane, cyclobutane, cyclopentane, cyclopentene, cyclohexane,cyclohexadiene, cycloheptane and, cycloheptatriene. A cycloalkyl groupmay be substituted or unsubstituted. When substituted, the substituentgroup(s) is preferably one or more individually selected from alkyl,aryl, heteroaryl, heteroalycyclic, hydroxy, alkoxy, aryloxy,thiohydroxy,.thioalkoxy, thioaryloxy, cyano, halogen, carbonyl,thiocarbonyl, C-carboxy, O-carboxy, O-carbamyl, N-carbamyl, C-amido,N-amido, S-sulfonamido, N-sulfonamido, nitro, amino and NR¹⁰R¹¹, whereR¹⁰ and R¹¹ are previously defined herein. Preferably the cycloalkylgroup is selected from unsubstituted cyclopropane, unsubstitutedcyclopentane, unsubstituted cyclohexane, and cyclopropane, cyclopentaneand cyclohexane substituted with one or more groups independentlyselected from halogen, nitro, cyano, hydroxy, unsubstituted loweralkoxy, C-carboxyl wherein R″ is unsubstituted lower alkyl andO-carboxyl wherein R″ is unsubstituted lower alkyl.

[0027] An “alkenyl” group refers to an alkyl group, as defined herein,consisting of at least two carbon atoms and at least one carbon—carbondouble bond. A “lower alkenyl” group refers to a lower alkyl groupcontaining at least one double bond.

[0028] A “cycloalkenyl” group refers to a cycloalkyl group whichcontains one or more double bonds in the ring wherein the double bondsdo not produce a completely conjugated pi-electron system within thering.

[0029] An “alkynyl” group refers to an alkyl group, as defined herein,consisting of at least two carbon atoms and at least one carbon-carbontriple bond. A “lower alkynyl” group refers to a lower alkyl groupcontaining at least one triple bond.

[0030] A “heteroalicyclic” group refers to a monocyclic or fused ringgroup having in the ring(s) one or more atoms selected from the groupconsisting of nitrogen, oxygen and sulfur. The rings may also have oneor more double bonds. However, none of the rings has a completelyconjugated pi-electron system. The heteroalicyclic ring may besubstituted or unsubstituted. When substituted, the substituted group(s)is preferably one or more selected from alkyl, cycloalkyl, halogen,trihalomethyl, hydroxy, alkoxy, aryloxy, thiohydroxy, thioalkoxy,thioaryloxy, cyano, nitro, carbonyl, thiocarbonyl, C-carboxy, O-carboxy,O-carbamyl, N-carbamyl, O-thiocarbamyl, N-thiocarbamyl, sulfinyl,sulfonyl, S-sulfonamido, N-sulfonamido, C-amido, N-amido, amino andNR¹⁰R¹¹ where R¹⁰ and R¹¹ are previously defined herein.

[0031] A “phenyl” group refers to a six-member ring aryl group.

[0032] A “benzyl” group refers to a phenyl-CH₂— group.

[0033] A “hydroxy” group refers to an —OH group.

[0034] An “alkoxy” group refers to both an —O-alkyl and an —O-cycloalkylgroup, as defined herein; preferably an alkoxy group refers to a methoxyor trihalomethoxy.

[0035] A “trihalomethoxy” group refers to a Y₃CO— group with Y asdefined herein; preferably Y is fluorine.

[0036] A “benzyloxy” refers to a benzyl-O— group.

[0037] An “aryloxy” group refers to both an —O-aryl and an —O-heteroarylgroup, as defined herein. A “phenoxy” group refers to an aryloxy groupin which the aryl group is a phenyl group. A “thiohydroxy” group refersto an —SH group.

[0038] A “thioalkoxy” group refers to both an S-alkyl and an—S-cycloalkyl group, as defined herein.

[0039] A “thioaryloxy” group refers to both an —S-aryl and an—S-heteroaryl group, as defined herein.

[0040] A “carbonyl” or “acyl” group refers to a —C(═O)—R″ group, whereR″ is selected from the group consisting of hydrogen, alkyl, cycloalkyl,aryl, heteroaryl (bonded through a ring carbon) and heteroalicyclic(bonded through a ring carbon), as defined herein.

[0041] An “formyl” group refers to a carbonyl group wherein R″ ishydrogen.

[0042] An “acetyl” group refers to a carbonyl group wherein R″ is CH₃.

[0043] A “thiocarbonyl” group refers to a —C(═S)—R″ group, with R″ asdefined herein.

[0044] A “trihalomethyl” group refers to a —CY₃ group wherein Y is ahalogen group; preferably Y is fluorine.

[0045] A “trihaloacetyl” group refers to a Y₃CC(═O)— group with Y asdefined herein.

[0046] A “C-carboxyl” group refers to a —C(═O)O—R″ groups, with R″ asdefined herein.

[0047] An “O-carboxyl” group refers to a R″C(═O)O— group, with R″ asdefined herein.

[0048] An “acetoxy” group refers to an O-carboxyl group in which R″ isCH₃.

[0049] A “carboxylic acid” group refers to a C-carboxyl group in whichR″ is hydrogen.

[0050] A “halo” or “halogen” group refers to fluorine, chlorine, bromineor iodine.

[0051] A “trihalomethanesulfonyl” group refers to a Y₃CS(═C)₂— groupswith Y as defined above.

[0052] A “trihalomethanesulfonamido” group refers to a Y₃CS(═O)₂NR¹⁰—group with Y and R¹⁰ as defined herein.

[0053] A “sulfinyl” group refers to a —S(═O)—R″ group, with R″ asdefined herein or R″ may not exist if both S-bonds are already in useinternally in a particular molecule.

[0054] A “sulfonyl” group refers to a —S(═O)₂R″ group, with R″ asdefined herein. or R″ may not exist is both S-bonds are already in useinternally in an particular molecule.

[0055] An “S-sulfonamido” group refers to a —S(═O)₂NR¹⁰R¹¹, with R¹⁰ andR¹¹ as defined herein.

[0056] An “N-sulfonamido” group refers to a R¹⁰S(═O)₂NR¹¹— group, withR¹⁰ and R¹¹ as defined herein.

[0057] An “O-carbamyl” group refers to a —OC(═O)NR¹⁰R¹¹ group with R¹⁰and R¹¹ as defined herein.

[0058] An “N-carbamyl” group refers to a R¹⁰OC(═O)NR¹¹— group, with R¹⁰and R¹¹ as defined herein.

[0059] An “O-thiocarbamyl” group refers to a —OC(═S)NR¹⁰R¹¹ group withR¹⁰ and R¹¹ as defined herein.

[0060] An “N-thiocarbamyl” group refers to a R¹⁰OC(═S)NR¹¹— group, withR¹⁰ and R¹¹ as defined herein.

[0061] An “amino” group refers to an —NR¹⁰R¹¹ group, with R¹⁰ and R¹¹ asdefined herein.

[0062] A “C-amido” group refers to a —C(═O)NR¹⁰R¹¹ group with R¹⁰ andR¹¹ as defined herein.

[0063] An “N-amido” group refers to a R¹⁰C(═O)NR¹¹— group, with R¹⁰ andR¹¹ as defined herein.

[0064] A “nitro” group refers to a —NO₂ group.

[0065] A “methylenedioxy” group refers to a —OCH₂O— group in which thetwo oxygens are covalently bonded to adjacent carbon atoms of an aryl orheteroaryl group.

[0066] An “ethylenedioxy” group refers to a —OCH₂CH₂O— groups in whichthe two oxygens are covalently bonded to adjacent carbon atoms of anaryl or heteroaryl group.

[0067] Preferably, in the formula (1), R⁵ is selected from the groupconsisting of hydrogen, unsubstituted lower alkyl and lower alkylsubstituted with one or more halogens; R¹, R², R³, R⁴, R⁵, R⁶ and R⁷ arehydrogen; and R⁸ and R⁹ are independently selected from the groupconsisting of hydrogen, unsubstituted alkyl, lower alkyl substitutedwith one or more halogens, unsubstituted alkenyl, lower alkenylsubstituted with one or more halogens, unsubstituted alkynyl, alkynylsubstituted with one or more halogens and, combined, unsubstitutedcycloalkyl and cycloalkenyl. Also preferably, Ar₁ is selected from thegroup consisting of phenyl, naphthyl, indolyl, fluorenyl,dibenzofuranyl, carbazolyl, benzoxazole-2-yl, benzthiazole-2-yl,pyridin-4-yl, quinolin-2-yl and dibenzylamino and Ar₂ is selected fromthe group consisting of phenyl, naphthyl, quinolin-4-yl, pyridin-2-yl,pyridin-3-yl, pyridin-4-yl, pyrimidinyl, furan-2-yl, furan-3-yl,thiophen-2-yl, thiophen-3-yl, pyrrol-2-yl and pyrrol-3-yl. Morepreferably, Ar₁ is phenyl substituted with one or more groups selectedfrom the group consisting of unsubstituted lower alkyl, halogen,trihalomethyl, unsubstituted lower alkoxy, trihalomethoxy, trihaloacetyland nitro, and Ar₂ is selected from the group consisting of optionallysubstituted phenyl and optionally substituted naphthyl. Even morepreferably, Ar₂ is 3-methoxyphenyl or unsubstituted naphthyl.Preferably, R⁸ is hydrogen, R⁹ is methyl and X is oxygen or sulfur.

[0068] In another aspect, the present invention provides a compound ofthe formula:

Ar₃—(CHR¹²)_(r)—Q—(CH₂)_(s)—CHR¹³—NH—CR¹⁴R¹⁵—Ar₄  (2)

[0069] wherein:

[0070] Ar₃ is selected from the group consisting of aryl and heteroaryloptionally substituted with one or more groups independently selectedfrom the group consisting of unsubstituted lower alkyl, lower alkylsubstituted with one or more halogens, unsubstituted lower alkenyl,lower alkenyl substituted with one or more halogens, halogen, hydroxy,unsubstituteci lower alkoxy, lower alkoxy substituted with one or morehalogens, unsubstituted lower thioalkoxy, nitro, formyl, acetoxy,acetyl, —CH₂OH, CH₃CH(OH)—, —(═O)NH₂, cyano, —N(lower alkyl)₂, phenyl,phenoxy, benzyl, benzyloxy, methylenedioxy, ethylenedioxy, ca,α-dimethylbenzyl, and —OCH₂COOH;

[0071] Ar₄ is selected from the group consisting of aryl and heteroaryloptionally substituted with one or more groups independently selectedfrom the group consisting of unsubstituted lower alkyl, lower alkylsubstituted with one or more halogens, unsubstituted lower alkenyl,lower alkenyl substituted with one or more halogens, unsubstituted loweralkoxy, lower alkoxy substituted with one or more halogens, hydroxy,lower thioalkoxy, halogen; methylenedioxy, ethylenedioxy, acetoxy,—OCH₂COOH, —C(═O)NH₂, cyano, and —CH₂OH;

[0072] r is an integer of from 0 to 6, inclusive;

[0073] s is an integer of from 0 to 14, inclusive;

[0074] Q is selected from the group consisting of oxygen, sulfur,carbonyl and —NH—;

[0075] R¹³ is hydrogen or lower alkyl; and

[0076] R¹⁴ and R¹⁵ are independently selected from the group consistingof hydrogen, alkyl and, combined, cycloalkyl and cycloalkenyl;

[0077] or a pharmaceutically acceptable salt or hydrate of saidcompound.

[0078] Preferably, in the formula (2), Ar₃ is selected from the groupsconsisting of unsubstituted phenyl, phenyl substituted with one or moregroups selected from the group consisting of unsubstituted lower alkyl,lower alkyl substituted with one or more halogens, halogen,unsubstituted lower alkoxy, lower alkoxy substituted with one or morehalogens, nitro, dimethylamino and unsubstituted phenyl, and optionallysubstituted naphthyl; and Ar₄ is selected from the groups consisting ofunsubstituted phenyl, phenyl substituted with one or more groupsselected from the group consisting of unsubstituted lower alkyl, loweralkyl substituted with one or more halogens, unsubstituted lower alkoxy,lower alkoxy substituted with one or more halogens, and halogen, andoptionally substituted naphthyl.

[0079] In another aspect, the present invention provides a compound ofthe formula:

Ar₅—(CHR¹⁶)_(t)—W—(CH₂)_(u)—CHR¹⁷—NH—CH(R¹⁸)—Ar₆  (3)

[0080] wherein:

[0081] Ar₅ is aryl, dicyclic or tricyclic heteroaryl,arylmethyl(arylmethyl)amino, heteroarylmethy(heteroarylmethyl) amino or

[0082] arylmethyl(heteroarylmethyl)amino optionally substituted with oneor more groups independently selected from the group consisting ofunsubstituted lower alkyl, unsubstituted lower alkenyl, halogen,hydroxy, unsubstituted lower alkoxy, unsubstituted lower thicalkoxy,lower alkyl substituted with one or more halogens, lower alkenylsubstituted with one or more halogens, lower alkoxy substituted with oneor more halogens, nitro, formyl, acetoxy, acetyl, —CH₂OH, CH₃CH(OH)—,—C(═O)NH₂, cyano, -N(unsubstituted lower alkyl)₂, phenyl, phenoxy,benzyl, benzyloxy, α, α-dimethylbenzyl, methylenedioxy, ethylenedioxyand —OCH₂COOH;

[0083] Ar₆ is aryl or dicyclic or tricyclic heteroaryl optionallysubstituted with one or more groups independently selected from thegroup consisting of unsubstituted lower alkyl, lower alkyl substitutedwith one or more halogens, unsubstituted lower alkenyl, lower alkenylsubstituted with one or more halogens, unsubstituted lower alkoxy, loweralkoxy substituted with one or more halogens, halogen, hydroxy,unsubstituted lower thioalkoxy, lower thioalkoxy substituted with one ormore halogens, benzyloxy, methylenedioxy, ethylenedioxy, acetoxy,—OCH₂COOH, —C(═O)NH₂, cyano, and —CH₂OH;

[0084] t is 0 or 1;

[0085] u is an integer of from 0 to 11, inclusive;

[0086] W is selected from.the group consisting of oxygen, sulfur,sulfinyl, sulfonyl, carbonyl and amino;

[0087] R¹⁶ and R¹⁷ are H or unsubstituted lower alkyl; and

[0088] R¹⁸ is unsubstituted lower alkyl;

[0089] or a pharmaceutically acceptable salt or hydrate of saidcompound.

[0090] Preferably, in the formula (3), Ar₅ is phenyl, indole,benzothiazcole, benzoxazole, dibenzofuran, carbazole, pyridine,fluorene, quinoline, naphthalene, chromenone, tetrahydrobenzothiazepine,dibenzylamino, benzyl(naphthylmethyl)amino, benzyl(pyridylmethyl)amino,thienylmethyl(benzyl)amino, furylmethyl(benzyl)amino orN-alkyl-pyrrolylmethyl(benzyl)amino optionally substituted with one ormore groups independently selected from the group consisting ofunsubstituted lowsr alkyl, halogen, unsubstituted lower alkoxy, loweralkyl substituted with one or more halogens, lower alkoxy substitutedwith one or more halogens, nitro, dimethylamino and unsubstitutedphenyl; and Ar₆ is thiophene, furan, pyrrole, phenyl, naphthalene,pyridine, pyrazine or thiazole optionally substituted with one or moregroups independently selected from the group consisting of unsubstitutedlower alkyl, halogen, unsubstituted lower alkoxy, lower alkylsubstituted with one or more halogens, lower alkoxy substituted with oneor more halogens, hydroxy and benzyloxy optionally substituted withhalogen or methyl. More preferably, Ar₅ is selected from the groupconsisting of phenyl optionally substituted with one or more groupsindependently selected from the group consisting of unsubstituted loweralkyl, halogen, unsubstituted lower alkoxy, lower alkyl substituted withone or more halogens and lower alkoxy substituted with one or morehalogens; and Ar₆ is 3-methoxyphenyl or α-naphthyl, more preferably,α-naphthyl. Also preferably, Ar₅ is dibenzylamino, benzyl (naphthylmethyl) amino or benzyl(pyridylmethyl)amino optionally substituted withone or more groups independently selected from the group consisting ofunsubstituted lower alkyl, halogen, unsubstituted lower alkoxy, loweralkyl substituted with one or more halogens and lower alkoxy substitutedwith one or more halogens, and Ar₆ is naphthyl or methoxyphenyl. Morepreferably, Ar₅ is dibenzylamino optionally substituted withunsubstituted alkyl, and Ar₆ is α-naphthyl.

[0091] Preferably, the compound of the present invention represented bythe formulae (1), (2) or (3) is the R enantiomer. The present inventionalso provides a prodrug of any of the compounds described above.

[0092] The present invention provides a method for modulating calciumreceptor activity by using a compound described herein. The featuredcompounds preferably modulate an interaction of Ca²⁺ with Ca²⁺ receptorsby mimicking (including potentiating) the effect of Ca²⁺ on a Ca²⁺receptor (calcimimetic modulation) or blocking the effect of Ca²⁺ on aCa²⁺ receptor (calcilytic modulation); preferably calcimimeticmodulation.

[0093] Also provided is a method for the treatment in a patient ofdisorders characterized by an abnormal concentrations of one or moreinorganic ions or other physiological biochemical substances, theconcentration of which is regulated by an activity of one or morecalcium receptors. In particular, treatment using the compoundsdisclosed hereof is contemplated for disorders characterized by abnormalextracellular Ca²⁺ concentration ([Ca²⁺]) or abnormal intracellular Ca²⁺concentration ([Ca²⁺]_(i)) in one or more cells including for example,but without limitation, parathyroid cells, bone osteoclasts,juxtaglomerular kidney cells, proximal tubule kidney cells,keratinocytes, parafollicular thyroid cells and placental trophoblasts.

[0094] An “abnormal” state is characterized by a level of a propertythat is statistically different from the level of that property observedin patients not suffering from a particular disorder. Thus, for example,the term “abnormal” as it relates to inorganic ion concentrations refersto a concentration of the ion in question which would be recognized bymembers of the medical community as being outside the normal range ofsuch ion concentration in healthy patients.

[0095] As used herein, the terms “treat”, “treating” and “treatment”refer to a method of alleviating, abrogating, and/or having aprophylactic effect with regard to, a disease or disorder and/or one ormore, preferably all, its attendant symptoms.

[0096] In another aspect, the present invention provides a method forthe treatment or prevention of primary and secondaryhyperparathyroidism, renalosteodystrophy, hypercalcemia malignancy,osteoporosis, Paget's disease and hypertension comprising administeringa therapeutically effective amount of a compound of this invention to apatient.

[0097] The term “administering” as used herein refers to a method forintroducing a compound of this invention in vitro or in vivo. Thus, forexample, the importance of inorganic ion receptor activity can bestudied and associated diseases and disorders prevented or treated bythe compounds and methods set forth herein. Cells existing outside theorganism can be maintained or grown in cell culture dishes. In thiscontext, the ability of a particular compound to affect an inorganic ionreceptor activity can be determined; i.e., the IC50 or EC50, preferablythe EC50, of a compound, defined below, before the use of the compoundsin complex multicellular living organisms such as a human is attempted.For cells outside the organism, multiple methods exist, and arewell-known to those skilled in the arts, to administer compoundsincluding, but not limited to, cell micro-injection, transformation andnumerous carrier techniques.

[0098] For cells harbored within a multicellular living organism, myriadmethods also exist, and are likewise well-known to those skilled in theart, to administer compounds including, but not limited to, oral,parenteral, dermal, injection and aerosol applications.

[0099] The present invention features a method for the modulation of oneor more activities of an inorganic ion receptor using the compoundsdisclosed herein. Preferably, the inorganic ion receptor is a Ca²⁺receptor. The compounds of this invention can either mimic (includingpotentiation) or block the effect of extracellular Ca²⁺ on a calciumreceptor. The preferred use of such compounds is to treat selecteddisorders by modulating the inorganic ion receptor activity. Inparticular the compounds of this invention can be used to treat theindicated disorders by modulating Ca²⁺ receptor activity.

[0100] Extracellular Ca²⁺ is under tight homeostatic control andcontrols various processes such as blood clotting, nerve and muscleexcitability, and proper bone formation. Calcium receptor proteinsenable certain specialized cells to respond to changes in extracellularCa²⁺ concentration. For example, extracellular Ca²⁺ inhibits thesecretion of parathyroid hormone from parathyroid cells, inhibits boneresorption by osteoclasts, and stimulates secretion of calcitonin fromC-cells.

[0101] Compounds modulating inorganic ion receptor activity can be usedto treat diseases or disorders by affecting one or more activities of aninorganic ion receptor resulting in a beneficial effect to the patient.For example, osteoporosis is an age related disorder characterized byloss of bone mass and increased risk of bone fracture. Compoundsblocking osteoclastic bone resorption either directly (e.g., aosteoclast ionmimetic compound) or indirectly by increasing endogenouscalcitonin levels (e.g., a C-cell ionmimetic), and/or by decreasingparathyroid hormone levels (e.g., a parathyroid cell ionmimetic). canretard bone loss and, thus, result in beneficial effects to patientssuffering from osteoporosis.

[0102] In addition, it is known that intermittent low dosing with PTHresults in an anabolic effect on bone mass and appropriate boneremodeling. Thus, compounds and dosing regiments evoking transientincreases in parathyroid hormone (e.g., intermittent dosing with aparathyroid cell ionlytic) can increase bone mass in patients sufferingfrom osteoporosis.

[0103] Additionally, diseases or disorders characterized by a defect inone or more inorganic ion receptor activities may be treated by thepresent invention. For example, certain forms of primaryhyperparathyroidism are characterized by abnormally high levels ofparathyroid hormone and decreased parathyroid gland responsiveness tocirculating calcium. Calcium receptor modulating agents can be used tomodulate parathyroid cell responsiveness to calcium.

[0104] Preferably, the compound modulates calcium receptor activity andis used in the treatment of diseases or disorders which can be affectedby modulating one or more activities of a calcium receptor. Preferably,the disease or disorder is characterized by abnormal bone and mineralhomeostasis, more preferably calcium homeostasis.

[0105] Abnormal calcium homeostasis is characterized by one or more ofthe following activities: (1) an abnormal increase or decrease in serumcalcium; (2) an abnormal increase or decrease in urinary excretion ofcalcium; (3) an abnormal increase or decrease in bone calcium levels,for example, as assessed by bone mineral density measurements; (4) anabnormal absorption of dietary calcium; and (5) an abnormal increase ordecrease in the production and/or release of circulating messengers orhormones which affect calcium homeostasis such as parathyroid hormoneand calcitonin. The abnormal increase or decrease in these differentaspects of calcium homeostasis is relative to that occurring in thegeneral population and is generally associated with a disease ordisorder.

[0106] More generally, a molecule which modulates the activity of aninorganic ion receptor is useful in the treatment of diseasescharacterized by abnormal inorganic ion homeostasis. Preferably, themolecule modulates one or more effects of an inorganic ion receptor.Inorganic ion receptor modulating agents include ionmimetics, ionlytics,calcimimetics, and calcilytics.

[0107] Ionmimetics are molecules which mimic the effects of increasingion concentration at an inorganic ion receptor. Preferably, the moleculeaffects one or more calcium receptor activities. Calcimimetics areionmimetics which affect one or more calcium receptor activities andpreferably binds to a calcium receptor.

[0108] Ionlytics are molecules which reduce or block one or moreactivities caused by an inorganic ion on an inorganic ion receptor.Preferably, the molecule inhibits one or more calcium receptoractivities. Calcilytics are ionlytics which inhibit one or more calciumreceptor activities evoked by extracellular calcium and preferably bindto a calcium receptor.

[0109] Inorganic ion receptor modulating agents can be formulated aspharmacological agents or compositions to facilitate administration in apatient. Pharmacological agents or compositions are agents orcompositions in a form suitable for administration into a mammal,preferably a human. considerations concerning forms suitable foradministration are known in the art and include toxic effects,solubility, route of administration, and maintaining activity.

[0110] Other aspects of the present invention feature methods for usingthe agents described herein for treating diseases or disorders bymodulating inorganic ion receptor activity. Patients in need of suchtreatments can be identified by standard medical techniques, such asroutine blood analysis. For example, by detecting a deficiency ofprotein whose production or secretion is affected by changes ininorganic ion concentrations, or by detecting abnormal levels ofinorganic ions or hormones which effect inorganic ion homeostasis.

[0111] Therapeutic methods involve administering to the patient atherapeutically effective amount of an inorganic ion receptor modulatingagent. In preferred embodiments these methods are used to treat adisease or disorder characterized by abnormal inorganic ion homeostasis,more preferably a disease or disorder characterized by abnormal calciumhomeostasis. Diseases and disorders characterized by abnormal calciumhomeostasis include hyperparathyroidism, osteoporosis,renalosteodystrophy and other bone and mineral-related disorders, andthe like (as described, e.g., in standard medical text books, such as“Harrison's Principles of Internal Medicine”). Such diseases anddisorders are treated using calcium receptor modulating agents whichmimic or block one or more of the effects of Ca²⁺ and, thereby, directlyor indirectly affect the levels of proteins or other molecules in thebody of the patient.

[0112] By “therapeutically effective amount” is meant an amount of anagent which relieves to some extent one or more symptoms of the diseaseor disorder in the patient: or returns to normal either partially orcompletely one or more physiological or biochemical parametersassociated with or causative of the disease or disorder.

[0113] In a preferred embodiment, the patient has a disease or disordercharacterized by an abnormal level of one or more calcium receptorregulated components and the molecule is active on a. calcium receptorof a cell selected from the group consisting of parathyroid cell, boneosteoclast, juxtaglomerular kidney cell, proximal tubule kidney cell,distal tubule kidney cell, central nervous system cell, peripheralnervous system cell, cell of the thick ascending limb of Henle's loopand/or collecting duct, keratinocyte in the epidermis, parafollicularcell in the thyroid (C-cell), intestinal cell, trophoblast in theplacenta, platelet, vascular smooth muscle cell, cardiac atrial cell,gastrin-secreting cell, glucagon-secreting cell, kidney mesangial cell,mammary cell, beta cell, fat/adipose cell, immune cell and GI tractcell.

[0114] More preferably, the cell is a parathyroid cell and the moleculereduces the level of parathyroid hormone in the serum of the patient,even more preferably the level is reduced to a degree sufficient tocause a decrease in plasma Ca²⁺, most preferably the parathyroid hormonelevel is reduced to that present in a normal individual.

[0115] Thus, the present invention features agents and methods useful inthe treatment of diseases and disorders by modulating inorganic ionreceptor activity. For example, the molecules of the present inventioncan be used to target calcium receptors on different cell types thatdetect and respond to changes to external calcium. For example,molecules mimicking external calcium may be used to selectively depresssecretion of parathyroid hormone from parathyroid cells, or depress boneresorption by osteoclasts, or stimulate secretion of calcitonin fromC-cells. Such molecules can be used to treat diseases or disorderscharacterized by abnormal calcium homeostasis such ashyperparathyroidism, renalosteodystrophy and osteoporosis.

[0116] Other features and advantages of the invention will be apparentfrom the following description of the preferred embodiments thereof andfrom the claims.

BRIEF DESCRIPTION OF DRAWINGS

[0117]FIG. 1 shows the structures of the compounds of the presentinvention synthesized in Examples 1 to 23.

[0118]FIG. 2 shows the scheme of the synthesis of the compound of thepresent invention of the formula (1) wherein X is O.

[0119]FIG. 3 shows the scheme of the synthesis of the compound of thepresent invention of the formula (1) wherein X is S.

[0120]FIG. 4 shows the scheme of the synthesis of the compound of thepresent invention of the formula (1) wherein Ar₁ is benzothiazole orbenzoxazole.

[0121]FIG. 5 shows the structures of the compounds of the presentinvention synthesized in Examples 24 to 26 and the scheme of thesynthesis thereof.

[0122]FIG. 6 shows the structures of the compounds of the presentinvention synthesized in Examples 27 to 32 and the scheme of thesynthesis thereof.

[0123]FIG. 7 shows the structures of the compounds of the presentinvention synthesized in Examples 33 to 36 and the scheme of thesynthesis thereof.

[0124]FIG. 8 shows the structures of the compounds of the presentinvention synthesized in Examples 37 to 40 and the scheme of thesynthesis thereof.

[0125]FIG. 9 shows the structures of the compounds of the presentinvention synthesized in Examples 41 and 42 and the scheme of thesynthesis thereof.

[0126]FIG. 10 shows the structures of the compounds of the presentinvention synthesized in Examples 43 to 56.

[0127]FIG. 11 shows the structures of the compounds of the presentinvention synthesized in Examples 57 to 70.

[0128]FIG. 12 shows the structures of the compounds of the presentinvention synthesized in Examples 71 to 84.

[0129]FIG. 13 shows the structures of the compounds of the presentinvention synthesized in Examples 85 and 86.

[0130]FIG. 14 shows the structure of the compound of the presentinvention synthesized in Example 88 and the scheme of the synthesisthereof.

[0131]FIG. 15 shows the structures of the compounds of the presentinvention synthesized in Examples 89 and 90.

[0132]FIG. 16 shows the structure of the compound of the presentinvention synthesized in Examples 91 to 93 and the scheme of thesynthesis thereof.

[0133]FIG. 17 shows the structures of the compounds of the presentinvention synthesized in Examples 94 to 96 and the scheme of thesynthesis thereof.

[0134]FIG. 18 shows the structures of the compounds of the presentinvention synthesized in Examples 97 to 100 and the scheme of thesynthesis thereof.

[0135]FIG. 19 shows the structures of the compounds of the presentinvention synthesized in Examples 101 to 103 and the scheme of thesynthesis thereof.

[0136]FIG. 20 shows the structures of the compounds of the presentinvention synthesized in Examples 104 to 106 and the scheme of thesynthesis thereof.

[0137]FIG. 21 shows the structures of the compounds of the presentinvention synthesized in Examples 107 to 109 and the scheme of thesynthesis thereof.

[0138]FIG. 22 shows the structures of the compounds of the presentinvention synthesized in Examples 110 to 112 and the scheme of thesynthesis thereof.

[0139]FIG. 23 shows the structures of the compounds of the presentinvention synthesized in Examples 113 to 115 and the scheme of thesynthesis thereof.

[0140]FIG. 24 shows the structures of the compounds of the presentinvention synthesized in Examples 116 to 118 and the scheme of thesynthesis thereof.

[0141]FIG. 25 shows the structures of the compounds of the presentinvention synthesized in Examples 119 to 121 and the scheme of thesynthesis thereof.

[0142]FIG. 26 shows the structures of the compounds of the presentinvention synthesized in Examples 122 to 134.

[0143]FIG. 27 shows the structures of the compounds of the presentinvention synthesized in Examples 135 to 147.

[0144]FIG. 28 shows the structures of the compounds of the presentinvention synthesized in Examples 148 to 189.

[0145]FIG. 29 shows the structures of the compounds of the presentinvention synthesized in Examples 190 to 231.

[0146]FIG. 30 shows the structures of the compounds of the presentinvention synthesized in Examples 232 to 271.

[0147]FIG. 31 shows the structures of the compounds of the presentinvention synthesized in Examples 272 to 313.

[0148]FIG. 32 shows the structures of the compounds of the presentinvention synthesized in Examples 314 to 355.

[0149]FIG. 33 shows the structures of the compounds of the presentinvention synthesized in Examples 356 to 387.

[0150]FIG. 34 shows the structures of the compounds of the presentinvention synthesized in Examples 388 to 407.

[0151]FIG. 35 shows the structures of the compounds of the presentinvention synthesized in Examples 408 to 413.

[0152]FIG. 36 shows the structures of the compounds of the presentinvention synthesized in Examples 416 to 428.

[0153]FIG. 37 shows the structures of the compounds of the presentinvention synthesized in Examples 429 to 441.

[0154]FIG. 38 shows the structures of the compounds of the presentinvention synthesized in Examples 442 to 455.

[0155]FIG. 39 shows the structures of the compounds of the presentinvention synthesized in Examples 456 to 469.

[0156]FIG. 40 shows the structures of the compounds of the presentinvention synthesized in Examples 470 to 480.

[0157]FIG. 41 shows the structures of the compounds of the presentinvention synthesized in Examples 481 to 490.

[0158]FIG. 42 shows the structures of the compounds of the presentinvention synthesized in Examples 491 to 495.

[0159]FIG. 43 shows the structures of the compounds of the presentinvention synthesized in Examples 496 to 504.

[0160]FIG. 44 shows the structures of the compounds of the presentinvention synthesized in Examples 505 to 517.

[0161]FIG. 45 shows the structures of the compounds of the presentinvention synthesized in Examples 518 to 529.

[0162]FIG. 46 shows changes in the plasma Ca²⁺ level of the rats towhich the compound of the present invention K-2027 was administered.

[0163]FIG. 47 shows changes in the plasma Ca²⁺ level of the rats towhich the compound of the present invention K-2052 was administered.

[0164]FIG. 48 shows changes in the plasma Ca²⁺ level of the rats towhich the compound of the present invention K-2076 was administered.

[0165]FIG. 49 shows changes in the plasma Ca²⁺ level of the rats towhich the compound of the present invention K-2087 was administered.

[0166]FIG. 50 shows changes in the plasma Ca²⁺ level of the rats towhich the compound of the present invention K-2117 was administered.

[0167]FIG. 51 shows changes in the plasma Ca²⁺ level of the rats towhich the compound of the present invention K-2240 was administered.

[0168]FIG. 52 shows changes in the plasma Ca²⁺ level of the rats towhich the compound of the present invention K-2243 was administered.

[0169]FIG. 53 shows changes in the plasma Ca²⁺ level of the rats towhich the compound of the present invention K-2246 was administered.

[0170]FIG. 54 shows changes in the plasma Ca²⁺ level of the rats towhich the compound of the present invention K-2247 was administered.

[0171]FIG. 55 shows changes in the plasma Ca²⁺ level of the rats towhich the compound of the present invention K-2250 was administered.

[0172]FIG. 56 shows changes in the plasma Ca²⁺ level of the rats towhich the compound of the present invention K-2257 was administered.

[0173]FIG. 57 shows changes in the plasma Ca²⁺ level of the rats towhich the compound of the present invention K-2259 was administered.

[0174]FIG. 58 shows changes in the plasma Ca²⁺ level of the rats towhich the compound of the present invention K-2262 was administered.

[0175]FIG. 59 shows changes in the plasma Ca²⁺ level of the rats towhich the compound of the present invention K-2263 was administered.

[0176]FIG. 60 shows changes in the plasma Ca²⁺ level of the rats towhich the compound of the present invention K-2264 was administered.

[0177]FIG. 61 shows changes in the plasma Ca²⁺ level of the rats towhich the compound of the present invention K-2265 was administered.

[0178]FIG. 62 shows changes in the plasma Ca²⁺ level of the rats towhich the compound of the present invention K-2266 was administered.

[0179]FIG. 63 shows changes in the plasma Ca²⁺ level of the rats towhich the compound of the present invention K-2267 was administered.

[0180]FIG. 64 shows changes in the plasma Ca²⁺ level of the rats towhich the compound of the present invention K-2269 was administered.

[0181]FIG. 65 shows changes in the plasma Ca²⁺ level of the rats towhich the compound of the present invention K-2270 was administered.

[0182]FIG. 66 shows changes in the plasma Ca²⁺ level of the rats towhich the compound of the present invention K-2271 was administered.

[0183]FIG. 67 shows changes in the plasma Ca²⁺ level of the rats towhich the compound of the present invention K-2272 was administered.

[0184]FIG. 68 shows changes in the plasma Ca²⁺ level of the rats towhich the compound of the present invention K-2279 was administered.

[0185]FIG. 69 shows changes in the plasma Ca²⁺ level of the rats towhich the compound of the present invention K-2280 was administered.

[0186]FIG. 70 shows changes in the plasma Ca²⁺ level of the rats towhich the compound of the present invention K-2281 was administered.

[0187]FIG. 71 shows changes in the plasma Ca²⁺ level of the rats towhich the compound of the present invention K-2282 was administered.

[0188]FIG. 72 shows changes in the plasma Ca²⁺ level of the rats towhich the compound of the present invention K-2283 was administered.

[0189]FIG. 73 shows changes in the plasma Ca²⁺ level of the rats towhich the compound of the present invention K-2284 was administered.

[0190]FIG. 74 shows changes in the plasma Ca²⁺ level of the rats towhich the compound of the present invention K-2286 was administered.

[0191]FIG. 75 shows changes in the plasma Ca²⁺ level of the rats towhich the compound of the present invention K-2287 was administered.

[0192]FIG. 76 shows changes in the plasma Ca²⁺ level of the rats towhich the compound of the present invention K-2288 was administered.

[0193]FIG. 77 shows changes in the plasma Ca²⁺ level of the rats towhich the compound of the present invention K-2289 was administered.

[0194]FIG. 78 shows changes in the plasma Ca²⁺ level of the rats towhich the compound of the present invention K-2290 was administered.

[0195]FIG. 79 shows changes in the plasma Ca²⁺ level of the rats towhich the compound of the present invention K-2291 was administered.

[0196]FIG. 80 shows changes in the plasma Ca²⁺ level of the rats towhich the compound of the present invention K-2292 was administered.

[0197]FIG. 81 shows changes in the plasma Ca²⁺ level of the rats towhich the compound of the present invention K-2293 was administered.

[0198]FIG. 82 shows changes in the plasma Ca²⁺ level of the rats towhich the compound of the present invention K-2294 was administered.

[0199]FIG. 83 shows changes in the plasma Ca²⁺ level of the rats towhich the compound of the present invention K-2296 was administered.

[0200]FIG. 84 shows changes in the plasma Ca²⁺ level of the rats towhich the compound of the present invention K-2297 was administered.

[0201]FIG. 85 shows changes in the plasma Ca²⁺ level of the rats towhich the compound of the present invention K-2298 was administered.

[0202]FIG. 86 shows changes in the plasma Ca²⁺ level of the rats towhich the compound of the present invention K-2299 was administered.

[0203]FIG. 87 shows changes in the plasma Ca²⁺ level of the rats towhich the compound of the present invention K-2300 was administered.

[0204]FIG. 88 shows changes in the plasma Ca²⁺ level of the rats towhich the compound of the present invention K-2301 was administered.

[0205]FIG. 89 shows changes in the plasma Ca²⁺ level of the rats towhich the compound of the present invention K-2302 was administered.

[0206]FIG. 90 shows changes in the plasma Ca²⁺ level of the rats towhich the compound of the present invention K-2303 was administered.

[0207]FIG. 91 shows changes in the plasma Ca²⁺ level of the rats towhich the compound of the present invention K-2304 was administered.

[0208]FIG. 92 shows changes in the plasma Ca²⁺ level of the rats towhich the compound of the present invention K-2305 was administered.

[0209]FIG. 93 shows changes in the plasma Ca²⁺ level of the rats towhich the compound of the present invention K-2309 was administered.

[0210]FIG. 94 shows changes in the plasma Ca²⁺ level of the rats towhich the compound of the present invention K-2310 was administered.

[0211]FIG. 95 shows changes in the serum PTH level of the rats to whichthe compound of the present invention K-2076, K-2117 or K-2259 wasadministered.

[0212]FIG. 96 shows relative changes in the serum PTH level of the ratsto which the compound of the present invention K-2076, K-2117 or K-2259was administered to the pre-administration level.

PREFERRED EMBODIMENTS OF THE INVENTION

[0213] The present invention describes inorganic ion receptor modulatingagents able to mimic or block an effect of an inorganic ion at aninorganic ion receptor. The preferred use of inorganic ion receptormodulating agents is to treat a disease or disorder by modulatinginorganic ion receptor activity. Preferably, the molecules are used totreat diseases or disorders characterized by abnormal ion homeostasis,more preferably abnormal calcium homeostasis. Other uses of inorganicion receptor modulating agents, such as diagnostics uses, are known inthe art. Nemeth et al., PCT/US93/01642, International Publication NumberWO 94/18959.

I. CALCIUM RECEPTORS

[0214] Calcium receptors and nucleic acid encoding calcium receptors aredescribed by Nemeth et al., PCT/US93/01642, International PublicationNumber WO 94/18959. Calcium receptors are present on different celltypes such as parathyroid cell, bone osteoclast, juxtaglomerular kidneycell, proximal tubule kidney cell, distal tubule kidney cell, centralnervous system cell, peripheral nervous system cell, cell of the thickascending limb of Henle's loop and/or collecting duct, keratinocyte inthe epidermis, parafollicular cell in the thyroid (C-cell), intestinalcell, trophoblast in the placenta, platelet, vascular smooth musclecell, cardiac atrial cell, gastrin-secreting cell, glucagon-secretingcell, kidney mesangial cell, mammary cell, beta cell, fat/adipose cell,immune cell, and GI tract cell. The calcium receptor on these cell typesmay be different. It is also possible that a cell can have more than onetype of calcium receptor.

[0215] Comparison of calcium receptor activities and amino acidsequences from different cells indicate that distinct calcium receptortypes exist. For example, calcium receptors can respond to a variety ofdi- and trivalent cations. The parathyroid calcium receptor responds tocalcium and Gd³⁺, while osteoclasts respond to divalent cations such ascalcium but does not respond to Gd³⁺. Thus, the parathyroid calciumreceptor is pharmacologically distinct from calcium receptor on theosteoclast.

[0216] On the other hand, the nucleic acid sequences encoding calciumreceptors present in parathyroid cells and C-cells indicate that thesereceptors have a very similar amino acid structure. Nevertheless,calcimimetic compounds exhibit differential pharmacology and regulatedifferent activities at parathyroid cells and C-cells. Thus,pharmacological properties of calcium receptors may vary significantlydepending upon the cell type or organ in which they are expressed eventhough the calcium receptors may have similar structures.

[0217] Calcium receptors, in general, have a low affinity forextracellular Ca²⁺ (apparent K_(d) generally greater than about 0.5 mM).Calcium receptors may include a free or bound effector mechanism asdefined by Cooper, Bloom and Roth, “The Biochemical Basis ofNeuropharmacology”, Ch. 4, and are thus distinct from intracellularcalcium receptors, e.g., calmodulin and the troponins.

[0218] Calcium receptors respond to changes in extracellular calciumlevels. The exact changes depend on the particular receptor and cellline containing the receptor. For example, the in vitro effect ofcalcium on the calcium receptor in a parathyroid cell include thefollowing:

[0219] 1. An increase in internal calcium. The increase is due to theinflux of external calcium and/or mobilization of internal calcium.Characteristics of the increase in internal calcium include thefollowing:

[0220] (a) A rapid (time to peak <5 seconds) and transient increase in[Ca²⁺]_(i), that is refractory to inhibition by 1 mM La³⁺ or 1 mM Gd³⁺and is abolished by pretreatment with ionomycin (in the absence ofextracellular Ca²⁺);

[0221] (b) The increase is not inhibited by dihydropyridines;

[0222] (c) The transient increase is abolished by pretreatment for 10minutes with 10 mM sodium fluoride;

[0223] (d) The transient increase is diminished by pretreatment with anactivator of protein kinase C (PKC), such as phorbol myristate acetate(PMA), mezerein or (−)-indolactam V. The overall effect of the proteinkinase C activator is to shift the concentration-response curve tocalcium to the right without affecting the maximal response; and

[0224] (e) Treatment with pertussis toxin (100 ng/ml for >4 hours) doesnot affect the increase.

[0225] 2. A rapid (<30 seconds) increase in the formation ofinositol-1,4,5-triphosphate or diacylglycerol. Treatment with pertussistoxin (100 ng/ml for >4 hours) does not affect this increase;

[0226] 3. The inhibition of dopamine- and isoproterenol-stimulatedcyclic AMP formation. This effect is blocked by pretreatment withpertussis toxin (100 ng/ml for >4 hours); and

[0227] 4. The inhibition of PTH secretion. Treatment with pertussistoxin (100 ng/ml for >4 hours) does not affect the inhibition in PTHsecretion.

[0228] Using techniques known in the art, the effect of calcium on othercalcium receptors in different cells can be readily determined. Sucheffects may be similar in regard to the increase in internal calciumobserved in parathyroid cells. However, the effect is expected to differin other aspects, such as causing or inhibiting the release of a hormoneother than parathyroid hormone.

II. INORGANIC ION RECEPTOR MODULATING AGENTS

[0229] Inorganic ion receptor modulating agents either evokes one ormore inorganic ion receptor activities, or blocks one or more inorganicion receptor activities caused by an extracellular inorganic ion.Calcium receptor modulating agents can mimic or block an effect ofextracellular Ca²⁺ on a calcium receptor. Preferred calcium receptormodulating agents are calcimimetics and calcilytics.

[0230] Inorganic ion receptor modulating agents can be identified byscreening molecules which are modeled after a molecule shown to have aparticular activity (i.e., a lead molecule). Nemeth et al.,PCT/US93/01642, International Publication Number WO 94/18959.

[0231] Preferred inorganic ion receptor modulation agents described bythe present invention have considerably low EC₅₀ values.

[0232] The EC₅₀ is the concentration of the molecule which evokes ahalf-maximal effect. The IC₅₀ is the concentration of molecule whichcauses a half-maximal blocking effect. The EC₅₀ or IC₅₀ can bedetermined by assaying one or more of the activities of an inorganic ionat an inorganic ion receptor. Preferably, such assays are specific to aparticular calcium receptor. For example, assays which measure hormoneswhose production or secretion is modulated by a particular inorganic ionreceptor are preferred.

[0233] Increases in [Ca²⁺]_(i) can be detected using standard techniquessuch as by using fluorimetric indicators or by measuring an increase inCl⁻ current in a Xenopus oocyte injected with nucleic acid coding for acalcium receptor. Nemeth et al., PCT/US93/01642, InternationalPublication Number WO 94/18959. For example, poly(A)⁺ mRNA can beobtained from cells expressing a calcium receptor, such as a parathyroidcell, bone osteoclast, juxtaglomerular kidney cell, proximal tubulekidney cell, distal tubule kidney cell, cell of the thick ascending limbof Henle's loop and/or collecting duct, keratinocyte in the epidermis,parafollicular cell in the thyroid (C-cell), intestinal cell, centralnervous system cell, peripheral nervous system cell, trophoblast in theplacenta, platelet, vascular smooth muscle cell, cardiac atrial cell,gastrin-secreting cell, glucagon-secreting cell, kidney mesangial cell,mammary cell, beta cell, fat/adipose cell, immune cell, and GI tractcell. Preferably, the nucleic acid is from a parathyroid cell, C-cell,or osteoclast. More preferably, the nucleic acid encodes a calciumreceptor and is present on a plasmid or vector.

[0234] Preferably, the molecule is either a calcimimetic or calcilytichaving an EC₅₀ or IC₅₀ at a calcium receptor of less than or equal to 5mM, and even more preferably less than or equal to 1 mM, 100 nmolar, 10nmolar, or 1 nmolar. Such lower EC₅₀'s or IC₅₀'s are advantageous sincethey allow lower concentrations of molecules to be used in vivo or invitro for therapy or diagnosis. The discovery of molecules with such lowEC₅₀'s and IC₅₀'s enables the design and synthesis of additionalmolecules having similar potency and effectiveness.

[0235] In preferred embodiments the calcium receptor modulating agent isa calcimimetic which inhibits parathyroid hormone secretion from aparathyroid cell in vitro and decreases PTH secretion in vivo;stimulates calcitonin secretion from a C-cell in vitro and elevatescalcitonin levels in vivo; or blocks osteoclastic bone resorption invitro and inhibits bone resorption in vivo.

[0236] In another preferred embodiment the calcium receptor modulatingagent is a calcilytic which evokes the secretion of parathyroid hormonefrom parathyroid cells in vitro and elevates the level of parathyroidhormone in vivo.

[0237] Preferably, the agent selectively targets inorganic ion receptoractivity, more preferably calcium receptor activity, in a particularcell. By “selectively” is meant that the molecule exerts a greatereffect on inorganic ion receptor activity in one cell type than atanother cell type for a given concentration of agent. Preferably, thedifferential effect is 10-fold or greater. Preferably, the concentrationrefers to blood plasma concentration and the measured effect is theproduction of extracellular messengers such as plasma calcitonin,parathyroid hormone or plasma calcium. For example, in a preferredembodiment, the agent selectively targets PTH secretion over calcitoninsecretion.

[0238] In another preferred embodiment, the molecule has an EC₅₀ or IC₅₀less than or equal to 1 mM at one or more, but not all cells chosen fromthe group consisting of parathyroid cell, bone osteoclast,juxtaglomerular kidney cell, proximal tubule kidney cell, distal tubulekidney cell, cell of the thick ascending limb of Henle's loop and/orcollecting duct, central nervous system cell, peripheral nervous systemcell, keratinocyte in the epidermis, parafollicular cell in the thyroid(C-cell), intestinal cell, trophoblast in the placenta, platelet,vascular smooth muscle cell, cardiac atrial cell, gastrin-secretingcell, glucagon-secreting cell, kidney mesangial cell, mammary cell, betacell, fat/adipose cell, immune cell and GI tract cell.

[0239] Preferably, inorganic ion receptor modulating agents mimic orblock all of the effects of extracellular ion in a cell having aninorganic ion receptor. For example, calcium receptor modulating agentspreferably mimic or block all of the effects of extracellular ion in acell having a calcium receptor. Calcimimetics need not possess all thebiological activities of extracellular Ca²⁺, but, rather, at least onesuch activity is mimicked. Similarly, calcilytics need not reduce orprevent all of the activities caused by extracellular calcium.Additionally, different calcimimetics and different calcilytics do notneed to bind to the same site on the calcium receptor as doesextracellular Ca²⁺ to exert their effects.

[0240] A. Calcimimetics

[0241] The ability of molecules to mimic or block the activity of Ca²⁺at calcium receptors can be determined using procedures known in the artand described by Nemeth et al., PCT/US93/01642, InternationalPublication Number WO 94/18959. For example, calcimimetics possess oneor more and preferably all of the following activities when tested onparathyroid cells in vitro:

[0242] 1. The molecule causes a rapid (time to peak <5 seconds) andtransient increase in [Ca²⁺]_(i) that is refractory to inhibition by 1mM La³⁺ or 1 mM Gd³⁺. The increase in [Ca²⁺]_(i) persists in the absenceof extracellular Ca²⁺ but is abolished by pretreatment with ionomycin(in the absence of extracellular Ca²⁺);

[0243] 2. The molecule potentiates increases in [Ca²⁺]_(i) elicited bysubmaximal concentrations of extracellular Ca²⁺;

[0244] 3. The increase in [Ca²⁺]_(i) elicited by extracellular Ca²⁺ isnot inhibited by dihydropyridines;

[0245] 4. The transient increase in [Ca²⁺]_(i) caused by the molecule isabolished by pretreatment for 10 minutes with 10 mM sodium fluoride;

[0246] 5. The transient increase in [Ca²⁺]_(i) caused by the molecule isdiminished by pretreatment with an activator of protein kinase C (PKC),such as phorbol myristate acetate (PMA), mezerein or (−)-indolactam V.The overall effect of the protein kinase C activator is to shift theconcentration-response curve of the molecule to the right withoutaffecting the maximal response;

[0247] 6. The molecule causes a rapid (<30 seconds) increase in theformation—of inositol-1,4,5-triphosphate and/or diacylglycerol;

[0248] 7. The molecule inhibits dopamine- or isoproterenol-stimulatedcyclic AMP formation;

[0249] 8. The molecule inhibits PTH secretion;

[0250] 9. Pretreatment with pertussis toxin (100 ng/ml for >4 hours)blocks the inhibitory effect of the molecule on cyclic AMP formation butdoes not effect increases in [Ca²⁺]_(i), inositol-1,4,5-triphosphate, ordiacylglycerol, nor decreases in PTH secretion;

[0251] 10. The molecule elicits increases in Cl⁻ current in Xenopusoocytes injected with poly (A)⁺-enriched mRNA from bovine or humanparathyroid cells, but is without effect in Xenopus oocytes injectedwith water, or rat brain or liver mRNA; and

[0252] 11. Similarly, using a cloned calcium receptor from a parathyroidcell, the molecule will elicit a response in Xenopus oocytes injectedwith the specific cDNA or mRNA encoding the receptor.

[0253] Different calcium activities can be measured using availabletechniques. Nemeth et al., PCT/US93/01642, International PublicationNumber WO 94/18959. Parallel definitions of molecules mimicking Ca²⁺activity on other calcium responsive cell, preferably at a calciumreceptor, are evident from the examples provided herein and Nemeth etal., PCT/US93/01642, International Publication Number WO 94/18959.

[0254] Preferably, the agent as measured by the bioassays describedherein, or by Nemeth et al., PCT/US93/01642, International PublicationNumber WO 94/18959, has one or more, more preferably all of thefollowing activities: evokes a transient increase in internal calcium,having a duration of less that 30 seconds (preferably by mobilizinginternal calcium); evokes a rapid increase in [Ca²⁺]_(i), occurringwithin thirty seconds; evokes a sustained increase(greater than thirtyseconds) in [Ca²⁺]_(i) (preferably by causing an influx of externalcalcium); evokes an increase in inositol-1,4,5-triphosphate ordiacylglycerol levels, preferably within less than 60 seconds; andinhibits dopamine- or isoproterenol-stimulated cyclic AMP formation.

[0255] The transient increase in [Ca²⁺]_(i) is preferably abolished bypretreatment of the cell for ten minutes with 10 mM sodium fluoride, orthe transient increase is diminished by brief pretreatment (not morethan ten minutes) of the cell with an activator of protein kinase C,preferably, phorbol myristate acetate (PMA), mezerein or (−)-indolactamV.

[0256] B. Calcilytics

[0257] The ability of a molecule to block the activity of externalcalcium can be determined using standard techniques. Nemeth et al.,PCT/US93/01642, International Publication Number WO 94/18959. Forexample, molecules which block the effect of external calcium, when usedin reference to a parathyroid cell, possess one or more, and preferablyall of the following characteristics when tested on parathyroid cells invitro:

[0258] 1. The molecule blocks, either partially or completely, theability of increased concentrations of extracellular Ca²⁺ to:

[0259] (a) increase [Ca²⁺]_(i)

[0260] (b) mobilize intracellular Ca²⁺,

[0261] (c) increase the formation of inositol-1,4,5-triphosphate,

[0262] (d) decrease dopamine- or isoproterenol-stimulated cyclic AMPformation, and

[0263] (e) inhibit PTH secretion;

[0264] 2. The molecule blocks increases in Cl⁻ current in Xenopusoocytes. injected with poly (A)⁺ mRNA from bovine or human parathyroidcells elicited by extracellular Ca²⁺ or calcimimetic compounds, but notin Xenopus oocytes injected with water or liver mRNA;

[0265] 3. Similarly, using a cloned calcium receptor from a parathyroidcell, the molecule will block a response in Xenopus oocytes injectedwith the specific cDNA, mRNA or cRNA encoding the calcium receptor,elicited by extracellular Ca²⁺ or a calcimimetic compound.

[0266] Parallel definitions of molecules blocking Ca²⁺ activity on acalcium responsive cell, preferably at a calcium receptor, are evidentfrom the examples provided herein and Nemeth et al., PCT/US93/01642,International Publication Number WO 94/18959.

III. TREATMENT OF DISEASES OR DISORDERS

[0267] A preferred use of the compounds described by the presentinvention is in the treatment or prevention of different diseases ordisorders by modulating inorganic ion receptor activity. The inorganicion receptor modulating agents of the present invention can exert anaffect on a inorganic ion receptor causing one or more cellular effectsultimately producing a therapeutic effect.

[0268] Different diseases and disorders can be treated by the presentinvention by targeting cells having an inorganic ion receptor, such as acalcium receptor. For example, primary hyperparathyroidism (HPT) ischaracterized by hypercalcemia and elevated levels of circulating PTH. Adefect associated with the major type of HPT is a diminished sensitivityof parathyroid cells to negative feedback regulation by extracellularCa²⁺. Thus, in tissue from patients with primary HPT, the “set-point”for extracellular Ca²⁺ is shifted to the right so that higher thannormal concentrations of extracellular Ca²⁺ are required to depress PTHsecretion. Moreover, in primary HPT, even high concentrations ofextracellular Ca²⁺ often depress PTH secretion only partially. Insecondary (uremic) HPT, a similar increase in the set-point forextracellular Ca²⁺ is observed even though the degree to which Ca²⁺suppresses PTH secretion is normal. The changes in PTH secretion areparalleled by changes in [Ca²⁺]_(i): the set-point for extracellularCa²⁺-induced increases in [Ca²⁺]_(i) is shifted to the right and themagnitude of such increases is reduced.

[0269] Molecules that mimic the action of extracellular Ca²⁺ arebeneficial in the long-term management of both primary and secondaryHPT. Such molecules provide the added impetus required to suppress PTHsecretion which the hypercalcemic condition alone cannot achieve and,thereby, help to relieve the hypercalcemic condition. Molecules withgreater efficacy than extracellular Ca²⁺ may overcome the apparentnonsuppressible component of PTH secretion which is particularlytroublesome in adeiomatous tissue. Alternatively or additionally, suchmolecules can depress synthesis of PTH, as prolonged hypercalcemia hasbeen shown to depress the levels of preproPTH mRNA in bovine and humanadenomatbus parathyroid tissue. Prolonged hypercalcemia also depressesparathyroid cell proliferation in vitro, so calcimimetics can also beeffective in limiting the parathyroid cell hyperplasia characteristic ofsecondary HPT.

[0270] Cells other than parathyroid cells can respond directly tophysiological. changes in the concentration of extracellular Ca²⁺. Forexample, calcitonin secretion from parafollicular cells in the thyroid(C-cells) is regulated by changes in the concentration of extracellularCa²⁺.

[0271] Isolated osteoclasts respond to increases in the concentration ofextracellular Ca²⁺ with corresponding increases in [Ca²⁺ that arisepartly from the mobilization of intracellular Ca²⁺. Increases in[Ca²⁺]_(i) in osteoclasts are associated with the inhibition of boneresorption. Release of alkaline phosphatase from bone-formingosteoblasts is directly stimulated by calcium.

[0272] Renin secretion from juxtaglomerular cells in the kidney, likePTH secretion, is depressed by increased concentrations of extracellularCa²⁺. Extracellular Ca²⁺ causes the mobilization of intracellular Ca²⁺in these cells. Other kidney cells respond to calcium as follows:elevated Ca²⁺ inhibits formation of 1,25(OH)₂-vitamin D by proximaltubular cells, stimulates production of calcium-binding protein indistal tubular cells, and inhibits tubular reabsorption of Ca²⁺ and Mg²⁺and the action of vasopressin on the medullary thick ascending limb ofHenle's loop (MTAL), reduces vasopressin action in the corticalcollecting duct cells, and affects vascular smooth muscle cells in bloodvessels of the renal glomerulus.

[0273] Calcium also promotes the differentiation of intestinal gobletcells, mammary cells, and skin cells; inhibits atrial natriureticpeptide secretion from cardiac atria; reduces cAMP accumulation inplatelets; alters gastrin and glucagon secretion; acts on vascularsmooth muscle cells to modify cell secretion of vasoactive factors; andaffects cells of the central nervous system and peripheral nervoussystem.

[0274] Thus, there are sufficient indications to suggest that Ca²⁺, inaddition to its ubiquitous role as an intracellular signal, alsofunctions as an extracellular signal to regulate the responses ofcertain specialized cells. Molecules of this invention can be used inthe treatment of diseases or disorders associated with disrupted Ca²⁺responses in these cells.

[0275] Specific diseases and disorders which might be treated orprevented, based upon the affected cells, also include those of thecentral nervous system such as seizures, stroke, head trauma, spinalcord injury, hypoxia-induced nerve cell damage such as in cardiac arrestor neonatal distress, epilepsy, neurodegenerative diseases such asAlzheimer's disease, Huntington's disease and Parkinson's disease,dementia, muscle tension, depression, anxiety, panic disorder,obsessive-compulsive disorder, post-traumatic stress disorder,schizophrenia, neuroleptic.malignant syndrome, and Tourette's syndrome;diseases involving excess water reabsorption by the kidney such assyndrome of inappropriate ADH secretion (SIAH), cirrhosis, heartfailure, and nephrosis; hypertension; preventing and/or decreasing renaltoxicity from cationic antibiotics (e.g., aminoglycoside antibiotics);gut motility disorders such as diarrhea, and spastic colon; GI ulcerdiseases; GI absorption diseases such as sarcoidosis; and autoimmunediseases and organ transplant rejection.

[0276] While inorganic ion receptor modulating agents of the presentinvention will typically be used in therapy for human patients, they maybe used to treat similar or identical diseases or disorders in otherwarm-blooded animal species such as other primates, farm animals such asswine, cattle, and poultry; and sports animals and pets such as horses,dogs and cats.

IV. ADMINISTRATION

[0277] A compound of the present invention, or its pharmaceuticallyacceptable salt, hydrate or prodrug, can be administered to a humanpatient per se, or in pharmaceutical compositions where it is mixed withsuitable carriers or excipient(s). Techniques for formulation andadministration of drugs may be found in “Remington's PharmaceuticalSciences,” Mack Publishing Co., Easton, Pa., latest edition.Administration of ionmimetics and ionlytics is discussed by Nemeth, etal., PCT/US93/01642, International Publication No. WO 94/18959.

[0278] A “pharmaceutical composition” refers to a mixture of one or moreof the compounds described herein, or pharmaceutically acceptable salts,hydrates or prodrugs thereof, with other chemical components, such asphysiologically acceptable carriers and excipients. The purpose of apharmacological composition is to facilitate administration of acompound to an organism.

[0279] A “prodrug” refers to an agent which is converted into the parentdrug in vivo. Prodrugs are often useful because, in some situations,they may be easier to administer than the parent drug. They may, forinstance, be bioavailable by oral administration whereas the parent drugis not. The prodrug may also have improved solubility in pharmacologicalcompositions over the parent drug. An example, without limitation, of aprodrug would be a compound of the present invention wherein it isadministered as an ester (the “prodrug”) to facilitate transmittalacross a cell membrane where water solubility is not beneficial, butthen it is metabolically hydrolyzed to the carboxylic acid once insidethe cell where water solubility is beneficial.

[0280] As used herein, an “ester” is a carboxyl group, as definedherein, wherein R″ is any of the listed groups other than hydrogen.

[0281] As used herein, a “physiologically acceptable carrier” refers toa carrier or diluent that does not cause significant irritation to anorganism and does not abrogate the biological activity and properties ofthe administered compound.

[0282] An “excipient” refers to an inert substance added to apharmacological composition to further facilitate. administration of acompound. Examples, without limitation, of excipients include calciumcarbonate, calcium phosphate, various sugars and types of starch,cellulose derivatives, gelatin, vegetable oils and polyethylene glycols.

[0283] Suitable forms, in part, depend upon the use or the route ofentry, for example oral, transdermal, or by injection. Such forms shouldallow the agent to reach a target cell whether the target cell ispresent in a multicellular host or in culture. For example,pharmacological agents or compositions injected into the blood streamshould be soluble in the concentrations used. Other factors are known inthe art, and include considerations such as toxicity and forms whichprevent the agent or composition from exerting its effect.

[0284] Agents can also be formulated as pharmaceutically acceptablesalts (e.g., acid addition salts) and complexes thereof. The preparationof such salts can facilitate the pharmacological use by altering thephysical characteristics of the agent without preventing it fromexerting its physiological effect. Examples of useful alterations inphysical properties include lowering the melting point to facilitatetransmucosal administration and increasing the solubility to facilitateadministering higher concentrations of the drug.

[0285] For systemic administration, oral administration is preferred.Alternatively, injection may be used, e.g., intramuscular, intravenous,intraperitoneal, and subcutaneous. For injection, the molecules of theinvention are formulated in liquid solutions, preferably inphysiologically compatible buffers such as Hank's solution or Ringer'ssolution. In addition, the molecules may be formulated in solid form andredissolved or suspended immediately prior to use. Lyophilized forms canalso be produced.

[0286] Systemic administration can also be by transmucosal ortransdermal means, or the molecules can be administered orally. Fortransmucosal or transdermal administration, penetrants appropriate tothe barrier to be permeated are used in the formulation. Such penetrantsare generally known in the art, and include, for example, fortransmucosal administration, bile salts and fusidic acid derivatives. Inaddition, detergents may be used to facilitate permeation. Transmucosaladministration may be through nasal sprays, for example, or usingsuppositories. For oral administration, the molecules are formulatedinto conventional oral administration dosage forms such as capsules,tablets, and tonics.

[0287] For topical administration, the molecules of the invention areformulated into ointments, salves, gels, or creams, as is generallyknown in the art.

[0288] Generally, a therapeutically effective amount is between about 1nmole and 3 mmole of the molecule, preferably 0.1 nmole and 1 mmoledepending on its EC₅₀ or IC₅₀ and on the age and size of the patient,and the disease or disorder associated with the patient. Generally it isan amount between about 0.1 and 50 mg/kg, preferably 0.01 and 20 mg/kg,animal to be treated.

EXAMPLES

[0289] Examples of the synthesis of the compounds of the presentinvention are described below. However, it is to be understood that thepresent invention is not restricted by the exemplified compounds.

[0290] In Examples 1 to 23, compounds represented by FIG. 1 weresynthesized. The compounds of the present invention represented by theformula (1) wherein X is O were synthesized in accordance with thescheme of FIG. 2 with the use of 2-, 3- or 4-chlorophenol as thestarting material. The compounds of the present invention represented bythe formula (1) wherein X is S were synthesized in accordance with thescheme of FIG. 3 with the use of 2- or 4-chlorothiophenol as thestarting material. However, methylene chloride was used as the solventin some cases. The compounds of the present invention represented by theformula (1) wherein Ar₁ is benzthiazole or benzoxazole were synthesizedin accordance with the scheme of FIG. 4.

[0291] In Examples 24 to 36, the compounds of the present invention weresynthesized in accordance with the schemes shown in FIGS. 5 to 7.

Example 1 Synthesis of compound 2

[0292] 500 mg (3.88 mmol) of 2-chlorophenol was dissolved in 10 ml ofacetonitrile. After adding thereto 582 mg (4.28 mmol) of potassiumcarbonate and 1,4-dibromobutane at room temperature, the mixture wasreacted while heating to 80° C. under reflux for 3 hours. After thecompletion of the reaction, the reaction mixture was allowed to stand atroom temperature and water was added thereto followed by separatingextraction with ethyl acetate. The organic layer thus obtained waswashed with a saturated aqueous solution of sodium chloride and driedover sodium sulfate. Then the organic layer was concentrated underreduced pressure and the residue thus obtained was purified by silicagel column chromatography (50 g; hexane/acetone=12:1) to thereby give994 mg (3.88 mmol) of the compound 1 as a colorless and transparentsyrup at a yield of 100%.

[0293] Next, 994 mg (3.88 mmol) of the compound 1 obtained above wasdissolved in 18 ml of acetonitrile. After adding thereto 652 mg (4.7mmol) of potassium carbonate and 1.1 g (7.28 mmol) of(R)-3-methoxy-a-methylbenzylamine at room temperature, the mixture wasstirred while heating to 90° C. under reflux for 12 hours. After thecompletion of the reaction, the reaction mixture was allowed to stand atroom temperature and water was added thereto. Then it was subjected toseparating extraction with ethyl acetate and washed with a saturatedaqueous solution of sodium chloride. The organic layer thus obtained wasdried over sodium sulfate and concentrated under reduced pressure. Theresidue thus obtained was purified by silica gel column chromatography(100 g; chloroform/methanol=50:1) to thereby give 643 mg (1.93 mmol) ofthe compound 2 as a pale yellow and transparent syrup at a yield of50.2%.

[0294] MS m/z: 333. 1H-NMR d: 1.34 (3H, d, J=6.7 Hz), 1.60-1.73 (1 H,m), 1.78-1.90 (1H, m), 2.48-2.62 (2H, m), 3.75 (3H, q, J=6.7 Hz), 3.81(3H, s), 3.98 (2H, t, J=6.7 Hz), 6.77 (1H, dd, J=7.4 Hz, J=2.0 Hz),6.89-6.90 (4H, m), 7.16-7.26 (2H, m), 7.34 (1 H, dd, J=9.0 Hz, J=2.6Hz).

Example 2 Synthesis of compound 4

[0295] The two steps described above were repeated but substituting the1,4-dibromobutane with 1,5-dibromopentane to thereby give the desiredcompound 4.

[0296] MS m/z: 347. 1H-NMR d: 1.35 (3H, d, J=6.5 Hz), 1.48-1.57 (4H, m),1.79-1.84 (2H, m), 2.44-2.55 (2H, m), 3.74 (1 H, q, J=6.5 Hz), 3.81 (3H,s), 4.00 (2H, t, J=6.5 Hz), 6.77-6.79 (1H, m), 6.85-6.89 (4H, m),7.16-7.26 (2H, m)

Example 3 Synthesis of compound 6

[0297] The two steps described above were repeated but substituting the1,4-dibromobutane with 1,6-dibromohexane to thereby give the desiredcompound 6.

[0298] MS m/z: 361. 1H-NMR d: 1.35 (3H, d, J=7.0 Hz), 1.34-1 .39 (2H,m), 1.45-1.54 (4H, m), 1.78-1.84 (2H, m), 2.41-2.54 (2H, m), 3.73 (1 H,q, J=7.0 Hz), 3.81 (3H, s), 4.00 (2H, t, J=6.5 Hz), 6.77-6.78 (1H, m),6.85-6.90 (4H, m), 7.17-7.26 (2H, m), 7.34 (1H, dd, J=8.0 Hz, J=1.0 Hz).

Example 4 Synthesis of compound 8

[0299] 548 mg (4.25 mmol) of 3-chlorophenol was dissolved in 10 ml ofacetonitrile. After adding thereto 652 mg (4.72 mmol) of potassiumcarbonate and 0.56 ml (4.69 mmol) of 1,4-dibromobutane at roomtemperature, the mixture was reacted while heating to 80° C. underreflux for 3 hours. After the completion of the reaction, the reactionmixture was allowed to stand at room temperature and water was addedthereto followed by separating extraction with ethyl acetate. Theorganic layer thus obtained was washed with a saturated aqueous solutionof sodium chloride and dried over sodium sulfate. Then the organic layerwas concentrated under reduced pressure and the residue thus obtainedwas purified by silica gel column chromatography (50 g;hexane/acetone=12:1) to thereby give 846 mg (3.31 mmol) of the compound7 as a colorless and transparent syrup at a yield of 88.3%.

[0300] Next, 846 mg (3.31 mmol) of the compound 7 obtained above wasdissolved in 18 ml of acetonitrile. After adding thereto 523 mg (3.78mmol) of potassium carbonate and 550 mg (3.64 mmol) of(R)-3-methoxy-a-methylbenzylamine at room temperature, the mixture wasstirred while heating to 90° C. under reflux for 12 hours. After thecompletion of the reaction, the reaction mixture was allowed to stand atroom temperature and water was added thereto. Then it was subjected toseparating extraction with ethyl acetate and washed with a saturatedaqueous solution of sodium chloride. The organic layer thus obtained wasdried over sodium sulfate and concentrated under reduced pressure. Theresidue thus obtained was purified by silica gel column chromatography(100 g; chloroform/methanol=50:1) to thereby give 481 mg (1.46 mmol) ofthe compound 8 as a pale yellow and transparent syrup at a yield of45.0%.

[0301] MS m/z :333. 1H-NMR d: 1.35 (3H, d, J=6.5 Hz), 1.57-1.67 (2H, m),1.73-1.83 (2H, m), 2.46-2.60 (2H, m), 3.74 (1H, q), 3.81 (3H, s), 3.90(2H, t, J=6.5 Hz), 6.74 (1H, dd, J=8.0 Hz, J=2.5 Hz), 6.85-6.86 (1 H,m), 7.5-7.18 (1H, dd, J=2.7 Hz), 7.22-7.26 (1H, m).

Example 5 Synthesis of compound 10

[0302] The two steps described above were repeated but substituting the1,4-dibromobutane with 1,5-dibromopentane to thereby give the desiredcompound 10.

[0303] MS m/z: 347. 1H-NMR d: 1.35 (3H, d, J=6.0 Hz), 1.43-1.56 (4H, m),1.72-1.77 (2H, m), 2.43-2.56 (2H, m), 3.73 (1H, q, J=6.5 Hz), 3.81 (3H,s), 3.90 (2H, t, J=7.0 Hz), 6.76 (1H, dd, J=2.0 Hz, J=8.5 Hz), 6.70-6.79(1H, m), 6.86-6.91 (4H, m), 7.17 (1H, dd, J=3.0 Hz), 7.22-7.26 (1H, m).

Example 6 Synthesis of compound 12

[0304] The two steps described above were repeated but substituting the1,4-dibromobutane with 1,6-dibromohexane to thereby give the desiredcompound 12.

[0305] MS m/z: 361. 1H-NMR d: 1.35 (3H, d, J=6.5 Hz), 1.33-1.53 (6H, m),1.72-1.77 (2H, m), 3.73 (1H, m), 3.81 (3H, s), 3.90 (2H, t, J=6.5 Hz),6.74-6.79 (2H, m), 6.86-6.91 (4H, m), 7.17 (1H, dd, J=8.3 Hz), 7.22-7.26(1H, m).

Example 7 Synthesis of compound 14

[0306] 362 mg (2.82 mmbl) of 4-chlorophenol was dissolved in 5 ml ofacetonitrile. After adding thereto 429 mg (3.10 mmol) of potassiumcarbonate and 0.36 ml (3.01 mmol) of dibromobutane at room temperature,the mixture was reacted while heating to 80° C. under reflux for 3hours. After the completion of the reaction, the reaction mixture wasallowed to stand at room temperature and water was added theretofollowed by separating extraction with ethyl acetate. The organic layerthus obtained was washed with a saturated aqueous solution of sodiumchloride and dried over sodium sulfate. Then the organic layer wasconcentrated under reduced pressure and the residue thus obtained waspurified by silica gel column chromatography (50 g; hexane/acetone=12:1)to thereby give 414 mg (1.62 mmol) of the compound 13 as a colorless andtransparent syrup at a yield of 69.4%.

[0307] Next, 846 mg (3.31 mmol) of the compound 13 obtained above wasdissolved in 18 ml of acetonitrile. After adding thereto 523 mg (3.78mmol) of potassium carbonate and 550 mg (3.64 mmol) of(R)-3-methoxy-a-methylbenzylamine at room temperature, the mixture wasstirred while heating to 90° C. under reflux for 12 hours. After thecompletion of the reaction, the reaction mixture was allowed to stand atroom temperature and water was added thereto. Then it was subjected toseparating extraction with ethyl acetate and washed with a saturatedaqueous solution of sodium chloride. The organic layer thus obtained wasdried over sodium sulfate and concentrated under reduced pressure. Theresidue thus obtained was purified by silica gel column chromatography(100 g; chloroform/methanol=50:1) to thereby give 481 mg (1.46 mmol) ofthe compound 14 as a pale yellow and transparent syrup at a yield of45.0%.

[0308] MS m/z: 333. 1H-NMR d: 1.35 (3H, d, J=6.5 Hz), 1.56-1.67 (2H, m),1.73-1.83 (2H, m), 2.46-2.60 (2H, m), 3.72-3.76 (1 H, q, J=6.5 Hz), 3.81(3H, s), 3.89 (2H, t, J=7.0 Hz), 6.77-6.79 (3H, m), 6.88-6.90 (2H, m),7.19-7.26 (3H, m).

Example 8 Synthesis of compound 16

[0309] The two steps described above were repeated but substituting the1,4-dibromobutane with 1,5-dibromopentane to thereby give the desiredcompound 16.

[0310] MS m/z: 347. 1H-NMR d: 1.34 (3H, d, J=6.5 Hz), 1.43-1.56 (4H, m),1.71-1.77 (2H, m), 2.42-2.55 (2H, m), 3.72 (2H, q, J=6.5 Hz), 3.80 (3H,s), 3.89 (2H, t, J=6.5 Hz), 6.76-6.80 (3H, m), 6.87-6.89 (2H, m),7.19-7.26 (3H, m).

Example 9 Synthesis of compound 18

[0311] The two steps described above were repeated but substituting the1,4-dibromobutane with 1,6-dibromohexane to thereby give the desiredcompound 18.

[0312] MS m/z: 361. 1H-NMR d: 1.35 (3H, d, J=7.0 Hz), 1.32-1 .53 (6H,m), 1.71 -1.77 (2H, m), 2.41-2.53 (2H,m) 3.73 (1H, m), 3.81 (3H, s),3.89 (2H, t, J=7.0 Hz), 6.77-6.81 (3H, m), 6.88-6.89 (3H, m), 7.19-7.26(3H, m).

Example 10 Synthesis of compound 20

[0313] 330 mg (2.28 mmol) of 2-chlorothiophenol was dissolved in 6.5 mlof methylene chloride. After adding thereto 0.35 ml (2.51 mmol) oftriethylamine and 0.23 ml (2.26 mmol) of 1,3-dibromopropane at roomtemperature, the mixture was reacted while heating to 45° C. underreflux for 6 hours. After the completion of the reaction, 0.30 ml (2.15mmol) of triethylamine was dropped again into the reaction at roomtemperature. Then 350 mg (2.31 mmol) of(R)-3-methoxy-a-methylbenzylamine was added thereto and the resultingmixture was stirred while heating to 90° C. under reflux for 12 hours.After the completion of the reaction, the reaction mixture was allowedto stand at room temperature and water was added thereto. Then it wassubjected to separating extraction with ethyl acetate and washed with asaturated aqueous solution of sodium chloride. The organic layer thusobtained was dried over sodium sulfate and concentrated under reducedpressure. The residue thus obtained was purified by silica gel columnchromatography (50 g; chloroform/methanol=65:1) to thereby give 102 mg(0.304 mmol) of the compound 20 as a pale yellow and transparent syrupat an overall yield of the two steps of 13.2%.

[0314] MS m/z: 335. 1H-NMR d: 1.35 (3H, d, J=6.7 Hz), 1.79-1.86 (2H, m),2.55-2.69 (2H, m), 2.91-3.03 (2H, m), 3.74 (1H, q, J=6.7 Hz), 3.81 (3H,s), 6.78 (1 H, dd, J=2.5 Hz, J=8.0 Hz), 6.88-6.90 (2H, m), 7.07-7.11(1H, m), 7.18-7.26 (3H, m), 7.34 (1 H, dd, J=8.0 Hz, J=1.2 Hz).

Example 11 Synthesis of compound 22

[0315] The two steps described above were repeated but substituting the1,3-dibromopropane with 1,4-dibromopentane to thereby give the desiredcompound 22.

[0316] MS m/z: 349. 1H-NMR d: 1.33 (3H, d, J=6.5 Hz), 1.58-1.72 (4H, m),2.43-2.56 (2H, m), 2.90 (2H, t, J=7.5 Hz), 3.72 (1 H, q, J=6.5 Hz), 3.80(3H, s), 6.76-6.78 (1H, m), 6.87-6.88 (2H, m), 7.07-7.10 (1H, m),7.18-7.26 (3H, m), 7.35 (1H, dd, J=8.0 Hz).

Example 12 Synthesis of compound 24

[0317] The two steps described above were repeated but substituting the1,3-dibromopropane with 1,5-dibromopentane to thereby give the desiredcompound 24.

[0318] MS m/z: 363. 1H-NMR d: 1.34 (3H, d, J=7.0 Hz), 1.42-1.55 (4H, m),1.64-1.72 (2H, m), 2.40-2.53 (2H, m), 2.90 (2H, t, J=7.5 Hz), 3.72 (1H,q, J=7.0 Hz), 3.81 (3H, s),6.77-6.79 (1H, m), 6.87-6.91 (2H, m),7.07-7.10 (1H, m), 7.18-7.26 (3H, m), 7.35 (1 H, d, J=8.0 Hz).

Example 13 Synthesis of compound 26

[0319] The two steps described above were repeated but substituting the1,3-dibromopropane with 1,6-dibromohexane to thereby give the desiredcompound 26.

[0320] MS m/z: 377. 1H-NMR d: 1.34 (3H, d, J=6.5 Hz), 1.41-1.50 (4H, m),1.64-1.70 (2H, m), 2.90 (2H, t, J=7.5 Hz), 3.72 (1 H, q, J=6.5 Hz), 3.81(3H, s), 6.77-6.79 (1H, m), 6.88-6.89 (2H, m), 7.06-7.11 (1H, m),7.19-7.26 (3H, m), 7.35 (1H, d, J=8.0 Hz).

Example 14 Synthesis of compound 28

[0321] 540 mg (3.77 mmol) of 4-chlorothiophenol was dissolved in 10 mlof methylene chloride. After adding thereto 1.60 ml (11.5 mmol) oftriethylamine and 0.63.ml (4.10 mmol) of 1,3-dibromopropane at roomtemperature, the mixture was reacted while heating to 45° C. underreflux for 3 hours. After the completion of the reaction, the methylenechloride was once removed under reduced pressure and the residue wasdissolved in 9 ml of acetonitrile. Next, 500 mg (3.62 mmol) of potassiumcarbonate was added thereto at room temperature and 350 mg (2.31 mmol)of (R)-3-methoxy-a-methylbenzylamine was dropped thereinto. Then theresulting mixture was stirred while heating to 90° C. under reflux for12 hours. After the completion of the reaction, the reaction mixture wasallowed to stand at room temperature and water was added thereto. Thenit was subjected to separating extraction with ethyl acetate and washedwith a saturated aqueous solution of sodium chloride. The organic layerthus obtained was dried over sodium sulfate and concentrated underreduced pressure. The residue thus obtained was purified by silica gelcolumn chromatography (75 g; chloroform/methanol=65:1) to thereby give397 mg (1.13 mmol) of the compound 23 as a pale yellow and transparentsyrup at an overall yield of the two steps of 33.1%.

[0322] MS m/z: 335. 1H-NMR d: 1.33 (3H, d, J=7.0 Hz), 1.72-1.78 (2H, m),2.50-2.55 (1H, m), 2.56-2.64 (1H, m), 2.86-2.97 (2H, m), 3.71 (1H, q,J=7.0 Hz), 3.81 (3H, s), 6.77-6.79 (1H, m), 6.85-6.89 (2H, m), 7.22-7.25(4H, m).

Example 15 Synthesis of compound 30

[0323] The two steps described above were repeated but substituting the1,3-dibromopropane with 1,4-dibromobutane to thereby give the desiredcompound 30.

[0324] MS m/z: 363. 1H-NMR d: 1.35 (3H, d, J=6.7 Hz), 1.39-1.49 (2H, m),1.60 (2H, tt, J=7.5 Hz), 2.39-2.44 (1H, m), 2.86 (2H, t, J=7.3 Hz), 3.72(1H, q, J=6.7 Hz), 3.81 (3H, s), 6.77-6.79 (1H, m), 6.87-6.88 (2H, m),7.20-7.26 (5H, m).

Example 16 Synthesis of compound 32

[0325] The two steps described above were repeated but substituting the1,3-dibromopropane with 1,5-dibromopentane to thereby give the desiredcompound 32.

[0326] MS m/z: 377. 1H-NMR d: 1.35 (3H, d, J=6.7 Hz), 1.27-1.48 (4H, m),1.60 (2H, tt, J=7.5 Hz), 2.39-2.44 (1H, m), 2.46-2.51 (1H, m), 2.85 (2H,t, J=7.3 Hz), 3.72 (1H, q, J=6.7 Hz), 3.81 (3H, s), 6.76-6.79 (1 H, m),6.87-6.89 (2H, m), 7.21 -7.26 (5H, m).

Example 17 Synthesis of compound 34

[0327] The two steps described above were repeated but substituting the1,3-dibromopropane with 1,6-dibromohexane to thereby give the desiredcompound 34.

[0328] MS m/z: 349. 1H-NMR d: 1.34 (3H, d, J=6.5 Hz), 1.52-1.67 (6H, m),2.40-2.45 (1H, m), 2.48-2.53 (1H, m), 2.86 (2H, t, J=7.0 Hz), 3.71 (1H,q, J=6.5 Hz), 3.80 (3H, s), 6.76-6.79 (1H, m), 6.86-6.88 (2H, m)

Example 18 Synthesis of compound 36

[0329] 440 mg (2.63 mmol) of 2-mercaptobenzothiazole was dissolved in 9ml of methylene chloride. After adding thereto 1.1 ml (7.89 mmoi) oftriethylamine and 0.35 ml (2.93 mmol) of 1,4-dibromobutane at roomtemperature, the mixture was reacted at the same temperature for 12hours. After the completion of the reaction, the methylene chloride wasonce removed under reduced pressure and the residue was dissolved in 8ml of acetonitrile. Next, 800 mg (5.79 mmol) of potassium carbonate wasadded thereto at room temperature and 320 mg (2.12 mmol) of(R)-3-methoxy-a-methylbenzylamine was dropped thereinto. Thenthe-resulting mixture was stirred while heating to 90° C. under refluxfor 12 hours. After the completion of the reaction, the reaction mixturewas allowed to stand at room temperature and water was added thereto.Then it was subjected to separating extraction with ethyl acetate andwashed with a saturated aqueous solution of sodium chloride. The organiclayer thus obtained was dried over sodium sulfate and concentrated underreduced pressure. The residue thus obtained was purified by silica gelcolumn chromatography (70 g; chloroform/methanol=50:1) to thereby give267 mg (0.72 mmol) of the compound 36 as a pale yellow and transparentsyrup at an overall yield of the two steps of 27.1%.

[0330] MS m/z: 372. 1H-NMR d: 1.34 (3H, d, J=6.5 Hz), 1.61-1.68 (2H, m),1.82-1.88 (2H, m), 2.46-2.60 (2H, m), 3.32( 2H, t, J=7.5 Hz), 3.73 (1H,q, J=6.5 Hz), 3.80 (3H, s),6.76-6.78 (1H, m), 6.87-6.89 (2H, m),7.21-7.30 (2H, m), 7.38-7.42 (1H, m), 7.74 (1H, d, J=8.0 Hz), 7.84 (1H,d, J=8.0 Hz).

Example 19 Synthesis of compound 38

[0331] 409 mg (2.45 mmol) of 2-mercaptobenzothiazole was dissolved in 4ml of acetonitrile. After adding thereto 690 mg (4.99 mmol) of potassiumcarbonate and 0.32 ml (2.68 mmol) of 1,5-dibromopentane at roomtemperature, the mixture was stirred at the same temperature for 1 hour.After the completion of the reaction, 420 mg (3.04 mmol) of potassiumcarbonate was added thereto again and 260 mg (1.72 mmol) of(R)-3-methoxy-a-methylbenzylamine was dropped thereinto. Then theresulting mixture was stirred while heating to 90° C. under reflux for12 hours. After the completion of the reaction, the reaction mixture wasallowed to stand at room temperature and water was added thereto. Thenit was subjected to separating extraction with ethyl acetate and washedwith a saturated aqueous solution of sodium chloride. The organic layerthus obtained was dried over sodium sulfate and concentrated underreduced pressure. The residue thus obtained was purified by silica gelcolumn chromatography (50 g; chloroform/methanol=50:1) to thereby give215 mg (0.57 mmol) of the compound 38 as a pale yellow and transparentsyrup at an overall yield of the two steps of 45.0%.

[0332] MS m/z: 386. 1H-NMR d: 1.33 (3H, d, J=6.5 Hz), 1.44-1.56 (4H, m),1.78-1.84 (2H, m), 2.42-2.51 (2H, m), 3.32 (2H, t, J=7.3 Hz), 3.71 (1H,q, J=6.5 Hz), 3.81 (3H, s), 6.76-6.78 (1H, m), 6.86-6.88 (2H, m), 7.22(1 H, dd, J=8.0 Hz), 7.26-7.30 (1H, m), 7,39-7.42 (1 H, m), 7.74 (1 H,d, J=7.5 Hz), 7.85 (1H, d, J=8.5 Hz).

Example 20 Synthesis of compound 40

[0333] The two steps described above were repeated but substituting the1,5-dibromopentane with 1,6-dibromohexane to thereby give the desiredcompound 40.

[0334] MS m/z: 400. 1H-NMR d: 1.34 (3H, d, J=6.5 Hz), 1.43-1.50 (6H, m),1.80 (2H, tt, J=7.5 Hz), 2.40-2.52 (2H, m), 3.32 (2H, t, J=7.8 Hz), 3.72(1H, q, J=6.5 Hz), 3.81 (3H, s), 6.76-6.78 (1H, m), 6.87-6.89 (2H, m),7.22-7.30 (2H, m), 7.40 (1H, dd, J=7.5 Hz), 7.74 (1H, d, J=7.5 Hz), 7.85(1 H, d, J=8.0 Hz).

Example 21 Synthesis of compound 42

[0335] 467 mg (3.09 mmol) of 2-mercaptobenzothiazole was dissolved in 7ml of acetonitrile. After adding thereto 527 mg (3.81 mmol) of potassiumcarbonate and 0.41 ml (3.43 mmol) of 1,4-dibromobutane at roomtemperature, the mixture was stirred at the same temperature for 12hours. After the completion of the reaction, 4.4 ml of acetonitrile and420 mg (3.04 mmol) of potassium carbonate were added thereto again and320 mg (2.12 mmol) of (R)-3-methoxy-a-methylbenzylamine was droppedthereinto. Then the resulting mixture was stirred while heating to 90°C. under reflux for 12 hours. After the completion of the reaction, thereaction mixture was allowed to stand at room temperature and water wasadded thereto. Then it was subjected to separating extraction with ethylacetate and washed with a saturated aqueous solution of sodium chloride.The organic layer thus obtained was dried over sodium sulfate. Then theorganic layer was concentrated under reduced pressure and the residuethus obtained was purified by silica gel column chromatography (50 g;chloroform/methanol=60:1) to thereby give 147 mg (0.41 mmol) of thecompound 42 as a pale yellow and transparent syrup at an overall yieldof the two steps of 13.4%.

[0336] MS m/z: 356. 1H-NMR d: 1.35 (3H, d, J=6.7), 1.61-1.68 (2H, m),1.81-1.89 (2H, m), 2.46-2.59 (2H, m), 3.28 (2H, t, J=7.5 Hz), 3.73 (1H,q, J=6.7 Hz), 3.80 (3H, s), 6.76-6.78 (1H, m), 6.88-6.89 (2H, m),7.21-7.28 (3H, m), 7.42 (1H, d, J=8.0 Hz), 7.58 (1H, d, J=8.0 Hz).

Example 22 Synthesis of compound 44

[0337] The two steps described above were repeated but substituting the1,4-dibromobutane with 1,5-dibromopentane to thereby give the desiredcompound 44.

[0338] MS m/z: 370. 1H-NMR d: 1.33 (3H, d, J=6.8 Hz), 1.46-1.56 (4H, m),1.81 (2H, m), 2.41 -2.53 (2H, m), 3.29 (2H, t, J=7.3 Hz), 3.72 (1H, q,J=6.8 Hz), 3.81 (3H, s), 6.76-6.78 (1H, m), 6.86-6.89 (2H, m),7.20-7.29. (1H, d, J=8.0 Hz), 7.42 (1H, d, J=8.0 Hz), 7.59 (1H, d, J=7.5Hz).

Example 23 Synthesis of compound 46

[0339] The two steps described above were repeated but substituting the1,4-dibromobutane with 1,6-dibromohexane to thereby give the desiredcompound 46.

[0340] MS m/z: 384. 1H-NMR d: 1.34 (3H, d, J=6.5 Hz), 1.32-1.62 (6H, m),1.81 (2H, qq, J=7.5 Hz), 2.40-2.52 (2H, m), 3.29 (2H, t, J=7.5 Hz), 3.72(1 H, q, J=6.5 Hz), 3.81 (3H, s), 6.76-6.79 (1H, m), 6.87-6.89 (2H, m),7.21-7.29 (3H, m), 7.43 (1H, d, J=8.0 Hz), 7.59 (1H, d, J=8.0 Hz).

Example 24 Synthesis of compounds 52 and 53

[0341] To a solution of 25 g (122.4 mmol) of 5-methoxygramine 47 in 500ml of ethanol was added 21.5 g (568.3 mmol, 4.6 moleq.) of sodiumtetrahydroborate and the mixture was stirred under heating for 5.5hours. After the completion of the reaction, ammonium chloride was addedto the reaction mixture. Then the mixture was stirred at roomtemperature, poured into water and extracted with ethyl acetate. Theethyl acetate layer was washed with water and a saturated aqueoussolution of sodium chloride and dried over sodium sulfate. Afterdistilling off the solvent under reduced pressure, the obtained crystalswere purified by column chromatography (silica gel, chloroform-ethylacetate) to thereby give 17.31 g (87.8%) of colorless prism crystals 48.

[0342] To a solution of 17.3 g of the compound 48 (107.5 mmol) in 500 mlof absolute tetrahydrofuran was added 20 g (500 mmol, 4.6 moleq.) of52.9% sodium hydride and the mixture was stirred at room temperature for1.5 hours. Then 30 g (d=1.333, 157.4 mmol, 1.5 moleq.) of tosyl chloridewas added thereto and the resulting mixture was stirred at roomtemperature for 6 hours. After the completion of the reaction, thereaction mixture was poured into water under ice-cooling and extractedwith ethyl acetate. The ethyl acetate layer was washed with water and asaturated aqueous solution of sodium chloride and dried over sodiumsulfate. After distilling off the solvent under reduced pressure, theobtained crystals were purified by column chromatography (silica gel,chloroform-ethyl acetate) to thereby give 36.8 g (82.8%) of colorlessprism crystals 49.

[0343] 17 ml (d=2.698, 183.1 mmol) of boron tribromide was dropped intoa solution of 28.43 g (90.25 mmol) of the compound 49 in 800 ml ofmethylene chloride at an internal temperature of 0 to 5° C. The mixturewas stirred at room temperature for 4 hours. After the completion of thereaction, the reaction mixture was poured into water under ice-coolingand extracted with methylene chloride. The methylene chloride layer waswashed with water and a saturated aqueous solution of sodium chlorideand dried over sodium sulfate. After distilling off the solvent underreduced pressure, the obtained crystals were purified by columnchromatography (silica gel: 400 g, chloroform-methanol=1000:1) tothereby give 16.46 g (60.6%) of colorless prism crystals 50.

[0344] To a solution of 16.46 g (54.7 mmol) of the compound 50 in 300 mlof acetonitrile were added 11.2 ml (d=1.333, 109.5 mmol, 2.0 moleq.) of1,3-dibromopropane and 22 g (1 59.2 mmol, 2.9 moleq.) of potassiumcarbonate and the resulting mixture was stirred under heating at anexternal temperature of 60° C. for 2.5 hours. After the completion ofthe reaction, the reaction mixture was poured into water and extractedwith ethyl acetate. The ethyl acetate layer was washed with water and asaturated aqueous solution of sodium chloride and dried over sodiumsulfate. After distilling off the solvent under reduced pressure, theobtained crystals were purified by column chromatography (silica gel,n-hexane-acetone) to thereby give 18.34 g (79.7%) of colorless prismcrystals 51.

[0345] To a solution of 200 mg (0.48 mmol) of the compound 51 in 3 ml ofacetonitrile were added 142.52 mg (0.95 mmol, 2.0 moleq.) of(R)-3-methoxy-a-methylbenzylamine and 131.3 mg.(0.95 mmol, 2.0 moleq.)of potassium carbonate and the resulting mixture was stirred underheating at an external temperature of 60° C. for 4 hours. After thecompletion of the reaction, the reaction mixture was poured into waterand extracted with ethyl acetate. The ethyl acetate layer was washedwith water and a saturated aqueous solution of sodium chloride and driedover sodium sulfate. After distilling off the solvent under reducedpressure, the obtained yellowish brown residue was dissolved.in 3 ml ofethanol and 1 ml of a 35% aqueous solution of potassium hydroxide wasadded thereto. Then the mixture was stirred under heating at an externaltemperature of 80° C. for 2 hours. After the completion of the reaction,the reaction mixture was concentrated, poured into water and extractedwith ethyl acetate. The ethyl acetate layer was washed with water and asaturated aqueous solution of sodium chloride and dried over sodiumsulfate. After distilling off the solvent under reduced pressure, theobtained residue was purified by column chromatography (silica gel,ethyl acetate-n-hexane) to thereby give 122.6 mg (93.8%) of a colorlessoil 52.

[0346] MS m/z: 338(M⁺). ¹H-NMR d: 1.36 (3H, d, J=6.7 Hz, CH₃), 1.97 (2H,dt, J=6.7, 12.8 Hz, CH₂), 2.30 (3H, s, CH₃), 2.67 (1H, dt, J=6.7, 11.6Hz, CH₂), 2.74 (1H, dt, J=6.7, 13.4 Hz, CH₂), 3.77 (1H, q, J=6.7 Hz,CH), 3.78 (3H, s, OCH₃), 4.07 (2H, m, CH₂), 6.78 (1H, dd, J=1.8, 7.9 Hz,C₆—H), 6.82 (1H, dd, J=1.8, 7.9 Hz, C₆′—H), 6.90 (2H, d, J=1.8 Hz,C₂—H), 6.91 (1H, d, J=7.9 Hz, C₄—H), 6.94 (1H, s, C₂′—H), 6.99 (1H, d,J=1.8 Hz, C₄′—H), 7.21 (1H, d, J=7.9 Hz, C₇′—H), 7.23 (1H, t, J=7.9 Hz,C₅—H), 7.81 (1H, s, NH).

[0347] To a solution of 200 mg (0.48 mmol) of the compound 51 in 3 ml ofacetonitrile were added 162.7 mg (0.95 mmol, 2.0 moleq.) of(R)-1-(1-naphthyl)ethylamine and 131.3 mg (0.95 mmol, 2.0 moleq.) ofpotassium carbonate and the resulting mixture was stirred under heatingat an external temperature of 60° C. for 4 hours. After the completionof the reaction, the reaction mixture was poured into water andextracted with ethyl acetate. The ethyl acetate layer was washed withwater and a saturated aqueous solution of sodium chloride and dried oversodium sulfate. After distilling off the solvent under reduced pressure,the obtained yellowish brown residue was dissolved in 1 ml of ethanoland 1 ml of a 35% aqueous solution of potassium hydroxide was addedthereto. Then the mixture was stirred under heating at an externaltemperature of 80° C. for 2 hours. After the completion of the reaction,the reaction mixture was concentrated, poured into water and extractedwith ethyl acetate. The ethyl acetate layer was washed with water and asaturated aqueous solution of sodium chloride and dried over sodiumsulfate. After distilling off the solvent under reduced pressure, theobtained residue was purified by column chromatography (silica gel,ethyl acetate-n-hexane) to thereby give 122.6 mg (93.8%) of a colorlessoil 53.

[0348] MS m/z: 358(M⁺). ¹H-NMR d: 1.53 (3H, d, J=6.7 Hz, CH₃), 2.03 (2H,dt, J=6.7, 12.8 Hz, CH₂), 2.30 (3H, s, CH₃), 2.83 (2H, dt, J=6.7, 12.8Hz, CH₂), 4.12 (2H, dt, J=3.1, 9.2 Hz, CH₂), 4.68 (1H, q, J=6.7 Hz, CH),6.83 (1H, dd, J=1.8, 9.2 Hz, C₂—H), 6.94 (1H, s, C₂′—H), 7.01 (1 H, d,J=1.8 Hz, C₄′—H), 7.21 (1H, d, J=7.9 Hz, C₄—H), 7.48 (1H, t, J=7.9 Hz,C₃—H), 7.49 (1H, t, J=7.9 Hz, C₅—H), 7.50 (1H, t, J=7.9 Hz, C₇—H), 7.68(1H, d, J=7.9 Hz, C₅—H), 7.75 (1H, d, J=7.9 Hz, C₈—H), 7.82 (1H, s, NH),7.88 (1H, dd, J=1.8, 7.9 Hz, C₆′—H), 8.21 (1H, d, J=7.9 Hz, C₇′—H).

Example 25 Synthesis of compound 56

[0349] To a solution of 500 mg (2.74 mmol) of 9-hydroxyfluorene 54 in 5ml of toluene were added 0.273 ml (d=1.537, 3.02 mmol, 1.1 moleq.) of3-bromo-1-propanol and 5.1 mg (0.027 mmol, 0.01 moleq.) ofp-toluenesulfonic acid and the resulting mixture was stirred at roomtemperature for 1 hour. After the completion of the reaction, thereaction mixture was poured into water and extracted with ethyl acetate.The ethyl acetate layer was washed with water and a saturated aqueoussolution of sodium chloride and dried over sodium sulfate. Afterdistilling off the solvent under reduced pressure, the obtained residuewas purified by column chromatography (silica gel, n-hexane-ethylacetate) to thereby give 723.4 mg (87.0%) of a colorless oil 55.

[0350] To a solution of 200 mg (0.66 mmol) of the compound 55 in 3 ml ofacetonitrile were added 148.5 mg (0.99 mmol, 1.5 moleq.) of(R)-3-methoxy-a-methylbenzylamine and 136.8 mg (0.99 mmol, 1.5 moleq.)of potassium carbonate and the resulting mixture was stirred underheating at an external temperature of 60° C. for 4 hours. After thecompletion of the reaction, the reaction mixture was poured into waterand extracted with ethyl acetate. The ethyl acetate layer was washedwith water and a saturated aqueous solution of sodium chloride and driedover sodium sulfate. After distilling off the solvent under reducedpressure, the obtained residue was purified by column chromatography(silica gel, ethyl acetate-n-hexane) to thereby give 216.6 mg (88.0%) ofa colorless oil 56.

[0351] MS m/z: 373(M⁺). ¹H-NMR d: 1.30 (3H, d, J=6.7 Hz, CH₃), 1.67 (2H,dt, J=6.7, 13.4 Hz, CH₂), 2.49 (1H, dt, J=6.7, 14.0 Hz, CH₂), 2.56 (1H,dt, J=6.7, 11.6 Hz, CH₂), 3.21 (2H, t, J=6.7 Hz, CH₂), 3.69 (1H, q,J=6.7 Hz, CH), 3.78 (3H, s, OCH₃), 5.59 (1H, s, CH), 6.76 (1H, dd,J=1.8, 7.9 Hz, C₆—H), 6.85 (1H, d, J=1.8 Hz, C₂—H ), 6.87 (1H, d, J=7.9Hz, C₄—H ), 7.21 (1H, t, J=7.9 Hz C₅—H), 7.28 (2H, t, J=7.9 Hz, C₃′,C₆′—H), 7.37 (2H, t, J =7.9 Hz, C₂′, C₇′—H), 7.53 (1H, d, J=7.9 Hz,C₄′—H), 7.55 (1H, d, J=7.9 Hz, C₅′—H), 7.65 (2H, d, J=7.9 Hz, C₁′,C₈′—H), 7.81 (1H, s, NH).

Example 26 Synthesis of compound 59

[0352] To a solution of 200 mg (1.1 mmol) of 2-hydroxyfluorene 57 in 3ml of acetonitrile were added 0.22 ml (d=1.333, 2.2 mmol, 2.0 moleq.) of1,3-dibromopropane and 182.0 mg (1.32 mmol, 1.2 moleq.) of potassiumcarbonate and the resulting mixture was stirred under heating at anexternal temperature of 60° C. for 4 hours. After the completion of thereaction, the reaction mixture was poured into water and extracted withethyl acetate. The ethyl acetate layer was washed with water and asaturated aqueous solution of sodium chloride and dried over sodiumsulfate. After distilling off the solvent under reduced pressure, theobtained crystals were purified by column chromatography (silica gel,n-hexane-ethyl acetate) to thereby give 202.4 mg (73.3%) of a colorlessprism crystals 58.

[0353]¹H-NMR d: 2.35 (2H, dt, J=6.1, 12.2 Hz, CH₂), 3.64 (2H, t, J=6.1Hz, CH₂), 3.86 (2H, s, C₉—H₂), 4.17 (2H, t, J=6.1 Hz, CH₂), 6.93 (1H,dd, J=1.8, 7.3 Hz, C₂—H), 7.11 (1H, d, J=1.8 Hz, C₄—H), 7.23 (1H, t,J=7.3 Hz, C₆—H), 7.34 (1H, t, J=7.3 Hz, C₇—H), 7.50 (1H, d, J=7.3 Hz,C₁—H), 7.67 (1H, d, J=6.7 Hz, C₈—H),7.69 (1H, t, J=6.7 Hz, C₅—H).

[0354] To a solution of 100 mg (0.33 mmol) of the compound 58 in 3 ml ofacetonitrile were added 49.5 mg (0.33 mmol, 1.0 moleq.) of(R)-3-methoxy-a-methylbenzylamine and 54.7 mg (0.40 mmol, 1.2 moleq.) ofpotassium carbonate and the resulting mixture was stirred under heatingat an external temperature of 60° C. for 4 hours. After the completionof the reaction, the reaction mixture was poured into water andextracted with ethyl acetate. The ethyl acetate layer was washed withwater and a saturated aqueous solution of sodium chloride and dried oversodium sulfate. After distilling off the solvent under reduced pressure,the obtained residue was purified by column chromatography (silica gel,ethyl acetate-n-hexane) to thereby give 216.6 mg (88.0%) of a colorlessoil 59.

[0355] MS m/z: 373(M⁺). ¹H-NMR d: 1.36 (3H, d, J=6.7 Hz, CH₃),1.96 (2H,m, CH₂), 2.65 (1H, dt, J=6.7, 11.6 Hz, CH₂), 2.73 (1H, dt, J=6.7, 12.2Hz, CH₂), 3.77 (1H, q, J=6.7 Hz, CH), 3.78 (3H, s, OCH₃), 3.85 (2H, s,CH₂), 4.07 (2H, q, J=5.5 Hz, C₉—H), 6.77 (1H, dd, J=1.8, 7.3 Hz, C₆—H),6.89 (1H, d, J=1.2 Hz, C₂—H), 6.90 (1H, d, J=7.3 Hz, C₄—H), 6.90 (1H, d,J=7.3 Hz, C₂′—H), 7.06 (1H, s, C₄′—H), 7.22 (1H, t, J=7.3 Hz, C₅—H),7.22 (1H, t, J=7.3 Hz, C₆′—H), 7.33 (1H, t, J=7.3 Hz, C₇′—H), 7.49 (1H,d, J=7.3 Hz, C₁′—H), 7.65 (1H, d, J=7.3 Hz, C₈′—H), 7.68 (1H, d, J=7.3Hz, C₅′—H).

Example 27 Synthesis of compound 62

[0356] To a solution of 500 mg (3.89 mmol) of o-chlorophenol 60 in 3 mlof acetonitrile were added 0.39 ml (d=1.989, 3.89 mmol, 1.0 moleq.) of1,3-dibromopropane and 591.2 mg (4.28 mmol, 1.1 moleq.) of potassiumcarbonate and the resulting mixture was stirred under heating at anexternal temperature of 60° C. for 4 hours. After the completion of thereaction, the reaction mixture was poured into water and extracted withethyl acetate. The ethyl acetate layer was washed with water and asaturated aqueous solution of sodium chloride and dried over sodiumsulfate. After distilling off the solvent under reduced pressure, theobtained residue was purified by column chromatography (silica gel,ethyl acetate-n-hexane) to thereby give 824.0 mg (84.9%) of a colorlessoil 61.

[0357] To a solution of 200 mg (0.66 mmol) of the compound 61 in 3 ml ofacetonitrile were added 148.5 mg (0.99 mmol, 1.5 moleq.) of(R)-3-methoxy-a-methylbenzylamine and 136.8 mg (0.99 mmol, 1.5 moleq.)of potassium carbonate and the resulting mixture was stirred underheating at an external temperature of 60° C. for 4 hours. After thecompletion of the reaction, the reaction mixture was poured into waterand extracted with ethyl acetate. The ethyl acetate layer was washedwith water and a saturated aqueous solution of sodium chloride and driedover sodium sulfate. After distilling off the solvent under reducedpressure, the obtained residue was purified by column chromatography(silica gel, ethyl acetate-n-hexane) to thereby give 222.6 mg (87.1%) ofa colorless oil 62.

[0358] MS m/z: 319(M⁺). ¹H-NMR d: 1.37 (3H, d, J=6.7 Hz, CH₃), 1.99 (2H,dt, J=6.7, 12.2 Hz, CH₂), 2.67 (1H, dt, J=6.7, 13.4 Hz, CH₂), 2.75 (1H,dt, J=6.7, 11.6 Hz, CH₂), 3.75-3.79 (1H, m, CH), 3.78 (3H, s, OCH₃),4.09 (2H, dt, J=1.8, 6.1 Hz, CH₂), 6.77 (1H, dd, J=1.8, 7.3 Hz, C₆—H),6.89 (1H, t, J=7.9 Hz, C₄—H), 6.90 (1H, d, J=1.8 Hz, C₂—H), 6.90 (1H, d,J=7.9 Hz, C₄—H), 6.90 (1 H, d, J=7.9 Hz, C₃′—H), 7.20 (1H, dt, J=1.8,7.3 Hz, C₅′—H), 7.22 (1H, t, J=7.9 Hz, C₅—H), 7.4 (1H, dd, J=1.8, 7.9Hz, C₆′—H).

Example 28 Synthesis of compound 65

[0359] To a solution of 500 mg (3.89 mmol) of m-chlorophenol 63 in 3 mlof acetonitrile were added 0.39 ml (d=1.989, 3.89 mmol, 1.0 moleq.) of1,3-dibromopropane and 591.2 mg (4.28 mmol, 1.1 moleq.) of potassiumcarbonate and the resulting mixture was stirred under heating at anexternal temperature of 60° C. for 4 hours. After the completion of thereaction, the reaction mixture was poured into water and extracted withethyl acetate. The ethyl acetate layer was washed with water and asaturated aqueous solution of sodium chloride and dried over sodiumsulfate. After distilling off the solvent under reduced pressure, theobtained residue was purified by column chromatography (silica gel,ethyl acetate-n-hexane) to thereby give 884.2 mg (91.1%) of a colorlessoil 64.

[0360] To a solution of 200 mg (0.66 mmol) of the compound 64 in 3 ml ofacetonitrile were added 148.5 mg (0.99 mmol, 1.5 moleq.) of(R)-3-methoxy-a-methylbenzylamine and 136.8 mg (0.99 mmol, 1.5 moleq.)of potassium carbonate and the resulting mixture was stirred underheating at an external temperature of 60° C. for 4 hours. After thecompletion of the reaction, the reaction mixture was poured into waterand extracted with ethyl acetate. The ethyl acetate layer was washedwith water and a saturated aqueous solution of sodium chloride and driedover sodium sulfate. After distilling off the solvent under reducedpressure, the obtained residue was purified by column chromatography(silica gel, ethyl acetate-n-hexane) to thereby give 229.3 mg (89.7%) ofa colorless oil 65.

[0361] MS m/z: 319(M⁺). ¹H-NMR d: 1.35 (3H, d, J=6.7 Hz, CH₃), 1.88-1.96(2H, m, CH₂), 2.61 (1H, dt, J=6.7, 11.5 Hz, CH₂), 2.70 (1H, dt, J=6.7,11.6 Hz, CH₂), 3.75 (1H, q, J=6.7 Hz, CH), 3.80 (3H, s, OCH₃), 3.96-4.04(2H, m, CH₂), 6.75 (1H, d, J=7.9 Hz, C₆—H), 6.78 (1H, d, J=7.9 Hz,C₆—H), 6.88 (1H, s), 6.88-6.92. (3H, m), 7.17 (1H, t, J=7.9 Hz, C₅′—H),7.23 (1H, t, J=7.9 Hz, C₅—H).

Example 29 Synthesis of compound 68

[0362] To a solution of 500 mg (3.89 mmol) of p-chlorophenol 66 in 3 mlof acetonitrile were added 0.39 ml (d=1.989, 3.89 mmol, 1.0 moleq.) of1,3-dibromopropane and 591.2 mg (4.28 mmol, 1.1 moleq.) of potassiumcarbonate and the resulting mixture was stirred under heating at anexternal temperature of 60° C. for 4 hours. After the completion of thereaction, the reaction mixture was poured into water and extracted withethyl acetate. The ethyl acetate layer was washed with water and asaturated aqueous solution of sodium chloride and dried over sodiumsulfate. After distilling off the solvent under reduced pressure, theobtained residue was purified by column chromatography (silica gel,ethyl acetate-n-hexane) to thereby give 876.5 mg (90.3%) of a colorlessoil 67.

[0363] To a solution of 200 mg (0.66 mmol) of the compound 67 in 3 ml ofacetonitrile were added 148.5 mg (0.99 mmol, 1.5 moleq.) of(R)-3-methoxy-a-methylbenzylamine and 136.8 mg (0.99 mmol, 1.5 moleq.)of potassium carbonate and the resulting mixture was stirred underheating at an external temperature of 60° C. for 4 hours. After thecompletion of the reaction, the reaction mixture was poured into waterand extracted with ethyl acetate. The ethyl acetate layer was washedwith water and a saturated aqueous solution of sodium chloride and driedover sodium sulfate. After distilling off the solvent under reducedpressure, the obtained residue was purified by column chromatography(silica gel, ethyl acetate-n-hexane) to thereby give 293.1 mg (87.2%) ofa colorless oil 68.

[0364] MS m/z: 319 (M⁺). ¹H-NMR (90 MHz) d: 1.35 (3H, d, J=6.4 Hz, CH₃),1.91 (2H, dt, J=6.4, 12.7 Hz, CH₂), 2.67 (2H, dt, J=2.4, 6.4 Hz, CH₂),3.75 (1H, q, J=6.4 Hz, CH), 3.79 (3H, s, OCH₃), 3.98 (2H, t, J=6.4 Hz,CH₂), 6.70-6.91 (5H, m), 7.14 (3H, m).

Example 30 Synthesis of compound 71

[0365] To a solution of 500 mg (2.71 mmol) of 3-hydroxybenzofuran 69 in5 ml of acetonitrile were added 0.55 ml (d=1.989, 5.43 mmol, 2.0 moleq.)of 1,3-dibromopropane and 750.1 mg (5.43 mmol, 2.0 moleq.) of potassiumcarbonate and the resulting mixture was stirred under heating at anexternal temperature of 60° C. for 4 hours. After the completion of thereaction, the reaction mixture was poured into water and extracted withethyl acetate. The ethyl acetate layer was washed with water and asaturated aqueous solution of sodium chloride and dried over sodiumsulfate. After distilling off the solvent under reduced pressure, theobtained residue was purified by column chromatography (silica gel,ethyl acetate-n-hexane) to thereby give 804.3 mg (77.0%) of colorlessprism crystals 70.

[0366] To a solution of 800 mg (2.62 mmol) of the compound 70 in 5 ml ofacetonitrile were added 590.2 mg (3.93 mmol, 1.5 moleq.) of(R)-3-methoxy-a-methylbenzylamine and 543.7 mg (3.93 mmol, 1.5 moleq.)of potassium carbonate and the resulting mixture was stirred underheating at an external temperature of 60° C. for 4 hours. After thecompletion of the reaction, the reaction mixture was poured into waterand extracted with ethyl acetate. The ethyl acetate layer was washedwith water and a saturated aqueous solution of sodium chloride and driedover sodium sulfate. After distilling off the solvent under reducedpressure, the obtained residue was purified by column chromatography(silica gel, ethyl acetate-n-hexane) to thereby give 880.8 mg (89.5%) ofa colorless oil 71.

[0367] MS m/z: 375(M⁺). ¹H-NMR d: 1.38 (3H, d, J=6.7 Hz, CH₃), 2.01 (2H,m, CH₂), 2.70 (1H, dt, J=6.7, 14.0 Hz, CH₂), 2.77 (1H, dt, J=6.7, 13.4Hz, CH₂), 3.80 (1H, q, J=6.7 Hz, CH), 3.80 (3H, s, OCH₃), 4.10-4.17 (2H,m, CH₂), 6.79 (1H, dd, J=1.8, 7.3 Hz, C₆—H), 6.91 (1H, d, J=1.8 Hz,C₂—H), 6.92 (1H, d, J=7.3 Hz, C₄—H), 7.02 (1H, dd, J=2.5, 8.6 Hz,C₃′—H), 7.24 (1H, t, J=7.3 Hz, C₅—H), 7.33 (1H, t, J=7.3 Hz, C₆′—H),7.41 (1H, d, J=2.5 Hz, C₁′—H), 7.45 (1H, dt, J=1.2, 7.3 Hz, C₇′—H), 7.46(1H, d, J=7.3 Hz, C₅′—H), 7.55 (1H, d, J=3.6 Hz, C₄′—H), 7.91 (1H, d,J=7.3 Hz, C₈′—H).

Example 31 Synthesis of compound 74

[0368] To a solution of 300.0 mg (2.16 mmol) of 2-naphthol 72 in 3 ml ofabsolute tetrahydrofuran were added 300 ml (d=1.537, 2.16 mmol, 1.0moleq.) of 3-bromo-1-propanol and 622.7 mg (2.37 mmol, 1.1 moleq.) oftriphenylphosphine. Then a solution of 0.41 ml (d=1.106, 2.37 mmol, 1.1moleq.) of DEAD in 3 ml of absolute tetrahydrofuran was added theretoand the resulting mixture was stirred at room temperature for 4 hours.After the completion of the reaction, the reaction mixture was pouredinto water and extracted with ethyl acetate. The ethyl acetate layer waswashed with water and a saturated aqueous solution of sodium chlorideand dried over sodium sulfate. After distilling off the solvent underreduced pressure, the obtained residue was purified by columnchromatography (silica gel, ethyl acetate-n-hexane) to thereby give551.8 mg (100%) of a colorless oil 73.

[0369] To a solution of 200 mg (0.75 mmol) of the compound 73 in 5 ml ofacetonitrile were added 169.8 mg (1.13 mmol, 1.5 moleq.) of(R)-3-methoxy-a-methylbenzylamine and 156.5 mg (1.13 mmol, 1.5 moleq.)of potassium carbonate and the resulting mixture was stirred underheating at an external temperature of 60° C. for 4 hours. After thecompletion of the reaction, the reaction mixture was poured into waterand extracted with ethyl acetate. The ethyl acetate layer was washedwith water and a saturated aqueous solution of sodium chloride and driedover sodium sulfate. After distilling off the solvent under reducedpressure, the obtained residue was purified by column chromatography(silica gel, ethyl acetate-n-hexane) to thereby give 230.8 mg (91.3%) ofa colorless qil 74.

[0370] MS m/z: 335 (M⁺). ¹H-NMR d: 1.41 (3H, d, J=6.7 Hz, CH₃), 2.13(2H, dt, J=6.7, 12.8 Hz, CH₂), 2.73 (1H, dt, J=6.7, 11.6 Hz, CH₂), 2.85(1H, dt, J=6.7, 11.6 Hz, CH₂), 3.79 (3H, s, OCH₃), 3.83 (1H, q, J=6.7Hz, CH), 4.23 (2H, dt, J=1.2, 6.1 Hz, CH₂), 6.80 (1H, dd, J=2.4, 7.9 Hz,C₆—H), 6.83 (1H, d, J=7.3 Hz, C₂′—H), 6.92 (1H, d, J=2.4 Hz, C₂—H), 6.93(1H, d, J=7.9 Hz, C₄—H), 7.24 (1H, t, J=7.9 Hz, C₅—H), 7.39 (1H, t,J=7.9 Hz, C₆′—H), 7.45 (1H, d, J=7.9 Hz, C₄′—H), 7.48 (1H, dd, J=1.2,7.9 Hz, C₃′—H), 7.52 (1H, dt, J=1.2, 7.9 Hz, C₇′—H), 7.83 (1H, d, J=7.9Hz, C₅′—H), 8.22 (1H, d, J=7.9 Hz, C₈′—H).

Example 32 Synthesis of compound 77

[0371] To a solution of 300 mg (1.87 mmol) of 2-naphthalenethio. 75 in 5ml of methylene chloride were added 0.23 ml (d=1.989, 2.25 mmol, 1.2moleq.) of 1,3-dibromopropane and 0.31 mg (d=0.726, 2.25 mmol, 1.2moleq.) of triethylamine and the resulting mixture was stirred underheating at an external temperature of 40° C. for 4 hours. After thecompletion of the reaction, the reaction mixture was poured into waterand extracted with ethyl acetate. The ethyl acetate layer was washedwith a 5% aqueous solution of hydrochloric acid, water and a saturatedaqueous solution of sodium chloride and dried over sodium sulfate. Afterdistilling off the solvent under reduced pressure, the obtained residuewas purified by column chromatography (silica gel, ethylacetate-n-hexane) to thereby give 241.3 mg (45.9%) of a colorless oil76.

[0372] To a solution of 241 mg (0.86 mmol) of the compound 76 in 5 ml ofacetonitrile were added 193.0 mg (1.29 mmol, 1.5 moleq.) of(R)-3-methoxy-a-methylbenzylamine and 177.8 mg (1.29 mmol, 1.5 moleq.)of potassium carbonate and the resulting mixture was stirred underheating at an external temperature of 60° C. for 4 hours. After thecompletion of the reaction, the reaction mixture was poured into waterand extracted with ethyl acetate. The ethyl acetate layer was washedwith water and a saturated aqueous solution of sodium chloride and driedover sodium sulfate. After distilling off the solvent under reducedpressure, the obtained residue was purified by column chromatography(silica gel, ethyl acetate-n-hexane) to thereby give 209.8 mg (69.7%) ofa colorless oil 77.

[0373] MS m/z: 351 (M⁺). ¹H-NMR d: 1.38 (3H, d, J=6.7 Hz, CH₃), 2.01(2H, dt, J=6.7 Hz, CH₂), 2.73 (2H, dt, J=6.7, 25.0 Hz, CH₂), 3.80 (1H,q, J=6.7 Hz, CH), 3.80 (3H, s, OCH₃), 4.13 (2H, m, CH₂), 6.79 (1H, dd,J=1.8, 7.3 Hz, C₆—H), 6.91 (1H, d, J=1.2 Hz, C₂—H), 6.92 (1H, d, J=7.3Hz, C₄—H), 7.02 (1H, dd, J=2.5, 7.3 Hz, C₃′—H), 7.24 (1H, t, J=7.3 Hz,C₅—H), 7.33 (1H, t, J=7.3 Hz, C₆′—H), 7.41 (1H, d, J=2.5 Hz, C₁′—H),7.45 (1H, dt, J=1.2, 7.3 Hz, C₇′—H), 7.46 (1H, d, J=7.3 Hz, C₄′—H), 7.55(1H, d, J=7.3 Hz, C₅′—H), 7.91 (1H, d, J=7.3 Hz, C₈′—H).

Example 33 Synthesis of compound 80

[0374] To a solution of 500 mg (3.76 mmol) of 5-hydroxyindole 78 in 5 mlof acetonitrile were added 833.9 mg (d=1.989, 4.13 mmol, 1.1 moleq.) of1,3-dibromopropane and 570.9 mg (4.13 mmol, 1.1 moleq.) of potassiumcarbonate and the resulting mixture was stirred under heating at anexternal temperature of 60° C. for 4 hours. After the completion of thereaction, the reaction mixture was poured into water and extracted withethyl acetate. The ethyl acetate layer was washed with water and asaturated aqueous solution of sodium chloride and dried over sodiumsulfate. After distilling off the solvent under reduced pressure, theobtained residue was purified by column chromatography (silica gel,ethyl acetate-n-hexane) to thereby give 586 mg (61.4%) of a colorlessoil 79.

[0375]¹H-NMR d: 2.33 (2H, dt, J=6.1, 12.2 Hz, CH₂), 3.63 (2H, t, J=6.1Hz, CH₂), 4.13 (2H, t, J=6.1 Hz, CH₂), 6.47 (1H, t, J=2.4 Hz, C₃—H),6.85 (1H, dd, J=2.4, 8.5 Hz, C₆—H), 7.12 (1H, d, J=2.4 Hz, C₄—H), 7.17(1H, t, J=2.4 Hz, C₂—H), 7.26 (1H,d, J=8.5 Hz, C₇—H), 8.03 (1H, s, NH).

[0376] To a solution of 200 mg (0.79 mmol) of the compound 79 in 3 ml ofacetonitrile were added 118.1 g (0.79 mmol, 1.5 moleq.) of(R)-3-methoxy-a-methylbenzylamine and 130.6 mg (0.94 mmol, 1.2 moleq.)of potassium carbonate and the resulting mixture was stirred underheating at an external temperature of 40° C. for 4 hours. After thecompletion of the reaction, the reaction mixture was poured into waterand extracted with ethyl acetate. The ethyl acetate layer was washedwith water and a saturated aqueous solution of sodium chloride and driedover sodium sulfate. After distilling off the solvent under reducedpressure, the obtained residue was purified by column chromatography(silica gel, ethyl acetate-n-hexane) to thereby give 265.1 mg (82.8%) ofa colorless oil 80.

[0377] MS m/z: 324(M⁺). ¹H-NMR d: 1.38 (3H, d, J=6.7 Hz, CH₃), 2.01 (2H,dt, J=6.7, 12.8 Hz, CH₂), 2.67 (1H, dt, J=6.7, 11.6 Hz, CH₂), 2.74 (1H,dt, J=6.7, 13.4 Hz, CH₂), 3.78 (1H, q, J=6.7 Hz, CH), 3.81 (3H, s,OCH₃), 4.02-4.09 (2H, m, CH₂), 6.47 (1H, t, J=3.1 Hz, C₃′—H), 6.78 (1H,dd, J=3.1, 7.9 Hz, C₆—H), 6.83 (1H, dd, J=2.4, 8.5 Hz, C₆′—H), 6.90 (1H,d, J=3.1 Hz, C₂—H), 6.91 (1H, d, J=7.9 Hz, C₄—H), 7.09 (1H, d, J=2.4 Hz,C₄′—H), 7.18 (1H, t, J=3.1 Hz, C₂′—H), 7.23 (1H, t, J=7.9 Hz, C₅—H),7.27 (1H, d, J=8.5 Hz, C₇′—H), 8.07 (1H, s, NH).

Example 34 Synthesis of compound 83

[0378] To a solution of 400 mg (2.35 mmol) of 4-phenylphenol 81 in 5 mlof acetonitrile were added 0.48 ml (d=1.989, 4.7 mmol, 2.0 moleq.) of1,3-dibromoprbpane and 389.7 mg (2.82 mmol, 1.2 moleq.) of potassiumcarbonate and the resulting mixture was stirred under heating at anexternal temperature of 60° C. for 4 hours. After the completion of thereaction, the reaction mixture was poured into water and extracted withethyl acetate. The ethyl acetate layer was washed with water and asaturated aqueous solution of sodium chloride and dried over sodiumsulfate. After distilling off the solvent under reduced pressure, theobtained residue was purified by column chromatography (silica gel,ethyl acetate-n-hexane) to thereby give 564.9 mg (82.5%) of colorlessprism crystals 82.

[0379] To a solution of 300 mg (1.03 mmol) of the compound 82 in 4 ml ofacetonitrile were added 309.3 mg (2.06 mmol, 2.0 moleq.) of(R)-3-methoxy-a-methylbenzylamine and 284.9 mg (2.06 mmol, 2.0 moleq.)of potassium carbonate and the resulting mixture was stirred underheating at an external temperature of 60° C. for 4 hours. After thecompletion of the reaction, the reaction mixture was poured into waterand extracted with.ethyl acetate. The ethyl acetate layer was washedwith water and a saturated aqueous solution of sodium chloride and driedover sodium sulfate. After distilling off the solvent under reducedpressure, the obtained residue was purified by column chromatography(silica gel, ethyl acetate-n-hexane) to thereby give 311.9 mg (83.8%) ofcolorless prism crystals 83.

[0380] MS m/z: 361 (M⁺). ¹H-NMR d: 1.36 (3H, d, J=6.7 Hz, CH₃),1.93-2.01 (2H, m, CH₂), 2.65 (1H, dt, J=6.7, 11.6 Hz, CH₂), 2.73 (1H,dt, J=6.7,11.6 Hz, CH₂), 3.77 (1H, q, J=6.7 Hz, CH), 3.80 (3H, s, OCH₃),4.02-4.10 (2H, m, CH₂), 6.79 (1H,dd, J=1.8, 7.3 Hz, C₆—H), 6.90 (1H, d,J=1.8 Hz, C₂—H), 6.91 (1H, d, J=7.3 Hz, C₄—H), 6.95 (2H, dt, J=2.4, 9.2Hz, C₃′—H), 7.24 (1H, t, J=7.3 Hz, C₅—H), 7.30 (1H, t, J=7.3 Hz, C₄″—H),7.42 (2H, t, J=7.3 Hz, C₃″, ₅″-H), 7.51 (2H, dt, J=2.4, 9.2 Hz, C₂″,₆″H), 7.55 (2H, dd, J=1.2, 7.3 Hz, C₂′, ₆′-H).

Example 35 Synthesis of compound 88

[0381] To a solution of 600 mg (4.0 mmol) of(R)-3-methoxy-a-methylbenzylamine 84 in 5 ml of methylene chloride wereadded 662.4 mg (d=1.176,4.4 mmol, 1.1 moleq.) of ethylmalonyl chlorideand 0.66 ml (d=0.726, 4.8 mmol, 1.2 moleq.) of triethylamine and theresulting mixture was stirred at room temperature for 2 hours. After thecompletion of the reaction, the reaction mixture was poured into waterand extracted with methylene chloride. The methylene chloride layer waswashed with a 5% aqueous solution of hydrochloric acid, water and asaturated aqueous solution of sodium chloride and dried over sodiumsulfate. After distilling off the solvent under reduced pressure, theobtained crystals were purified by column chromatography (silica gel,n-hexane-ethyl acetate) to thereby give 790.0 mg (98.4%) of colorlessprism crystals 85.

[0382] H-NMR d: 1.21 (3H, t, J=6.7 Hz, CH₂CH₃), 1.42 (3H, d, J=6.7 Hz,CH₃), 3.23 (2H, d, J=4.3 Hz, CH₂), 3.73 (3H, s, OCH₃), 4.12 (2H, q,J=6.7 Hz, CH₂CH₃), 5.04 (1H, dt, J=6.7, 14.0 Hz, CH), 6.72 (1H, dd,J=1.8, 7.9 Hz, C₆—H), 6.79 (1H, d, J=1.8 Hz, C₂—H), 6.83 (1H, d, J=7.9Hz, C₄—H), 7.18 (1H, t, J=7.9 Hz, C₅—H), 7.36 (1H, s, NH).

[0383] To a solution of 897.6 mg (3.39 mmol) of the compound 85 in 5 mlof ethanol was added 2 ml of a 10% aqueous solution of sodium hydroxideand the resulting mixture was stirred under heating at an externaltemperature of 80° C. for 1 hour. After the completion of the reaction,the reaction mixture was concentrated and acidified with a 5% aqueoussolution of hydrochloric acid. Then the reaction mixture was poured intowater and extracted with ethyl acetate. The ethyl acetate layer waswashed with a 5% aqueous solution of hydrochloric acid, water and asaturated aqueous solution of sodium chloride and dried over sodiumsulfate. After distilling off the solvent under reduced pressure, theobtained crystals were was purified by column chromatography (silicagel, n-hexane-ethyl acetate) to thereby give 790.0 mg (98.4%) ofcolorless prism crystals 86.

[0384]¹H-NMR d: 1.47 (3H, d, J=6.7 Hz, CH₃), 3.27 (2H, d, J=9.2 Hz,CH₂), 3.77 (3H, s, OCH₃), 5.05 (1H, dt, J=6.7, 14.0 Hz, CH), 6.78 (1H,dd, J=2.4, 7.9 Hz, C₆—H), 6.83 (1H, d, J=2.4 Hz, C₂—H), 6.86 (1H, d,J=7.9 Hz, C₄—H), 7.23 (1H, t, J=7.9 Hz, C₅—H ), 7.47 (1H, d, J=7.9 Hz,NH).

[0385] To a solution of 400 mg (1.68 mmol) of the compound 86 in 5 ml ofdimethylformamide were added 278.5 mg (1.86 mmol, 1.1 moleq.) of(R)-3-methoxy-a-methylbenzylamine and 389.5 mg (2.02 mmol, 1.2 moleq.)of WSC×HCl and the resulting mixture was stirred at room temperature for1 hour. After the completion of the reaction, the reaction mixture waspoured into water and extracted with ethyl acetate. The ethyl acetatelayer was washed with water and a saturated aqueous solution of sodiumchloride and dried over sodium sulfate. After distilling off the solventunder reduced pressure, the obtained crystals were purified by columnchromatography (silica gel, n-hexane-ethyl acetate) to thereby give615.4 mg (98.5%) of colorless prism crystals 87.

[0386] MS m/z: 370 (M⁺). ¹H-NMR d: 1.42 (6H, d, J=6.7 Hz, CH₃), 3.15(2H, s, CH₂), 3.75 (6H, s, OCH₃), 5.04 (2H, dt, J=7.9, 14.7 Hz, CH),6.77 (2H, dd, J=2.4, 7.9 Hz, C_(6,6′)—H), 6.80 (2H, d, J=2.4 Hz,C_(2,2′)—H), 6.83 (2H, d, J=7.9 Hz, C_(4,4′)—H), 7.20 (2H, t, J=7.9 Hz,C_(5,5′)—H), 7.47 (2H, s, NH).

[0387] To a solution of 100 mg (0.270 mmol) of the compound 87 in 5 mlof absolute tetrahydrofuran was added 0.59 ml (0.59 mmol, 1.2 moleq.) ofa 1 mel solution of boron trihydride in tetrahydrofuran. The resultingmixture was heated to room temperature and then stirred for 3 hours.After the completion of the reaction, the reaction mixture was pouredinto water, acidified with a 5% aqueous solution of hydrochloric acidand then extracted with ethyl acetate. The hydrochloric acid layer wasmade alkaline by adding a 5% aqueous solution of sodium hydroxide andextracted with ethyl acetate. The ethyl acetate layer was washed withwater and a saturated aqueous solution of sodium chloride and dried oversodium sulfate. After distilling off the solvent under reduced pressure,the obtained residue was purified by column chromatography (silica gel,n-hexane-ethyl acetate) to thereby give 76.3 mg (82.6%) of a colorlessoil 88.

[0388] MS m/z: 342 (M⁺). ¹H-NMR d: 1.43 (6H, d, J=6. 7Hz, CH₃), 1.62(2H, dt, J=6.7, 13.4 Hz, CH₂), 2.46 (2H, dt, J=6.7, 13.4 Hz, CH₂), 2.54(2H, dt, J=6.7, 11.6 Hz, CH₂), 3.70 (2H, q, J=6.7 Hz, CH), 3.80 (6H, s,OCH₃), 6.77 (2H, dd, J=2.4, 7.3 Hz, C_(6,6′)—H), 6.86 (2H, d, J=2.4 Hz,C_(2,2′)—H), 6.87 (2H, d, J=7.3 Hz, C_(4,4′)—H), 7.23 (2H, t, J=7.3 Hz,C_(5,5′)—H).

Example 36 Synthesis of compound 93

[0389] To a solution of 600 mg (3.5 mmol) of(R)-1-(1-naphthyl)ethylamine 89 in 5 ml of methylene chloride were added580.3 mg (d=1.176, 3.85 mmol, 1.1 moleq.) of ethylmalonyl chloride and0.59 ml (d=0.726, 4.2 mmol, 1.2 moleq.) of triethylamine and theresulting mixture was stirred at room temperature for 2 hours. After thecompletion of the reaction, the reaction mixture was poured into waterand extracted with methylene chloride. The methylene chloride layer waswashed with a 5% aqueous solution of hydrochloric acid, water and asaturated aqueous solution of sodium chloride and dried over sodiumsulfate. After distilling off the solvent, the obtained crystals werepurified by column chromatography (silica gel, n-hexane-ethyl acetate)to thereby give 662.9 mg (66.5%) of colorless prism crystals 90.

[0390]¹H-NMR d: 1.16 (3H, t, J=7.3 Hz, CH₂CH₃), 1.60 (3H, d, J=7.3 Hz,CH₃), 3.24 (2H, dd, J=17.7, 26.3 Hz, CH₂), 4.07 (2H, q, J=7.3 Hz,CH₂H₃), 5.89 (1H, dt, J=7.3, 14.6 Hz, CH), 7.35 (1H, d, J=7.9 Hz, NH),7.38 (1H, t, J=7.9 Hz, C₃—H), 7.44 (1H, t, J=12.2 Hz, C₆—H), 7.45 (1H,d, J=7.9 Hz, C₂—H), 7.46 (1H, t, J=12.2 Hz, C₇—H), 7.72 (1H, d, J=7.9Hz, C₄—H), 7.79 (1H, d, J=7.9 Hz, C₅—H), 8.03 (1H, d, J=7.9 Hz, C₈—H).

[0391] To a solution of 662.5 mg (2.32 mmol) of the compound 90 in 5 mlof ethanol was added 2 ml of a 10% aqueous solution of sodium hydroxide.The resulting mixture was stirred under heating at an externaltemperature of 80° C. for 1 hour. After the completion of the reaction,the reaction mixture was concentrated, acidified with a 5% aqueoussolution of hydrochloric acid. The reaction mixture was poured intowater and extracted with ethyl acetate. The ethyl acetate layer waswashed with a 5% aqueous solution of hydrochloric acid, water and asaturated aqueous solution of sodium chloride and dried over sodiumsulfate. After distilling off the solvent under reduced pressure, theobtained crystals were purified by column chromatography (silica gel,n-hexane-ethyl acetate) to thereby give 596.0 mg (99.8%) of colorlessprism crystals 91.

[0392]¹H-NMR d: 1.66 (3H, d, J=6.7 Hz, CH₃), 3.20 (2H, dd, J=18.3, 29.9Hz, CH₂), 5.91 (1H, dt, J=6.7, 14.7 Hz, CH), 6.99 (1H, d, J=7.3 Hz, NH),7.43 (1H, t, J=7.9 Hz, C₃—H), 7.48 (1H, t, J=7.9 Hz, C₆—H), 7.49 (1H, d,J=7.9 Hz, C₂—H), 7.53 (1H, dt, J=1.2, 7.9 Hz, C₇—H), 7.77 (1H, d, J=7.9Hz, C₄—H), 7.83 (1H, d, J=7.9 Hz, C₅—H), 8.00 (1H, d, J=7.9 Hz, C₈—H).

[0393] To a solution of 400 mg (1.56 mmol) of the compound 91 in 5 ml ofdimethylformamide were added 293.2 mg (1.71 mmol, 1.1 moleq.) of(R)-1-(1-naphthyl)ethylamine and 359.2 mg (1.87 mmol, 1.2 moleq.) ofWSC×HCl and the resulting mixture was stirred at room temperature for 1hour. After the completion of the reaction, the reaction mixture waspoured into water and extracted with ethyl acetate. The ethyl acetatelayer was washed with water and a saturated aqueous solution of sodiumchloride and dried over sodium sulfate. After distilling off the solventunder reduced pressure, the obtained crystals were purified by columnchromatography (silica gel, n-hexane-ethyl acetate) to thereby give615.1 mg (96.4%) of colorless prism crystals 92.

[0394] To a solution of 100 mg (0.24 mmol) of the compound 92 in 5 ml ofabsolute tetrahydrofuran was added 0.54 ml (0.54 mmol, 2.2 moleq.) of a1 mol solution of boron trihydride in tetrahydrofuran. The resultingmixture was heated to room temperature and then stirred for 3 hours.After the completion of the reaction, the reaction mixture was pouredinto water, acidified with a 5% aqueous solution of hydrochloric acidand then extracted with ethyl acetate. The hydrochloric acid layer wasmade alkaline by adding a 5% aqueous solution of sodium hydroxide andextracted with ethyl acetate. The ethyl acetate layer was washed withwater and a saturated aqueous solution of sodium chloride and dried oversodium sulfate. After distilling off the solvent under reduced pressure,the obtained residue was purified by column chromatography (silica gel,n-hexane-ethyl acetate) to thereby give 82.0 mg (88.0%) of a colorlessoil 93.

[0395] MS m/z: 382 (M⁺). ¹H-NMR d: 1.47 (6H, d, J=6.7 Hz, CH₃), 1.72(2H, dt, J=6.7, 13.4 Hz, CH₂), 2.62 (2H, dt, J=6.7, 13.4 Hz, CH₂), 2.68(2H, dt, J=6.7, 11.6 Hz, CH₂), 4.60 (2H, q, J=6.7, CH), 7.45 (2H, t,J=7.9 Hz, C_(3,3′)—H), 7.48 (2H, dt, J=1.8, 7.9 Hz, C_(6,6′)—H), 7.50(2H, t, J=7.9 Hz, C_(7,7′)—H), 7.60 (2H, d, J=7.9 Hz, C_(2,2′)—H), 7.74(2H, d, J=7.9 Hz, C_(4,4′)H), 7.87 (2H, dd, J=1.8, 7.9 Hz, C_(5,5′)—H),8.16 (2H, d, J=7.9 Hz, C_(8,8′)—H).

Example 37 Synthesis of compound 103

[0396] Compound 102:

[0397] To a solution of 6-hydroxyflavone 101 (300 mg, 1.26 mmol) inacetonitrile (5 ml) were added 1,3-dibromopropane (0.26 ml, d=1.989,2.52 mmol, 2.0 mol eq.) and potassium carbonate (208.8 mg, 1.51 mmol,1.2 mol eq.) and the resulting mixture was stirred under heating at anouter temperature of 60° C. for 4 hours.

[0398] After the completion of the reaction, the reaction mixture waspoured into water and extracted with ethyl acetate. The ethyl acetatelayer was washed with water and a saturated aqueous solution of sodiumchloride. After drying over sodium sulfate, the solvent was distilledoff under reduced pressure. The residue thus obtained was purified bycolumn chromatography [silica gel, ethyl acetate/n-hexane] to therebygive 361.8 mg (80.0%) of the compound 102 as colorless prisms.

[0399] MS m/z: 375(M⁺).¹H-NMR δ: 2.34-2.39(2H, m, CH₂), 3.62(2H, t,J=6.7 Hz, CH₂), 4.22(2H, t, J=6.7 Hz, CH₂), 6.82(1H, s, Ar—H), 7.29(1H,dd, J=3.1, 9.2 Hz, Ar—H), 7.51 (4H, m, Ar—H), 7.61(1H, d, J=3.1 Hz,Ar—H), 7.92(1H, dd, J=1.8, 7.9 Hz, Ar—H), 7.19(1H, dd, J=3.1, 9.2 Hz,Ar—H), 7.44-7.53(7H, m, Ar—H), 7.57(1H, d, J=3.1 Hz, Ar—H), 7.68(1H, d,J=7.3 Hz, Ar—H), 7.74(1H, d, J=7.9 Hz, Ar—H), 7.86(1H, d, J=7.9 Hz,Ar—H), 7.91-7.93(2H, m, Ar—H), 8.19(1H, d, J=8.5 Hz, Ar—H).

[0400] Compound 103:

[0401] To a solution of the above compound 102 (125.8 mg, 0.38 mmol, 1.2mol eq.) in acetonitrile (3 ml) were added(R)-(+)-(1-naphthyl)ethylamine (50 mg, 0.29 mmol) and potassiumcarbonate (60.5 mg, 0.44 mmol, 1.5 mol eq.) and the resulting mixturewas stirred under heating at an outer temperature of 40° C. for 6 hours.

[0402] After the completion of the reaction, the reaction mixture waspoured into water and extracted with ethyl acetate. The ethyl acetatelayer was washed with water and a saturated aqueous solution of sodiumchloride. After drying over sodium sulfate, the solvent was distilledoff under reduced pressure. The residue thus obtained was purified bycolumn chromatography [silica gel, ethyl acetate/n-hexane] to therebygive 67.1 mg (89.5%) of the compound 103 as a colorless oil.

[0403] MS m/z: 449(M⁺). ¹H-NMR δ: 1.55(3H, d, J=6.7 Hz, CH₃), 2.04(2H,t, J=6.1 Hz, CH₂), 2.07(1H, s, NH), 2.82(2H, m, CH₂), 4.15(1H, t, J=6.1Hz, CH₂), 4.71 (1H, q, J=6.7 Hz, CH), 6.82(1H, s, Ar—H), 7.19(1H, dd,J=3.1, 9.2 Hz, Ar—H), 7.44-7.53(7H, m, Ar—H), 7.57(1H, d, J=3.1 Hz,Ar—H), 7.68(1H, d, J=7.3 Hz, Ar—H), 7.74(1H, d, J=7.9 Hz, Ar—H),7.86(1H, d, J=7.9 Hz, Ar—H), 7.91-7.93(2H, m, Ar—H), 8.19(1H, d, J=8.5Hz, Ar—H).

Example 38 Synthesis of compound 106

[0404] Compound 105:

[0405] To a solution of 9-hydroxyfluorene 104 (500 mg, 2.74 mmol) intoluene (5 ml) were added 3-bromo-1-propanol (0.273 ml, d=1.537, 3.02mmol, 1.1 mol eq.) and p-toluenesulfonic acid hydrate (5.1 mg, 0.027mmol, 0.01 mol eq.) and the resulting mixture was stirred at roomtemperature for 1 hour.

[0406] After the completion of the reaction, the reaction mixture waspoured into water and extracted with ethyl acetate. The ethyl acetatelayer was washed with water and a saturated aqueous solution of sodiumchloride. After drying over sodium sulfate, the solvent was distilledoff under reduced pressure. The residue thus obtained was purified bycolumn chromatography [silica gel, n-hexane/ethyl acetate] to therebygive the compound 105 (723.4 mg, 87.0%) as a colorless oil.

[0407] Compound 106:

[0408] To a solution of the above compound 105 (106.2 mg, 0.35 mmol, 1.2mol eq.) in acetonitrile (3 ml) were added(R)-(+)-(1-naphthyl)ethylamine (50 mg, 0.29 mmol) and potassiumcarbonate (48.4 mg, 0.35 mmol, 1.2 mol eq.) and the resulting mixturewas stirred under heating at an outer temperature of 60° C. for 6 hours.

[0409] After the completion of the reaction, the reaction mixture waspoured into water and extracted with ethyl acetate. The ethyl acetatelayer was washed with water and a saturated aqueous solution of sodiumchloride. After drying over sodium sulfate, the solvent was distilledoff under reduced pressure. The residue thus obtained was purified bycolumn chromatography [silica gel, ethyl acetate/n-hexane] to therebygive 33.7 mg (76.1%) of the compound 106 as a colorless oil.

[0410] MS m/z: 393(M⁺).¹H-NMR δ: 1.47(3H, d, J=6.1 Hz, CH₃),1.70-1.76(2H, m, CH₂), 2.60-2.71(2H, m, CH₂), 3.26(2H, t, J=6.1 Hz,CH₂), 4.61(1H, q, J=6.7 Hz, CH), 5.59(1H, s, CH), 7.26(1H, t, J=7.3 Hz,Ar—H), 7.28(1H, t, J=7.3 Hz, Ar—H), 7.37(1H, d, J=7.3 Hz, Ar—H),7.38(1H, t, J=7.3 Hz, Ar—H), 7.46(1H, t, J=7.3 Hz, Ar—H), 7.48(1H, t,J=7.3 Hz, Ar—H), 7.49(1H, t, J=7.9 Hz, Ar—H), 7.53(1H, d, J=7.3 Hz,Ar—H), 7.54(1H, d, J=7.3 Hz, Ar—H), 7.63(1H, d, J=6.7 Hz, Ar—H),7.66(2H, d, J=7.9 Hz, Ar—H), 7.75(1H, d, J=8.5 Hz, Ar—H), 7.88(1H, d,J=7.9 Hz, Ar—H), 8.20(1H, d, J=8.5 Hz, Ar—H).

Example 39 Synthesis of compound 109

[0411] Compound 108:

[0412] To a solution of 2-hydroxybenzofuran 107 (500 mg, 2.71 mmol) inacetonitrile (5 ml) were added 1,3-dibromopropane (0.55 ml, d=1.989,5.43 mmol, 2.0 mol eq.) and potassium carbonate (750.1 mg, 5.43 mmol,2.0 mol eq.) and the resulting mixture was stirred at an outertemperature of 60° C. for 4 hours.

[0413] After the completion of the reaction, the reaction mixture waspoured into water and extracted with ethyl acetate. The ethyl acetatelayer was washed with water and a saturated aqueous solution of sodiumchloride. After drying over sodium sulfate, the solvent was distilledoff under reduced pressure. The residue thus obtained was purified bycolumn chromatography [silica gel, ethyl acetate/n-hexane] to therebygive 804.3 mg (77.0%) of the compound 108 as colorless prisms.

[0414] Compound 109:

[0415] To a solution of the above compound 108 (106.9 mg, 0.35 mmol, 1.2mol eq.) in acetonitrile (3 ml) were added(R)-(+)-1-(1-naphthyl)ethylamine (50 mg, 0.29 mmol) and potassiumcarbonate (60.5 mg, 0.44 mmol, 1.5 mol eq.) and the resulting mixturewas stirred under heating at an outer temperature of 60° C. for 6 hours.

[0416] After the completion of the reaction, the reaction mixture waspoured into water and extracted with ethyl acetate. The ethyl acetatelayer was washed with water and a saturated aqueous solution of sodiumchloride. After drying over sodium sulfate, the solvent was distilledoff under reduced pressure. The residue thus obtained was purified bycolumn chromatography [silica gel, ethyl acetate/n-hexane] to therebygive 67.2 mg (58.3%) of the compound 109 as a colorless oil.

[0417] MS m/z: 395(M⁺). ¹H-NMR δ: 1.53(3H, d, J=6.7 Hz, CH₃),2.02-2.07(2H, m, CH₂), 2.78-2.89(2H, m, CH₂), 4.13-4.16(2H, m, CH₂),4.69(1H, q, J=6.7 Hz, CH), 7.00(1H, dd, J=2.4, 8.6 Hz, Ar—H), 7.33(1H,t, J=7.3 Hz, Ar—H), 7.38(1H, d, J=2.4 Hz, Ar—H), 7.44-7.51 (6H, m,Ar—H), 7.67(1H, d, J=7.3 Hz, Ar—H), 7.75(1H, d, J=7.9 Hz, Ar—H),7.87(1H, dd, J=2.4, 9.7H, Ar—H), 7.89(1H, d, J=7.9 Hz, Ar—H), 8.22(1H,d, J=8.6 Hz, Ar—H).

Example 40 Synthesis of compound 112

[0418] Compound 111:

[0419] To a solution of 5-hydroxyindole 110 (500 mg, 3.76 mmol) inacetonitrile (5 ml) were added 1,3-dibromopropane (833.9 mg, d=1.989,4.13 mmol, 1.1 mol eq.) and potassium carbonate (570.9 mg, 4.13 mmol,1.1 mol eq.) and the resulting mixture was stirred under heating at anouter temperature of 60° C. for 4 hours.

[0420] After the completion of the reaction, the reaction mixture waspoured into water and extracted with ethyl acetate. The ethyl acetatelayer was washed with water and a saturated aqueous solution of sodiumchloride. After drying over sodium sulfate, the solvent was distilledoff under reduced pressure. The residue thus obtained was purified bycolumn chromatography [silica gel, ethyl acetate/n-hexane] to therebygive 586 mg (61.4%) of the compound 111 as a colorless oil.

[0421]¹H-NMR δ: 1.70(3H, d, J=6.7 Hz, CH₂), 3.63(2H, t, J=6.7 Hz, CH₃),4.13(2H, t, J=6.7 Hz, CH₂), 6.47(1H, t, J=2.4 Hz, Ar—H), 6.85(1H, dd,J=2.4, 9.2 Hz, Ar—H), 7.12(1H, d, J=2.4 Hz, Ar—H), 7.17(1H, t, J=2.4 Hz,Ar—H), 7.26(1H, d, J=8.5 Hz, Ar—H), 8.03(1H, s, NH).

[0422] Compound 112:

[0423] To a solution of the above compound 111 (65.3 mg, 0.26 mmol, 1.5mol eq.) in acetonitrile (3 ml) were added(R)-(+)-1-(1-naphthyl)ethylamine (29.3 mg, 0.17 mmol) and potassiumcarbonate (35.5 mg, 0.26 mmol, 1.5 mol eq.) and the resulting mixturewas stirred under heating at an outer temperature of 60° C. for 6 hours.

[0424] After the completion of the reaction, the reaction mixture waspoured into water and extracted with ethyl acetate. The ethyl acetatelayer was washed with water and a saturated aqueous solution of sodiumchloride. After drying over sodium sulfate, the solvent was distilledoff under reduced pressure. The residue thus obtained was purified bycolumn chromatography [silica gel, ethyl acetate/n-hexane] to therebygive 36.5 mg (62.0%) of the compound 112 as a colorless oil.

[0425] MS m/z: 344(M⁺). ¹H-NMR δ: 1.52(3H, d, J=6.1 Hz, CH₃),1.99-2.04(2H, m, CH₂), 2.76-2.86(2H, m, CH₂), 4.05-4.12(2H, m, CH₂),4.67(1H, q, J=6.1 Hz, CH), 6.47(1H, s, Ar—H), 6.83(1H, dd, J=2.4, 8.6Hz, Ar—H), 7.09(1H, d, J=2.4 Hz, Ar—H), 7.17(1H, t, J=2.4 Hz, Ar—H),7.26(1H, d, J=9.2 Hz, Ar—H), 7.44-7.50(3H, m, Ar—H), 7.67(1H, d, J=7.3Hz, Ar—H), 7.74(1H, d, J=8.5 Hz, Ar—H), 7.87(1H, dd, J=2.4, 6.7 Hz,Ar—H), 8.10(1H, s, NH), 8.20(1H, d, J=7.9 Hz, Ar—H).

Example 41 Synthesis of compound 117

[0426] Compound 114:

[0427] To a solution of (R)-(+)-1-(1-naphthyl)ethylamine (600 mg, 3.5mmol) in dichloromethane (5 ml) were added ethylmalonyl chloride 113(580.3 mg, 3.85 mmol, 1.1 mol eq.) and triethylamine (0.59 ml,d=0.726,3.85 mmol, 1.1 mol eq.) and the resulting mixture was stirred atroom temperature for 2 hours.

[0428] After the completion of the reaction, the reaction mixture waspoured into water and extracted with dichloromethane. Thedichloromethane layer was washed successively with a 5% aqueous solutionof hydrochloric acid, water and a saturated aqueous solution of sodiumchloride. After drying over sodium sulfate, the solvent was distilledoff under reduced pressure. The crystals thus obtained were purified bycolumn chromatography [silica gel, ethyl acetate/n-hexane] to therebygive 662.9 mg (66.5%) of the compound 114 as colorless prisms.

[0429]¹H-NMR δ: 1.16(3H, t, J=7.3 Hz, CH₂CH₃), 1.60(3H, d, J=7.3 Hz,CH₃), 3.24(2H, dd, J=17.7, 26.3 Hz, CH₂), 4.07(2H, q, J=7.3 Hz, CH₂CH₃),5.89(1H, dt, J=7.3, 14.6 Hz, CH), 7.35(1H, d, J=7.9 Hz, NH), 7.38(1H, t,J=7.9 Hz), Ar—H, 7.44(1H, t, J=12.2 Hz, Ar—H), 7.46(1H, t, J=12.2 Hz,Ar—H), 7.72(1H, d, J=7.9 Hz, Ar—H) 7.79(1H, d, J=7.9 Hz, Ar—H), 8.03(1H,d, J=7.9 Hz, Ar—H).

[0430] Compound 115:

[0431] To a solution of the above compound 114 (662.5 mg, 2.32 mmol) inethanol (5 ml) was added a 10% aqueous solution of sodium hydroxide (1ml) and the resulting mixture was stirred under heating at an outertemperature of 80° C. for 1 hour.

[0432] After the completion of the reaction, the reaction mixture wasconcentrated, acidified with a 5% aqueous solution of hydrochloric acid,poured into water and extracted with ethyl acetate. The ethyl acetatelayer was washed successively with a 5% aqueous solution of hydrochloricacid, water and a saturated aqueous solution of sodium chloride. Afterdrying over sodium sulfate, the solvent was distilled off under reducedpressure. The crystals thus obtained were purified by columnchromatography [silica gel, ethyl acetate/n-hexane] to thereby give659.5 mg of the compound 115 as colorless prisms.

[0433]¹H-NMR δ: 1.66(3H, d, J=6.7 Hz, CH₃), 3.20(2H, dd, J=18.3, 29.9Hz, CH₂), 5.91(1H, dt, J=6.7, 14.7 Hz, CH), 6.99(1H, d, J=7.3 Hz, NH),7.43(1H, t, J=7.9 Hz, Ar—H), 7.48(1H, d, J=7.9 Hz, Ar—H), 7.53(1H, dt,J=1.2, 6.7 Hz, Ar—H), 7.77(1H, d, J=8.5 Hz, Ar—H), 7.83(1H, d, J=7.9 Hz,Ar—H), 8.00(1H, d, J=8.5 Hz, Ar—H).

[0434] Compound 116:

[0435] To a solution of the above compound 115 (50 mg, 0.19 mmol) inN,N-dimethylformamide (3 ml) were added (R)-(+)-1-(1-naphthyl)ethylamine(45.0 mg, 0.21 mmol, 1.1 mol eq.) and WSC HCl (44.9 mg, 0.23 mmol,1.2mol eq.) and the resulting mixture was stirred at room temperature for 1hour.

[0436] After the completion of the reaction, the reaction mixture waspoured into water and extracted with ethyl acetate. The ethyl acetatelayer was washed with water and a saturated aqueous solution of sodiumchloride. After drying over sodium sulfate, the solvent was distilledoff under reduced pressure. The crystals thus obtained were purified bycolumn chromatography [silica gel, ethyl acetate/n-hexane] to therebygive 61.6 mg (70.5%) of the compound 116 as colorless prisms.

[0437]¹H-NMR δ: 1.43(3H, d, J=6.7 Hz, CH₂CH₃), 1.72(3H, d, J=6.7 Hz,CH₃), 3.38(2H, d, J=2.5 Hz, CH₂), 4.36(2H, q, J=6.7 Hz, CH₂CH₃),5.32-6.01 (1 H, m, CH), 6.88(1H, d, J=9.2 Hz, Ar—H), 7.21 (1H, t, J=6.7Hz, Ar—H), 7.33(1H, d, J=8.6 Hz, Ar—H), 7.40(1H, d, J=7.9 Hz, Ar—H),7.44-7.56(5H, m, Ar—H), 7.80(1H, d, J=7.9 Hz, Ar—H), 7.88(1H, d, J=9.2Hz, Ar—H), 8.06(1H, d, J=7.9 Hz, Ar—H), 8.11 (1H, d, J=8.5 Hz, Ar—H),8.29(1H, d, J=1.8 Hz, Ar—H).

[0438] Compound 117:

[0439] To a solution of the above compound 116 (50 mg, 0.11 mol) intetrahydrofuran (3 ml) was added a 1 M solution ofborane-tetrahydrofuran (0.24 ml, 0.24 mmol, 2.2 mol eq.) underice-cooling. Then the temperature was elevated to room temperature andthe mixture was stirred for 6 hours.

[0440] After the completion of the reaction, water was poured into thereaction mixture. Then the mixture was acidified with a 5% aqueoussolution of hydrochloric acid and extracted with ethyl acetate. Thelayer of the 5% aqueous solution of hydrochloric acid was made alkalineby adding a 5% aqueous solution of sodium hydroxide and then extractedwith ethyl acetate. After washing with water and a saturated aqueoussolution of sodium chloride and drying over sodium sulfate, the solventwas distilled off under reduced pressure. The crystals thus obtainedwere purified by column chromatography [silica gel, ethylacetate/n-hexane] to thereby give 18.0 mg (88.0%) of the compound 117 asa colorless oil.

[0441] MS m/z: 421 (M⁺). ¹H-NMR δ: 1.38(3H, d, J=7.3 Hz, CH₂CH₃),1.56(3H, d, J=6.7 Hz, CH₃), 1.90(2H, m, CH₂), 2.75(1H, m, CH₂), 2.81(2H, m, CH₂), 3.29(2H, t, J=6.7 Hz, CH₂), 4.29(2H, q, J=7.3 Hz, CH₂CH₃),4.79(1H, q, J=6.1 Hz, CH), 6.81 (1H, dd, J=1.8, 8.6 Hz, Ar—H), 7.13(1H,t, J=7.3 Hz, Ar—H), 7.20(1H, d, J=8.6 Hz, Ar—H), 7.27(1H, d, J=1.8 Hz,Ar—H), 7.32(1H, d, J=7.9 Hz, Ar—H), 7.39(1H, t, J=7.3 Hz, Ar—H),7.46(3H, m, Ar—H), 7.65(1H, d, J=10.4 Hz, Ar—H), 7.75(1H, d, J=8.6 Hz,Ar—H), 7.86(1H, dd, J=2.4, 6.7 Hz, Ar—H), 7.98(1H, d, J=7.3 Hz, Ar—H),8.16(1H, d, J=8.6 Hz, Ar—H).

Example 42 Synthesis of compound 123

[0442] Compound 119:

[0443] 2-Methoxycarbonylthiophenol 118 (9.7 g) was dissolved inN,N-dimethylformamide (200 ml) and sodium hydride (60%) (2.7 g) wasadded thereto at 0° C. When foaming was ceased,(±)-2-tert-butoxycarbonylamino-1-methanesulfonyloxy-2-phenylethane (20.0g) was added thereto and the resulting mixture was stirred at roomtemperature for 12 hours.

[0444] After the completion of the reaction, ammonium chloride was addedthereto in excess and the reaction. mixture was extracted with ethylacetate. The extract was washed with a saturated aqueous solution ofsodium chloride and dried over sodium sulfate. After distilling off thesolvent under reduced pressure, the crystals thus obtained were purifiedby column chromatography [silica gel, ethyl acetate/n-hexane] to therebygive 16.0 g of the compound 119.

[0445] Compound 120:

[0446] The above compound 119 (1.9 g) was dissolved in diphenyl etherand p-toluenesulfonic acid hydrate (100 mg) was added thereto. Theresulting mixture was heated at 250 to 260° C. for 40 minutes.

[0447] After cooling by allowing to stand, it was purified by columnchromatography and eluted with ethyl acetate/n-hexane to thereby give700 mg of the compound 120.

[0448] Compound 121:

[0449] The above compound 120 (150 g) was dissolved in tetrahydrofuranand lithium aluminum hydride (310 mg) was added thereto. The resultingmixture was then heated under reflux for 5 hours.

[0450] After the completion of the reaction, sodium sulfate decahydratewas added in excess thereto and the mixture was filtered through celite.The filtrate was concentrated and thus 330 mg of the compound 121 wasobtained.

[0451] Compound 122:

[0452] The above compound 121 (3.0 g) and triethylamine (1.5 g) weredissolved in tetrahydrofuran and acryloyl chloride (1.2 g) was addedthereto under ice-cooling. After stirring the mixture at roomtemperature for 30 minutes, a saturated aqueous solution of sodiumhydrogen carbonate was added thereto followed by extraction withchloroform. The extract was washed with a saturated aqueous solution ofsodium chloride and dried over sodium sulfate. After distilling off thesolvent under reduced pressure, the obtained residue was purified bycolumn chromatography [silica gel, ethyl acetate/n-hexane] to therebygive 1.5 g of the compound 122.

[0453] Compound 123:

[0454] The above compound 122 (150 mg, 0.51 mmol) and(R)-(+)-1-(1-naphthyl)ethylamine (104.5 mg, 0.61 mmol, 1.2 mol eq.) weredissolved in chloroform/methanol (3 ml) and then allowed to stand atroom temperature for 1 week.

[0455] After the completion of the reaction, the solvent was distilledoff under reduced pressure. The oil thus obtained was purified by columnchromatography [silica gel, chloroform/methanol] to thereby give 167.4mg (70.7%) of the compound 123 as a colorless oil.

[0456] MS m/z: 466(M⁺).¹H-NMR δ: 1.46(3H, q, J=6.7 Hz, CH₃),2.33-2.36(1H, m, CH₂), 2.79-2.93(3H, m, CH₂), 3.25-3.38(1H, m, CH₂),3.57-3.65(1 H, m, CH₂), 4.41-4.45(1H, m, CH₂), 4.56-4.65(2H, m, CH₂),6.30-6.34(1H, m, CH), 7.07-7.17(3H, m, Ar—H), 7.27-7.51(9H, m, Ar—H),7.63(1H, t, J=4.9 Hz, Ar—H), 7.73(1H, t, J=8.5 Hz, Ar—H), 7.84-7.87(1H,m, Ar—H), 8.11-8.19(1H, m, Ar—H).

Example 43 Synthesis of K-2003

[0457] 4-Bromophenol (520 mg, 3.01 mmol) was dissolved in acetonitrile(11 ml) and then potassium carbonate (1.243 g, 8.99 mmol) and1,3-dibromopropane (0.37 ml, 3.64 mmol) were successively added theretoat room temperature. The resulting mixture was stirred under heat-refluxat 95° C. for 4 hours. After confirming the completion of the reactionby TLC, potassium carbonate (800 mg, 5.79 mmol) and(R)-(+)-3-methoxy-α-methylbenzylamine (450 mg, 2.98 mmol) were added atroom temperature to the reaction system and the resulting mixture wasstirred at 95° C. for additional 18 hours.

[0458] After the completion of the reaction, the reaction mixture wascooled by allowing to stand at room temperature. After pouring waterthereinto, the mixture was subjected to separatory extraction withchloroform and washed with a saturated aqueous solution of sodiumchloride. The organic layer thus obtained was dried over anhydroussodium sulfate and concentrated under reduced pressure. The organicresidue was purified by silica gel column chromatography(chloroform:methanol=100:1) to thereby give 364 mg (1.00 mmol) of thecompound K-2003 as a pale yellow syrup at a yield of 33%.

[0459] 500 MHz NMR 7.22(1H, dd, J=8.3 Hz, J=8.3 Hz), 7.34(2H, dd, J=8.3Hz, J=8.3 Hz), 6.87-6.88(1H, m), 6.87(1H, s), 6.76-6.78(1H, m), 6.74(2H,dd, J=8.3 Hz, J=2.0 Hz), 3.93-4.00(2H, m), 3.79(3H, s), 3.74(1H, q,J=6.5 Hz), 2.58-2.71(2H, m), 1.88-1.95(2H, m), 1.53(1H, m), 1.34(3H, d,J=6.5 Hz), m/z=363, 365.

Example 44 Synthesis of K-2004

[0460] 4-Bromophenol (570 mg, 3.29 mmol) was dissolved in acetonitrile(11 ml) and then potassium carbonate (1.08 g, 7.81 mmol) and1,4-dibromobutane (0.44 ml, 3.68 mmol) were successively added theretoat room temperature. The resulting mixture was stirred under heat-refluxat 95° C. for 4 hours. After confirming the completion of the reactionby TLC, potassium carbonate (455 mg, 3.29 mmol) and(R)-(+)-3-methoxy-α-methylbenzylamine (400 mg, 2.64 mmol) were added atroom temperature to the reaction system and the resulting mixture wasstirred at 95° C. for additional 18 hours.

[0461] After the completion of the reaction, the reaction mixture wascooled by allowing to stand at room temperature. After pouring waterthereinto, the mixture was subjected to separatory extraction withchloroform and washed with a saturated aqueous solution of sodiumchloride. The organic layer thus obtained was dried over anhydroussodium sulfate and concentrated under reduced pressure. The organicresidue was purified by silica gel column chromatography(chloroform:methanol=100:1) to thereby give 422 mg (1.11 mmol) of thecompound K-2004 as a pale yellow syrup at a yield of 43%.

[0462] 500 MHz NMR 7.34(2H, d, J=9.0 Hz), 7.23(1H, dd, J=8.3 Hz, J=8.3Hz), 6.77-6.88(3H, m), 6.73(2H, d, J=6.5 Hz), 3.86(2H, t, J=6.5 Hz),3.80(3H, s), 3.72(1H, q, J=7.0 Hz), 2.46-2.59(2H, m), 1.73-1.83(2H, m),1.56-1.67(2H, m),1.51 (1H, s),1.34(3H, d, J=7.0 Hz), m/z=377, 379.

Example 45 Synthesis of K-2005

[0463] 4-Bromophenol (710 mg, 4.10 mmol) was dissolved in acetonitrile(11 ml) and then potassium carbonate (710 mg, 5.14 mmol) and1,5-dibromopentane (0.44 ml, 4.55 mmol) were successively added theretoat room temperature. The resulting mixture was stirred under heat-refluxat 95° C. for 4 hours. After confirming the completion of the reactionby TLC, potassium carbonate (455 mg, 3.29 mmol) and(R)-(+)-3-methoxy-α-methylbenzylamine (370 mg, 2.45 mmol) were added atroom temperature to the reaction system and the resulting mixture wasstirred at 95° C. for additional 24 hours.

[0464] After the completion of the reaction, the reaction mixture wascooled by allowing to stand at room temperature. After pouring waterthereinto, the mixture was subjected to separatory extraction withchloroform and washed with a saturated aqueous solution of sodiumchloride. The organic layer thus obtained was dried over anhydroussodium sulfate and concentrated under reduced pressure. The organicresidue was purified by silica gel column chromatography(chloroform:methanol=100:1) to thereby give 295 mg (0.75 mmol) of thecompound K-2005 as a pale yellow syrup at a yield of 31%.

[0465] 500 MHz NMR 7.34(2H, d, J=7.0 Hz), 7.23(1H, dd, J=8.5 Hz, J=8.5Hz), 6.87-6.89(2H, m), 6.77(1H, dd, J=8.5 Hz, J=1.5 Hz), 6.74(2H, d,J=8.5 Hz), 3.88(2H, t, J=6.3 Hz), 3.80(3H, m), 3.72(1H, q, J=6.5 Hz),2.36-2.55(4H, m), 1.55-1.77(2H, m), 1.43-1.57(2H, m), 1.34(3H, d, J=6.5Hz), m/z=391, 393.

Example 46 Synthesis of K-2006

[0466] 4-Bromophenol (500 mg, 2.89 mmol) was dissolved in acetonitrile(10 ml) and then potassium carbonate (540 mg, 3.90 mmol) and1,6-dibromohexane (0.49 ml, 3.18 mmol) were successively added theretoat room temperature. The resulting mixture was stirred under heat-refluxat 95° C. for 4 hours. After confirming the completion of the reactionby TLC, potassium carbonate (400 mg, 2.89 mmol) and(R)-(+)-3-methoxy-α-methylbenzylamine (270 mg, 1.79 mmol) were added atroom temperature to the reaction system and the resulting mixture wasstirred at 95° C. for additional 24 hours.

[0467] After the completion of the reaction, the reaction mixture wascooled by allowing to stand at room temperature. After pouring waterthereinto, the mixture was subjected to separatory extraction withchloroform and washed with a saturated aqueous solution of sodiumchloride. The organic layer thus obtained was dried over anhydroussodium sulfate and concentrated under reduced pressure. The organicresidue was purified by silica gel column chromatography(chloroform:methanol=100:1) to thereby give 364 mg (0.896 mmol) of thecompound K-2006 as a pale yellow syrup at a yield of 50%.

[0468] 500 MHz NMR 7.34(2H, d, J=8.0 Hz), 7.23(1H, dd, J=8.0 Hz, J=8.0Hz), 6.88-6.89(1H, m), 6.88(1H, s), 6.78(1H, dd, J=8.0 Hz, J=3.0Hz),6.75(2H, d, J=8.0 Hz), 3.88(2H, t, J=6.3 Hz), 3.81(3H, s), 3.73(1H, q,J=7.0 Hz), 2.41-2.53(2H, m), 1.71-1.77(2H, m), 1.35-1.52(7H, m),1.34(3H, d, J=7.0 Hz), m/z=405, 407.

Example 47 Synthesis of K-2007

[0469] 4-Bromophenol (490 mg, 2.83 mm ol) was dissolved in acetonitrile(10 ml) and then potassium carbonate (495 mg, 3.58 mmol) and1,7-dibromoheptane (0.53 ml, 3.10 mmol) were successively added theretoat room temperature. The resulting mixture was stirred under heat-refluxat 95° C. for 4 hours. After confirming the completion of the reactionby TLC, potassium carbonate (400 mg, 2.89 mmol) and(R)-(+)-3-methoxy-α-methylbenzylamine (300 mg, 1.98 mmol) were added atroom temperature to the reaction system and the resulting mixture wasstirred at 95° C. for additional 24 hours.

[0470] After the completion of the reaction, the reaction mixture wascooled by allowing to stand at room temperature. After pouring waterthereinto, the mixture was subjected to separatory extraction withchloroform and washed with a saturated aqueous solution of sodiumchloride. The organic layer thus obtained was dried over anhydroussodium sulfate and concentrated under reduced pressure. The organicresidue was purified by silica gel column chromatography(chloroform:methanol=100:1) to thereby give 150 mg (0.36 mmol) of thecompound K-2007 as a pale yellow syrup at a yield of 18%.

[0471] 500 MHz NMR 7.34(2H, d, J=8.5 Hz), 7.24(1H, dd, J=7.8 Hz, J=7.8Hz), 6.90-6.93(2H, m), 6.79(1H, dd, J=7.8 Hz, J=1.8 Hz), 6.75(2H, d,J=8.5 Hz), 3.88(2H, t, J=6.3 Hz), 3.82(3H, s), 3.79-3.80(1H, m),2.43-2.54(2H, m), 1.70-1.84(2H, m), 1.20-1.56(9H, m), 1.41(3H, d, J=6.5Hz), m/z=419, 421.

Example 48 Synthesis of K-2010

[0472] 3-Trifluoromethylthiophenol (61 5 mg, 3.45 mmol) was dissolved inacetonitrile (12 ml) and then potassium carbonate (467 mg, 3.38 mmol)and 1,4-dibromobutane (0.46 ml, 3.85 mmol) were successively addedthereto at room temperature. The resulting mixture was stirred at thesame temperature for 5 hours. After confirming the completion of thereaction by TLC, potassium carbonate (210 mg, 1.52 mmol) and(R)-(+)-3-methoxy-α-methylbenzylamine (360 mg, 2.38 mmol) were added atroom temperature to the reaction system and the resulting mixture wasstirred at 95° C. for additional 18 hours.

[0473] After the completion of the reaction, the reaction mixture wascooled by allowing to stand at room temperature. After pouring waterthereinto, the mixture was subjected to separatory extraction withchloroform and washed with a saturated aqueous solution of sodiumchloride. The organic layer thus obtained was dried over anhydroussodium sulfate and concentrated under reduced pressure. The organicresidue was purified by silica gel column chromatography(chloroform:methanol=150:1) to thereby give 180 mg (0.47 mmol) of thecompound K-2010 as a pale yellow syrup at a yield of 20%.

[0474] 500 MHz NMR 7.51 (1H, s), 7.35-7.44(3H, m), 7.23(1H, dd, J=8.0HZ, J=8.0 Hz), 6.86-6.88(2H, m), 6.76-6.78(1H, m), 3.80(3H, s), 3.71(1H, q, J=6.5 Hz), 2.93(2H, t, J=7.5 Hz), 2.50-2.55(1H, m),2.42-2.47(1H, m), 1.55-1.71 (4H, m), 1.45(1H, s), 1.33(3H, d, J=6.5 Hz),m/z=383.

Example 49 Synthesis of K-2011

[0475] 3-Trifluoromethylthiophenol (600 mg, 3.37 mmol) was dissolved inacetonitrile (12 ml) and then potassium carbonate (540 mg, 3.96 mmol)and 1,5-dibrornopentane (0.50 ml, 3.67 mmol) were successively addedthereto at room temperature. The resulting mixture was stirred at thesame temperature for 5 hours. After confirming the completion of thereaction by TLC, potassium carbonate (240 mg, 1.74 mmol) and(R)-(+)-3-methoxy-α-methylbenzylamine (300 mg, 1.98 mmol) were added atroom temperature to the reaction system and the resulting mixture wasstirred at 95° C. for additional 18 hours.

[0476] After the completion of the reaction, the reaction mixture wascooled by allowing to stand at room temperature. After pouring waterthereinto, the mixture was subjected to separatory extraction withchloroform and washed with a saturated aqueous solution of sodiumchloride. The organic layer thus obtained was dried over anhydroussodium sulfate and concentrated under reduced pressure. The organicresidue was purified by silica gel column chromatography(chloroform:methanol=150:1) to thereby give 220 mg (0.55 mmol) of thecompound K-2011 as a pale yellow syrup at a yield of 28%.

[0477] 500 MHz NMR 7.51 (1H, s), 7.45-7.44(1H, m), 7.35-7.40(2H, m),7.23(1H, dd, J=8.0 Hz, J=8.0 Hz), 6.86-6.88(2H, m), 6.76-6.79(1H, m),3.81(3H, s), 3.71 (1H, q, J=6.5 Hz), 2.93(2H, t, J=7.3 Hz),2.47-2.52(1H, m), 2.40-2.45(1H, m), 1.61-1.67(2H, m), 1.41-1.52(5H, m),1.34(3H, d, J=6.5 Hz), m/z=397.

Example 50 Synthesis of K-2012

[0478] 3-Trifluoromethylthiophenol (515 mg, 2.89 mmol) was dissolved inacetonitrile (10 ml) and then potassium carbonate (440 mg, 3.18 mmol)and 1,6-dibromohexane (0.45 ml, 2.93 mmol) were successively addedthereto at room temperature. The resulting mixture was stirred at thesame temperature for 5 hours. After confirming the completion of thereaction by TLC, potassium carbonate (270 mg, 1.95 mmol) and(R)-(+)-3-methoxy-α-methylbenzylamine (260 mg, 1.72 mmol) were added atroom temperature to the reaction system and the resulting mixture wasstirred at 95° C. for additional 24 hours.

[0479] After the completion of the reaction, the reaction mixture wascooled by allowing to stand at room temperature. After pouring waterthereinto, the mixture was subjected to separatory extraction withchloroform and washed with a saturated aqueous solution of sodiumchloride. The organic layer thus obtained was dried over anhydroussodium sulfate and concentrated under reduced pressure. The organicresidue was purified by silica gel column chromatography(chloroform:methanol=150:1) to thereby give 272 mg (0.66 mmol) of thecompound K-2012 as a pale yellow syrup at a yield of 38%.

[0480] 500 MHz NMR 7.51 (1H, s), 7.43-7.45(1H, m), 7.35-7.40(2H, m),7.23(1H, dd, J=7.5 Hz, J=7.5 Hz), 6.87-6.89(2H, m), 6.76-6.79(1H, m),3.81 (3H, s), 3.71 (1H, q, J=6.5 Hz), 2.93(2H, t, J=7.5 Hz), 2.46-2.51(1H, m), 2.40-2.44(1H, m), 1.61-1.67(2H, m), 1.38-1.50(7H, m), 1.34(3H,d, J=6.5 Hz), m/z=411.

Example 51 Synthesis of K-2015

[0481] 2-Bromobenzenethiol (445 mg, 2.35 mmol) was dissolved inacetonitrile (10 ml) and then potassium carbonate (420 mg, 3.04 mmol)and 1-bromo-2-chloroethane (0.22 ml, 2.64 mmol) were successively addedthereto at room temperature. The resulting mixture was stirred at thesame temperature for 4 hours. After confirming the completion of thereaction by TLC, potassium carbonate (315 mg, 2.28 mmol) and(R)-(+)-3-methoxy-α-methylbenzylamine (250 mg, 1.65 mmol) were added atroom temperature to the reaction system and the resulting mixture wasstirred at 95° C. for additional 120 hours.

[0482] After the completion of the reaction, the reaction mixture wascooled by allowing to stand at room temperature. After pouring waterthereinto, the mixture was subjected to separatory extraction withchloroform and washed with a saturated aqueous solution of sodiumchloride. The organic layer thus obtained was dried over anhydroussodium sulfate and concentrated under reduced pressure. The organicresidue was purified by silica gel column chromatography(chloroform:methanol=150:1) to thereby give 207 mg (0.57 mmol) of thecompound K-2015 as a pale yellow syrup at a yield of 34%.

[0483] 500 MHz NMR 7.53(1H, d, J=8.0 Hz), 7.18-7.26(4H, m),6.87-6.88(2H, m), 6.78-6.81(1H, m), 3.81 (3H, s), 3.04(2H, t, J=7.0 Hz),3.76(1H, q, J=6.5 Hz), 2.67-2.81 (2H, m), 1.73(1H, s), 1.35(3H, d, J=6.5Hz), m/z=365, 367.

Example 52 Synthesis of K-2016

[0484] 2-Bromobenzenethiol (517 mg, 2.73 mmol) was dissolved inacetonitrile (10 ml) and then potassium carbonate (475 mg, 3.44 mmol)and 1,3-dibromopropane (0.31 ml, 3.05 mmol) were successively addedthereto at room temperature. The resulting mixture was stirred at thesame temperature for 4 hours. After confirming the completion of thereaction by TLC, potassium carbonate (352 mg, 2.76 mmol) and(R)-(+)-3-methoxy-α-methylbenzylamine (250 mg, 1.65 mmol) were added atroom temperature to the reaction system and the resulting mixture wasstirred at 100° C. for additional 12 hours.

[0485] After the completion of the reaction, the reaction mixture wascooled by allowing to stand at room temperature. After pouring waterthereinto, the mixture was subjected to separatory extraction withchloroform and washed with a saturated aqueous solution of sodiumchloride. The organic layer thus obtained was dried over anhydroussodium sulfate and concentrated under reduced pressure. The organicresidue was purified by silica gel column chromatography(chloroform:methanol=150:1) to thereby give 249 mg (0.66 mmol) of thecompound K-2016 as a pale yellow syrup at a yield of 40%.

[0486] 500 MHz NMR 7.52(1H, d, J=7.5 Hz), 7.22-7.26(3H, m), 7.00(1H,ddd, J=7.5 Hz, J=7.5 Hz, J=2.0 Hz), 6.88(1H, d, J=7.5 Hz), 6.87(1H, s),6.77(1H, dd, J=7.5 Hz, J=2.0 Hz), 3.81(3H, s), 3.73(1H, q, J=7.0 Hz),2.90-3.02(2H, m), 2.55-2.69(2H, m), 1.80-1.86(2H, m), 1.46(1H, s),1.34(3H, d, J=7.0 Hz), m/z=379, 3.81.

Example 53 Synthesis of K-2017

[0487] 2-Bromobenzenethiol (505 mg, 2.67 mmol) was dissolved inacetonitrile (10 ml) and then potassium carbonate (445 mg, 3.22 mmol)and 1,4-dibromobutane (0.35 ml, 2.93 mmol) were successively addedthereto at room temperature. The resulting mixture was stirred at thesame temperature for 4 hours. After confirming the completion of thereaction by TLC, potassium carbonate (330 mg, 2.39 mmol) and(R)-(+)-3-methoxy-α-methylbenzylamine (250 mg, 1.65 mmol) were added atroom temperature to the reaction system and the resulting mixture wasstirred at 95° C. for additional 12 hours.

[0488] After the completion of the reaction, the reaction mixture wascooled by allowing to stand at room temperature. After pouring waterthereinto, the mixture was subjected to separatory extraction withchloroform and washed with a saturated aqueous solution of sodiumchloride. The organic layer thus obtained was dried over anhydroussodium sulfate and concentrated under reduced pressure. The organicresidue was purified by silica gel column chromatography(chloroform:methanol=150:1) to thereby give 311 mg (0.79 mmol) of thecompound K-2017 as a pale yellow syrup at a yield of 48%.

[0489] 500 MHz NMR 7.52(1H, d, J=8.0 Hz), 7.19-7.25(3H, m), 7.00(1H,ddd, J=8.0 Hz, 8.0 Hz, J=2.0 Hz), 6.87-6.88(2H, m), 6.78(1H, dd, J=2.0Hz, J=8.0 Hz), 3.80(3H, s), 3.72(1H, q, J=6.5 Hz), 2.90(2H, t, J=7.5Hz), 2.43-2.56(2H, m), 1.68-1.73(2H, m), 1.68-1.73(2H, m), 1.58-1.67(2H,m), 1.47(1H, s), 1.34(3H, d, J=6.5 Hz), m/z=393, 395.

Example 54 Synthesis of K-2018

[0490] 2-Bromobenzenethiol (445 mg, 2.35 mmol) was dissolved inacetonitrile (10 ml) and then potassium carbonate (407 mg, 2.95 mmol)and 1,5-dibromopentene (0.31 ml, 2.60 mmol) were successively addedthereto at room temperature. The resulting mixture was stirred at thesame temperature for 4 hours. After confirming the completion of thereaction by TLC, potassium carbonate (330 mg, 2.39 mmol) and(R)-(+)-3-methoxy-α-methylbenzylamine (220 mg, 1.46 mmol) were added atroom temperature to the reaction system and the resulting mixture wasstirred at 95° C. for additional 12 hours.

[0491] After the completion of the reaction, the reaction mixture wascooled by allowing to stand at room temperature. After pouring waterthereinto, the mixture was subjected to separatory extraction withchloroform and washed with a saturated aqueous solution of sodiumchloride. The organic layer thus obtained was dried over anhydroussodium sulfate and concentrated under reduced pressure. The organicresidue was purified by silica gel column chromatography(chloroform:methanol=150:1) to thereby give 307 mg (0.75 mmol) of thecompound K-2018 as a pale yellow syrup at a yield of 52%.

[0492] 500 MHz NMR 7.52(1H, d, J=6.5 Hz), 7.18-7.25(3H, m), 6.99(1H, dd,J=7.5 Hz, J=7.5 Hz), 6.87-6.89(2H, m), 6.78(1H, dd, J=7.5 Hz, J=2.0 Hz),3.81 (3H, s), 3.72(1H, q, J=6.5 Hz), 2.90(2H, q, J=7.5 Hz), 2.41-2.51(2H, m), 1.65-1.69(2H, m), 1.44-1.53(5H, m), 1.34(3H, d, J=6.5 Hz),m/z=409.

Example 55 Synthesis of K-2027(N-{5-[(4-chlorophenyl)thio]pentyl}-N-[(1R)-1-(1-naphthyl)ethyl]amine)

[0493] 4-Chlorobenzenethiol (550 mg, 3.80 mmol) was dissolved inacetonitrile (6.0 ml) and then potassium carbonate (520 mg, 3.76 mmol)and 1,5-dibromopentane (0.52 ml, 3.82 mmol) were successively addedthereto at room temperature. The resulting mixture was stirred at thesame temperature for 1 hour. After confirming the completion of thereaction by TLC, potassium carbonate (241 mg, 1.74 mmol) and(R)-(+)-1-(1-naphthyl)ethylamine (0.31 ml, 1.92 mmol) were added at roomtemperature to the reaction system and the resulting mixture was stirredat 95° C. for additional 12 hours.

[0494] After the completion of the reaction, the reaction mixture wascooled by allowing to stand at room temperature. After pouring waterthereinto, the mixture was subjected to separatory extraction withchloroform and washed with a saturated aqueous solution of sodiumchloride. The organic layer thus obtained was dried over anhydroussodium sulfate and concentrated under reduced pressure. The organicesidue was purified by silica gel column chromatography(chloroform:methanol=150:1) to thereby give 288 mg (0.75 mmol) of thecompound K-2027 as a pale yellow syrup at a yield of 40%.

[0495] 500 MHz NMR 8.17(1H, d, J=8.0 Hz), 7.87(1H, d, J=7.5 Hz),7.74(1H, d, J=9.0 Hz), 7.63(1H, d, J=9.0 Hz), 7.63(1H, d, J=7.5 Hz),7.45-7.52(3H, m), 7.19-7.23(4H, m), 4.61 (1H, q, J=6.5 Hz), 2.85(2H, t,J=7.2 Hz), 2.50-2.61(2H, m), 1.41-1.63(7H, m), 1.48(3H, d, J=6.5 Hz),m/z=383.

Example 56 Synthesis of K-2030

[0496] 3-Chlorophenol (420 mg, 3.27 mmol) was dissolved in acetonitrile(9.0 ml) and then potassium carbonate (1.19 g, 8.61 mmol) and1-bromo-2-chloroethane (0.41 ml, 4.93 mmol) were successively addedthereto at room temperature. The resulting mixture was stirred at 70° C.for 24 hours. After confirming the completion of the reaction by TLC,potassium carbonate (1.70 g, 12.3 mmol) and(R)-(+)-1-(1-naphthyl)ethylamine (0.45 ml, 2.79 mmol) were added at roomtemperature to the reaction system and the resulting mixture was stirredat 100° C. for additional 120 hours.

[0497] After the completion of the reaction, the reaction mixture wascooled by allowing to stand at room temperature. After pouring waterthereinto, the mixture was subjected to separatory extraction withchloroform and washed with a saturated aqueous solution of sodiumchloride. The organic layer thus obtained was dried over anhydroussodium sulfate and concentrated under reduced pressure. The organicresidue was purified by silica gel column chromatography(chloroform:methanol=150:1) to thereby give 321 mg (0.99 mmol) of thecompound K-2030 as a pale yellow syrup at a yield of 35%.

[0498] 500 MHz NMR 8.21 (1H, d, J=8.5 Hz), 7.87(1H, d, J=7.5 Hz),7.75(1H, d, J=8.0 Hz), 7.69(1H, d, J=8.0 Hz), 7.46-7.53(3H, m), 7.18(1H,dd, J=8.0 Hz), 6.89-3.93(2H, m), 6.76-6.78(1H, dd, J=1.5 Hz, J=8.0 Hz),4.71 (1H, q, J=6.5 Hz), 4.04(2H, t, J=5.3 Hz), 2.90-3.00(2H, m),1.78(1H, s), 1.53(3H, d, J=6.5 Hz), m/z=325.

Example 57 Synthesis of K-2033

[0499] 4-Nitrobenzenethiol (470 mg, 3.03 mmol) was dissolved inacetonitrile (7.0 ml) and then potassium carbonate (450 mg, 3.26 mmol)and 1,4-dibromobutane (0.36 ml, 3.01 mmol) were successively addedthereto at room temperature. The resulting mixture was stirred at thesame temperature for 3 hours. After confirming the completion of thereaction by TLC, potassium carbonate (250 mg, 1.81 mmol) and(R)-(+)-3-methoxy-α-methylbenzylamine (250 mg, 1.65 mmol) were added atroom temperature to the reaction system and the resulting mixture wasstirred at 100° C. for additional 12 hours.

[0500] After the completion of the reaction, the reaction mixture wascooled by allowing to stand at room temperature. After pouring waterthereinto, the mixture was subjected to separatory extraction withchloroform and washed with a saturated aqueous solution of sodiumchloride. The organic layer thus obtained was dried over anhydroussodium sulfate and concentrated under reduced pressure. The organicresidue was purified by silica gel column chromatography(chloroform:methanol=150:1) to thereby give 206 mg (0.57 mmol) of thecompound K-2033 as a yellow syrup at a yield of 35%.

[0501] 500 MHz NMR 8.11 (2H, d, J=9.0 Hz), 7.29(2H, d, J=9.0 Hz),7.24(1H, dd, J=8.0 Hz, J=8.0 Hz), 6.88(1H, d, J=8.0 Hz), 6.87(1H, s),6.79(1H, dd, J=8.0 Hz, J=2.5 Hz), 3.81 (3H, s), 3.72(1H, q, J=6.5 Hz),2.99(2H, t, J=7.5 Hz), 2.44-2.60(2H, m), 1.71-1.76(2H, m), 1.60-1.66(3H,m), 1.35(3H, d, J=6.5 Hz), m/z=360.

Example 58 Synthesis of K-2034

[0502] 4-Nitrobenzenethiol (520 mg, 3.35 mmol) was dissolved inacetonitrile (7.0 ml) and then potassium carbonate (492 mg, 3.56 mmol)and 1,5-dibromopentane (0.46 ml, 3.38 mmol) were successively addedthereto at room temperature. The resulting mixture was stirred at thesame temperature for 3 hours. After confirming the completion of thereaction by TLC, potassium carbonate (300 mg, 2.17 mmol) and(R)-(+)-3-methoxy-α-methylbenzylamine (300 mg, 1.98 mmol) were added atroom temperature to the reaction system and the resulting mixture wasstirred at 100° C. for additional 12 hours.

[0503] After the completion of the reaction, the reaction mixture wascooled by allowing to stand at room temperature. After pouring waterthereinto, the mixture was subjected to separatory extraction withchloroform and washed with a saturated aqueous solution of sodiumchloride. The organic layer thus obtained was dried over anhydroussodium sulfate and concentrated under reduced pressure. The organicresidue was purified by silica gel column chromatography(chloroform:methanol=150:1) to thereby give 102 mg (0.27 mmol) of thecompound K-2034 as a yellow syrup at a yield of 14%.

[0504] 500 MHz NMR 8.11 (2H, d, J=9.5 Hz), 7.28(2H, d, J=9.5 Hz),7.24(1H, dd, J=7.8 Hz, J=7.8 Hz), 6.87-6.89(2H, m), 6.77-6.79(1H, m),3.81 (3H, s), 3.72(1H, q, J=6.5 Hz), 2.99(2H, q, J=7.5 Hz),2.49-2.52(1H, m), 2.41-2.45(1H, m), 1.67-1.72(2H, m), 1.45-1.53(5H, m),1.35(3H, d, J=6.5 Hz), m/z=374.

Example 59 Synthesis of K-2035

[0505] 4-Nitrobenzenethiol (460 mg, 2.96 mmol) was dissolved inacetonitrile (7.0 ml) and then potassium carbonate (432 mg, 3.13 mmol)and 1,6-dibromohexane (0.46 ml, 2.99 mmol) were successively addedthereto at room temperature. The resulting mixture was stirred at thesame temperature for 3 hours. After confirming the completion of thereaction by TLC, potassium carbonate (120 mg, 0.86 mmol) and(R)-(+)-3-methoxy-α-methylbenzylamine (230 mg, 1.52 mmol) were added atroom temperature to the reaction system and the resulting mixture wasstirred at 100° C. for additional 12 hours.

[0506] After the completion of the reaction, the reaction mixture wascooled by allowing to stand at room temperature. After pouring waterthereinto, the mixture was subjected to separatory extraction withchloroform and washed with a saturated aqueous solution of sodiumchloride. The organic layer thus obtained was dried over anhydroussodium sulfate and concentrated under reduced pressure. The organicresidue was purified by silica gel column chromatography(chloroform:methanol=150:1) to thereby give 133 mg (0.342 mmol) of thecompound K-2035 as a yellow syrup at a yield of 23 %.

[0507] 500 MHz NMR 8.12(2H, d, J=9.0 Hz), 7.29(2H, d, J=9.0 HZ),7.24(1H, dd, J=8.0 Hz), 6.88(1H, d, J=8.0 Hz), 6.88(1H, s),6.77-6.79(1H, m), 3.81(3H, s), 3.73(1H, q, J=6.5 Hz), 2.99(2H, t, J=7.5Hz), 2.40-2.53(2H, m), 1.67-1.73(2H, m), 1.41-1.50(5H, m), 1.25-1.36(2H,m), 1.35(3H, d, J=6.5 Hz), m/z=388.

Example 60 Synthesis of K-2040

[0508] 4-Fluorobenzenethiol (520 mg, 4.06 mmol) was dissolved inacetonitrile (10.0 ml) and then potassium carbonate (864 mg, 6.26 mmol)and 1,4-dibromobutane (0.49 ml, 4.12 mmol) were successively addedthereto at room temperature. The resulting mixture was stirred at thesame temperature for 10 hours. After confirming the completion of thereaction by TLC, potassium carbonate (320 mg, 2.32 mmol) and(R)-(+)-3-methoxy-α-methylbenzylamine (310 mg, 2.05 mmol) were added atroom temperature to the reaction system and the resulting mixture wasstirred at 100° C. for additional 12 hours.

[0509] After the completion of the reaction, the reaction mixture wascooled by allowing to stand at room temperature. After pouring waterthereinto, the mixture was subjected to separatory extraction withchloroform and washed with a saturated aqueous solution of sodiumchloride. The organic layer thus obtained was dried over anhydroussodium sulfate and concentrated under reduced pressure. The organicresidue was purified by silica gel column chromatography(chloroform:methanol=150:1) to thereby give 170 mg (0.51 mmol) of thecompound K-2040 as a pale yellow syrup at a yield of 25%.

[0510] 500 MHz NMR 7.28-7.32(2H, m), 7.23(1H, dd, J=8.3 Hz, J=8.3 Hz),6.95-6.70(2H, m), 6.86-6.87(2H, m), 6.76-6.79(1H, m), 3.80(3H, s), 3.71(1H, q, J=6.5 Hz), 2.83(2H, dd, J=7.0 Hz, J=7.0 Hz), 2.47-2.52(1H, m),2.39-2.44(1H, m), 1.52-1.64(5H, m), 1.33(3H, d, J=6.5 Hz), m/z=333.

Example 61 Synthesis of K-2041

[0511] 4-Fluorobenzenethiol (590 mg, 4.61 mmol) was dissolved inacetonitrile (10.0 ml) and then potassium carbonate (340 mg, 2.46 mmol)and 1,5-dibromopentane (0.63 ml, 4.62 mmol) were successively addedthereto at room temperature. The resulting mixture was stirred at thesame temperature for 3 hours. After confirming the completion of thereaction by TLC, potassium carbonate (340 mg, 2.46 mmol) and(R)-(+)-3-methcxy-α-methylbenzylamine (350 mg, 2.31 mmol) were added atroom temperature to the reaction system and the resulting mixture wasstirred at 100° C. for additional 12 hours.

[0512] After the completion of the reaction, the reaction mixture wascooled by allowing to stand at room temperature. After pouring waterthereinto, the mixture was subjected to separatory extraction withchloroform and washed with a saturated aqueous solution of sodiumchloride. The organic layer thus obtained was dried over anhydroussodium sulfate and concentrated under reduced pressure. The organicresidue was purified by silica gel column chromatography(chloroform:methanol=150:1) to thereby give 245 mg (0.71 mmol) of thecompound K-2041 as a pale yellow syrup at a yield of 31%.

[0513] 500 MHz NMR 7.29-7.32(2H, m), 7.23(1H, dd, J=8.0 Hz, J=8.0 Hz),6.96-6.99(2H, m), 6.86-6.88(2H, m), 6.77-6.79(1H, m), 3.81 (3H, s), 3.71(1H, q, J=7.0 Hz), 2.83(2H, t, J=7.2 Hz), 2.45-2.50(1 H, m),2.38-2.43(1H, m), 1.54-1.60(2H, m), 1.38-1.48(3H, m), 1.34(3H, d, J=7.0Hz), m/z=347.

Example 62 Synthesis of K-2045

[0514] 3-Bromobenzenethiol (650 mg, 3.44 mmol) was dissolved inacetonitrile (10.0 ml) and then potassium carbonate (524 mg, 3.79 mmol)and 1-bromo-2-chloroethane (0.29 ml, 3.48 mmol) were successively addedthereto at room temperature. The resulting mixture was stirred at thesame temperature for 3 hours. After confirming the completion of thereaction by TLC, potassium carbonate (280 mg, 2.02 mmcl) and(R)-(+)-3-methoxy-α-methylbenzylamine (420 mg, 2.78 mmol) were added atroom temperature to the reaction system and the resulting mixture wasstirred at 100° C. for additional 120 hours.

[0515] After the completion of the reaction, the reaction mixture wascooled by allowing to stand at room temperature. After pouring waterthereinto, the mixture was subjected to separatory extraction withchloroform and washed with a saturated aqueous solution of sodiumchloride. The organic layer thus obtained was dried over anhydroussodium sulfate and concentrated under reduced pressure. The organicresidue was purified by silica gel column chromatography(chloroform:methanol=185:1) to thereby give 395 mg (1.23 mmol) of thecompound K-2045 as a pale yellow syrup at a yield of 44%.

[0516] 500 MHz NMR 7.43(1H, s), 7.28(1H, d, J=8.0 Hz), 7.22(1H, dd,J=8.0 Hz, J=8.0 Hz), 7.18(1H, d, J=8.0 Hz), 7.19(1H, dd, J=7.5 Hz, J=7.5Hz), 6.87(1H, d, J=7.5 Hz), 6.86(1H, s), 6.77(1H, dd, J=7.5 Hz, J=1.5Hz), 3.80(3H, s), 3.74(1H, q, J=6.5 Hz), 3.02(2H, t, J=6.5 Hz),2.66-2.77(2H, m), 1.68(1H, s), 1.34(3H, d, J=6.5 Hz), m/z=365, 367.

Example 63 Synthesis of K-2046

[0517] 3-Bromobenzenethiol (580 mg, 3.06 mmol) was dissolved inacetonitrile (9.0 ml) and then potassium carbonate (432 mg, 3.13 mmol)and 1,3-dibromopropane (0.31 ml, 3.05 mmol) were successively addedthereto at room temperature. The resulting mixture was stirred at thesame temperature for 5 hours. After confirming the completion of thereaction by TLC, potassium carbonate (280 mg, 2.02 mmol) and(R)-(+)-3-methoxy-α-methylbenzylamine (230 mg, 1.52 mmol) were added atroom temperature to the reaction system and the resulting mixture wasstirred at 100° C. for additional 24 hours.

[0518] After the completion of the reaction, the reaction mixture wascooled by allowing to stand at room temperature. After pouring waterthereinto, the mixture was subjected to separatory extraction withchloroform and washed with a saturated aqueous solution of sodiumchloride. The organic layer thus obtained was dried over anhydroussodium sulfate and concentrated under reduced pressure. The organicresidue was purified by silica gel column chromatography(chloroform:methanol=150:1) to thereby give 213 mg (0.56 mmol) of thecompound K-2046 as a pale yellow syrup at a yield of 37%.

[0519] 500 MHz NMR, 7.40-7.41(1H, m), 7.18-7.28(3H, m), 7.11(1H, dd,J=8.0 Hz, J=8.0 Hz), 6.86-6.88(2H, m), 6.76-6.79(1H, m), 3.80(3H, s),3.72(1H, q, J=7.0 Hz), 2.88(2H, m), 2.49-2.54(1H, m), 2.41-2.46(1H, m),1.54-1.69(2H, m), 1.34(3H, d, J=7.0 Hz), m/z=379, 381.

Example 64 Synthesis of K-2047

[0520] 3-Bromobenzenethiol (470 mg, 2.49 mmol) was dissolved inacetonitrile (10.0 ml) and then potassium carbonate (347 mg, 2.51 mmol)and 1,4-dibromobutane (0.30 ml, 2.51 mmol) were successively addedthereto at room temperature. The resulting mixture was stirred at thesame temperature for 5 hours. After confirming the completion of thereaction by TLC, potassium carbonate (320 mg, 2.32 mmol) and(R)-(+)-3-methoxy-α-methylbenzylamine (200 mg, 1.32 mmol) were added atroom temperature to the reaction system and the resulting mixture wasstirred at 100° C. for additional 24 hours.

[0521] After the completion of the reaction, the reaction mixture wascooled by allowing to stand at room temperature. After pouring waterthereinto, the mixture was subjected to separatory extraction withchloroform and washed with a saturated aqueous solution of sodiumchloride. The organic layer thus obtained was dried over anhydroussodium sulfate and concentrated under reduced pressure. The organicresidue was purified by silica gel column chromatography(chloroform:methanol=150:1) to thereby give 185 mg (0.47 mmol) of thecompound K-2047 as a pale yellow syrup at a yield of 36%.

[0522] 500 MHz NMR 7.19-7.28(3H, m), 7.02-7.13(2H, m), 6.86-6.88(2H, m),6.76-6.79(1H, m), 3.81 (3H, s), 3.77(1H, q, J=6.5 Hz), 1.76-1.79(2H, m),2.89-3.01 (2H, m), 2.60-2.65(1H, m), 2.51-2.56(1 H, m), 2.31-2.42(2H,m), 1.52(1H, s), 1.33(3H, d, J=6.5 Hz), m/z=393, 395.

Example 65 Synthesis of K-2048

[0523] 3-Bromobenzenethiol (530 mg, 2.80 mmol) was dissolved inacetonitrile (10.0 ml) and then potassium carbonate (395 mg, 2.86 mmol)and 1,5-dibromopentane (0.38 ml, 2.78 mmol) were successively addedthereto at room temperature. The resulting mixture was stirred at thesame temperature for 2 hours. After confirming the completion of thereaction by TLC, potassium carbonate (213 mg, 1.54 mmol) and(R)-(+)-3-methoxy-α-methylbenzylamine (200 mg, 1.32 mmol) were added atroom temperature to the reaction system and the resulting mixture wasstirred at 100° C. for additional 24 hours.

[0524] After the completion of the reaction, the reaction mixture wascooled by allowing to stand at room temperature. After pouring waterthereinto, the mixture was subjected to separatory extraction withchloroform and washed with a saturated aqueous solution of sodiumchloride. The organic layer thus obtained was dried over anhydroussodium sulfate and concentrated under reduced pressure. The organicresidue was purified by silica gel column chromatography(chloroform:methanol=150:1) to thereby give 226 mg (0.55 mmoi) of thecompound K-2048 as a pale yellow syrup at a yield of 42%.

[0525] 500 MHz NMR 7.41 (1H, s), 7.18-7.28(3H, m), 7.11 (1H, dd, J=7.5Hz, J=7.5 Hz), 6.88(1H, d, J=7.5 Hz), 6.87(1H, s), 6.78(1H, dd, J=7.5Hz, J=2.5 Hz), 3.81 (3H, s), 3.72(1H, q, J=6.5 Hz), 2.89(2H, q, J=7.2Hz), 2.47-2.51 (1H, m), 2.40-2.43(1H, m), 1.62(2H, m), 1.40-1.50(5H, m),1.234(3H, d, J=6.5 Hz).

Example 66 Synthesis of K-2049

[0526] 3-Bromobenzenethiol (600 mg, 3.17 mmol) was dissolved inacetonitrile (10.0 ml) and then potassium carbonate (500 mg, 3.62 mmol)and 1,6-dibromohexane (0.50 ml, 3.25 mmol) were successively addedthereto at room temperature. The resulting mixture was stirred at thesame temperature for 2 hours. After confirming the completion of thereaction by TLC, potassium carbonate (205 mg, 1.48 mmol) and(R)-(+)-3-methoxy-α-methylbenzylamine (250 mg, 1.66 mmol) were added atroom temperature to the reaction system and the resulting mixture wasstirred at 100° C. for additional 24 hours.

[0527] After the completion of the reaction, the reaction mixture wascooled by allowing to stand at room temperature. After pouring waterthereinto, the mixture was subjected to separatory extraction withchloroform and washed with a saturated aqueous solution of sodiumchloride. The organic layer thus obtained was dried over anhydroussodium sulfate and concentrated under reduced pressure. The organicresidue was purified by silica gel column chromatography(chloroform:methanol=150:1) to thereby give 267 mg (0.63 mmol) of thecompound K-2049 as a pale yellow syrup at a yield of 38%.

[0528] 500 MHz NMR 7.41 (1H, dd, J=1.8 Hz, J=1.8 Hz), 7.19-7.27(3H, m),7.11 (1H, dd, J=8.0 Hz, J=8.0 Hz), 6.87-6.89(2H, m), 6.77(1H, dd, J=8.0Hz, J=2.5 Hz), 3.81 (3H, s), 3.72(1H, t, J=6.5 Hz), 2.88(2H, t, J=7.8Hz), 2.39-2.51 (2H, m), 1.50-1.65(2H, m), 1.25-1.49(7H, m), 1.34(3H, d,J=6.5 Hz).

Example 67 Synthesis of K-2050

[0529] 3-Bromobenzenethiol (525 mg, 2.78 mmol) was dissolved inacetonitrile (10.0 ml) and then potassium carbonate (325 mg, 2.36 mmol)and 1,7-dibromoheptane (0.47 ml, 2.75 mmol) were successively addedthereto at room temperature. The resulting mixture was stirred at thesame temperature for 1 hour. After confirming the completion of thereaction by TLC, potassium carbonate (182 mg, 1.32 mmol) and(R)-(+)-3-methoxy-α-methylbenzylamine (210 mg, 1.39 mmol) were added atroom temperature to the reaction system and the resulting mixture wasstirred at 100° C. for additional 24 hours.

[0530] After the completion of the reaction, the reaction mixture wascooled by allowing to stand at room temperature. After pouring waterthereinto, the mixture was subjected to separatory extraction withchloroform and washed with a saturated aqueous solution of sodiumchloride. The organic layer thus obtained was dried over anhydroussodium sulfate and concentrated under reduced pressure. The organicresidue was purified by silica gel column chromatography(chloroform:methanol=150:1) to thereby give 260 mg (0.60 mmol) of thecompound K-2050 as a pale yellow syrup at a yield of 43%.

[0531] 500 MHz NMR 7.41 (1H, dd, J=2.0 Hz, J=2.0 Hz), 7.23-7.27(2H, m),7.18-7.21 (1H, m), 7.11 (1H, dd, J=8.0 Hz, J=8.0 Hz), 6.90-6.93(2H, m),6.80(1H, dd, J=8.0 Hz, J=2.5 Hz), 3.82(3H, s), 3.77-3.80(1H, m),2.88(2H, t, J=7.5 Hz), 2.42-2.54(2H, m), 1.58-1.64(2H, m), 1.50-1.55(1H,m), 1.35-1.45(4H, m), 1.42(3H, d, J=7.5 Hz), 1.21-1.29(4H, m), m/z=4.35,437.

Example 68 Synthesis of K-2051

[0532] 3-Bromobenzenethiol (610 mg, 3.22 mmol) was dissolved inacetonitrile (10.0 ml) and then potassium carbonate (490 mg, 3.55 mmol)and 1,8-dibromooctane (0.59 ml, 3.20 mmol) were successively addedthereto at room temperature. The resulting mixture was stirred at thesame temperature for 1 hour. After confirming the completion of thereaction by TLC, potassium carbonate (218 mg, 1.58 mmol) and(R)-(+)-3-methoxy-α-methylbenzylamine (250 mg, 1.66 mmol) were added atroom temperature to the reaction system and the resulting mixture wasstirred at 100° C. for additional 24 hours.

[0533] After the completion of the reaction, the reaction mixture wascooled by allowing to stand at room temperature. After pouring waterthereinto, the mixture was subjected to separatory extraction withchloroform and washed with a saturated aqueous solution of sodiumchloride. The organic layer thus obtained was dried over anhydroussodium sulfate and concentrated under reduced pressure. The organicresidue was purified by silica gel column chromatography(chloroform:methanol=150:1) to thereby give 170 mg (0.33 mmol) of thecompound K-2051 as a pale yellow syrup at a yield of 24%.

[0534] 500 Hz NMR 7.41-7.42(1H, m), 7.19-7.27(3H, m), 7.11 (1H, dd,J=7.8 Hz, J=7.8 Hz), 6.90-6.92(2H, m), 6.79(1H, dd, J=7.5 Hz, J=2.0 Hz),3.82(3H, s), 3.76-3.82(1H, m), 2.89(2H, t, J=7.8 Hz), 2.42-2.53(2H, m),1.59-1.65(2H, m), 1.49(1H, m), 1.41(3H, d, J=6.5 Hz), 1.36-1.43(4H, m),1.22-1.28(6H, m), m/z=449, 451.

Example 69 Synthesis of K-2052(N-{5-[(4-fuluorophenyl)thio]pentyl}-N-[(1R)-1-(1-naphthyl)ethyl]amine)

[0535] 4-Fluorobenzenethiol (460 mg, 3.60 mmol) was dissolved inacetonitrile (10.0 ml) and then potassium carbonate (500 mg, 3.62 mmol)and 1,5-dibromopentane (0.50 ml, 3.67 mmol) were successively addedthereto at room temperature. The resulting mixture was stirred at thesame temperature for 1 hour. After confirming the completion of thereaction by TLC, potassium carbonate (210 mg, 1.52 mmol) and(R)-(+)-1-(1-naphthyl)ethylamine (300 mg, 1.86 mmol) were added at roomtemperature to the reaction system and the resulting mixture was stirredat 100° C. for additional 24 hours.

[0536] After the completion of the reaction, the reaction mixture wascooled by allowing to stand at room temperature. After pouring waterthereinto, the mixture was subjected to separatory extraction withchloroform and washed with a saturated aqueous solution of sodiumchloride. The organic layer thus obtained was dried over anhydroussodium sulfate and concentrated under reduced pressure. The organicresidue was purified by silica gel column chromatography(chloroform:methanol=150:1) to thereby give 210 mg (0.57 mmol) of thecompound K-2052 as a pale yellow syrup at a yield of 31%.

[0537] 500 MHz NMR 8.17(1H, d, J=8.0 Hz), 7.87(1H, d, J=8.5 Hz),7.74(1H, d, J=8.0 Hz), 7.62(1H, d, J=8.0 Hz), 7.41-7.50(5H, m), 7.29(2H,d, J=8.5 Hz), 4.61(1H, q, J=6.5 Hz), 2.82(2H, t, J=7.5 Hz),2.56-2.57(2H, m), 2.37-2.43(2H, m), 1.40-1.59(5H, m), 1.46(3H, d, J=6.5Hz), m/z=367.

Example 70 Synthesis of K-2055

[0538] 4-Trifluoromethylbenzenethiol (408 mg, 2.29 mmol) was dissolvedin acetonitrile (10.0 ml) and then potassium carbonate (330 mg, 2.39mmol) and 1,3-dibromopropane (0.23 ml, 2.28 mmol) were successivelyadded thereto at room temperature. The resulting mixture was stirred atthe same temperature for 1 hour. After confirming the completion of thereaction by TLC, potassium carbonate (172 mg, 1.25 mmol) and(R)-(+)-3-methoxy-α-methylbenzylamine (210 mg, 1.39 mmol) were added atroom temperature to the reaction system and the resulting mixture wasstirred at 100° C. for additional 24 hours.

[0539] After the completion of the reaction, the reaction mixture wascooled by allowing to stand at room temperature. After pouring waterthereinto, the mixture was subjected to separatory extraction withchloroform and washed with a saturated aqueous solution of sodiumchloride. The organic layer thus obtained was dried over anhydroussodium sulfate and concentrated under reduced pressure. The organicresidue was purified by silica gel column chromatography(chloroform:methanol=150:1) to thereby give 122 mg (0.33 mmol) of thecompound K-2055 as a pale yellow syrup at a yield of 24%.

[0540] 500 MHz NMR 7.44-7.50(2H, m), 7.32(1H, d, J=8.5 Hz), 7.23(1H, dd,J=8.5 Hz, J=8.5 Hz), 7.17-7.20(1H, m), 6.85-6.88(2H, m), 6.77-6.79(1H,m), 3.80(3H, s), 3.70-3.74(1H, m), 1.77-1.83(2H, m), 1.34(3H, d, J=6.5Hz), 1.25-1.26(1H, m), m/z=369.

Example 71 Synthesis of K-2056

[0541] 4-Trifluoromethylbenzenethiol (487 mg, 2.74 mmol) was dissolvedin acetonitrile (10.0 ml) and then potassium carbonate (374 mg, 2.71mmol) and 1,4-dibromobutane (0.33 ml, 2.77 mmol) were successively addedthereto at room temperature. The resulting mixture was stirred at thesame temperature for 1 hour. After confirming the completion of thereaction by TLC, potassium carbonate (172 mg, 1.25 mmol) and(R)-(+)-3-methoxy-α-methylbenzyiamine (250 mg, 1.65 mmol) were added atroom temperature to the reaction system and the resulting mixture wasstirred at 100° C. for additional 24 hours.

[0542] After the completion of the reaction, the reaction mixture wascooled by allowing to stand at room temperature. After pouring waterthereinto, the mixture was subjected to separatory extraction withchloroform and washed with a saturated aqueous solution of sodiumchloride. The organic layer thus obtained was dried over anhydroussodium sulfate and concentrated under reduced pressure. The organicresidue was purified by silica gel column chromatography(chloroform:methanol=150:1) to thereby give 152 mg (0.40 mmol) of thecompound K-2056 as a pale yellow syrup at a yield of 24%.

[0543] 500 MHz NMR 7.49(2H, d, J=8.5 Hz), 7.32(2H, d, J=8.0 Hz),7.23(1H, dd, J=8.0 Hz, J=8.0 Hz), 6.86-6.88(2H, m), 6.76-6.79(1H, m),3.80(1H, s), 3.71(1H, q, J=6.5 Hz), 2.92-2.95(2H, t, J=7.5 Hz),1.55-1.73(4H, m), 1.47(1H, s),1.33(3H, d, J=6.5 Hz), 2.50-2.55(1H, m),2.42-2.47(1H, m), m/z=383.

Example 72 Synthesis of K-2057

[0544] 4-Trifluoromethylbenzenethiol (560 mg, 3.15 mmol) was dissolvedin acetonitrile (10.0 ml) and then potassium carbonate (440 mg, 3.19mmol) and 1,5-dibromopentane (0.43 ml, 3.16 mmol) were successivelyadded thereto at room temperature. The resulting mixture was stirred atthe same temperature for 1 hour. After confirming the completion of thereaction by TLC, potassium carbonate (240 mg, 1.74 mmol) and(R)-(+)-3-methoxy-α-methylbenzylamine (290 mg, 1.92 mmol) were added atroom temperature to the reaction system and the resulting mixture wasstirred at 100° C. for additional 24 hours.

[0545] After the completion of the reaction, the reaction mixture wascooled by allowing to stand at room temperature. After pouring waterthereinto, the mixture was subjected to separatory extraction withchloroform and washed with a saturated aqueous solution of sodiumchloride. The organic layer thus obtained was dried over anhydroussodium sulfate and concentrated under reduced pressure. The organicresidue was purified by silica gel column chromatography(chloroform:methanol=150:1) to thereby give 129 mg (0.32 mmol) of thecompound K-2057 as a pale yellow syrup at a yield of 17%.

[0546] 500 MHz NMR 7.49(2H, d, J=8.5 Hz), 7.31 (2H, d, J=8.0 Hz),7.23(1H, dd, J=8.0 Hz, J=8.0 Hz), 6.86-6.89(2H, m), 6.76-6.79(1H, m),3.81 (3H, s), 3.71 (1H, q, J=6.8 Hz), 2.94(2H, t, J=7.3 Hz), 2.40-2.51(2H, m), 1.63-1.68(2H, m), 1.42-1.51(5H, m), 14.34(3H, d, J=6.8 Hz),m/z=397.

Example 73 Synthesis of K-2058

[0547] 4-Trifluoromethylbenzenethiol (500 mg, 2.81 mmol) was dissolvedin acetonitrile (10.0 ml) and then potassium carbonate (420 mg, 3.64mmol) and 1,6-dibromohexane (0.43 ml, 2.79 mmol) were successively addedthereto at room temperature. The resulting mixture was stirred at thesame temperature for 1 hour. After confirming the completion of thereaction by TLC, potassium carbonate (150 mg, 1.09 mmol) and(R)-(+)-3-methoxy-α-methylbenzylamine (260 mg, 1.72 mmol) were added atroom temperature to the reaction system and the resulting mixture wasstirred at 100° C. for additional 24 hours.

[0548] After the completion of the reaction, the reaction mixture wascooled by allowing to stand at room temperature. After pouring waterthereinto, the mixture was subjected to separatory extraction withchloroform and washed with a saturated aqueous solution of sodiumchloride. The organic layer thus obtained was dried over anhydroussodium sulfate and concentrated under reduced pressure. The organicresidue was purified by silica gel column chromatography(chloroform:methanol=150:1) to thereby give 155 mg (0.38 mmol) of thecompound K-2058 as a pale yellow syrup at a yield of 22%.

[0549] 500 MHz NMR 7.49(2H, d, J=8.5 Hz), 7.32(2H, d, J=7.0 Hz),7.23(1H, dd, J=8.0 Hz, J=8.0 Hz), 6.87-6.89(2H, m), 6.76-6.79(1H, m),3.81(3H, s), 3.72(1H, q, J=6.5 Hz), 2.94(2H, t, J=7.5 Hz), 2.39-2.52(2H,m), 1.63-1.69(2H, m), 1.39-1.50(5H, m), 1.29-1.34(2H, m), 1.34(3H, d,J=6.5 Hz), m/z=411.

Example 74 Synthesis of K-2059

[0550] 4-Trifluoromethylbenzenethiol (500 mg, 2.81 mmol) was dissolvedin acetonitrile (10.0 ml) and then potassium carbonate (420 mg, 3.64mmol) and 1,7-dibromoheptane (0.48 ml, 2.81 mmol) were successivelyadded thereto at room temperature. The resulting mixture was stirred atthe same temperature for 1 hour. After confirming the completion of thereaction by TLC, potassium carbonate (150 mg, 1.09 mmol) and(R)-(+)-3-methoxy-α-methylbenzylamine (260 mg, 1.72 mmol) were added atroom temperature to the reaction system and the resulting mixture wasstirred at 100° C. for additional 24 hours.

[0551] After the completion of the reaction, the reaction mixture wascooled by allowing to stand at room temperature. After pouring waterthereinto, the mixture was subjected to separatory extraction withchloroform and washed with a saturated aqueous solution of sodiumchloride. The organic layer thus obtained was dried over anhydroussodium sulfate and concentrated under reduced pressure. The organicresidue was purified by silica gel column chromatography(chloroform:methanol=150:1) to thereby give 204 mg (0.48 mmol) of thecompound K-2059 as a pale yellow syrup at a yield of 28%.

[0552] 500 MHz NMR 7.49(2H, d, J=8.5 Hz), 7.32(2H, d, J=6.5 Hz),7.23(1H, dd, J=6.0 Hz, J=6.0 Hz), 6.87-6.89(2H, m), 6.76-6.79(1H, m),3.81 (3H, s), 3.73(1H, q, J=6.0 Hz), 2.94(2H, t, J=6.5 Hz), 2.39-2.51(2H, m), 1.62-1.68(2H, m), 1.34-1.48(9H, m), 1.35(3H, d, J=6.0 Hz),m/z=425.

Example 75 Synthesis of K-2061

[0553] 3-Chlorobenzenethiol (460 mg, 3.18 mmol) was dissolved inacetonitrile (10.0 ml) and then potassium carbonate (440 mg, 3.19 mmol)and 1,3-dibromopropane (0.32 ml, 3.15 mmol) were successively addedthereto at room temperature. The resulting mixture was stirred at thesame temperature for 2 hours. After confirming the completion of thereaction by TLC, potassium carbonate (210 mg, 1.52 mmol) and(R)-(+)-3-methoxy-α-methylbenzylamine (300 mg, 1.99 mmol) were added atroom temperature to the reaction system and the resulting mixture wasstirred at 100° C. for additional 24 hours.

[0554] After the completion of the reaction, the reaction mixture wascooled by allowing to stand at room temperature. After pouring waterthereinto, the mixture was subjected to separatory extraction withchloroform and washed with a saturated aqueous solution of sodiumchloride. The organic layer thus obtained was dried over anhydroussodium sulfate and concentrated under reduced pressure. The organicresidue was purified by silica gel column chromatography(chloroform:methanol=150:1) to thereby give 272 mg (0.81 mmol) of thecompound K-2061 as a pale yellow syrup at a yield of 41%.

[0555] 500 MHz NMR 7.11-7.27(5H, m), 6.86-6.88(2H, m), 6.77-6.-9(l H,m), 3.81(3H, s), 3.70(1H, q, J=6.5 Hz), 2.89-3.01(2H, m), 2.60-2.65(1H,m), 2.51-2.56(1H, m), 1.75-1.81(2H, m), 1.47(1H, s), 1.33(3H, d, J=6.5Hz), m/z=335.

Example 76 Synthesis of K-2066

[0556] 2,5-Dichlorobenzenethiol (575 mg, 3.21 mmol) was dissolved inacetonitrile (11.0 ml) and then potassium carbonate (440 mg, 3.19 mmol)and 1-bromo-2-chloroethane (0.26 ml, 3.12 mmol) were successively addedthereto at room temperature. The resulting mixture was stirred at thesame temperature for 1 hour. After confirming the completion of thereaction by TLC, potassium carbonate (225 mg, 1.63 mmol) and(R)-(+)-3-methoxy-α-methylbenzylamine (340 mg, 2.25 mmol) were added atroom temperature to the reaction system and the resulting mixture wasstirred at 100° C. for additional 100 hours.

[0557] After the completion of the reaction, the reaction mixture wascooled by allowing to stand at room temperature. After pouring waterthereinto, the mixture was subjected to separatory extraction withchloroform and washed with a saturated aqueous solution of sodiumchloride. The organic layer thus obtained was dried over anhydroussodium sulfate and concentrated under reduced pressure. The organicresidue was purified by silica gel column chromatography(chloroform:methanol=150:1) to thereby give 182 mg (0.51 mmol) of thecompound K-2066 as a pale yellow syrup at a yield of 23%.

[0558] 500 MHz NMR 7.21-7.30(3H, m), 7.19(1H, d, J=2.5 Hz),6.88-6.89(2H, m), 6.77(1H, dd, J=8.5 Hz, J=2.5 Hz), 3.81 (3H, s),3.76(1H, q, J=6.5 HZ), 3.04(2H, t, J=7.0 Hz), 2.72-2.83(2H, m), 1.66(1H, s), 1.36(3H, d, J=6.5 Hz), m/z=355, 357.

Example 77 Synthesis of K-2075

[0559] 2-Bromobenzenethiol (702 mg, 3.71 mmol) was dissolved inacetonitrile (14.0 ml) and then potassium carbonate (525 mg, 3.80 mmol)and 1,5-dibromopentane (0.50 ml, 3.67 mmol) were successively addedthereto at room temperature. The resulting mixture was stirred at thesame temperature for 1 hour. After confirming the completion of thereaction by TLC, potassium carbonate (247 mg, 1.79 mmol) and(R)-(+)-1-(1-naphthyl)ethylamine (0.30 ml, 1.86 mmol) were added at roomtemperature to the reaction system and the resulting mixture was stirredat 100° C. for additional 24 hours.

[0560] After the completion of the reaction, the reaction mixture wascooled by allowing to stand at room temperature. After pouring waterthereinto, the mixture was subjected to separatory extraction withchloroform and washed with a saturated aqueous solution of sodiumchloride. The organic layer thus obtained was dried over anhydroussodium sulfate and concentrated under reduced pressure. The organicresidue was purified by silica gel column chromatography(chloroform:methanol=200:1) to thereby give 144 mg (0.34 mmol) of thecompound K-2075 as a pale yellow syrup at a yield of 18%.

[0561] 500 MHz NMR 8.18(1H, d, J=8.5 Hz), 7.87(1H, d, J=8.5 Hz),7.64(1H, d, J=8.5 Hz), 7.74(1H, d, J=8.5 Hz), 7.45-7.53(4H, m),7.13-7.25(2H, m), 6.99(1H, ddd, J=1.5 Hz, J=6.0 Hz, J=6.0 Hz), 4.62(1H,q, J=7.0Hz), 2.89(2H, t, J=7.5 Hz), 2.52-2.63(2H, m), 1.66-1.71(2H, m),1.45-1.59(5H, m), 1.49(3H, d, J=7.0 Hz), m/z=427.

Example 78 Synthesis of K-2076(N-[(1R)-1-(1-naphthyl)ethyl]-N-(5-{[4-(trifluoromethyl)phenyl]thio}pentyl)amine)

[0562] 4-Trifluoromethylbenzenethiol (510 mg, 2.861 mmol) was dissolvedin acetonitrile (12.0 ml) and then potassium carbonate (400 mg, 2.89mmol) and 1,5-dibromopentane (0.39 ml, 2.86 mmol) were successivelyadded thereto at room temperature. The resulting mixture was stirred atthe same temperature for 1 hour. After confirming the completion of thereaction by TLC, potassium carbonate (200 mg, 1.45 mmol) and(R)-(+)-1-(1-naphthyl)ethylamine (0.28 ml, 1.73 mmol) were added at roomtemperature to the reaction system and the resulting mixture was stirredat 100° C. for additional 24 hours.

[0563] After the completion of the reaction, the reaction mixture wascooled by allowing to stand at room temperature. After pouring waterthereinto, the mixture was subjected to separatory extraction withchloroform and washed with a saturated aqueous solution of sodiumchloride. The organic layer thus obtained was dried over anhydroussodium sulfate and concentrated under reduced pressure. The organicresidue was purified by silica gel column chromatography(chloroform:methanol=180:1) to thereby give 53 mg (0.13 mmol) of thecompound K-2076 as a pale yellow syrup at a yield of 7%.

[0564] 500 MHz NMR 8.18(1H, d, J=8.5 Hz), 7.87(1H, d, J=7.0 Hz),7.74(1H, d, J=6.5 Hz), 7.63(1H, d, J=6.5 Hz), 7.45-7.52(5H, m), 7.30(2H,d, J=8.0 Hz), 4.62(1H, q, J=6.5 Hz), 2.93(2H, t, J=6.5 Hz), 2.93(2H, t,J=7.0 Hz), 2.51-2.63(2H, m), 1.63-1.69(2H, m), 1.44-1.56(5H, m),1.49(3H, d, J=6.5 Hz), m/z=417.

Example 79 Synthesis of K-2078

[0565] 3,4-Dichlorobenzenethiol (469 mg, 2.62 mmol) was dissolved inacetonitrile (10.0 ml) and then potassium carbonate (400 mg, 2.89 mmol)and 1,3-dibromopropane (0.27 ml, 2.67 mmol) were successively addedthereto at room temperature. The resulting mixture was stirred at thesame temperature for 1 hour. After confirming the completion of thereaction by TLC, potassium carbonate (180 mg, 1.30 mmol) and(R)-(+)-3-methoxy-α-methylbenzylamine (240 mg, 1.59 mmol) were added atroom temperature to the reaction system and the resulting mixture wasstirred at 100° C. for additional 24 hours.

[0566] After the completion of the reaction, the reaction mixture wascooled by allowing to stand at room temperature. After pouring waterthereinto, the mixture was subjected to separatory extraction withchloroform and washed with a saturated aqueous solution of sodiumchloride. The organic layer thus obtained was dried over anhydroussodium sulfate and concentrated under reduced pressure. The organicresidue was purified by silica gel column chromatography(chloroform:methanol=150:1) to thereby give 143 mg (0.39 mmol) of thecompound K-2078 as a pale yellow syrup at a yield of 25%.

[0567] 500 MHz NMR 7.36(1H, d, J=1.5 Hz), 7.31 (1H, d, J=8.5 Hz),7.24(1H, dd, J=6.5 Hz, J=6.5 Hz), 7.10(1H, dd, J=8.5 Hz, J=1.5 Hz),6.85-6.88(2H, m), 6.77-6.79(1H, m), 3.81 (3H, s), 3.71 (1H, q, J=6.5Hz), 2.88-3.00(2H, m), 2.50-2.64(2H, m), 1.71-1.81(2H, m), 1.52(1 H, s),1.33(3H, d, J=6.5 Hz), m/z=369, 371.

Example 80 Synthesis of K-2079

[0568] 3,4-Dichlorobenzenethiol (556 mg, 3.11 mmol) was dissolved inacetonitrile (12.0 ml) and then potassium carbonate (412 mg, 2.99 mmol)and 1,4-dibromobutane (0.37 ml, 3.10 mmol) were successively addedthereto at room temperature. The resulting mixture was stirred at thesame temperature for 1 hour. After confirming the completion of thereaction by TLC, potassium carbonate (242 mg, 1.75 mmol) and(R)-(+)-3-methoxy-α-methylbenzylamine (280 mg, 1.85 mmol) were added atroom temperature to the reaction system and the resulting mixture wasstirred at 100° C. for additional 24 hours.

[0569] After the completion of the reaction, the reaction mixture wascooled by allowing to stand at room temperature. After pouring waterthereinto, the mixture was subjected to separatory extraction withchloroform and washed with a saturated aqueous solution of sodiumchloride. The organic layer thus obtained was dried over anhydroussodium sulfate and concentrated under reduced pressure. The organicresidue was purified by silica gel column chromatography(chloroform:methanol=150:1) to thereby give 156 mg (0.41 mmol) of thecompound K-2079 as a pale yellow syrup at a yield of 22%.

[0570] 500 MHz NMR 7.34(1H, d, J=2.5 Hz), 7.31 (1H, d, J=8.5 Hz),7.23(1H, dd, J=7.5 Hz, J=7.5 Hz), 7.10(1H, dd, J=8.5 Hz, J=2.5 Hz),6.87(1H, d, J=7.5 Hz), 6.86(1H, s), 6.76-6.79(1H, m), 3.80(3H, s), 3.71(1H, q, J=7.0 Hz), 2.87(2H, t, J=7.0 Hz), 2.41-2.54(2H, m),1.53-1.68(4H, m), 1.46(1H, s), 1.33(3H, d, J=7.0 Hz), m/z=383, 385.

Example 81 Synthesis of K-2080

[0571] 3,4-Dichlorobenzenethiol (515 mg, 2.88 mmol) was dissolved inacetonitrile (11.0 ml) and then potassium carbonate (410 mg, 2.97 mmol)and 1,5-dibromopentane (0.39 ml, 2.86 mmol) were successively addedthereto at room temperature. The resulting mixture was stirred at thesame temperature for 1 hour. After confirming the completion of thereaction by TLC, potassium carbonate (230 mg, 1.66 mmol) and(R)-(+)-3-methoxy-α-methylbenzylamine (260 mg, 1.72 mmol) were added atroom temperature to the reaction system and the resulting mixture wasstirred at 100° C. for additional 24 hours.

[0572] After the completion of the reaction, the reaction mixture wascooled by allowing to stand at room temperature. After pouring waterthereinto, the mixture was subjected to separatory extraction withchloroform and washed with a saturated aqueous solution of sodiumchloride. The organic layer thus obtained was dried over anhydroussodium sulfate and concentrated under reduced pressure. The organicresidue was purified by silica gel column chromatography(chloroform:methanol=150:1) to thereby give 250 mg (0.63 mmol) of thecompound K-2080 as a pale yellow syrup at a yield of 37%.

[0573] 500 MHz NMR 7.34(1H, d, J=2.5 Hz), 7.31 (1H, d, J=8.5 Hz),7.22-7.25(1H, m), 7.09(1H, dd, J=2.5 Hz, J=8.5 Hz), 6.88(1H, d, J=8.5Hz), 6.87(1H, s), 6.78(1H, dd, J=8.5 Hz, J=2.5 Hz), 3.81 (3H, s),3.72(1H, q, J=6.5 Hz), 2.87(2H, t, J=8.0 Hz), 2.39-2.52(2H, m),1.59-1.64(2H, m), 1.38-1.51(5H, m), 1.34(3H, d, J=6.5 Hz), m/z=395, 397.

Example 82 Synthesis of K-2082

[0574] 3,4-Dichlorobenzenethiol (720 mg, 4.02 mmol) was dissolved inacetonitrile (15.0 ml) and then potassium carbonate (550 mg, 3.98 mmol)and 1,7-dibromoheptane (0.64 ml, 3.75 mmol) were successively addedthereto at room temperature. The resulting mixture was stirred at thesame temperature for 1 hour. After confirming the completion of thereaction by TLC, potassium carbonate (230 mg, 1.66 mmol) and(R)-(+)-3-methoxy-α-methylbenzylamine (360 mg, 2.38 mmol) were added atroom temperature to the reaction system and the resulting mixture wasstirred at 100° C. for additional 24 hours.

[0575] After the completion of the reaction, the reaction mixture wascooled by allowing to stand at room temperature. After pouring waterthereinto, the mixture was subjected to separatory extraction withchloroform and washed with a saturated aqueous solution of sodiumchloride. The. organic layer thus obtained was dried over anhydroussodium sulfate and concentrated under reduced pressure. The organicresidue was purified by silica gel column chromatography(chloroform:methanol=150:1) to thereby give 253 mg (0.59 mmol) of thecompound K-2082 as a pale yellow syrup at a yield of 25%.

[0576] 500 MHz NMR 7.35(1H, d, J=2.5 Hz), 7.31 (1H, d, J=8.0 Hz),7.22-7.25(1H, m), 7.10(1H, dd, J=8.5 Hz, J=2.5 Hz), 6.88-6.90(1H, m),6.90(1H, s), 6.78(1H, dd, J=2.5 Hz, J=8.5 Hz), 3.81 (3H, s), 3.75(1H, q,J=6.5 Hz), 2.87(2H, t, J=7.3 Hz), 2.40-2.52(2H, m), 1.58-1.64(2H, m),1.48(1H, s), 1.34-1.64(2H, m), 1.37(3H, d, J=6.5 Hz), 1.24-1.33(4H, m),m/z=425, 427.

Example 83 Synthesis of K-2084

[0577] 2,6-Dichlorobenzenethiol (540 mg, 3.02 mmol) was dissolved inacetonitrile ( 11.0 ml) and then potassium carbonate (420 mg, 3.04 mmol)and 1,3-dibromopropane (0.31 ml, 3.05 mmol) were successively addedthereto at room temperature. The resulting mixture was stirred at thesame temperature for 1 hour. After confirming the completion of thereaction by TLC, potassium carbonate (234 mg, 1.69 mmol) and(R)-(+)-3-methoxy-α-methylbenzylamine (230 mg, 1.52 mmol) were added atroom temperature to the reaction system and the resulting mixture wasstirred at 100° C. for additional 24 hours.

[0578] After the completion of the reaction, the reaction mixture wascooled by allowing to stand at room temperature. After pouring waterthereinto, the mixture was subjected to separatory extraction withchloroform and washed with a saturated aqueous solution of sodiumchloride. The organic layer thus obtained was dried over anhydroussodium sulfate and concentrated under reduced pressure. The organicresidue was purified by silica gel column chromatography(chloroform:methanol=150:1) to thereby give 182 mg (0.49 mmol) of thecompound K-2084 as a pale yellow syrup at a yield of 32%.

[0579] 500 MHz NMR 7.6(2H, d, J=8.0 Hz), 7.22(1H, dd, J=8.0 Hz, J=8.0Hz), 7.16(1H, dd, J=8.0 Hz, J=8.0 Hz), 6.86(1H, d, J=8.0 Hz), 6.85(1H,s), 6.76-6.78(1H, m), 3.81 (3H, s), 3.70(1H, q, J=6.0 Hz), 2.89-2.98(2H,m), 2.52-2.64(2H, m), 1.65-1.71 (2H, , m), 1.46(1 H, s), 1.32(3H, d,J=6.0 Hz), m/z=369, 371.

Example 84 Synthesis of K-2085

[0580] 2,6-Dichlorobenzenethiol (500 mg, 2.79 mmol) was dissolved inacetonitrile (10.0 ml) and then potassium carbonate (400 mg, 2.90 mmol)and 1,4-dibromobutane (0.33 ml, 2.76 mmol) were successively addedthereto at room temperature. The resulting mixture was stirred at thesame temperature for 1 hour. After confirming the completion of thereaction by TLC, potassium carbonate (230 mg, 1.65 mmol) and(R)-(+)-3-methoxy-α-methylbenzylamine (250 mg, 1.65 mmol) were added atroom temperature to the reaction system and the resulting mixture wasstirred at 100° C. for additional 24 hours.

[0581] After the completion of the reaction, the reaction mixture wascooled by allowing to stand at room temperature. After pouring waterthereinto, the mixture was subjected to separatory extraction withchloroform and washed with a saturated aqueous solution of sodiumchloride. The organic layer thus obtained was dried over anhydroussodium sulfate and concentrated under reduced pressure. The organicresidue was purified by silica gel column chromatography(chloroform:methanol=150:1) to thereby give 293 mg (0.76 mmol) of thecompound K-2085 as a pale yellow syrup at a yield of 46%.

[0582] 500 MHz NMR 7.36(2H, d, J=7.5 Hz), 7.23(1H, dd, J=7.5 Hz, J=7.5Hz), 7.16(1H, dd, J=8.0 Hz, J=8.0 Hz), 6.85-6.87(1 H, m), 6.86(1H, s),6.76-6.78(1H, m), 3.81 (3H, s), 3.70(1H, q, J=6.5 Hz), 2.89(2H, t, J=7.0Hz), 2.38-2.51 (2H, m), 1.51-1.63(4H, m), 1.49(1H, s), 1.32(3H, d, J=6.5Hz).

Example 85 Synthesis of K-2087(N-[(1R)-1-(1-naphthyl)ethyl]-N-(4-{[3-(trifluoromethyl)phenyl]thio}butyl)amine)

[0583] 3-Trifluoromethylbenzenethiol (670 mg, 3.76 mmol) was dissolvedin acetonitrile (14.0 ml) and then potassium carbonate (516 mg, 3.73mmol) and 1,4-dibromobutane (0.45 ml, 3.77 mmol) were successively addedthereto at room temperature. The resulting mixture was stirred underice-cooling for 2 hours. After confirming the completion of the reactionby TLC, potassium carbonate (300 mg, 2.17 mmol) and(R)-(+)-1-(1-naphthyl)ethylamine (0.30 ml, 1.86 mmol) were added at roomtemperature to the reaction system and the resulting mixture was stirredat 100° C. for additional 12 hours.

[0584] After the completion of the reaction, the reaction mixture wascooled by allowing to stand at room temperature. After pouring waterthereinto, the mixture was subjected to separatory extraction withchloroform and washed with a saturated aqueous solution of sodiumchloride. The organic layer thus obtained was dried over anhydroussodium sulfate and concentrated under reduced pressure. The organicresidue was purified by silica gel column chromatography(chloroform:methanol=150:1) to thereby give 298 mg (0.74 mmol) of thecompound K-2087 as a pale yellow syrup at a yield of 40%.

[0585] 500 MHz NMR 8.18(1H, d, J=8.0 Hz), 7.86-7.88(1H, m), 7.74(1H, d,J=8.0 Hz), 7.63(1H, d, J=7.5 Hz), 7.45-7.52(4H, m), 7.41-7.43(1H, m),7.33-7.39(2H, m), 4.62(1H, q, J=6.5 Hz), 2.92(2H, d, J=7.0 Hz),2.60-2.65(1H, m), 2.52-2.57(1H, m), 1.63-1.72(4H, m), 4.54(1H, s),1.48(3H, d, J=6.5 Hz), m/z=403.

Example 86 Synthesis of K-2117((R)-N-[1-(1′-naphthyl)ethyl]-2-(2′,5′-dichlorophenylthio)ethylamine)

[0586] 2,5-Dichlorobenzenethiol (5.10 g, 28.5 mmol) was dissolved inacetonitrile (30 ml) and then potassium carbonate (4.20 g, 30.4 mmol)and 1-bromo-2-chloroethane (2.45 ml, 29.4 mmol) were successively addedthereto at room temperature. The resulting mixture was stirred underice-cooling for 2 hours. After confirming the completion of the reactionby TLC, potassium carbonate (4.0 g, 28.9 mmol) and(R)-(+)-1-(1-naphthyl)ethylamine (3.70 ml, 22.9 mmol) were added at roomtemperature to the reaction system and the resulting mixture was stirredat 100° C. for additional 120 hours.

[0587] After the completion of the reaction, the reaction mixture wascooled by allowing to stand at room temperature. After pouring waterthereinto, the mixture was subjected to separatory extraction withchloroform and washed with a saturated aqueous solution of sodiumchloride. The organic layer thus obtained was dried over anhydroussodium sulfate and concentrated under reduced pressure. The organicresidue was purified by silica gel column chromatography(chloroform:methanol=200:1) to thereby give 5.70 g (15.2 mmol) of thecompound K-2117 as a pale yellow syrup at a yield of 66%.

[0588] 500 MHz NMR 8.17(1H, d, J=8.5 Hz), 7.85-7.87(1H, m), 7.73(1H, d,J=8.0 Hz), 7.65(1H, d, J=7.5 Hz), 7.44-7.52(4H, m), 7.26(1H, d, J=8.5Hz), 7.20(1H, d, J=2.5 Hz), 7.05(1H, dd, J=2.5 Hz, J=8.5 Hz), 4.65(1H,q, J=6.5 Hz), 3.09(2H, m), 2.82-2.91 (2H, m), 1.68(1H, s), 1.51 (3H, d,J=6.5 Hz), m/z=375, 377.

Example 87 Synthesis of K-2117 hydrochloride

[0589] The compound K-2117 (7.01 g, 18.6 mmol) was dissolved in a 30%hydrochloric acid-methanol solution (HCl-MeOH) (40 mi) and stirred atroom temperature for 5 minutes.

[0590] After the completion of the reaction, the reaction system wasconcentrated in situ under reduced pressure to thereby completely removethe hydrochloric acid-methanol solution. The residue was filteredthrough a Kiriyama funnel and the resulting crystals were washed withhexane. Thus 5.87 g (14.2 mmol) of K-2117 hydrochloride was obtained inthe form of white crystals at a yield of 76%.

[0591] m/z=375, 377. ¹H-NMR (400 MHz) 10.97 (1H, bs), 10.30 (1H, bs),8.18 (1H, d, J=7.32 Hz), 7.88-7.97 (3H, m), 7.53-7.66 (3H, m), 7.31 (1H,d, J=2.4 Hz), 7.14 (1H, d, J=8.56 Hz), 7.01 (1H, dd, J=1.36 Hz, J=8.56Hz), 5.23-5.27 (1H, m), 3.55-3.61 (2H, m), 2.95-3.10 (2H, m), 2.04 (3H,d, J=6.60 Hz).

Example 88 Synthesis of K-2177

[0592] Dibenzylamine (1.0 g, 0.51 mmol) and triethylamine (0.85 ml, 0.61mmol, 1.2 mol eq.) were dissolved in chloroform and acryloyl chloride(0.505 g, 0.56 mmol, 1.1 mol eq.) was added under-ice cooling thereto.The resulting mixture was stirred at room temperature for 30 minutes.

[0593] After the completion of the reaction, the reaction mixture waspoured into water and extracted with chloroform. The chloroform layerwas washed with water and a saturated aqueous solution of sodiumchloride. After drying over sodium sulfate, the solvent was distilledoff under reduced pressure. The crystals thus obtained were purified bycolumn chromatography (silica gel, chloroform-methanol) to thereby givecolorless prisms (1.085 g, 85.0%).

[0594] The compound thus obtained (50 mg, 0.20 mmol) and(R)-(+)-1-(1-naphthyl)ethylamine (41.0 mg, 0.24 mmol, 1.2 mol eq.) weredissolved in chloroform-methanol (2 ml) and allowed to stand at roomtemperature for 1 week.

[0595] After the completion of the reaction, the solvent was distilledoff under reduced pressure. The oil thus obtained was purified by columnchromatography (silica gel, chloroform-methanol) to thereby give 50.9 mgof K-2177 as a colorless oil at a yield of 60.5%.

[0596] MS m/z: 422(M⁺). ¹H-NMR δ: 1.53(3H, d, J=6.7 Hz, CH₃),2.60-2.70(2H, m, CH₂), 2.86-2.96(2H, m, CH₂), 4.42(2H, s, CH₂), 4.62(2H,s, CH₂), 4.69(1H, q, J=6.7 Hz, CH), 7.13(2H, d, J=7.3 Hz, Ar—H), 7.21(2H, d, J=6.7 Hz, Ar—H), 7.27-7.36(6H, m, Ar—H), 7.45-7.50(3H, m, Ar—H),7.70(1H, d, J=6.7 Hz, Ar—H), 7.74(1H, d, J=7.9 Hz, Ar—H), 7.86(1H, dd,J=1.8, 6.7 Hz, Ar—H), 8.16(1H, d, J=7.9 Hz, Ar—H).

Example 89 Synthesis of K-2246(N-[(1R)-1-(1-naphthyl)ethyl]-N-(4-{[4-(trifluoromethyl)phenyl]thio}butyI) amine)

[0597] 960 mg (5.39 mmol) of 4-trifluoromethylthiophenol was dissolvedin 8 ml of acetonitrile. Subsequently, 802 mg (5.80 mmol) of potassiumcarbonate and 0.65 ml (5.44 mmol) of 1,4-dibromobutane were addedthereto at room temperature and the obtained mixture was stirred at thesame temperature for 30 minutes. After confirming the completion of thereaction by TLC, 5 ml of acetonitrile, 693 mg (5.01 mmol) of potassiumcarbonate and 0.49 ml (2.96 mmol) of (R)-(+)-1-(1-naphthyl)ethylaminewere added thereto at room temperature and the obtained mixture wasstirred at 85° C. for 12 hours.

[0598] After the completion of the reaction, the mixture was cooled byallowing to stand at room temperature and water was poured thereinto.Next, it was subjected to separating extraction with chloroform and asaturated aqueous solution of sodium chloride and the organic layer thusobtained was dried over sodium sulfate. Further, the organic layer wasconcentrated under reduced pressure and the obtained residue waspurified by silica gel column chromatography (80 g,chloroform/methanol=200/1) to thereby give 210 mg (0.52 mmol, 17.6%) ofK-2246 as a pale yellow transparent syrup.

[0599] Subsequently, the K-2246 thus obtained was dissolved in a 10%solution of hydrochloric acid in methanol, stirred for 5 minutes andthen concentrated as such under reduced pressure. The crystals thusformed were washed with diethyl ether to thereby give 104 mg (0.24 mmol,8.1%) of K-2246 hydrochloride as white crystals.

[0600]¹H-NMR (400 MHz) 10.6 (1H, bs), 10.1 (1H, bs), 8.24 (1H, d, J=7.08Hz), 7.99 (1H, d, J=8.52 Hz), 7.90-7.96 (2H, m), 7.55-7.67 (3H, m),7.39-7.41 (2H, m), 7.17-7.19 (2H, m), 5.17-5.24 (1H, m), 2.73-2.84 (4H,m), 2.11-2.18 (2H, m), 2.06 (3H, d, J=6.60 Hz), 1.57-1.62 (4H, m),m/z=403.

Example 90 Synthesis of K-2076

[0601] 1.040 g (5.83 mmol) of 4-trifluoromethylthiophenol was dissolvedin 10 ml of acetonitrile. Subsequently, 1.024 g (7.40 mmol) of potassiumcarbonate and 0.80 ml (5.87 mmol) of 1,5-dibromopentane were addedthereto at room temperature and the obtained mixture was stirred at thesame temperature for 1 hour. After confirming the completion of thereaction by TLC, 8 ml of acetonitrile, 853 mg (6.17 mmol) of potassiumcarbonate and 0.60 ml. (3.63 mmol) of (R)-(+)-1-(1-naphthyl)ethylaminewere added thereto at room temperature and the obtained mixture wasstirred at 85° C. for 12 hours.

[0602] After the completion of the reaction, the mixture was cooled byallowing to stand at room temperature and water was poured thereinto.Next, it was subjected to separating extraction with chloroform and asaturated aqueous solution of sodium chloride and the organic layer thusobtained was dried over sodium sulfate. Further, the organic layer wasconcentrated under reduced pressure and the obtained residue waspurified by silica gel column chromatography (100 g,chloroform/methanol=200/1) to thereby give 240 mg (0.57 mmol, 17.7%) ofK-2076 as a pale yellow transparent syrup.

[0603] Subsequently, the K-2076 thus obtained was dissolved in a 10%solution of hydrochloric acid in methanol, stirred for 5 minutes andthen concentrated as such under reduced pressure. The crystals thusformed were washed with diethyl ether to thereby give 115 mg (0.25 mmol,6.9%) of K-2076 hydrochloride as white crystals.

[0604]¹H-NMR (400 MHz) 10.55 (1H, bs), 10.01 (1H, bs), 8.24 (1H, d,J=7.08 Hz), 7.89-7.99 (3H, m), 7.52-7.66 (3H, m), 7.44 (2H, d, J=8.32Hz), 7.23 (2H, d, J=8.32 Hz), 5.19 (1H, bs), 2.82 (2H, t, J=7.08 Hz),2.74 (2H, bs), 2.04 (3H, d, J=6.36 Hz), 1.96-2.04 (2H, m), 1.50-1.57(2H, m), 1.30-1.38 (2H, m), m/z=417.

Example 91 Synthesis of K-2243(N1,N1-di(4-chlorobenzyl)-3{[(1R)-1-(1-naphthyl)ethyl]amino}propanamide)

[0605] To 500 mg (3.56 mmol) of p-chlorobenzaldehyde and 503.6 mg (3.56mmol, 1.0 mol eq.) of p-chlorobenzylamine was added 1.26 ml (4.27 mmol,1.2 mol eq.) of titanium tetraisopropoxide and the obtained mixture wasstirred at room temperature for 4 hours. After the completion of thereaction, the reaction mixture was dissolved in methanol and 538.7 mg(14.24 mmol, 4.0 mel eq.) of sodium boron hydride was added thereto. Theobtained mixture was stirred at room temperature for 12 hours.

[0606] After the completion of the reaction, the solvent was distilledoff under reduced pressure. Ethyl acetate and water were poured into theresidue, and filtered through celite. The residue was washed with ethylacetate and then the washing liquor was combined with the filtrate andextracted with ethyl acetate. The ethyl acetate layer was washed withwater and a saturated aqueous solution of sodium chloride and dried oversodium sulfate. After distilling off the solvent under reduced pressure,the obtained oil was purified by column chromatography (silica gel,chloroform) to thereby give 819 mg (86.6%) of the compound 124 as acolorless oil.

[0607] MS m/z:266. ¹H-NMR δ:3.74 (4H, d, J=2.7, CH₂×2), 7.24-7.30 (8H,m, Ar—H).

[0608] 500 mg (1.88 mmol) of the above-mentioned compound 124 and 0.31ml (2.26 mmol, 1.2 mol eq.) of triethylamine were dissolved inchloroform and 187.1 mg (2.07 mmol, 1.1 mol eq.) of acryloyl chloridewas added thereto under ice-cooling. The obtained mixture was thenstirred at room temperature for 30 minutes. After the completion of thereaction, the reaction mixture was poured into water and extracted withchloroform. The chloroform layer was washed with water and a saturatedaqueous solution of sodium chloride and dried over sodium sulfate. Afterdistilling off the solvent under reduced pressure, the obtained oil waspurified by column chromatography (silica gel, chloroform) to therebygive 570.3 mg (94.4%) of the compound 125 as a colorless oil.

[0609] MS m/z:320. ¹H-NMR 6:4.47 (2H, s, CH₂), 4.59 (2H, s, CH₂), 5.77(1H, dd, J=2.7, 9.8 Hz, CH═CH₂), 6.52 (1H, d, J=2.7 Hz, CH═CH₂), 6.54(1H, d, J=9.8 Hz, CH═CH₂), 7.08 (2H, d, J=8.1 Hz, Ar—H), 7.18 (2H, d,J=8.1 Hz, Ar—H), 7.29 (2H, d, J=8.1 Hz, Ar—H), 7.33 (2H, d, J=8.1 Hz,Ar—H).

[0610] 100 mg (0.31 mmol) of the above-mentioned compound 125 and 64.2mg (0.38 mmol, 1.2 mol eq.) of (R)-(+)-(1-naphthyl)ethylamine weredissolved in chloroform/methanol (4:1) and allowed to stand at roomtemperature for 1 week. After the completion of the reaction, thesolvent was distilled off under reduced pressure and the oil thusobtained was purified by column chromatography (silica gel, chloroform)to thereby give 106.6 mg (69.5%) of K-2243 as a colorless oil.

[0611] MS m/z:491. ¹H-NMR δ:1.51 (3H, d, J=6.6Hz, CH₃), 2.60 (2H, t,J=6.1 Hz, CH₂), 2.84-2.96 (2H, m, CH₂), 4.35 (2H, s, CH₂), 4.53 (2H, s,CH₂), 4.66 (1H, q, J=6.6 Hz, CH), 7.03 (2H, d, J=8.3 Hz, Ar—H), 7.12(2H, d, J=8.3 Hz, Ar—H), 7.27 (2H, d, J=8.3 Hz, Ar—H), 7.30 (2H, d,J=8.3 Hz, Ar—H), 7.47 (1H, t, J=5.1 Hz, Ar—H), 7.48 (1H, t, J=5.1 Hz,Ar—H), 7.49 (1H, t, J=5.1 Hz, Ar—H), 7.67 (1H, d, J=5.1 Hz, Ar—H), 7.74(1H, d, J=5.1 Hz, Ar—H), 7.87 (1H, d, J=7.5 Hz, Ar—H), 7.16 (1H, d,J=7.5 Hz, Ar—H).

Example 92 Synthesis of K-2257(N1,N1-di[4-(trifluoromethoxy)benzyl]-3-{[(1R)-1-(1-naphthyl)ethyl]amino}propanamide)

[0612] To 500 mg (2.62 mmol) of p-(trifluoromethoxy)benzylamine and497.3 mg (2.62 mmol, 1.0 mol eq.) of p-(trifluoromethoxy)-benzaldehydewas added 0.926 ml (3.14 mmol, 1.2 mol eq.) of titaniumtetraisopropoxide and the obtained mixture was stirred at roomtemperature for 4 hours. After the completion of the reaction, thereaction mixture was dissolved in methanol and 396.5 mg (10.48 mmol, 4.0mol eq.) of sodium boron hydride was added thereto. The obtained mixturewas stirred at room temperature for 12 hours. After the completion ofthe reaction, the solvent was distilled off under reduced pressure.Ethyl acetate and water were poured into the residue and filteredthrough celite. The residue was washed with ethyl acetate and then thewashing liquor was combined with the filtrate and extracted with ethylacetate. The ethyl acetate layer was washed with water and a saturatedaqueous solution of sodium chloride and dried over sodium sulfate. Afterdistilling off the solvent under reduced pressure, the obtained oil waspurified by column chromatography (silica gel, chloroform) to therebygive 835.2 mg (87.5%) of the compound 126 as a colorless oil.

[0613] MS m/z:365. ¹H-NMR δ:3.80 (4H, s, CH₂×2), 7.17 (4H, d, J=8.1 Hz,Ar—H), 7.36 (4H, d, J=8.1 Hz, Ar—H).

[0614] 500 mg (1.37 mmol) of the above-mentioned compound 126 and 0.23ml (1.64 mmol,1.2 mol eq.) of triethylamine were dissolved in chloroformand 136.3 mg (1.51 mmol, 1.1 mol eq.) of acryloyl chloride was addedthereto under ice-cooling. The obtained mixture was then stirred at roomtemperature for 30 minutes. After the completion of the reaction, thereaction mixture was poured into water and extracted with chloroform.The chloroform layer was washed with water and a saturated aqueoussolution of sodium chloride and dried over sodium sulfate. Afterdistilling off the solvent under reduced pressure, the obtained oil waspurified by column chromatography (silica gel, chloroform) to therebygive 519.3 mg (90.5%) of the compound 127 as a colorless oil.

[0615] MS m/z:419. ¹H-NMR 5:4.53 (2H, S, CH₂), 4.64 (2H, s, CH₂), 5.79(1H, dd, J=2.7, 9.5 Hz, CH═CH₂), 6.53 (1H, d, J=2.7 Hz, CH═CH₂),6.56(1H, d, J=9.5 Hz, CH═CH₂), 7.15-7.31 (8H, m, Ar—H).

[0616] 450 mg (1.07 mmol) of the above-mentioned compound 127 and 220.7mg (1.29 mmol, 1.2 mol eq.) of (R)-(+)-(1-naphthyl)ethylamine weredissolved in chloroform/methanol (4: 1) and allowed to stand at roomtemperature for 1 week. After the completion of the reaction, thesolvent was distilled off under reduced pressure and the oil thusobtained was purified by column chromatography (silica gel, chloroform)to thereby give 363 mg (57.3%) of K-2257 as a colorless oil.

[0617] MS m/z:590. ¹H-NMR δ:1.50 (3H, d, J=6.6 Hz, CH₃), 2.60 (2H, t,J=5.9 Hz, CH₂), 2.84-2.97 (2H, m, CH₂), 4.41 (2H, s, CH₂), 4.57 (2H, s,CH₂), 6.65 (1H, q, J=6.6 Hz, CH), 7.12-7.29 (8H, m, Ar—H), 7.44-7.51(3H, m, Ar—H), 7.66 (1H, d, J=6.8 Hz, Ar—H), 7.73 (1H, d, J=8.3 Hz,Ar—H), 7.86 (1H, dd, J=2.4, 7.1 Hz, Ar—H), 8.17 (1H, d, J=7.1 Hz, Ar—H).

Example 93 Synthesis of K-2259(N1,N1-di[4-(trifluoromethyl)benzyl]-3-{[(lR)-1-(1-naphthyl)ethyl]amino}propanamide)

[0618] To 500 mg (2.85 mmol) of p-(trifluoromethyl)benzylamine and 497.1mg (2.85 mmol, 1.0 mol eq.) of p-(trifluoromethyl)- benzaldehyde wasadded 1.01 ml (3.43 mmol, 1.2 mol eq.) of titanium tetraisopropoxide andthe obtained mixture was stirred at room temperature for 4 hours. Afterthe completion of the reaction, the reaction mixture was dissolved inmethanol and 431.3 mg (11.4 mmol, 4.0 mol eq.) of sodium boron hydridewas added thereto. The obtained mixture was stirred at room temperaturefor 12 hours. After the completion of the reaction, the solvent wasdistilled off under reduced pressure. Ethyl acetate and water werepoured into the residue and filtered through celite. The residue waswashed with ethyl acetate and then the washing liquor was combined withthe filtrate and extracted with ethyl acetate. The ethyl acetate layerwas washed with water and a saturated aqueous solution of sodiumchloride and dried over sodium sulfate. After distilling off the solventunder reduced pressure, the obtained oil was purified by columnchromatography (silica gel, chloroform) to thereby give 458.7 mg (48.3%)of the compound 128 as a colorless oil.

[0619] MS m/z:333. ¹H-NMR δ:3.86 (4H, s, CH₂×2), 7.47 (4H, d, J=8.1 Hz,Ar—H), 7.59 (4H, d, J=8.1 Hz, Ar—H).

[0620] 450 mg (1.35 mmol) of the above-mentioned compound 128 and 0.23ml (1.62 mmol, 1.2 mol eq.) of triethylamine were dissolved inchloroform and 134.4 mg (1.48 mmol, 1.1 mol eq.) of acryloyl chloridewas added thereto under ice-cooling. The obtained mixture was thenstirred at room temperature for 30 minutes. After the completion of thereaction, the reaction mixture was poured into water and extracted withchloroform. The chloroform layer was washed with water and a saturatedaqueous solution of sodium chloride and dried over sodium sulfate. Afterdistilling off the solvent under reduced pressure, the obtained oil waspurified by column chromatography (silica gel, chloroform) to therebygive 519.3 mg (99.3%) of the compound 129 as a colorless oil.

[0621] MS m/z:387. ¹H-NMR δ:4.59 (2H, s, CH₂), 4.70 (2H, s, CH₂), 5.80(1H, dd, J=3.7, 8.8 Hz, CH═CH₂), 6.54 (1H, d, J=3.7 Hz, CH═CH₂), 6.56(1H, d, J=8.8 Hz, CH═CH₂), 7.23-7.64 (8H, m, Ar—H).

[0622] 800 mg (2.06 mmol) of the above-mentioned compound 129 and 424.0mg (2.48 mmol, 1.2 mol eq.) of (R)-(+)-(1-naphthyl)ethylamine weredissolved in chloroform/methanol (4:1) and allowed to stand at roomtemperature for 1 week. After the completion of the reaction, thesolvent was distilled off under reduced pressure and the oil thusobtained was purified by column chromatography (silica gel, chloroform)to thereby give 580.7 mg (50.3%) of K-2259 as a colorless oil.

[0623] MS m/z:558. ¹H-NMR δ:1.51 (3H, d, J=6.6 Hz, CH₃), 2.60 (2H, t,J=6.1 Hz, CH₂), 2.85-2.98 (2H, m, CH₂), 4.47 (2H, s, CH₂), 4.64 (2H, s,CH₂), 4.65 (1H, q, J=6.6 Hz, CH), 7.23 (2H, d, J=8.3 Hz, Ar—H), 7.31(2H, d, J=8.3 Hz, Ar—H), 7.44-7.51 (3H, m, Ar—H), 7.55 (2H, d, J=8.3 Hz,Ar—H), 7.59 (2H, d, J=8.3 Hz, Ar—H), 7.66 (1H, d, J=8.1 Hz, Ar—H), 7.74(1H, d, J=8.1 Hz, Ar—H), 7.87 (1H, dd, J=2.4, 8.1 Hz, Ar—H), 8.18 (1H,dd, J=2.4, 8.1 Hz, Ar—H).

Example 94 Synthesis of K-2247(N1-benzyl-N1-(4-chlorobenzyl)-3-{[(1R)-1-(1-naphthyl)ethyl]amino}propanamide)

[0624] To 4-chlorobenzaldehyde (500 mg, 3.56 mmol) and benzylamine(381.2 mg, 3.56 mmol, 1.0 mol eq.) was added titanium tetraisopropoxide(1.26 ml, 4.27 mmol, 1.2 mol eq.) and the mixture was stirred at roomtemperature for 4 hours. After the completion of the reaction, thereaction mixture was dissolved in ethanol and sodium boron hydride(538.7 mg, 14.24 mmol, 4.0 mol eq.) was added thereto. Then the obtainedmixture was stirred at room temperature for 12 hours. After thecompletion of the reaction, the solvent was distilled off under reducedpressure. To the obtained residue were added ethyl acetate and water andthe mixture was filtered through celite. The residue was washed withethyl acetate and the washing liquor was combined with the filtrate andextracted with ethyl acetate. The ethyl acetate layer was washed withwater and a saturated aqueous solution of sodium chloride and dried oversodium sulfate and the solvent was distilled off under reduced pressure.The oil thus obtained was purified by column chromatography [silica gel,chloroform] to thereby give a colorless oil 201 (572.6 mg, 69.5%). MSm/z:231.

[0625] The dibenzylamine compound 201 (300 ma, 1.29 mmol) andtriethylamine (0.22 ml, 1.55 mmol, 1.2 mol eq.) were dissolved inchloroform and acryloyl chloride (128.9 mg, 1.42 mmol, 1.1 mol eq.)dissolved in chloroform was added thereto under ice-cooling. Thereaction mixture was stirred at room temperature for 30 minutes. Afterthe completion of the reaction, the reaction mixture was poured intowater and extracted with chloroform. The chloroform layer was washedwith water and a saturated aqueous solution of sodium chloride and driedover sodium sulfate. After distilling off the solvent, the oil thusobtained was purified by column chromatography [silica gel, chloroform]to thereby give a colorless oil 202 (372.1 mg, 100.0%). MS m/z: 285.

[0626] The conjugated ketone compound 202 (100.3 mg, 0.35 mmol, 1.2 moleq.) and (R)-(+)-1-(1-naphthyl)ethylamine (50 mg, 0.29 mmol) weredissolved in chloroform/methanol (4:1) and allowed to stand at roomtemperature for 1 week. After the completion of the reaction, thesolvent was distilled off under reduced pressure and the oil thusobtained was purified by column chromatography [silica gel, chloroform]to thereby give a colorless oil K-2247 (64.5 mg, 40.2%).

[0627] MS m/z: 456, ¹H-NMR δ: 1.53 (3H, d, J=6.7 Hz, CH₃), 2.60-2.67(2H, m, CH₂), 2.86-2.95 (2H, m, CH₂), 4.39 (2H, d, J=18.3 Hz, CH₂), 4.58(2H, d, J=13.4 Hz, CH₂), 4.69 (1H, q, J=6.7 Hz, CH), 7.04 (1H, d, J=8.5Hz, Ar—H), 7.12 (1H, d, J=6.7 Hz, Ar—H), 7.15 (1H, d, J=8.5 Hz, Ar—H),7.20 (1H, d, J=6.7 Hz, Ar—H), 7.28-7.36 (5H, m, Ar—H), 7.46-7.51 (3H, m,Ar—H), 7.69 (1H, d, J=7.3 Hz, Ar—H), 7.75 (1H, d, J=7.9 Hz, Ar—H), 7.87(1H, dd, J=1.8, 7.9 Hz, Ar—H), 8.17 (1H, d, J=7.9 Hz, Ar—H).

Example 95 Synthesis of K-2248

[0628] To 2-naphthaldehyde (500 mg, 3.20 mmol) and benzylamine (343.1mg, 3.20 mmol, 1.0 mol eq.) was added titanium tetraisopropoxide (1.13ml, 3.84 mmol, 1.2 mol eq.) and the mixture was stirred at roomtemperature for 4 hours. After the completion of the reaction, thereaction mixture was dissolved in ethanol and sodium boron hydride(484.2 mg, 12.8 mmol, 4.0 mol eq.) was added thereto. Then the obtainedmixture was stirred at room temperature for 12 hours. After thecompletion of the reaction, the solvent was distilled off under reducedpressure. To the obtained residue were added ethyl acetate and water andthe mixture was filtered through celite. The residue was washed withethyl acetate and the washing liquor was combined with the filtrate andextracted with ethyl acetate. The ethyl acetate layer was washed withwater and a saturated aqueous solution of sodium chloride and dried oversodium sulfate and the solvent was distilled off under reduced pressure.The oil thus obtained was purified by column chromatography [silica gel,chloroform] to thereby give a colorless oil 203 (769.1 mg, 97.1%). MSm/z: 247.

[0629] The dibenzylamine compound 203 (500 mg, 2.02 mmol) andtriethylamine (0.34 ml, 2.43 mmol, 1.2 mol eq.) were dissolved inchloroform and acryloyl chloride (201.3 mg, 2.22 mmol, 1.1 mol eq.)dissolved in chloroform was added thereto under ice-cooling. Thereaction mixture was stirred at room temperature for 30 minutes. Afterthe completion of the reaction, the reaction mixture was poured intowater and extracted with chloroform. The chloroform layer was washedwith water and a saturated aqueous solution of sodium chloride and driedover sodium sulfate. After distilling off the solvent, the oil thusobtained was purified by column chromatography [silica gel, chloroform]to thereby give a colorless oil 204 (579.7 mg, 95.0%). MS m/z: 301.

[0630] The conjugated ketone compound 204 (105.8 mg, 0.35 mmo, 1.2 moleq.) and (R)-(+)-1-(1-naphthyl)ethylamine (50 mg, 0.29 mmol) weredissolved in chloroform/methanol (4:1) and allowed to stand at roomtemperature for 1 week. After the completion of the reaction, thesolvent was distilled off under reduced pressure and the oil thusobtained was purified by column chromatography [silica gel, chloroform]to thereby give a colorless oil K-2248 (69.8 mg, 42.0%).

[0631] MS m/z: 472, ¹H-NMR δ: 1.52 (3H, dd, J=6.7, 8.5 Hz, CH₃),2.66-2.69 (2H, m, CH₂), 2.89-3.00 (2H, m, CH₂), 4.51 (2H, d, J=65.3 Hz,CH₂), 4.67 (1H, q, J=36.7 Hz, CH), 4.75 (2H, d, J=48.2 Hz, CH₂), 7.16(1H, d, J=7.3 Hz, Ar—H), 7.22-7.39 (5H, m, Ar—H), 7.43-7.52 (5H, m,Ar—H), 7.58 (1H, d, J=25.6 Hz, Ar—H), 7.68-7.88 (6H, m, Ar—H), 8.17 (1H,dd, J=7.9, 21.4 Hz, Ar—H).

Example 96 Synthesis of K-2249

[0632] To 2-chlorobenzaldehyde (500 mg, 3.56 mmol) and benzylamine(381.2 mg, 3.56 mmol, 1.0 mol eq.) was added titanium tetraisopropoxide(1.26 ml, 4.17 mmol, 1.2 mol eq.) and the mixture was stirred at roomtemperature for 4 hours. After the completion of the reaction, thereaction mixture was dissolved in ethanol and sodium boron hydride(538.7 mg, 14.24 mmol, 4.0 mol eq.) was added thereto. Then the obtainedmixture was stirred at room temperature for 12 hours. After thecompletion of the reaction, the solvent was distilled off under reducedpressure. To the obtained residue were added ethyl acetate and water andthe mixture was filtered through celite. The residue was washed withethyl acetate and the washing liquor was combined with the filtrate andextracted with ethyl acetate. The ethyl acetate layer was washed withwater and a saturated aqueous solution of sodium chloride and dried oversodium sulfate and the solvent was distilled off under reduced pressure.The oil thus obtained was purified by column chromatography [silica gel,chloroform] to thereby give a colorless oil 205 (427.7 mg, 51.9%). MSm/z: 231.

[0633] The dibenzylamine compound 205 (300 mg, 1.29 mmol) andtriethylamine (0.22 ml, 1.55 mmol, 1.2 mol eq.) were dissolved inchloroform and acryloyl chloride (128.9 mg, 1.42 mmol, 1.1 mol eq.)dissolved in chloroform was added thereto under ice-cooling. Thereaction mixture was stirred at room temperature for 30 minutes. Afterthe completion of the reaction, the reaction mixture was poured intowater and extracted with chloroform. The chloroform layer was washedwith water and a saturated aqueous solution of sodium chloride and driedover sodium sulfate. After distilling off the solvent, the oil thusobtained was purified by column chromatography [silica gel, chloroform]to thereby give a colorless oil 206 (358.8 mg, 96.8%). MS m/z: 285.

[0634] The conjugated ketone compound 206 (100.3 mg, 0.35 mmol, 1.2 moleq.) and (R)-(+)-1-(1-naphthyl)ethylamine (50 mg, 0.29 mmol) weredissolved in chloroform/methanol (4:1) and allowed to stand at roomtemperature for 1 week. After the completion of the reaction, thesolvent was distilled off under reduced pressure and the oil thusobtained was purified by column chromatography [silica gel, chloroform]to thereby give a colorless oil K-2249 (67.8 mg, 50.8%).

[0635] MS m/z: 456, ¹H-NMR δ: 1.53 (3H, dd, J=6.7,-4.3 Hz, CH₃),2.51-2.74 (2H, m, CH₂), 2.85-2.98 (2H, m, CH₂), 4.50 (2H, d, J=9.8 Hz,CH₂), 4.64 (1H, s, CH₂), 4.66-4.70 (1H, m, CH), 4.78 (1H, s, CH₂), 7.15(1H, d, J=7.9 Hz, Ar—H), 7.19-7.39 (8H, m, Ar—H), 7.45-7.51 (3H, m,Ar—H), 7.70 (1H, t, J=7.9 Hz, Ar—H), 7.74 (1H, dd, J=3.7, 7.9 Hz, Ar—H),7.87 (1H, d, J=7.3 Hz, Ar—H), 8.17 (1H, t, J=7.3 Hz, Ar—H).

Example 97 Synthesis of K-2250(N1-benzyl-N1-(3,4-dichloro-benzyl)-3-{[(1R)-1-(1-naphthyl)ethyl]amino}propanamide)

[0636] To benzaldehyde (300 mg, 2.83 mmol) and 3,4-dichlorobenzylamine(497.7 mg, 2.83 mmol, 1.0 mol eq.) was added titanium tetraisopropoxide(1.00 ml, 3.39 mmol, 1.2 mol eq.) and the mixture was stirred at roomtemperature for 4 hours. After the completion of the reaction, thereaction mixture was dissolved in ethanol and sodium boron hydride(428.2 mg, 11.32 mmol, 4.0 mol eq.) was added thereto. Then the obtainedmixture was stirred at room temperature for 12 hours. After thecompletion of the reaction, the solvent was distilled off under reducedpressure. To the obtained residue were added ethyl acetate and water andthe mixture was filtered through celite. The residue was washed withethyl acetate and the washing liquor was combined with the filtrate andextracted with ethyl acetate. The ethyl acetate layer was washed withwater and a saturated aqueous solution of sodium chloride and dried oversodium sulfate and the solvent was distilled off under reduced pressure.The oil thus obtained was purified by column chromatography [silica gel,chloroform] to thereby give a colorless oil 207 (568 mg, 75.5%). MS m/z:266.

[0637] The dibenzylamine compound 207 (300 mg, 1.13 mmol) andtriethylamine (0.189 ml, 1.35 mmol, 1.2 mol eq.) were dissolved inchloroform and acryloyl chloride (112.3 mg, 1.24 mmol, 1.1 mol eq.)dissolved in chloroform was added thereto under ice-cooling. Thereaction mixture was stirred at room temperature for 30 minutes. Afterthe completion of the reaction, the reaction mixture was poured intowater and extracted with chloroform. The chloroform layer was washedwith water and a saturated aqueous solution of sodium chloride and driedover sodium sulfate. After distilling off the solvent, the oil thusobtained was purified by column chromatography [silica gel, chloroform]to thereby give a colorless oil 208 (358.3 mg, 99.3%). MS m/z: 320.

[0638] The conjugated ketone compound 208 (100 mg, 0.31 mmol) and(R)-(+)-1-(1-naphthyl)ethylamine (64.2 mg, 0.38 mmol, 1.2 mol eq.) weredissolved in chloroform/methanol (4:1) and allowed to stand at roomtemperature for 1 week. After the completion of the reaction, thesolvent was distilled off under reduced pressure and the oil thusobtained was purified by column chromatography [silica gel, chloroform]to thereby give a colorless oil K-2250 (96.5 mg, 62.9%).

[0639] MS m/z: 491, ¹H-NMR δ: 1.51 (3H, d, J=6.6 Hz, CH₃), 2.49-2.68(2H, m, CH₂), 2.82-2.96 (2H, m, CH₂), 4.38 (2H, d, J=32.4 Hz, CH₂), 4.54(1H, s, CH₂), 4.67 (1H, d, J=42.5 Hz, CH₂), 4.66 (1H, q, J=6.6 Hz, CH),7.11 (1H, d, J=6.6 Hz, Ar—H), 7.19 (1H, d, J=6.8 Hz, Ar—H), 7.21-7.41(6H, m, Ar—H), 7.43-7.51 (3H, m, Ar—H), 7.67 (1H, dd, J=2.0, 7.1 Hz,Ar—H), 7.74 (1H, d, J=8. 3Hz, Ar—H), 7.86 (1H, dd, J=2.2, 8.1 Hz, Ar—H),8.16 (1H, d, J=7.3 Hz, Ar—H).

Example 98 Synthesis of K-2251

[0640] To benzaldehyde (300 mg, 2.83 mmol) and 2,4-dichlorobenzylamine(497.7 mg, 2.83 mmol, 1.0 mol eq.) was added titanium tetraisopropoxide(1.00 ml, 3.39 mmol, 1.2 moi eq.) and the mixture was stirred at roomtemperature for 4 hours. After the completion of the reaction, thereaction mixture was dissolved in ethanol and sodium boron hydride(428.2 mg, 11.32 mmol, 4.0 mol eq.) was added thereto. Then the obtainedmixture was stirred at room temperature for 12 hours. After thecompletion of the reaction, the solvent was distilled off under reducedpressure. To the obtained residue were added ethyl acetate and water andthe mixture was filtered through celite. The residue was washed withethyl acetate and the washing liquor was combined with the filtrate andextracted with ethyl acetate. The ethyl acetate layer was washed withwater and a saturated aqueous solution of sodium chloride and dried oversodium sulfate and the solvent was distilled off under reduced pressure.The oil thus obtained was purified by column chromatography [silica gel,chloroform] to thereby give a colorless oil 209 (469 mg, 62.4%). MS m/z:266.

[0641] The dibenzylamine compound 209 (300 mg, 1.13 mmol) andtriethylamine (0.189 ml, 1.35 mmol, 1.2 mol eq.) were dissolved inchloroform and acryloyl chloride (112.3 mg, 1.24 mmol, 1.1 mol eq.)dissolved in chloroform was added thereto under ice-cooling. Thereaction mixture was stirred at room temperature for 30 minutes. Afterthe completion of the reaction, the reaction mixture was poured intowater and extracted with chloroform. The chloroform layer was washedwith water and a saturated aqueous solution of sodium chloride and driedover sodium sulfate. After distilling off the solvent, the oil thusobtained was purified by column chromatography [silica gel, chloroform]to thereby give a colorless oil 210 (311.6 mg, 86.3%). MS m/z: 320.

[0642] The conjugated ketone compound 210 (1 00 mg, 0.31 mmol) and(R)-(+)-1-(1-naphthyl)ethylamine (64.2 mg, 0.38 mmol, 1.2 mol eq.) weredissolved in chloroform/methanol (4:1) and allowed to stand at roomtemperature for 1 week. After the completion of the reaction, thesolvent was distilled off under reduced pressure and the oil thusobtained was purified by column chromatography [silica gel, chloroform]to thereby give a colorless oil K-2251 (126.7 mg, 82.6%).

[0643] MS m/z: 491, ¹H-NMR δ: 1.51 (3H, dd, J=2.5, 6.6 Hz, CH₃),2.51-2.53 (1H, m, CH₂), 2.64-2.68 (1H, m, CH₂), 2.84-2.96 (2H, m, CH₂),4.46 (2H, d, J=13.4 Hz, CH₂), 4.60 (1H, s, CH₂), 4.65-4.68 (1H, m, CH),4.69 (1H, s, CH₂), 7.13 (1H, d, J=7.3 Hz, Ar—H), 7.17-7.39 (7H, m,Ar—H), 7.44-7.50 (3H, m, Ar—H), 7.67 (1H, t, J=7.3 Hz, Ar—H), 7.73 (1H,dd, J=3.7, 7.9 Hz, Ar—H), 7.86 (1H, d, J=7.3 Hz, Ar—H), 8.16 (1H, d,J=7.9 Hz, Ar—H).

Example 99 Synthesis of K-2252

[0644] To benzaldehyde (500 mg, 4.71 mmol) and 3-chlorobenzylamine(667.2 mg, 4.71 mmol, 1.0 mol eq.) was added titanium tetraisopropoxide(1.67 ml, 5.65 mmol, 1.2 mol eq.) and the mixture was stirred at roomtemperature for 4 hours. After the completion of the reaction, thereaction mixture was dissolved in ethanol and sodium boron hydride(712.7 mg, 18.84 mmol, 4.0 mol eq.) was added thereto. Then the obtainedmixture was stirred at room temperature for 12 hours. After thecompletion of the reaction, the solvent was distilled off under reducedpressure. To the obtained residue were added ethyl acetate and water andthe mixture was filtered through celite. The residue was washed withethyl acetate and the washing liquor was combined with the filtrate andextracted with ethyl acetate. The ethyl acetate layer was washed withwater and a saturated aqueous solution of sodium chloride and driedover.sodium sulfate and the solvent was distilled off under reducedpressure. The oil thus obtained was purified by column chromatography[silica gel, chloroform] to thereby give a colorless oil 211 (930.5 mg,85.2%). MS m/z: 231.

[0645] The dibenzylamine compound 211 (500 mg, 2.16 mmol) andtriethylamine (0.36 ml, 2.59 mmol, 1.2 mol eq.) were dissolved inchloroform and acryloyl chloride (214.8 mg, 2.37 mmol, 1.1 mol eq.)dissolved in chloroform was added thereto under ice-cooling. Thereaction mixture was stirred at room temperature for 30 minutes. Afterthe completion of the reaction, the reaction mixture was poured intowater and extracted with chloroform. The chloroform layer was washedwith water and a saturated aqueous solution of sodium chloride and driedover sodium sulfate. After distilling off the solvent, the oil thusobtained was purified by column chromatography [silica gel, chloroform]to thereby give a colorless oil 212 (308.5 mg, 50.0%). MS m/z: 285.

[0646] The conjugated ketone compound 212 (100 mg, 0.35 mmol) and(R)-(+)-1-(1-naphthyl)ethylamine (71.8 mg, 0.42 mmol, 1.2 mol eq.) weredissolved in chloroform/methanol (4:1) and allowed to stand at roomtemperature for 1 week. After the completion of the reaction, thesolvent was distilled off under reduced pressure and the oil thusobtained was purified by column chromatography [silica gel, chloroform]to thereby give a colorless oil K-2252 (85.0 mg, 53.2%).

[0647] MS m/z: 456, ¹H-NMR δ: 1.50 (3H, d, J=6.6 Hz, CH₃), 2.61 (2H, dt,J=6.1, 21.0 Hz, CH₂), 2.82-2.96 (2H, m, CH₂), 4.40 (2H, d, J=19.3 Hz,CH₂), 4.60 (2H, d, J=13.7 Hz, CH₂), 4.66 (1H, q, J=6.6 Hz, CH), 7.13(2H, d, J=7.1 Hz, Ar—H), 7.20-7.37 (7H, m, Ar—H), 7.43-7.51 (3H, m,Ar—H), 7.68 (1H, d, J=8.1 Hz, Ar—H), 7.73 (1H, d, J=8.1 Hz, Ar—H), 7.86(1H, dd, J=2.2, 7.3 Hz, Ar—H), 8.17 (1H, d, J=7.6 Hz, Ar—H).

Example 100 Synthesis of K-2253

[0648] To 3-chlorobenzaldehyde (500 mg, 3.56 mmol) and3-chlorobenzylamine (503.7 mg, 3.56 mmol, 1.0 mol eq.) was addedtitanium tetraisopropoxide (1.26 ml, 4.27 mmol, 1.2 mol eq.) and themixture was stirred at room temperature for 4 hours. After thecompletion of the reaction, the reaction mixture was dissolved inethanol and sodium boron hydride (538.7 mg, 14.24 mmol, 4.0 mol eq.) wasadded thereto. Then the obtained mixture was stirred at room temperaturefor 12 hours. After the completion of the reaction, the solvent wasdistilled off under reduced pressure. To the obtained residue were addedethyl acetate and water and the mixture was filtered through celite. Theresidue was washed with ethyl acetate and the washing liquor wascombined with the filtrate and extracted with ethyl acetate. The ethylacetate layer was washed with water and a saturated aqueous solution ofsodium chloride and dried over sodium sulfate and the solvent wasdistilled off under reduced pressure. The oil thus obtained was purifiedby column chromatography [silica gel, chloroform] to thereby give acolorless oil 213 (756.5 mg, 80.3%). MS m/z: 266.

[0649] The dibenzylamine compound 213 (500 mg, 1.88 mmol) andtriethylamine (0.31 ml, 2.26 mmol, 1.2 mol eq.) were dissolved inchloroform and acryloyl chloride (187.1 g, 2.07 mmol, 1.1 mol eq.)dissolved in chloroform was added thereto under ice-cooling. Thereaction mixture was stirred at room temperature for 30 minutes. Afterthe completion of the reaction, the reaction mixture was poured intowater and extracted with chloroform. The chloroform layer was washedwith water and a saturated aqueous solution of sodium chloride and driedover sodium sulfate. After distilling off the solvent, the oil thusobtained was purified by column chromatography [silica gel, chloroform]to thereby give a colorless oil 214 (595.3 mg, 98.8%). MS m/z: 320.

[0650] The conjugated ketone compound 214 (100 mg, 0.31 mmol) and(R)-(+)-1-(1-naphthyl)ethylamine (64.2 mg, 0.38 mmol, 1.2 mol eq.) weredissolved in chloroform/methanol (4:1) and allowed to stand at roomtemperature for 1 week. After the completion of the reaction, thesolvent was distilled off under reduced pressure and the oil thusobtained was purified by column chromatography [silica gel, chloroform]to thereby give a colorless oil K-2253 (96.5 mg, 62.9%).

[0651] MS m/z: 491, ¹H-NMR δ: 1.51 (3H, d, J=6.1 Hz, CH₃), 2.58 (2H, t,J=6.1 Hz, CH₂), 2.85-2.97 (2H, m, CH₂), 4.38 (2H, s, CH₂), 4.57 (2H, d,J=3.1 Hz, CH₂), 4.65 (1H, q, J=6.1 Hz, CH), 6.99 (1H, d, J=5.5 Hz,Ar—H), 7.08 (1H, d, J=6.1 Hz, Ar—H), 7.11 (1H, s, Ar—H), 7.20 (1H, s,Ar—H), 7.23-7.27 (4H, m, Ar—H), 7.44-7.49 (3H, m, Ar—H), 7.67 (1H, d,J=7.3 Hz, Ar—H), 7.72 (1H, d, J=7.9 Hz, Ar—H), 7.85 (1H, d, J=7.9 Hz,Ar—H), 8.18 (1H, d, J=7.9 Hz, Ar—H).

Example 101 Synthesis of K-2254

[0652] To 2-chlorobenzaldehyde (500 mg, 3.56 mmol) and2-chlorobenzylamine (503.6 mg, 3.56 mmol, 1.0 mol eq.) was addedtitanium tetraisopropoxide (1.25 ml, 4.27 mmol, 1.2 mol eq.) and themixture was stirred at room temperature for 4 hours. After thecompletion of the reaction, the reaction mixture was dissolved inethanol and sodium boron hydride (538.7 mg, 14.2 mmol, 4.0 mol eq.) wasadded thereto. Then the obtained mixture was stirred at room temperaturefor 12 hours. After the completion of the reaction, the solvent wasdistilled off under reduced pressure. To the obtained residue were addedethyl acetate and water and the mixture was filtered through celite. Theresidue was washed with ethyl acetate and the washing liquor wascombined with the filtrate and extracted with ethyl acetate. The ethylacetate layer was washed with water and a saturated aqueous solution ofsodium chloride and dried over sodium sulfate and the solvent wasdistilled off under reduced pressure. The oil thus obtained was purifiedby column chromatography [silica gel, chloroform] to thereby give acolorless oil 215 (632.6 mg, 66.9%). MS m/z: 266.

[0653] The dibenzylamine compound 215 (400 mg, 1.50 mmol) andtriethylamine (0.25 ml, 1.80 mmol, 1.2 mol eq.) were dissolved inchloroform and acryloyl chloride (149.7 g, 1.65 mmol, 1.1 mol eq.)dissolved in chloroform was added thereto under ice-cooling. Thereaction mixture was stirred at room temperature for 30 minutes. Afterthe completion of the reaction, the reaction mixture was poured intowater and extracted with chloroform. The chloroform layer was washedwith water and a saturated aqueous solution of sodium chloride and driedover sodium sulfate. After distilling off the solvent, the oil thusobtained was purified by column chromatography [silica gel, chloroform]to thereby give a colorless oil 216 (391.7 mg, 81.2%). MS m/z: 320.

[0654] The conjugated ketone compound 216 (100 mg, 0.31 mmol) and(R)-(+)-1-(1-naphthyl)ethylamine (64.2 mg, 0.38 mmol, 1.2 mol eq.) weredissolved in chloroform/methanol (4:1) and allowed to stand at roomtemperature for 1 week. After the completion of the reaction, thesolvent was distilled off under reduced pressure and the oil thusobtained was purified by column chromatography [silica gel, chloroform]to thereby give a colorless oil K-2254 (72.7 mg, 47.4%).

[0655] MS m/z: 491, ¹H-NMR δ: 1.49 (3H, d, J=6.6 Hz, CH₃), 2.53-2.60(2H, m, CH₂), 2.83-2.93 (2H, m, CH₂), 4.57 (2H, s, CH₂), 4.64 (1H, q,J=6.6 Hz, CH₂), 4.77 (2H, s, CH₂), 7.13-7.38 (8H, m, Ar—H), 7.44-7.51(3H, m, Ar—H), 7.66 (1H, d, J=6.6 Hz, Ar—H), 7.72 (1H, d, J=8.1 Hz,Ar—H), 7.85 (1H, dd, J=2.4, 7.1 Hz, Ar—H), 8.14 (1H, dd, J=2.2, 7.1 Hz,Ar—H).

Example 102 Synthesis of K-2256

[0656] To 4-fluorobenzaldehyde (483.2 mg, 3.90 mmol) and4-fluorobenzylamine (500 mg, 3.90 mmol, 1.0 mol eq.) was added titaniumtetraisopropoxide (1.38 ml, 4.68 mmol, 1.2 mol eq.) and the mixture wasstirred at room temperature for 4 hours. After the completion of thereaction, the reaction mixture was dissolved in ethanol and sodium boronhydride (590.1 mg, 15.6 mmol, 4.0 mol eq.) was added thereto. Then theobtained mixture was stirred at room temperature for 12 hours. After thecompletion of the reaction, the solvent was distilled off under reducedpressure. To the obtained residue were added ethyl acetate and water andthe mixture was filtered through celite. The residue was washed withethyl acetate and the washing liquor was combined with the filtrate andextracted with ethyl acetate. The ethyl acetate layer was washed withwater and a saturated aqueous solution of sodium chloride and dried oversodium sulfate and the solvent was distilled off under reduced pressure.The oil thus obtained was purified by column chromatography [silica gel,chloroform] to thereby give a colorless oil 217 (783.2 mg, 84.0%). MSm/z: 233.

[0657] The dibenzylamine compound 217 (500 mg, 2.15 mmol) andtriethylamine (0.36 ml, 2.58 mmol, 1.2 mol eq.) were dissolved inchloroform and acryloyl chloride (213.6 g, 2.36 mmol, 1.1 mol eq.)dissolved in chloroform was added thereto under ice-cooling. Thereaction mixture was stirred at room temperature for 30 minutes. Afterthe completion of the reaction, the reaction mixture was poured intowater and extracted with chloroform. The chloroform layer was washedwith water and a saturated aqueous solution of sodium chloride and driedover sodium sulfate. After distilling off the solvent, the oil thusobtained was purified by column chromatography [silica gel, chloroform]to thereby give a colorless oil 218 (572.6 mg, 86.8%). MS m/z: 287.

[0658] The conjugated ketone compound 218 (800 mg, 1.63 mmol) and(R)-(+)-1-(1-naphthyl)ethylamine (33.7 mg, 1.95 mmol, 1.2 mol eq.) weredissolved in chloroform/methanol (4:1) and allowed to stand at roomtemperature for 1 week. After the completion of the reaction, thesolvent was distilled off under reduced pressure and the oil thusobtained was purified by column chromatography [silica gel, chloroform]to thereby give a colorless oil K-2256 (375.1 mg, 48.2%).

[0659] MS m/z: 458, ¹H-NMR δ: 1.50 (3H, d, J=6.6 Hz, CH₃), 2.60 (2H, t,J=6.1 Hz, CH₂), 2.84-2.96 (2H, m, CH₂), 4.36 (2H, s, CH₂), 4.54 (2H, s,CH₂), 4.66 (1H, q, J=6.6 Hz, CH), 6.95-7.09 (6H, m, Ar—H), 7.16 (1H, d,J=8.8 Hz, Ar—H), 7.17 (1H, d, J=8.8 Hz, Ar—H ), 7.43-7.51 (3H, m, Ar—H),7.67 (1H, d, J=6.6 Hz, Ar—H), 7.73 (1H, d, J=8.3 Hz, Ar—H), 7.87 (1H,dd, J=2.4, 7.0 Hz, Ar—H), 8.17 (1H, dd, J=2.0, 7.3 Hz, Ar—H).

Example 103 Synthesis of K-2261

[0660] To 3-chlorobenzaldehyde (992.7 mg, 7.06 mmol) and4-chlorobenzylamine (1 g, 7.06 mmol, 1.0 mol eq.) was added titaniumtetraisopropoxide (2.5 ml, 8.47 mmol, 1.2 mol eq.) and the mixture wasstirred at room temperature for 4 hours. After the completion of thereaction, the reaction mixture was dissolved in ethanol and sodium boronhydride (1.0683 g, 28.4 mmol, 4.0 mol eq.) was added thereto. Then theobtained mixture was stirred at room temperature for 12 hours. After thecompletion of the reaction, the solvent was distilled off under reducedpressure. To the obtained residue were added ethyl acetate and water andthe mixture was filtered through celite. The residue was washed withethyl acetate and the washing liquor was combined with the filtrate andextracted with ethyl acetate. The ethyl acetate layer was washed withwater and a saturated aqueous solution of sodium chloride and dried oversodium sulfate and the solvent was distilled off under reduced pressure.The oil thus obtained was purified by column chromatography [silica gel,chloroform] to thereby give a colorless oil 219 (1.5847 g, 84.4%). MSm/z: 266.

[0661] The dibenzylamine compound 219 (1.3 g, 4.89 mmol) andtriethylamine (0.82 ml, 5.86 mmol, 1.2 mol eq.) were dissolved inchloroform and acryloyl chloride (486.6 mg, 5.38 mmol, 1.1 mol eq.)dissolved in chloroform was added thereto under ice-cooling. Thereaction mixture was stirred at room temperature for 30 minutes. Afterthe completion of the reaction, the reaction mixture was poured intowater and extracted with chloroform. The chloroform layer was washedwith water and a saturated aqueous solution of sodium chloride and driedover sodium sulfate After distilling off the solvent, the oil thusobtained was purified by column chromatography [silica gel, chloroform]to thereby give a colorless oil 220 (1.2967 g, 82.7%). MS m/z: 320.

[0662] The conjugated ketone compound 220 (1 g, 3.13 mmol) and(R)-(+)-1-(1-naphthyl)ethylamine (642.2 mg, 3.75 mmol, 1.2 mol eq.) weredissolved in chloroform/methanol (4:1) and allowed to stand at roomtemperature for 1 week. After the completion of the reaction, thesolvent was distilled off under reduced pressure and the oil thusobtained was purified by column chromatography [silica gel, chloroform]to thereby give a colorless oil K-2261 (624.8 mg, 40.7%).

[0663] MS m/z: 491, ¹H-NMR δ: 1.50 (3H, d, J=6.6 Hz, CH₃), 2.54-2.63(2H, m, CH₂), 2.82-2.96 (2H, m, CH₂), 4.36 (2H, d, J=4.4 Hz, CH₂), 4.55(2H, d, J=2.9 Hz, CH₂), 4.65 (1H, q, J=6.6 Hz, CH), 7.04 (2H, d, J=8.6Hz, Ar—H), 7.13 (2H, d, J=8.6 Hz, Ar—H), 7.18-7.31 (4H, m, Ar—H),7.44-7.51 (3H, m, Ar—H), 7.67 (1H, d, J=7.3 Hz, Ar—H), 7.73 (1H, d,J=8.1 Hz, Ar—H), 7.85 (1H, dd, J=2.2 Hz, J=7.3 Hz, Ar—H), 8.16 (1H, d,J=7.6 Hz, Ar—H).

Example 104 Synthesis of K-2262(N1-(2-chlorobenzyl)-N1-(4-chlorobenzyl)-3-{[(1R)-1-(1-naphthyl)ethyl]amino}propanamide)

[0664] To 2-chlorobenzaldehyde (992.7 mg, 7.06 mmol) and4-chlorobenzylamine (1 g, 7.06 mmol, 1.0 mol eq.) was added titaniumtetraisoprbpoxide (2.5 ml, 8.47 mmol, 1.2 mol eq.) and the mixture wasstirred at room temperature for 4 hours. After the completion of thereaction, the reaction mixture was dissolved in ethanol and sodium boronhydride (1.0683 g, 28.4 mmol, 4.0 mol eq.) was added thereto. Then theobtained mixture was stirred at room temperature for 12 hours. After thecompletion of the reaction, the solvent was distilled off under reducedpressure. To the obtained residue were added ethyl acetate and water andthe mixture was filtered through celite. The residue was washed withethyl acetate and the washing liquor was combined with the filtrate andextracted with ethyl acetate. The ethyl acetate layer was washed withwater and a saturated aqueous solution of sodium chloride and dried oversodium sulfate and the solvent was distilled off under reduced pressure.The oil thus obtained was purified by column chromatography [silica gel,chloroform] to thereby give a colorless oil 221 (673.6 mg, 40%). MS m/z:266.

[0665] The dibenzylamine compound 221 (600 mg, 2.26 mmol) andtriethylamine (0.38 ml, 2.71 mmol, 1.2 mol eq.) were dissolved inchloroform and acryloyl chloride (224.6 mg, 2.48 mmol, 1.1 mol eq.)dissolved in chloroform was added thereto under ice-cooling. Thereaction mixture was stirred at room temperature for 30 minutes. Afterthe completion of the reaction, the reaction mixture was poured intowater and extracted with chloroform. The chloroform layer was washedwith water and a saturated aqueous solution of sodium chloride and driedover sodium sulfate. After distilling off the solvent, the oil thusobtained was purified by column chromatography [silica gel, chloroform]to thereby give a colorless oil 222 (684.2 mg, 94.8%). MS m/z: 320.

[0666] The conjugated ketone compound 222 (500 mg, 1.56 mmol) and(R)-(+)-1-(1-naphthyl)ethylamine (321.1 mg, 1.88 mmol,1.2 mol eq.) weredissolved in chloroform/methanol (4:1) and allowed to stand at roomtemperature for 1 week. After the completion of the reaction, thesolvent was distilled off under reduced pressure and the oil thusobtained was purified by column chromatography [silica gel, chloroform]to thereby give a colorless oil K-2262 (552.4 mg, 72.0%).

[0667] MS m/z: 491, ¹H-NMR δ: 1.56 (3H, d, J=6.6 Hz, CH₃), 2.51-2.72(2H, m, CH₂), 2.83-2.98 (2H, m, CH₂), 4.43 (1 H, s, CH₂), 4.48 (1H, s,CH₂), 4.56 (1H, d, J=4.5 Hz, CH₂), 4.68-4.72 (1 H, m, CH), 4.73 (1H, d,J=5.6 Hz, CH₂), 7.05 (1H, d, J=8.3 Hz, Ar—H), 7.15 (1H, d, J=8.3 Hz,Ar—H), 7.20-7.39 (6H, m, Ar—H), 7.45-7.52 (3H, m, Ar—H), 7.68 (1H, d,J=6.3 Hz, Ar—H), 7.75 (1H, d, J=8.3 Hz, Ar—H), 7.87 (1H, d, J=7.1 Hz,Ar—H), 8.14 (1H, d, J=6.6 Hz, Ar—H).

Example 105 Synthesis of K-2264(N1-(3,4-dichlorobenzyl)-N1-[(4-trifluoromethyl)benzyl]-3-{[(1R)-1-(1-naphthyl)ethyl]-amino}propanamide)

[0668] To 3,4-dichlcrobenzaldehyde (1 g, 5.71 mmol) and4-trifluoromethylbenzylamine (1 g, 5.71 mmol, 1.0 mol eq.) was addedtitanium tetraisopropoxide (2.02 ml, 6.86 mmol, 1.2 mol eq.) and themixture was stirred at room temperature for 4 hours. After thecompletion of the reaction, the reaction mixture was dissolved inethanol and sodium boron hydride (864.6 mg, 22.86 mmol, 4.0 mol eq.) wasadded thereto. Then the obtained mixture was stirred at room temperaturefor 12 hours. After the completion of the reaction, the solvent wasdistilled off under reduced pressure. To the obtained residue were addedethyl acetate and water and the mixture was filtered through celite. Theresidue was washed with ethyl acetate and the washing liquor wascombined with the filtrate and extracted with ethyl acetate. The ethylacetate layer was washed with water and a saturated aqueous solution ofsodium chloride and dried over sodium sulfate and the solvent wasdistilled off under reduced pressure. The oil thus obtained was purifiedby column chromatography [silica gel, chloroform] to thereby give acolorless oil 223 (1.668 g, 87.4%).

[0669] MS m/z: 334, ¹H-NMR d: 3.75 (2H, s, CH₂), 3.84 (2H, s, CH₂), 7.17(1H, dd, J=2.2, 8.3 Hz, Ar—H), 7.39 (2H, d, 8.3 Hz, Ar—H), 7.45 (1H, d,J=8.3 Hz, Ar—H), 7.46 (1H, d, J=2.2 Hz, Ar—H), 7.59 (2H, d, J=8.3 Hz,Ar—H).

[0670] The dibenzylamine compound 223 (800 mg, 2.39 mmol) andtriethylamine (0.4 ml, 2.87 mmol, 1.2 mol eq.) were dissolved inchloroform and acryloyl chloride (238.4 mg, 2.63 mmol, 1.1 mol eq.)dissolved in chloroform was added thereto under ice-cooling. Thereaction mixture was stirred at room temperature for 30 minutes. Afterthe completion of the reaction, the reaction mixture was poured intowater and extracted with chloroform. The chloroform layer was washedwith water and a saturated aqueous solution of sodium chloride and driedover sodium sulfate. After distilling off the solvent, the oil thusobtained was purified by column chromatography [silica gel, chloroform]to thereby give a colorless oil 224 (930 mg, 100.0%).

[0671] MS m/z: 388, ¹H-NMR d: 4.54 (2H, d, J=42.0 Hz, CH₂), 4.64 (2H, d,J=39.0 Hz, CH₂), 5.79-5.82 (1H, m, CH═CH₂), 6.53-6.60 (2H, m, CH═CH₂),7.23-7.45 (5H, m, Ar—H), 7.58 (1H, d, J=7.8 Hz, Ar—H), 7.63 (1H, d,J=7.8 Hz, Ar—H).

[0672] The conjugated ketone compound 224 (800 mg, 2.06 mmol) and(R)-(+)-1-(1-naphthyl)ethylamine (387.7 mg, 2.26 mmol, 1.1 mol eq.) weredissolved in chloroform/methanol (4:1) and allowed to stand at roomtemperature for 1 week. After the completion of the reaction, thesolvent was distilled off under reduced pressure and the oil thusobtained was purified by column chromatography [silica gel, chloroform]to thereby give a colorless oil K-2264 (807.4 mg, 70.1%).

[0673] MS m/z: 559, ¹H-NMR d: 1.51 (3H, d, J=6.6 Hz, CH₃), 2.59 (2H, t,J=6.1 Hz, CH₂), 2.85-2.98 (2H, m, CH), 4.41 (2H, d, J=42.0 Hz, CH₂),4.58 (2H, d, J=38.1 Hz, CH₂), 4.66 (1H, q, J=6.6Hz, CH), 7.19 (1H, d,J=2.0 Hz, Ar—H), 7.22 (1H, d, J=8.3 Hz, Ar—H), 7.30 (2H, d, J=8.3 Hz,Ar—H), 7.44-7.52 (3H, m, Ar—H), 7.55 (1H, d, J=8.3 Hz, Ar—H), 7.59 (1H,d, J=8.3 Hz, Ar—H), 7.66 (1H, d, J=7.1 Hz, Ar—H), 7.74 (1H, d, J=8.3 Hz,Ar—H), 7.86 (1 H, dd, J=2.9, 6.6 Hz, Ar—H), 8.17 (1H, d, J=8.3 Hz,Ar—H).

Example 106 Synthesis of K-2265(N1,N1-di(3,4-dichlorobenzyl)-3{[(1R)-1-(1-naphthyl)ethyl]amino}propanamide)

[0674] To 3,4-dichlorobenzaldehyde (500 mg, 2.86 mmol) and3,4-dichlorobenzylamine (0.382 ml, 2.86 mmol) was added titaniumtetraisopropoxide (1.51 ml, 5.14 mmol, 1.8 mol eq.) and the mixture wasstirred at room temperature for 28 hours. After the completion of thereaction, the reaction mixture was dissolved in ethanol and sodium boronhydride (443 mg, 11.44 mmol, 4.0 mol eq.) was added thereto. Then theobtained mixture was stirred at room temperature for 20 hours. After thecompletion of the reaction, the solvent was distilled off under reducedpressure. To the obtained residue were added chloroform and water andthe mixture was filtered through celite. The residue was washed withchloroform and the washing liquor was combined with the filtrate andextracted with chloroform. The chloroform layer was washed with waterand a saturated aqueous solution of sodium chloride and dried oversodium sulfate and the solvent was distilled off under reduced pressure.The oil thus obtained was purified by column chromatography [silica gel,hexane:ethyl acetate (9:1-4:1)] to thereby give a colorless oil 225(71.2.2 mg, 74.3%).

[0675] MS m/z: 335, ¹H-NMR d: 3.74 (4H, d, J=2.7, CH₂×2), 7.17 (2H, dd,J=2.0, 8.3 Hz, Ar—H), 7.39 (2H, d, J=8.3 Hz, Ar—H), 7.44 (2H, d, J=2.0Hz, Ar—H).

[0676] The dibenzylamine compound 225 (31 5 mg, 0.94 mmol) andtriethylamine (0.16 ml, 1.13 mmol, 1.2 mol eq.) were dissolved inchloroform and acryloyl chloride (94 mg, 1.04 mmol, 1.1 mol eq.)dissolved in chloroform was added thereto under ice-cooling. Thereaction mixture was stirred at room temperature for 1 hour. After thecompletion of the reaction, the reaction mixture was poured into waterand extracted with chloroform. The chloroform layer was washed withwater and a saturated aqueous solution of sodium chloride and dried oversodium sulfate. After distilling off the solvent, the oil thus obtainedwas purified by column chromatography [silica gel, chloroform] tothereby give a colorless oil 226 (347.1 mg, 94.9%).

[0677] MS m/z: 389, ¹H-NMR d: 4.47 (2H, s, CH₂), 4.58 (2H, s, CH₂), 5.58(1H, dd, J=5.9, 6.6 Hz, CH═CH₂), 6.52 (1H, d, J=5.9 Hz, CH═CH₂), 6.52(1H, d, J=6.6 Hz, CH═CH₂), 6.99 (1H, d, J=7.6 Hz, Ar—H), 7.08 (1H, d,J=7.6 Hz, Ar—H), 7.23 (1H, s, Ar—H), 7.32 (1H, s, Ar—H), 7.39 (1H, d,J=7.8 Hz, Ar—H), 7.44 (1H, d, J=7.3 Hz, Ar—H).

[0678] The conjugated ketone compound 226 (280 mg, 0.72 mmol) and(R)-(+)-1-(1-naphthyl)ethylamine (148 mg, 0.864 mmol, 1.2 mol eq.) weredissolved in chloroform/methanol (4:1) and allowed to stand at roomtemperature for 8 days. After the completion of the reaction, thesolvent was distilled off under reduced pressure and the oil thusobtained was purified by column chromatography [silica gel, chloroform]to thereby give a colorless oil K-2265 (314.1 mg, 77.9%). Subsequently,the obtained K-2265 (201.7 mg, 0.36 mmol) was dissolved in a 10%solution of hydrochloric acid/methanol and stirred for 10 minutes. Thenit was concentrated as such under reduced pressure. The crystals thusformed were recrystallized from ethanol/water to thereby give K-2265hydrochloride (188.2 mg, 87.6%) as colorless crystals.

[0679] MS m/z: 560, ¹H-NMR d: 1.56 (3H, d, J=6.6 Hz, CH₃), 2.55-2.63(2H, m, CH₂), 2.86-2.99 (2H, m, CH₂), 4.35 (2H, s, CH₂), 4.51 (2H, s,CH₂), 4.71 (1H, q, J=6.6 Hz, CH), 6.94 (1H, dd, J=2.2, 8.3 Hz, Ar—H),7.04 (1H, dd, J=2.2, 8.1 Hz, Ar—H), 7.18 (1H, d, J=2.0 Hz, Ar—H), 7.27(1 H, d, J=2.0 Hz, Ar—H), 7.37 (1H, d, J=8.1 Hz, Ar—H), 7.40 (1H, d,J=8.3 Hz, Ar—H), 7.45-7.52 (3H, m, Ar—H), 7.68 (1H, d, J=6.6 Hz, Ar—H),7.75 (1H, d, J=8.1 Hz, Ar—H), 7.87 (1H, dd, J=2.2, 7.3 Hz, Ar—H), 8.15(1H, d, J=7.3 Hz, Ar—H).

Example 107 Synthesis of K-2266(N1-(4-chlorobenzyl)-N1-[(4-trifluoromethyl)benzyl]-3-{[(1R)-1-(1-naphthyl)ethyl]amino}propanamide)

[0680] To 4-(trifluoromethyl)benzaldehyde (19, 5.74 mmol) and4-chlorobenzylamine (813.2 mg, 5.74 mmol, 1.0 mol eq.) was addedtitanium tetraisopropoxide (2.03 ml, 6.89 mmol, 1.2 mol eq.) and themixture was stirred at room temperature for 4 hours. After thecompletion of the reaction, the reaction mixture was dissolved inethanol and sodium boron hydride (868.6 mg, 22.96 mmol, 4.0 mol eq.) wasadded thereto. Then the obtained mixture was stirred at room temperaturefor 12 hours. After the completion of the reaction, the solvent wasdistilled off under reduced pressure. To the obtained residue were addedethyl acetate and water and the mixture was filtered through celite. Theresidue was washed with ethyl acetate and the washing liquor wascombined with the filtrate and extracted with ethyl acetate. The ethylacetate layer was washed with water and a saturated aqueous solution ofsodium chloride and dried over sodium sulfate and the solvent wasdistilled off under reduced pressure. The oil thus obtained was purifiedby column chromatography [silica gel, chloroform] to thereby give acolorless oil 227 (1.6267 g, 94.5%).

[0681] MS m/z: 299, ¹H-NMR d: 3.77 (2H, s, CH₂), 3.84 (2H, s, CH₂), 7.27(2H, d, J=9.0 Hz, Ar—H), 7.30 (2H, d, J=9.0 Hz, Ar—H), 7.46 (2H, d,J=8.1 Hz, Ar—H), 7.58 (2H, d, J=8.1 Hz, Ar—H).

[0682] The dibenzylamine compound 227 (800 mg, 2.67 mmol) andtriethylamine (0.45 ml, 3.20 mmol, 1.2 mol eq.) were dissolved inchloroform and acryloyl chloride (265.7 mg, 2.94 mmol, 1.1 mol eq.)dissolved in chloroform was added thereto under ice-cooling. Thereaction mixture was stirred at room temperature for 30 minutes. Afterthe completion of the reaction, the reaction mixture was poured intowater and extracted with chloroform. The chloroform layer was washedwith water and a saturated aqueous solution of sodium chloride and driedover sodium sulfate. After distilling off the solvent, the oil thusobtained was purified by column chromatography [silica gel, chloroform]to thereby give a colorless oil 228 (938.5 mg, 99.3%).

[0683] MS m/z: 353, ¹H-NMR d: 4.53 (2H, d, J=26.8 Hz, CH₂), 4.65 (2H, d,J=24.4 Hz, CH₂), 5.79 (1H, dd, J=2.4, 9.8 Hz, CH═CH₂), 6.50 (1H, dd,J=2.4, 16.6 Hz, CH═CH₂), 6.59 (1H, dd, J=9.8, 16.6 Hz, CH═CH₂), 7.10(1H, d, J=8.3 Hz, Ar—H), 7.19 (1H, d, J=8.3 Hz, Ar—H), 7.27 (1 H, d,J=8.3 Hz, Ar—H), 7.29 (1H, d, J=8.3 Hz, Ar—H), 7.34 (1H, d, J=7.8 Hz,Ar—H), 7.36 (1H, d, J=6.5 Hz, Ar—H), 7.57 (1H, d, J=7.8 Hz, Ar—H), 7.62(1H, d, J=7.8 Hz, Ar—H).

[0684] The conjugated ketone compound 228 (800 mg, 2.26 mmol) and(R)-(+)-1-(1-naphthyl)ethylamine (425.4 mg, 2.48 mmol, 1.1 mol eq.) weredissolved in chloroform/methanol (4:1) and allowed to stand at roomtemperature for 1 week. After the completion of the reaction, thesolvent was distilled off under reduced pressure and the oil thusobtained was purified by column chromatography [silica gel, chloroform]to thereby give a colorless oil K-2266 (981.5 mg, 82.8%).

[0685] MS m/z: 524, ¹H-NMR d: 1.52 (3H, d, J=6.6 Hz, CH₃), 2.57-2.64(2H, m, CH₂), 2.84-2.97 (2H, m, CH₂), 4.41 (2H, d, J=23.9 Hz, CH₂), 4.59(2H, d, J=24.9 Hz, CH₂), 4.67 (1H, q, J=6.6 Hz, CH), 7.04 (1H, d, J=8.3Hz, Ar—H), 7.13 (1H, d, J=8.3 Hz, Ar—H), 7.21 (1H, d, J=8.3 Hz, Ar—H),7.26-7.31 (3H, m, Ar—H), 7.44-7.51 (3H, m, Ar—H), 7.55 (1H, d, J=8.1 Hz,Ar—H), 7.59 (1H, d, J=8.1 Hz, Ar—H), 7.67 (1H, dd, J=3.0, 6.6 Hz, Ar—H),7.74 (1H, d, J=8.1 Hz, Ar—H); 7.87 (1H dd, J=2.0, 8.1 Hz, Ar—H), 8.17(1H, d, J=8.1 Hz, Ar—H).

Example 108 Synthesis of K-2267(N1-(4-chlorobenzyl)-N1-(3,4-dichlorobenzyl)-3-{[(1R)-1(1-naphthyl)ethyl]amino}propanamide)

[0686] 4-Chlorobenzylamine (1 g, 7.06 mmol) and3,4-dichloro-benzaldehyde (1.36 g, 7.77 mmol, 1.1 mol eq.) weredissolved in methanol and MgSO₄ (1.02 g, 8.47 mmol, 1.2 mol eq.) andAcOH (10 drops) were added thereto. Then the obtained mixture wasstirred at room temperature for 2 hours. After the completion of thereaction, sodium boron hydride (334.0 mg, 8.83 mmol, 1.25 mol eq.) wasadded under ice-cooling to the reaction mixture. Then the obtainedmixture was stirred at room temperature for 12 hours. After thecompletion of the reaction, the solvent was distilled off under reducedpressure. The obtained residue was extracted with ethyl acetate. Theethyl acetate layer was washed with a saturated aqueous solution ofsodium hydrogencarbonate, water and a saturated aqueous solution ofsodium chloride and dried over sodium sulfate and the solvent wasdistilled off under reduced pressure. The oil thus obtained was purifiedby column chromatography [silica gel, chloroform] to thereby give acolorless oil 229 (1.6777 g, 79.2%).

[0687] MS m/z: 279, ¹H-NMR d: 3.72 (2H, s, CH₂), 3.73 (2H, s, CH₂), 7.15(1H, dd, J=2.0, 8.1 Hz, Ar—H), 7.24 (2H, d, J=8.8 Hz, Ar—H), 7.29 (2H,d, J=8.8 Hz, Ar—H), 7.38 (1H, d, J=8.1 Hz, Ar—H), 7.43 (1H, d, J=2.0 Hz,Ar—H).

[0688] The dibenzylamine compound 229 (800 mg, 2.66 mmol) andtriethylamine (0.45 ml, 3.19 mmol, 1.2 mol eq.) were dissolved inchloroform and acryloyl chloride (265 mg, 2.93 mmol, 1.1 mol eq.)dissolved in chloroform was added thereto under ice-cooling. Thereaction mixture was stirred at room temperature for 30 minutes. Afterthe completion of.the reaction, the reaction mixture was poured intowater and extracted with chloroform. The chloroform layer was washedwith water and a saturated aqueous solution of sodium chloride and driedover sodium sulfate. After distilling off the solvent, the oil thusobtained was purified by column chromatography [silica gel, chloroform]to thereby give a colorless oil 230 (768.9 mg, 81.4%).

[0689] MS m/z: 333, ¹H-NMR d: 4.47 (2H, d, J=13.4 Hz, CH₂), 4.57 (2H, d,J=13.9 Hz, CH₂), 5.79 (1H, dd, J=3.2, 9.0 Hz, CH═CH₂), 6.50 (1H, dd,J=3.2, 16.6 Hz, CH═CH₂), 6.57 (1H, dd, J=9.0, 16.6 Hz, CH═CH₂),7.08-7.46 (7H, m, Ar—H).

[0690] The conjugated ketone compound 230 (600 mg, 1.69 mmol) and(R)-(+)-1-(1-naphthyl)ethylamine (347.2 mg, 2.03 mmol, 1.2 mol eq.) weredissolved in chloroform/methanol (4:1) and allowed to stand at roomtemperature for 1 week. After the completion of the reaction, thesolvent was distilled off under reduced pressure and the oil thusobtained was purified by column chromatography [silica gel, chloroform]to thereby give a colorless oil K-2267 (721.3 mg, 81.1%).

[0691] MS m/z: 504, ¹H-NMR d: 1.51 (3H, d, J=6.6 Hz, CH₃), 2.55-2.62(2H, m, CH₂), 2.84-2.97 (2H, m, CH₂), 4.35 (2H, d, J=18.3 Hz, CH₂), 4.52(2H, d, J=12.9 Hz, CH₂), 4.66 (1H, q, J=6.6 Hz, CH), 7.04 (2H, d, J=8.3Hz, Ar—H), 7.13 (1H, d, J=8.3 Hz, Ar—H), 7.27-7.29 (1 H, m, Ar-H), 7.31(1H, d, J=8.3 Hz, Ar—H), 7.36 (1H, d, J=8.1 Hz, Ar—H), 7.39 (1 H, d,J=8.1 Hz, Ar—H), 7.45-7.50 (3H, m, Ar—H), 7.66 (1H, d, J=7.1 Hz, Ar—H),7.74 (1H, d, J=8.3 Hz, Ar—H), 7.87 (1H, dd, J=2.2, 8.3 Hz, Ar—H), 8.17(1H, d, J=7.1 Hz, Ar—H).

Example 109 Synthesis of K-2270(N1,N1-di(4-methoxybenzyl)-3-{[(1R)-1-(1-naphthyl)ethyl]amino}propanamide)

[0692] To 4-anisaldehyde (0.447 ml, 3.67 mmol) and 4-methoxybenzylamine(0.479 ml, 3.67 mmol, 1.0 mol eq.) was added titanium tetraisopropoxide(1.30 ml, 4.40 mmol, 1.2 mol eq.) and the mixture was stirred at roomtemperature for 10 hours. After the completion of the reaction, thereaction mixture was dissolved in ethanol and sodium boron hydride (555mg, 14.68 mmol, 4.0 mol eq.) was added thereto. Then the obtainedmixture was stirred at room temperature for 12 hours. After thecompletion of the reaction, the solvent was distilled off under reducedpressure. To the obtained residue were added ethyl acetate and water andthe mixture was filtered through celite. The residue was washed withethyl acetate and the washing liquor was combined with the fiitrate andextracted with ethyl acetate. The ethyl acetate layer was washed withwater and a saturated aqueous solution of sodium chloride and dried oversodium sulfate and the solvent was distilled off under reduced pressure.The oil thus obtained was purified by column chromatography [silica gel,chloroform] to thereby give a colorless oil 231 (762.7 mg, 80.9%).

[0693] MS m/z: 257, ¹H-NMR d: 3.73 (4H, s, CH₂), 3.80 (6H, s, OCH₂),6.86 (4H, d, J=8.5 Hz, Ar—H), 7.25 (4H, d, J=8.5 Hz, Ar—H).

[0694] The dibenzylamine compound 231 (500 mg, 1.95 mmol) andtriethylamine (0.33 ml, 2.33 mmol, 1.2 mol eq.) were dissolved inchloroform and acryloyl chloride (195 mg, 2.15 mmol, 1.1 mol eq.)dissolved in chloroform was added thereto under ice-cooling. Thereaction mixture was stirred at room temperature for 30 minutes. Afterthe completion of the reaction, the reaction mixture was poured intowater and extracted with chloroform. The chloroform layer was washedwith water and a saturated aqueous solution of sodium chloride and driedover sodium sulfate. After distilling off the solvent, the oil thusobtained was purified by column chromatography [silica gel, chloroform]to thereby give a colorless oil 232 (602.8 mg, 99.4%).

[0695] MS m/z: 311, ¹H-NMR d: 3.80 (3H, s, OCH₃), 3.81 (3H, s, OCH₃),4.43 (2H, s, CH₂), 4.56 (2H, s, CH₂), 5.73 (1H, dd, J=2.2, 10.2 Hz,CH═CH₂), 6.48 (1H, dd, J=2.2, 16.6 Hz, CH═CH₂), 6.62 (1H, dd, J=10.2,16.6 Hz, CH═CH₂), 6.85 (2H, d, J=8.5 Hz, Ar—H), 6.88 (3H, d, J=8.5 Hz,Ar—H), 7.08 (2H, d, J=8.5 Hz, Ar—H), 7.19 (1H, d, J=8.5 Hz, Ar—H).

[0696] The conjugated ketone compound 232 (450 mg, 1.45 mmol) and(R)-(+)-1-(1-naphthyl)ethylamine (297 mg, 1.74 mmol, 1.2 mol eq.) weredissolved in chloroform/methanol (4:1) and allowed to stand at roomtemperature for 2 weeks. After the completion of the reaction, thesolvent was distilled off under reduced pressure and the oil thusobtained was purified by column chromatography [silica gel, chloroform]to thereby give a colorless oil K-2270 (366.9 mg, 52.5%). Subsequently,the obtained K-2270 (244.5 mg, 0.51 mmol) was dissolved in a 10%solution of hydrochloric acid/methanol and stirred for 10 minutes. Thenit was concentrated as such under reduced pressure. The crystals thusformed were recrystallized from ethanol/water to thereby give K-2270hydrochloride (150.7 mg, 57.3%) as colorless crystals.

[0697] MS m/z: 482, ¹H-NMR d: 1.58 (3H, d, J=6.6 Hz, CH₃), 2.63-2.75(2H, m, CH₂), 2.86-2.98 (2H, m, CH₂), 3.79 (3H, s, OCH ), 3.80 (3H, s,OCH₃), 4.32 (2H, s, CH₂), 4.48 (1H, d, J=14.5 Hz, CH₂), 4.55 (1H, d,J=14.5 Hz, CH₂), 4.75 (1H, q, J=6.6 Hz, CH), 6.83 (2H, d, J=8.8 Hz,Ar—H), 6.86 (2H, d, J=8.6 Hz, Ar—H), 7.03 (2H, d, J=8.5 Hz, Ar—H), 7.14(2H, d, J=8.5 Hz, Ar—H), 7.46-7.53 (3H, m, Ar—H), 7.74 (1H, d, J=7.8 Hz,Ar—H), 7.76 (1H, d, J=8.8 Hz, Ar—H), 7.88 (1H, d, J=7.6 Hz, Ar—H), 8.15(1H, d, J=8.1 Hz, Ar—H).

Example 110 Synthesis of K-2272(N1-(3,4-dichlorobenzyl)-N1-[4-(trifluoromethoxy)benzyl)-3-{[(1R)-1-(1-naphthyl) ethyl]-amino}propanamide)

[0698] 3,4-Dichlorobenzylamine (0.379 ml, 2.84 mmol) and4-(trifluoromethoxy)benzaldehyde (503.6 mg, 3.56 mmol, 1.0 mol eq.) weredissolved in methanol and MgSO₄ (410.2 mg, 3.41 mmol, 1.2 mol eq.) andAcOH (3 drops) were added thereto. Then the obtained mixture was stirredat room temperature for 30 minutes. After the completion of thereaction, sodium boron hydride (134 mg, 3.55 mmol, 1.25 mol eq.) wasadded to the reaction mixture. Then the obtained mixture was stirred atroom temperature for 10 minutes. After the completion of the reaction,the solvent was distilled off under reduced pressure. The obtainedresidue was extracted with chloroform. The chloroform layer was washedwith a saturated aqueous solution of sodium hydrogencarbonate, water anda saturated aqueous solution of sodium chloride and dried over sodiumsulfate and the solvent was distilled off under reduced pressure. Theoil thus obtained was purified by column chromatography (silica gel,hexane : ethyl acetate (9:1-4:1)] to thereby give a colorless oil 233(777.3 mg, 78.2%).

[0699] MS m/z: 350, ¹H-NMR d: 3.76 (2H, s, CH₂), 3.79 (2H, s, CH₂), 7.18(1H, dd, J=2.0, 8.5 Hz, Ar—H), 7.18 (2H, d, J=8.5 Hz, Ar—H), 7.36 (2H,d, J=8.5 Hz, Ar—H), 7.39 (1H, d, J=8.5 Hz, Ar—H), 7.46 (1H, d, J=2.0 Hz,Ar—H).

[0700] The dibenzylamine compound 233 (500 mg, 1.43 mmol) andtriethylamine (0.238 ml, 1.71 mmol, 1.2 mol eq.) were dissolved inchloroform and acryloyl chloride (142 mg, 1.57 mmol, 1.1 mol eq.)dissolved in chloroform was added thereto under ice-cooling. Thereaction mixture was stirred at room temperature for 30 minutes. Afterthe completion of the reaction, the reaction mixture was poured intowater and extracted with chloroform. The chloroform layer was washedwith water and a saturated aqueous solution of sodium chloride and driedover sodium sulfate. After distilling off the solvent, the oil thusobtained was purified by column chromatography [silica gel, chloroform]to thereby give a colorless oil 234 (454.6 mg, 78.7%).

[0701] MS m/z: 404, ¹H-NMR d: 4.50 (2H, d, J=19.0 Hz, CH₂), 4.61 (2H, d,J=21.7 Hz, CH₂), 5.80 (1H, dd, J=1.7, 9.5 Hz, CH═CH₂), 6.53 (1H, d,J=1.7, 16.6 Hz, CH═CH₂), 6.58 (1H, d, J=9.5, 16.6 Hz, CH═CH₂), 7.16-7.22(5H, m, Ar—H), 7.32 (1H, s, Ar—H), 7.41 (1H, d, J=8.3 Hz, Ar—H).

[0702] The conjugated ketone compound 234 (350 mg, 0.87 mmol) and(R)-(+)-1-(1-naphthyl)ethylamine (178 mg, 1.04 mmol, 1.2 mol eq.) weredissolved in chloroform/methanol (4:1) and allowed to stand at roomtemperature for 1 week. After the completion of the reaction, thesolvent was distilled off under reduced pressure and the oil thusobtained was purified by column chromatography [silica gel, chloroform]to thereby give a colorless oil K-2272 (360.7 mg, 72.4%). Subsequently,the obtained K-2272 (250 mg, 0.435 mmol) was dissolved in a 10% solutionof hydrochloric acid/methanol and stirred for 10 minutes. Then it wasconcentrated as such under reduced pressure. The crystals thus formedwere recrystallized from ethanol/water to thereby give K-2270hydrochloride (230.2 mg, 86.5%) as colorless crystals.

[0703] MS m/z: 575, ¹H-NMR d: 1.60 (3H, d, J=6.6 Hz, CH₃), 2.60-2.76(2H, m, CH₂), 2.88-3.02 (2H, m, CH₂), 4.37 (2H, d, J=22.7 Hz, CH₂), 4.51(1H, d, J=2.4 Hz, CH₂), 4.57 (1H, d, J=6.1 Hz, CH₂), 4.72-4.82 (1H, m,CH), 7.13 (1H, d, J=8.8 Hz, Ar—H), 7.15 (1H, d, J=7.3 Hz, Ar—H), 7.17(1H, d, J=6.8 Hz, Ar—H), 7.19 (1H, d, J=8.8 Hz, Ar—H), 7.22 (1H, d,J=8.8 Hz, Ar—H), 7.28 (1H, d, J=2.0 Hz, Ar—H), 7.37 (1H, d, J=8.3 Hz,Ar—H), 7.38 (1H, dd, J=8.3, 9.3 Hz, Ar—H), 7.47-7.55 (3H, m, Ar—H), 7.72(1H, d, J=7.1 Hz, Ar—H), 7.77 (1H, d, J=8.1 Hz, Ar—H), 7.88 (1H, dd,J=2.0, 7.8 Hz, Ar—H), 8.14 (1H, d, J=7.8 Hz, Ar—H).

Example 111 Synthesis of K-2283(N1-(4-chlorobenzyl)-N1-[4-(triflucromethoxy)benzyl)-3-{[(1R)-1-(1-naphthyl)ethyl]-amino}propanamide)

[0704] 4-(Trifluoromethoxy)benzaldehyde (0.555 ml, 3.88 mmol, 1.1 moleq.) and 4-chlorobenzylamine (0.430 ml, 3.53 mrnol) were dissolved inmethanol and MgSO₄ (509:89 mg, 4.24 mmol, 1.2 mol eq.) and AcOH (3drops) were added thereto. Then the obtained mixture was stirred at roomtemperature for 10 minutes. After the completion of the reaction, sodiumboron hydride (167 mg, 4.41 mmol, 1.25 mol eq.) was added to thereaction mixture. Then the obtained mixture was stirred at roomtemperature for 10 minutes. After the completion of the reaction, thesolvent was distilled off under reduced pressure. The obtained residuewas extracted with chloroform. The chloroform layer was washed with asaturated aqueous solution of sodium hydrogencarbonate, water and asaturated aqueous solution of sodium chloride and dried over sodiumsulfate and the solvent was distilled off under reduced pressure. Theoil thus obtained was purified by column chromatography [silica gel,hexane ethyl acetate (9:1-4:1)] to thereby give a colorless oil 235(1.092 g, 98.1%).

[0705] MS m/z: 315, ¹H-NMR d: 3.77 (2H, s, CH₂), 3.79 (2H, s, CH₂), 7.18(2H, d, J=7.8 Hz, Ar—H), 7.29 (4H, d, J=2.2 Hz, Ar—H), 7.37 (2H, d,J=8.9 Hz, Ar—H).

[0706] The dibenzylamine compound 235 (500 mg, 1.58 mmol) andtriethylamine (0.265 ml, 1.90 mmol, 1.2 mol eq.) were dissolved inchloroform and acryloyl chloride (158 mg, 1.74 mmol, 1.1 mol eq.)dissolved in chloroform was added thereto under ice-cooling. Thereaction mixture was stirred at room temperature for 40 minutes. Afterthe completion of the reaction, the reaction mixture was poured intowater and extracted with chloroform. The chloroform layer was washedwith water and a saturated aqueous solution of sodium chloride and driedover sodium sulfate. After distilling off the solvent, the oil thusobtained was purified by column chromatography [silica gel, chloroform]to thereby give a colorless oil 236 (521.3 mg, 89.3%).

[0707] MS m/z: 369, ¹H-NMR d: 4.50 (2H, d, J=4.9 Hz, CH₂), 4.61 (2H, d,J=8.1 Hz, CH₂), 5.78 (1H, dd, J=2.7, 9.5 Hz, CH═CH₂), 6.50 (1H, dd,J=2.7, 16.6 Hz, CH═CH₂), 6.57 (1H, dd, J=9.5, 16.6 Hz, CH═CH₂), 7.09(1H, d, J=8.3 Hz, Ar—H), 7.15-7.21 (4H, m, Ar—H), 7.27 (1H, d, J=8.1 Hz,Ar—H), 7.28 (1H, d, J=8.1 Hz, Ar—H), 7.33 (1H, d, J=8.1 Hz, Ar—H).

[0708] The conjugated ketone compound 236 (400 mg, 1.08 mmol) and(R)-(+)-1-(1-naphthyl)ethylamine (222 mg, 1.30 mmol, 1 .2 mol eq.) weredissolved in chloroform/methanol (4:1) and allowed to stand at roomtemperature for 8 days. After the completion of the reaction, thesolvent was distilled off under reduced pressure and the oil thusobtained was purified by column chromatography [silica gel, chloroform]to thereby give a colorless oil K-2283 (452.0 mg, 77.4%). Subsequently,the obtained K-2283 (248.9 mg, 0.46 mmol) was dissolved in a 10%solution of hydrochloric acid/methanol and stirred for 15 minutes. Thenit was concentrated as such under reduced pressure. The crystals thusformed were washed with diethyl ether to thereby give K-2283hydrochloride (235.0 mg, 88.5%) as colorless crystals.

[0709] MS m/z: 540, ¹H-NMR d: 1.60 (3H, d, J=6.3 Hz, CH₃), 2.62-2.74(2H, m, CH₂), 2.87-2.99 (2H, m, CH₂), 4.38 (2H, d, J=4.9 Hz, CH₂), 4.55(2H, t, J=8.3 Hz, CH₂), 4.75-4.80 (1H, m, CH), 7.04 (1H, d, J=8.5 Hz,Ar—H), 7.12 (2H, d, J=8.5 Hz, Ar—H), 7.14 (1H, d, J=8.5 Hz, Ar—H), 7.22(1H, d, J=8.5 Hz, Ar—H), 7.27 (2H, d, J=8.5 Hz, Ar—H), 7.30 (1H, d,J=8.5 Hz, Ar—H), 7.45-7.53 (3H, m, Ar—H), 7.72 (1H, d, J=7.1 Hz, Ar—H),7.77 (1H, d, J=8.1 Hz, Ar—H), 7.88 (1H, dd, J=2.0, 7.3 Hz, Ar—H), 8.14(1H, d, J=7.8 Hz, Ar—H).

Example 112 Synthesis of K-2289(N1-(4-chlorobenzyl)-N1-(4-methoxybenzyl)-3-{[(1R)-1-(1-naphthyl)ethyl]amino}propanamide)

[0710] 4-Chlorobenzaldehyde (564 mg, 4.01 mmol, 1.1 mol eq.) and4-methoxybenzylamine (476 mg, 3.64 mmol) were dissolved in methanol andMgSO₄ (525.8 mg, 4.37 mmol, 3.64 mol eq.) and AcOH (5 drops) were addedthereto. Then the obtained mixture was stirred at room temperature for40 minutes. After the completion of the reaction, sodium boron hydride(172 mg, 4.55 mmol, 1.25 mol eq.) was added to the reaction mixture.Then the obtained mixture was stirred at room temperature for 15minutes. After the completion of the reaction, the solvent was distilledoff under reduced pressure. The obtained residue was extracted withchloroform. The chloroform layer was washed with a saturated aqueoussolution of sodium hydrogencarbonate, water and a saturated aqueoussolution of sodium chloride and dried over sodium sulfate and thesolvent was distilled off under reduced pressure. The oil thus obtainedwas purified by column chromatography [silica gel, hexane ethyl acetate(9:1-4:1)] to thereby give a colorless oil 237 (711.8 mg, 74.8%).

[0711] MS m/z: 261, ¹H-NMR d: 3.72 (2H, s, CH₂), 3.75 (2H, s, CH₂) 3.80(3H, s, OCH₃), 6.86 (2H, d, J=8.5 Hz, Ar—H), 7.24 (2H, d, J=8.5 Hz,Ar—H), 7.28 (4H, d, J=2.2 Hz, Ar—H).

[0712] The dibenzylamine compound 237 (501.4 mg, 1.92 mmol) andtriethylamine (0.32 ml, 2.30 mmol, 1.2 mol eq.) were dissolved inchloroform and acryloyl chloride (191 mg, 2.11 mmol, 1.1 mol eq.)dissolved in chloroform was added thereto under ice-cooling. Thereaction mixture was stirred at room temperature for 30 minutes. Afterthe completion of the reaction, the reaction mixture was poured intowater and extracted with chloroform. The chloroform layer was washedwith water and a saturated aqueous solution of sodium chloride and driedover sodium sulfate. After distilling off the solvent, the oil thusobtained was purified by column chromatography [silica gel, chloroform]to thereby give a colorless oil 238 (557.2 mg, 91.9%).

[0713] MS m/z: 315, ¹H-NMR d: 3.80 (3H, d, J=5.4 Hz, OCH₃), 4.44 (2H, d,J=8.5 Hz, CH₂), 4.57 (2H, d, J=4.1 Hz, CH₂), 5.75 (1H, dd, J=1.7, 10.3Hz, CH═CH₂), 6.48 (1H, dd, J=1.7, 16.6 Hz, CH═CH₂), 6.64 (1H, dd,J=10.3, 16.6 Hz, CH═CH₂), 6.85 (1H, d, J=8.3 Hz, Ar—H), 6.88 (1H, d,J=8.5 Hz, Ar—H), 7.07 (1H, d, J=8.3 Hz, Ar—H), 7.08 (1H, d, J=6.3 Hz,Ar—H), 7.17 (1H, d, J=8.8 Hz, Ar—H), 7.19 (1H, d, J=8.3 Hz, Ar—H), 7.28(1H, d, J=8.5 Hz, Ar—H), 7.32 (2H, d, J=7.8 Hz, Ar—H).

[0714] The conjugated ketone compound 238 (414 mg, 1.31 rnmol) and(R)-(+)-1-(1-naphthyl)ethylamine (270.mg, 1.57 mmol, 1.2 mol eq.) weredissolved in chloroform/methanol (4:1) and allowed to stand at roomtemperature for 12 days. After the completion of the reaction, thesolvent was distilled off under reduced pressure and the oil thusobtained was purified by column chromatography [silica gel, chloroform]to thereby give a colorless oil K-2289 (441.8 mg, 69.3%). Subsequently,the obtained K-2289 (269.4 mg, 0.55 mmol) was dissolved in a 10%solution of hydrochloric acid/methanol and stirred for 10 minutes. Thenit was concentrated as such under reduced pressure. The crystals thusformed were recrystallized from ethanol/water to thereby give K-2289hydrochloride (270.1 mg, 93.2%) as colorless crystals.

[0715] MS m/z: 486, ¹H-NMR d: 1.56 (3H, d, J=6.6 Hz, CH₃), 2.57-2.70(2H, m, CH₂), 2.84-2.95 (2H, m, CH₂), 3.80 (3H, d, J=2.2 Hz, OCH₃), 4.33(2H, d, J=5.4 Hz, CH₂), 4.52 (2H, t, J=6.6 Hz, CH₂), 4.70-4.74 (1H, m,CH), 6.83 (1H, d, J=9.0 Hz, Ar—H), 6.85 (1H, d, J=9.0 Hz, Ar—H), 7.02(1H, d, J=8.5 Hz, Ar—H), 7.03 (1H, d, J=8.5 Hz, Ar—H), 7.12 (1H, d,J=8.5 Hz, Ar—H), 7.13 (1H, d, J=8.3 Hz, Ar—H), 7.27 (1H, d, J=8.5 Hz,Ar—H), 7.29 (1H, d, J=8.5 Hz, Ar—H), 7.46-7.52 (3H, m, Ar—H), 7.71 (1H,dd, J=3.4, 6.8 Hz, Ar—H), 7.75 (1H, d, J=8.3 Hz, Ar—H), 7.87 (1H, d,J=7.6 Hz, Ar—H), 8.15 (1H, d, J=7.6 Hz, Ar—H).

Example 113 Synthesis of K-2290(N1-(4-methoxybenzyl)-N1-[4-(trifluoromethyl)benzyl)-3-{[(1R)-1-(1-naphthyl)ethyl]amino}propanamide)

[0716] 4-(Trifluoromethyl)benzaldehyde (1.269 g, 7.29 mmol) and4-methoxybenzylamine (1 g, 7.29 mmol, 1.0 mol eq.) were dissolved inmethanol and MgSO₄ (1.0530 9, 8.75 mmol, 1.2 mol eq.) and AcOH (10drops) were added thereto. Then the obtained mixture was stirred at roomtemperature for 2 hours. After the completion of the reaction, thereaction mixture was dissolved in methanol and sodium boron hydride(344.7 mg, 9.11 mmol, 1.25 mol eq.) was added thereto. Then the obtainedmixture was stirred at room temperature for 12 hours. After thecompletion of the reaction, the solvent was distilled off under reducedpressure. The obtained residue was extracted with ethyl acetate. Theethyl acetate layer was washed with a saturated aqueous solution ofsodium hydrogencarbonate, water and. a saturated aqueous solution ofsodium chloride and dried over sodium suifate and the solvent wasdistilled off under reduced pressure. The oil thus obtained was purifiedby column chromatography [silica gel, chloroform] to thereby give acolorless oil 239 (1.40 g, 65.0%).

[0717] MS m/z: 295, ¹H-NMR d: 3.73 (2H, s, CH₂), 3.80 (3H, s, OCH₃),3.83 (2H, s, CH₂), 6.87 (2H, d, J=8.5 Hz, Ar—H), 7.24 (2H, d, J=8.5 Hz,Ar—H), 7.45 (2H, d, J=3.5 Hz, Ar—H), 7.57 (1H, d, J=8.5 Hz, Ar—H), 7.59(1H, d, J=8.5 Hz, Ar—H).

[0718] The dibenzylamine compound 239 (1.30 g, 4.40 mmol) andtriethylamine (0.74 ml, 5.28 mmol, 1.2 mol eq.) were dissolved inchloroform and acryloyl chloride (438.3 mg, 4.84 mmol, 1.1 mol eq.)dissolved in chloroform was added thereto under ice-cooling. Thereaction mixture was stirred at room temperature for 30 minutes. Afterthe completion of the reaction, the reaction mixture was poured intowater and extracted with chloroform. The chloroform layer was washedwith water and a saturated aqueous solution of sodium chloride and driedover sodium sulfate. After distilling off the solvent, the oil thusobtained was purified by column chromatography [silica gel, chloroform]to thereby give a colorless oil 240 (974.7 mg, 63.5%).

[0719] MS m/z: 349, ¹H-NMR d: 3.80 (3H, d, J=4.9 Hz, OCH₃), 4.53 (2H, d,J=52.0 Hz, CH₂), 4.61 (2H, d, J=45.1 Hz, CH₂), 5.77 (1H, dd, J=2.0, 10.5Hz, CH═CH₂), 6.49 (1H, dd, J=2.0, 16.6 Hz, CH═CH₂), 6.65 (1H, dd,J=10.5, 16.6 Hz, CH═CH₂), 6.85 (1H, d, J=8.3 Hz, Ar—H), 6.89 (1 H, d,J=8.5 Hz, Ar—H), 7.07 (1H, d, J=8.3 Hz, Ar—H), 7.17 (1H, d, J=8.1 Hz,Ar—H), 7.27 (1H, d, J=6.8 Hz, Ar—H), 7.35 (1H, d, J=7.8 Hz, Ar—H), 7.56(1H, d, J=8.1 Hz, Ar—H), 7.61 (1H, d, J=7.3 Hz, Ar—H).

[0720] The conjugated ketone compound 240 (874.7 mg, 2.50 mmol) and(R)-(+)-1-(1-naphthyl)ethylamine (513.9 mg, 3.00 mmol, 1.2 mol eq.) weredissolved in chloroform/methanol (4:1) and allowed to stand at roomtemperature for 1 week. After the completion of the reaction, thesolvent was distilled off under reduced pressure and the oil thusobtained was purified by column chromatography [silica gel, chloroform]to thereby give a colorless oil K-2290 (1.005 g, 77.2%).

[0721] MS m/z: 520, ¹H-NMR d: 1.51 (3H, dd, J=3.0, 6.6 Hz, CH₃), 2.55(1H, t, J=6.1 Hz, CH₂), 2.67 (1H, t, J=6.1 Hz, CH₂), 2.82-2.98 (2H, m,CH₂), 3.79 (3H, d, J=4.6 Hz, OCH₃), 4.39 (2H, d, J=28.3 Hz, CH), 4.57(2H, d, J=30.0 Hz, CH₂), 4.64-4.70 (1H, m, CH), 6.83 (1H, d, J=8.8 Hz,Ar—H), 6.86 (1H, d, J=8.8 Hz, Ar—H), 7.03 (1H, d, J=8.8 Hz, Ar—H), 7.12(1H, d, J=8.6 Hz, Ar—H), 7.21 (1H, d, J=8.1 Hz, Ar—H), 7.30 (1H, d,J=8.3 Hz, Ar—H), 7.43-7.51 (3H, m, Ar—H), 7.54 (1H, d, J=8.3 Hz, Ar—H),7.57 (1H, d, J=8.1 Hz, Ar—H), 7.68 (1H, t, J=7.6 Hz, Ar—H), 7.73 (1H,dd, J=3.7, 8.1 Hz, Ar—H), 7.86 (1H, dd, J=2.4, 7.3 Hz, Ar—H), 8.17 (1H,d, J=7.6 Hz, Ar—H).

Example 114 Synthesis of K-2291(N1-(4-chlorobenzyl)-N1-(2-naphthylmethyl)-3-{[(1R)-1-(1-naphthyl)ethyl]amino}propanamide)

[0722] To 2-naphthaldehyde (500 mg, 3.20 mmol) and 4-chlorobenzylamine(0.389 ml, 3.20 mmol, 1.0 mol eq.) was added titanium isopropoxide (1.70ml, 5.76 mmol, 1.8 mol eq.) and the obtained mixture was stirred at roomtemperature for 4 hours. After the completion of the reaction, thereaction mixture was dissolved in ethanol and sodium boron hydride (485mg, 12.82 mmol, 4.0 mol eq.) was added thereto. Then the obtainedmixture was stirred. at room temperature for 29 hours. After thecompletion of the reaction, the solvent was distilled off under reducedpressure. To the obtained residue were added ethyl acetate and water andthe mixture was filtered through celite. The residue was washed withethyl acetate and the washing liquor was combined with the filtrate andextracted with ethyl acetate. The ethyl acetate layer was washed withwater and a saturated aqueous solution of sodium chloride and dried oversodium sulfate and the solvent was distilled off under reduced pressure.The oil thus obtained was purified by column chromatography [silica gel,chloroform] to thereby give a colorless oil 241 (767.4 mg, 85.2%).

[0723] MS m/z: 281, ¹H-NMR d: 3.80 (2H, s, CH₂), 3.95 (2H, s, CH₂), 7.26(2H, d, J=12.0 Hz, Ar—H), 7.31 (2H, d, J=12.0 Hz, Ar—H), 7.42-7.49 (3H,m, Ar—H), 7.75 (1H, s, Ar—H), 7.81 (1H, d, J=8.1 Hz, Ar—H), 7.82 (1H, d,J=8.5 Hz, Ar—H), 7.83 (1H, d, J=8.1 Hz, Ar—H).

[0724] The dibenzylamine compound 241 (506.7 mg, 1.80 mmol) andtriethylamine (0.301 ml, 2.16 mmol, 1.2 mol eq.) were dissolved inchloroform and acryloyl chloride (179 mg, 1.98 mmol, 1.1 mol eq.)dissolved in chloroform was added thereto under ice-cooling. Thereaction mixture was stirred at room temperature for 30 minutes. Afterthe completion of the reaction, the reaction mixture was poured intowater and extracted with chloroform. The chloroform layer was washedwith water and a saturated aqueous solution of sodium chloride and driedover sodium sulfate. After distilling off the solvent, the oil thusobtained was purified by column chromatography [silica gel, chloroform]to thereby give a colorless oil 242 (652.4 mg, 100%).

[0725] MS m/z: 335, ¹H-NMR d: 4.58 (2H, d, J=65.9 Hz, CH₂), 4.74 (2H, d,J=52.0 Hz, CH₂), 5.76 (1H, dd, J=2.0, 10.2 Hz, CH═CH₂), 6.53 (1H, dd,J=2.0, 16.6 Hz, CH═CH₂), 6.54 (1H, dd, J=10.2, 16.6 Hz, CH═CH₂), 7.10(1H, d, J=8.1 Hz, Ar—H), 7.21-7.35 (4H, m, Ar—H), 7.47-7.62 (3H, m,Ar—H), 7.79-7.86 (3H, m, Ar—H).

[0726] The conjugated ketone compound 242 (500 mg, 1.49 mmol) and(R)-(+)-1-(1-naphthyl)ethylamine (307 mg, 1.79 mmol, 1.2 mol eq.) weredissolved in chloroform/methanol (4:1) and allowed to stand at roomtemperature for 13 days. After the completion of the reaction, thesolvent was distilled off under reduced pressure and the oil thusobtained was purified by column chromatography [silica gel, chloroform]to thereby give a colorless oil K-2291 (521.1 g, 69.0%). Subsequently,the obtained K-2291 (394.1 mg, 0.78 mmol) was dissolved in a 10 solutionof hydrochloric acid/methanol and stirred for 15 minutes. Then it wasconcentrated as such under reduced pressure. The crystals thus formedwere recrystallized from ethanol/water to thereby give K-2291hydrochloride (358.7 mg, 85.1%) as colorless crystals.

[0727] MS m/z: 506, ¹H-NMR d: 1.56 (3H, d, J=6.8 Hz, CH₃), 2.61-2.76(2H, m, CH₂), 2.88-3.01 (2H, m, CH₂), 4.38 (1H, s, CH₂), 4.55 (1H, s,CH₂), 4.62 (1H, d, J=3.7 Hz, CH₂), 4.75 (1H, d, J=6.8 Hz, CH₂),4.70-4.76 (1H, m, CH), 7.05 (1H, d, J=8.5 Hz, Ar—H), 7.16 (1H, d, J=8.3Hz, Ar—H), 7.28 (1H, d, J=8.5 Hz, Ar—H), 7.30 (1H, d, J=8.5 Hz, Ar—H),7.44-7.58 (6H, m, Ar—H), 7.69-7.89 (7H, m, Ar—H), 8.10-8.17 (1H, m,Ar—H).

Example 115 Synthesis of K-2294(N1-(3,4-dichlorobenzyl)-N1-(4-methylbenzyl)-3{[(1R)-1-(1-naphthyl)ethyl]amino}propanamide)

[0728] 3,4-Dichlorobenzaldehyde (1.555 g, 8.25 mmol) and4-methylbenzylamine (1 g, 8.25 mmol, 1.0 mol eq.) were dissolved inmethanol and MgSO₄ (1.1920 g, 9.90 mmol, 1.2 mol eq.) and AcOH (10drops) were added thereto. Then the obtained mixture was stirred at roomtemperature for 2 hours. After the completion of the reaction, thereaction mixture was dissolved in methanol and sodium boron hydride(390.2 mg, 10.30 mmol, 1.25 mol eq.) was added thereto. Then theobtained mixture was stirred at room temperature for 12 hours. After thecompletion of the reaction, the solvent was distilled off under reducedpressure. The obtained residue was extracted with ethyl acetate. Theethyl acetate layer was washed with a saturated aqueous solution ofsodium hydrogencarbonate, water and a saturated aqueous solution ofsodium chloride and dried over sodium sulfate and the solvent wasdistilled off under reduced pressure. The oil thus obtained was purifiedby column chromatography [silica gel, chloroform] to thereby give acolorless oil 243 (1.5942 g, 69.2%).

[0729] MS m/z: 280, ¹H-NMR d: 2.34 (3H, s, CH₃), 3.73 (4H, s, CH₂×2),7.14 (2H, d, J=8.1 Hz, Ar—H), 7.16 (1H, dd, J=2.0, 8.1 Hz, Ar—H), 7.19(2H, d, J=8.1 Hz, Ar—H), 7.37 (1H, d, J=8.1 Hz, Ar—H), 7.43 (1H, d,J=2.0 Hz, Ar—H).

[0730] The dibenzylamine compound 243 (1.4942 g, 5.35 mmol) andtriethylamine (0.89 ml, 6.42 mmol, 1.2 mol eq.) were-dissolved inchloroform and acryloyl chloride (532.6 mg, 5.88 mmol, 1.1 mol eq.)dissolved in chloroform was added thereto under ice-cooling. Thereaction mixture was stirred at room temperature for 30 minutes. Afterthe completion of the reaction, the reaction mixture was poured intowater and extracted with chloroform. The chloroform layer was washedwith water and a saturated aqueous solution of sodium chloride and driedover sodium sulfate. After distilling off the solvent, the oil thusobtained was purified by column chromatography [silica gel, chloroform]to thereby give a colorless oil 244 (1.6587 g, 92.9%).

[0731] MS m/z: 334, ¹H-NMR d: 2.34 (3H, d, J=6.3 Hz, CH₃), 4.46 (2H, d,J=13.4 Hz, CH₂), 4.58 (2H, d, J=16.1 Hz, CH₂), 5.76 (1H, dd, J=2.0, 10.2Hz, CH═CH₂), 6.48 (1H, dd, J=2.0, 16.8 Hz, CH═CH₂), 6.63 (1H, dd,J=10.2, 16.8 Hz, CH═CH₂), 7.04 (2H, d, J=7.8 Hz, Ar—H), 7.09 (1 H, d,J=8.3 Hz, Ar—H), 7.17 (2H, d, J=7.8 Hz, Ar—H), 7.31 (1H, s, Ar—H), 7.37(1H, d, J=8.3 Hz, Ar—H).

[0732] The conjugated ketone compound 244 (1.5587 g, 4.67 mmol) and(R)-(+)-1-(1-naphthyl)ethylamine (959.6 mg, 5.60 mmol, 1.2 mol eq.) weredissolved in chloroform/methanol (4:1) and allowed to stand at roomtemperature for 1 week. After the completion of the reaction, thesolvent was distilled off under reduced pressure and the oil thusobtained was purified by column chromatography [silica gel, chloroform]to thereby give a colorless oil K-2294 (2.1115 g, 89.3%).

[0733] MS m/z: 505, ¹H-NMR d: 1.50 (3H, d, J=6.6 Hz, CH₃), 2.34 (3H, d,J=6.6 Hz, CH₃), 2.52 (1H, dt, J=3.4, 9.3 Hz, CH₂), 2.63 (1H, t, J=6.3 HzCH₂), 2.74-2.96 (2H, m, CH₂), 4.35 (2H, d, J=22.0 Hz, CH₂), 4.53 (2H, d,J=13.7 Hz, CH₂), 4.62-4.68 (1H, m, CH), 6.99 (1H, d, J=7.8 Hz, Ar—H),7.04 (1H, dd, J=2.0, 8.1 Hz, Ar—H), 7.09 (1H, d, J=8.3 Hz, Ar—H), 7.12(1H, d, J=8.1 Hz, Ar—H), 7.14 (1H, d, J=8.1 Hz, Ar—H), 7.26 (1H, d,J=2.0 Hz, Ar—H), 7.34 (1H, d, J=8.3 Hz, Ar—H), 7.43-7.52 (3H, m, Ar—H),7.68 (1H, d, J=7.1 Hz, Ar—H), 7.72 (1H, d, J=8.1 Hz, Ar—H), 7.85 (1H, d,J=7.1 Hz, Ar—H), 8.17 (1H, d, J=7.1 Hz, Ar—H).

Example 116 Synthesis of K-2299(N1-(4-methylbenzyl)-N1-[4-(trifluoromethyl) benzyl]-3-{[(1R)-1-(1-naphthyl)ethyl]amino}propanamide)

[0734] 4-(Trifluoromethyl)benzaldehyde (1.4369 9, 8.25 mmol) and4-methylbenzylamine (1 g, 8.25 mmol, 1.0 mol eq.) were dissolved inmethanol and MgSO₄ (1.1920 g, 9.90 mmol, 1.2 mol eq.) and AcOH (10drops) were added thereto. Then the obtained mixture was stirred at roomtemperature for 2 hours. After the completion of the reaction, thereaction mixture was dissolved in methanol and sodium boron hydride(390.2 mg, 10.30 mmol, 1.25 mol eq.) was added thereto. Then theobtained mixture was stirred at room temperature for 12 hours. After thecompletion of the reaction, the solvent was distilled off under reducedpressure. The obtained residue was extracted with ethyl acetate. Theethyl acetate layer was washed with a saturated aqueous solution ofsodium hydrogencarbonate, water and a saturated aqueous solution ofsodium chloride and dried over sodium sulfate and the solvent wasdistilled off under reduced pressure. The oil thus obtained was purifiedby column chromatography [silica gel, chloroform] to thereby give acolorless oil 245 (1.6877 g, 73.2%).

[0735] MS m/z: 279, ¹H-NMR d: 2.34 (3H, s, CH₃) 3.76 (2H, s, CH₂), 3.85(2H, s, CH₂), 7.14 (2H, d, J=7.8 Hz, Ar—H), 7.21 (2H, d, J=8.1 Hz,Ar—H), 7.46 (2H, d, J=8.1 Hz, Ar—H), 7.57 (2H, d, J=8.3 Hz, Ar—H).

[0736] The dibenzylamine compound 245 (1.5877 g, 5.68 mmol) andtriethylamine (0.95 ml, 6.82 mmol, 1.2 mol eq.) were dissolved inchloroform and acryloyl chloride (565.96 mg, 6.25 mmol, 1.1 mol eq.)dissolved in chloroform was added thereto under ice-cooling. Thereaction mixture was stirred at room temperature for 30 minutes. Afterthe completion of the reaction, the reaction mixture was poured intowater and extracted with chloroform. The chloroform layer was washedwith water and a saturated aqueous solution of sodium chloride anddried-over sodium sulfate. After distilling off the solvent, the oilthus obtained was purified by column chromatography [silica gel,chloroform] to thereby give a colorless oil 246 (1.5568 g, 82.0%).

[0737] MS m/z: 333, ¹H-NMR d: 2.34 (3H, d, J=6.8 Hz, CH₃), 4.52 (2H, d,J=26.8 Hz, CH₂), 4.65 (2H, d, J=22.4 Hz, CH₂), 5.76 (1H, dd, J=1.7, 10.2Hz, CH═CH₂), 6.49 (1H, dd, J=1.7, 16.8 Hz, CH═CH₂), 6.64 (1H, dd,J=10.2, 16.8 Hz, CH═CH₂), 7.05 (2H, d, J=7.8 Hz, Ar—H), 7.17 (2H, d,J=7.8 Hz, Ar—H), 7.35 (2H, d, J=8.1 Hz, Ar—H), 7.56 (2H, d, J=8.1 Hz,Ar—H).

[0738] The conjugated ketone compound 246 (1.4568 g, 4.36 mmol) and(R)-(+)-1-(1-naphthyl)ethylamine (896.8 mg, 5.24 mmol, 1.2 mol eq.) weredissolved in chloroform/methanol (4:1) and allowed to stand at roomtemperature for 1 week. After the completion of the reaction, thesolvent was distilled off under reduced pressure and the oil thusobtained was purified by column chromatography [silica gel, chloroform]to thereby give a colorless oil K-2299 (884.4 mg, 40.1%).

[0739] MS m/z: 504, ¹H-NMR d: 1.51 (3H, d, J=6.6 Hz, CH₃), 2.33 (3H, d,J=6.3 Hz, CH₃), 2.53 (1H, dt, J=6.1, 19.3 Hz, CH₂), 2.66 (1H, t, J=6.1Hz, CH₂), 2.77-2.97 (2H, m, CH₂), 4.40 (2H, d, J=19.8 Hz, CH₂), 4.59(2H, d, J=24.9 Hz, CH₂), 4.65-4.69 (1H, m, CH), 7.00 (1H, d, J=7.8 Hz,Ar—H), 7.08 (1H, d, J=8.3 Hz, Ar—H), 7.12 (1H, d, J=7.8 Hz, Ar—H), 7.14(1H, d, J=7.8 Hz, Ar—H), 7.20 (1H, d, J=8.1 Hz, Ar—H), 7.30 (1 H d,J=8.1 Hz, Ar—H), 7.43-7.51 (3H, m, Ar—H), 7.53 (1H, d, J=8.3 Hz, Ar—H),7.57 (H, d, J=8.1 Hz, Ar—H), 7.68 (1H, d, J=6.8 Hz, Ar—H), 7.73 (1H, dd,J=3.2, 8.1 Hz, Ar—H), 7.86 (1H, dd, J=2.2, 7.6 Hz, Ar—H), 8.17 (1H, d,J=7.6 Hz, Ar—H).

Example 117 Synthesis of K-2300(N1,N1-di(4-methylbenzyl)-3-{[(1R)-1-(1-naphthyl)ethyl]amino}propanamide)

[0740] 4-Tolualdehyde (500 mg, 3.56 mmol) and 4-methylbenzylamine (503.6mg, 3.56 mmol, 1.0 mol eq.) were dissolved in methanol and MgSO₄ (514.2mg, 4.27 mmol, 1.2 mol eq.) and ACOH (3 drops) were added thereto. Thenthe obtained mixture was stirred at room temperature for 50 minutes.After the completion of the reaction, sodium boron hydride (168.3 mg,4.45 mmol, 1.25 mol eq.) was added to the reaction mixture. Then theobtained mixture was stirred at room temperature for 15 minutes. Afterthe completion of the reaction, the solvent was distilled off underreduced pressure. The obtained residue was extracted with chloroform.The chloroform layer was washed with a saturated aqueous solution ofsodium hydrogencarbonate, water and a saturated aqueous solution ofsodium chloride and dried over sodium sulfate and the solvent wasdistilled off under reduced pressure. The oil thus obtained was purifiedby column chromatography [silica gel, hexane: ethyl acetate (9:1-4:1)]to thereby give a colorless oil 247 (819.4 mg, 88.2%).

[0741] MS m/z: 225, ¹H-NMR d: 2.33 (6H, s, CH₂×2), 3.75 (4H, s, CH₂×2),7.13 (4H, d, J=7.8 Hz, Ar—H), 7.22 (4H, d, J=7.8 Hz, Ar—H).

[0742] The dibenzylamine compound 247 (500 mg, 2.22 mmol) andtriethylamine (0.372 ml, 2.67 mmol, 1.2 mol eq.) were dissolved inchloroform and acryloyl chloride (221 mg, 2.44 mmol, 1.1 mol eq.)dissolved in chloroform was added thereto under ice-cooling. Thereaction mixture was stirred at room temperature for 30 minutes. Afterthe completion of the reaction, the reaction mixture was poured intowater and extracted with chloroform. The chloroform layer was washedwith water and a saturated aqueous solution of sodium chloride and driedover sodium sulfate. After distilling off the solvent, the oil thusobtained was purified by columr chromatography (silica gel, chloroform]to thereby give a colorless oil 248 (534.5 mg, 86.3%).

[0743] MS m/z: 279, ¹H-NMR d: 2.34 (3H, s, CH₃), 2.35 (3H, s, CH₃), 4.45(2H, s, CH), 4.60 (2H, s, CH₂), 5.71 (1H, dd, J=2.2, 10.2 Hz, CH═CH₂),6.47 (1H, dd, J=2.2, 16.6 Hz, CH═CH₂), 6.60 (1H, dd, J=10.2, 16.6 Hz,CH═CH₂), 7.05 (2H, d, J=7.8 Hz, Ar—H), 7.13-7.17 (6H, m, Ar—H).

[0744] The conjugated ketone compound 248 (400 mg, 1.43 mmol) and(R)-(+)-1-(1-naphthyl)ethylamine (295 mg, 1.72 mmol, 1.2 mol eq.) weredissolved in chloroform/methanol (4:1) and allowed to stand at roomtemperature for 2 weeks. After the completion of the reaction, thesolvent was distilled off under reduced pressure and the oil thusobtained was purified by column chromatography (silica gel, chloroform]to thereby give a colorless oil K-2300 (372.5 mg, 57.9%). Subsequently,the obtained K-2300 (253.6 mg, 0.56 mmol) was dissolved in a 10%solution of hydrochloric acid/methanol and stirred for 15 minutes. Thenit was concentrated as such under reduced pressure. The crystals thusformed were recrystallized from ethanol/water to thereby give K-2300hydrochloride (113.7 mg, 41.4%) as colorless crystals.

[0745] MS m/z: 450, ¹H-NMR d: 1.57 (3H, d, J=6.6 Hz, CH₃), 2.34 (3H, s,CH₃), 2.34 (3H, s, CH₃), 2.60-2.71 (2H, m, CH₂), 2.85-2.97 (2H, m, CH₂),4.35 (2H, s, CH₂), 4.52 (1H, d, J=14.6 Hz, CH₂), 4.59 (1H, d, J=14.6 Hz,CH₂), 4.74 (1H, q, J=6.6 Hz, CH), 7.00 (2H, d, J=8.1 Hz, Ar—H), 7.11(4H, d, J=1.2 Hz, Ar—H), 7.14 (2H, d, J=7.8 Hz, Ar—H), 7.45-7.52.(3H, m,Ar—H), 7.74 (1H, d, J=7.8 Hz, Ar—H), 7.75 (1H, d, J=8.8 Hz, Ar—H), 7.87(1H, dd, J=2.2, 7.8 Hz, Ar—H), 8.14 (1H, d, J=7.8 Hz, Ar—H).

Example 118 Synthesis of K-2309(N1-(3,4-dichlorobenzyl)-N1-(4-methoxybenzyl)-3-{[(1R)-1-(1-naphthyl)ethyl]amino}propanamide)

[0746] 3,4-Dichlorobenzaldehyde (702 mg, 4.01 mmol, 1.1 mol eq.) and4-methoxybenzyiamine (0.476 ml, 3.64 mmol) were dissolved in methanoland MgSO₄ (525.8 mg, 4.37 mmol, 1.2 mol eq.) and AcOH (5 drops) wereadded thereto. Then the obtained mixture was stirred at room temperaturefor 30 minutes. After the completion of the reaction, sodium boronhydride (172 mg, 4.55 mmol, 1.25 mol eq.) was added to the reactionmixture. Then the obtained mixture was stirred at room temperature for20 minutes. After the completion of the reaction, the solvent wasdistilled off under reduced pressure. The obtained residue was extractedwith chloroform. The chloroform layer was washed with a saturatedaqueous solution of sodium hydrogencarbonate, water and a saturatedaqueous solution of sodium chloride and dried over sodium sulfate andthe solvent was distilled off under reduced pressure. The oil thusobtained was purified by column chromatography [silica gel, hexane ethylacetate (9:1-4:1)] to thereby give a colorless oil 249 (827.0 mg,76.8%).

[0747] MS m/z: 296, ¹H-NMR d: 3.72 (2H, s, CH₂), 3.74 (2H, s, CH₂), 3.80(3H, s, OCH₃), 6.87 (2H, d, J=8.8 Hz, Ar—H), 7.18 (1H, dd, J=2.0, 8.3Hz, Ar—H), 7.24 (2H, d, J=8.3 Hz, Ar—H), 7.38 (1H, d, J=8.1 Hz, Ar—H),7.45 (1H, d, J=2.0 Hz, Ar—H).

[0748] The dibenzylamine compound 249 (711.2 mg, 2.41 mmol) andtriethylamine (0.402 ml, 2.89 mmol, 1.2 mol eq.) were dissolved inchloroform and acryloyl chloride (240 mg, 2.65 mmol, 1.1 mol eq.)dissolved in chloroform was added thereto under ice-cooling. Thereaction mixture was stirred at room temperature for 45 minutes. Afterthe completion of the reaction, the reaction mixture was poured intowater and extracted with chloroform. The chloroform layer was washedwith water and a saturated aqueous solution of sodium chloride and driedover sodium sulfate. After distilling off the solvent, the oil thusobtained was purified by column chromatography [silica gel, chloroform]to thereby give a colorless oil 250 (837.2 mg, 99.3%).

[0749] MS m/z: 350, ¹H-NMR d: 3.81 (3H, s, OCH₃), 4.50 (2H, d, J=44.2Hz, CH₂), 4.54 (2H, d, J=49.3 Hz, CH₂), 5.78 (1H, dd, J=1.7, 10.2 Hz,CH=CH₂), 6.59 (1H, dd, J=1.7, 16.6 Hz, CH═CH₂), 6.65 (1H, dd, J=1 0.2,16.6 Hz, CH═CH₂), 6.89 (2H, d, J=8.5 Hz, Ar—H), 7.07 (2H, d, J=8.5 Hz,Ar—H), 7.09 (1H, d, J=8.3 Hz, Ar—H), 7.30 (1H, s, Ar—H), 7.38 (1H, d,J=8.3 Hz, Ar—H).

[0750] The conjugated ketone compound 250 (692.4 mg, 1.98 mmol) and(R)-(+)-1-(1-naphthyl)ethylamine (407 mg, 2.37 mmol, 1.2 mol eq.) weredissolved in chloroform/methanol (4:1) and allowed to stand at roomtemperature for 2 weeks. After the completion of the reaction, thesolvent was distilled off under reduced pressure and the oil thusobtained was purified by column chromatography [silica gel, chloroform]to thereby give a colorless oil K-2309 (835.9 mg, 81.0%). Subsequently,the obtained K-2309 (630.1 mg, 1.21 mmol) was dissolved in a 10%solution of hydrochloric acid/methanol and stirred for 15 minutes. Thenit was concentrated as such under reduced pressure. The crystals thusformed were recrystallized from ethanol/water to thereby give K-2309hydrochloride (566.8 mg, 84.0%) as colorless crystals.

[0751] MS m/z: 521, ¹H-NMR d: 1.55 (3H, d, J=6.3 Hz, CH₃), 2.55-2.70(2H, m, CH₂), 2.86-2.97 (2H, m, CH₂), 3.80 (3H, d, J=3.4 Hz, OCH₃), 4.33(2H, d, J=12.7 Hz, CH₂), 4.51 (2H, d, J=8.8 Hz, CH₂), 4.68-4.73 (1H, m,CH), 6.85 (2H, d, J=8.8 Hz, Ar—H), 7.02 (2H, d, J=8.5 Hz, Ar—H), 7.11(1H, d, J=8.5 Hz, Ar—H), 7.26 (1H, s, Ar—H), 7.35 (1H, d, J=8.3 Hz,Ar—H), 7.45-7.52 (3H, m, Ar—H), 7.70 (1H, t, J=6.8 Hz, Ar—H), 7.75 (1H,d, J=8.3 Hz, Ar—H), 7.87 (1H, dd, J=2.2, 7.8 Hz, Ar—H), 8.16 (1H, d,J=7.8 Hz, Ar—H).

Example 119 Synthesis of K-2310(N1-(4-methylbenzyl)-N1-[4-(trifluoromethoxy)benzyl]-3-{[(1R)-1-(1-naphthyl)ethyl]amino}propanamide)

[0752] 4-(Trifluoromethoxy)benzaldehyde (0.648 ml, 4.54 mmol, 1.1 moleq.) and 4-methylbenzylamine (0.525 ml, 4.13 mmol) were dissolved inmethanol and MgSO₄ (596.6 mg, 4.96 mmol, 1.2 mol eq.) and AcOH (5 drops)were added thereto. Then the obtained mixture was stirred at roomtemperature for 40 minutes. After the completion of the reaction, sodiumboron hydride (195 mg, 5.16 mmol, 1.25 mol eq.) was added to thereaction mixture. Then the obtained mixture was stirred at roomtemperature for 20 minutes. After the completion of the reaction, thesolvent was distilled off under reduced. pressure. The obtained residuewas extracted with chloroform. The chloroform layer was washed with asaturated aqueous solution of sodium hydrogencarbonate, water and asaturated aqueous solution of sodium chloride and dried over sodiumsulfate and the solvent was distilled off under reduced pressure. Theoil thus obtained was purified by column chromatography [silica gel,hexane ethyl acetate (9:1-4:1)] to thereby give a colorless oil 251(979.1 mg, 80.4%).

[0753] MS m/z: 295, ¹H-NMR d: 2.34 (3H, s, CH₃), 3.76 (2H, s, CH₂), 3.79(2H, s, CH₂), 7.14 (2H, d, J=8.1 Hz, Ar—H), 7.16 (2H, d, J-8.5 Hz,Ar—H), 7.22 (2H, d, J=8.1 Hz, Ar—H), 7.36 (2H, d, J=8.5 Hz, Ar—H).

[0754] The dibenzylamine compound 251 (846.8 mg, 2.87 mmol) andtriethylamine (0.480 ml, 3.44 mmol, 1.2 mol eq.) were dissolved inchloroform and acryloyl chloride (286 mg, 3.16 mmol, 1.1 mol eq.)dissolved in chloroform was added thereto under ice-cooling. Thereaction mixture was stirred at room temperature for 45 minutes. Afterthe completion of the reaction, the reaction mixture was poured intowater and extracted with chloroform. The chloroform layer was washedwith water and a saturated aqueous solution of sodium chloride and driedover sodium sulfate. After distilling off the solvent, the oil thusobtained was purified by column chromatography [silica gel, chloroform]to thereby give a colorless oil 252 (844.5 mg, 84.3%).

[0755] MS m/z: 349, ¹H-NMR d: 2.34 (3H, d, J=6.8 Hz, CH₃), 4.55 (2H, d,J=49.0 Hz, CH₂), 4.56 (2H, d, J=50.2 Hz, CH₂),5.75 (1H, dd, J=2.2, 10.0Hz, CH═CH₂), 6.49 (1H, dd, J=2.2, 16.8 Hz, CH═CH₂), 6.62 (1H, dd,J=10.0, 16.8 Hz, CH═CH₂), 7.04 (2H, d, J=7.8 Hz, Ar—H), 7.13-7.21 (4H,m, Ar—H), 7.28 (2H, d, J=8.5 Hz, Ar—H).

[0756] The conjugated ketone compound 252 (685.1 mg, 1.96 mmol) and(R)-(+)-1-(1-naphthyl)ethylamine (403 mg, 2.36 mmol, 1.2 mol eq.) weredissolved in chloroform/methanol (4:1) and allowed to stand at roomtemperature for 12 days. After the completion of the reaction, thesolvent was distilled off under reduced pressure and the oil thusobtained was purified by column chromatography [silica gel, chloroform]to thereby give a colorless oil K-2310(777.8 mg, 76.3%). Subsequently,the obtained K-2310 (539.0 mg, 1.04 mmol) was dissolved in a 10%solution of hydrochloric acid/methanol and stirred for 15 minutes. Thenit was concentrated as such under reduced pressure. The crystals thusformed were recrystallized from ethanol/water to thereby give K-2310hydrochloride (493.0 mg, 85.1%) as colorless crystals.

[0757] MS m/z: 520, ¹H-NMR d: 1.52 (3H, d, J=6.6 Hz, CH₃), 2.34 (3H, d,J=5.4 Hz, CH₃), 2.62 (2H, dt, J=5.9, 21.7 Hz, CH₂), 2.84-2.96 (2H, m,CH₂), 4.38 (2H, s, CH₂), 4.56 (2H, d, J=8.6 Hz, CH₂), 4.67 (1H, q, J=6.6Hz, CH), 7.00 (2H, d, J=8.1 Hz, Ar—H), 7.07-7.18 (4H, m, Ar—H), 7.22(2H, d, J=8.6 Hz, Ar—H), 7.44-7.51 (3H, m, Ar—H), 7.68 (1H, d, J=6.6 Hz,Ar—H), 7.73 (1H, d, J=8.1 Hz, Ar—H), 7.86 (1H, dd, J=2.2, 8.1 Hz, Ar—H),8.16 (1H, d, J=8.5 Hz, Ar—H).

Example 120 Synthesis of K-2311

[0758] 4-(Trifluoromethoxy)benzaldehyde (0.573 ml, 4.01 mmol, 1.1 moleq.) and 4-methoxybenzylamine (0.476 ml, 3.64 mmol) were dissolved inmethanol and MgSO₄ (525.8 mg, 4.37 mmol, 1.2 mol eq.) and AcOH (5 drops)were added thereto. Then the obtained mixture was stirred at roomtemperature for 30 minutes. After the completion of the reaction, sodiumboron hydride (172 mg, 4.55 mmol, 1.25 mol eq.) was added to thereaction mixture. Then the obtained mixture was stirred at roomtemperature for 30 minutes. After the completion of the reaction, thesolvent was distilled off under reduced pressure. The obtained residuewas extracted with chloroform. The chloroform layer was washed with asaturated aqueous solution of sodium hydrogencarbonate, water and asaturated aqueous solution of sodium chloride and dried over sodiumsulfate and the solvent was distilled off under reduced pressure. Theoil thus obtained was purified by column chromatography (silica gel,hexane:ethyl acetate (9:1-4:1)] to thereby give a colorless oil 253(944.0 mg, 83.4%).

[0759] MS m/z: 311, ¹H-NMR d: 3.74 (2H, s, CH₂), 3.79 (2H, s, CH₂), 3.80(3H, s, OCH₃), 6.87 (2H, d, J=8.5 Hz, Ar—H), 7.17 (2H, d, J=8.3 Hz,Ar—H), 7.25 (2H, d, J=8.3 Hz, Ar—H), 7.37 (2H, d, J=8.5 Hz, Ar—H).

[0760] The dibenzylamine compound 253 (766.5 mg, 2.46 mmol) andtriethylamine (0.411 ml, 2.95 mmol, 1.2 mol eq.) were dissolved inchloroform and acryloyl chloride (245 mg, 2.71 mmol, 1.1 mol eq.)dissolved in chloroform was added thereto under ice-cooling. Thereaction mixture was stirred at room temperature for 45 minutes. Afterthe completion of the reaction, the reaction mixture was poured intowater and extracted with chloroform. The chloroform layer was washedwith water and a saturated aqueous solution of sodium chloride and driedover sodium sulfate. After distilling off the solvent, the oil thusobtained was purified by column chromatography [silica gel, chloroform]to thereby give a colorless oil 254 (749.0 mg, 83.4%).

[0761] MS m/z: 365, ¹H-NMR δ: 3.80 (3H, s, OCH₃), 4.48 (2H, d, J=13.4Hz, CH₂), 4.60 (2H, d, J=12.4 Hz, CH₂), 5.76 (1H, dd, J=2.0, 10.2 Hz,CH═CH₂), 6.49 (1H, dd, J=2.0, 16.8 Hz, CH═CH₂), 6.65 (1H, dd, J=10.2,16.8 Hz, CH═CH₂), 6.84 (1H, d, J=8.5 Hz, Ar—H), 6.88 (1H, d, J=8.5 Hz,Ar—H), 7.07 (1H, d, J=8.3 Hz, Ar—H), 7.16 (1H, d, J=8.8 Hz, Ar—H), 7.18(3H, d, J=7.6 Hz, Ar—H), 7.27 (1H, d, J=9.5 Hz, Ar—H).

[0762] The conjugated ketone compound 254 (612.8 mg, 1.68 mmol) and(R)-(+)-1-(1-naphthyl)ethylamine (345 mg, 2.01 mmol, 1.2 mol eq.) weredissolved in chloroform/methanol (4:1) and allowed to stand at roomtemperature for 12 days. After the completion of the reaction, thesolvent was distilled off under reduced pressure and the oil thusobtained was purified by column chromatography [silica gel, chloroform]to thereby give a colorless oil K-2311 (668.3 mg, 74.2%).

[0763] MS m/z: 536, ¹H-NMR d: 1.53 (3H, d, J=6.6 Hz, CH₃), 2.55-2.73(2H, m, CH₂), 2.84-2.96 (2H, m, CH₂), 3.79 (3H, d, J=3.2 Hz, OCH₃), 4.36(2H, d, J=10.0 Hz, CH₂), 4.54 (2H, d, J=12.9 Hz, CH₂), 4.70 (1H, q,J=6.6 Hz, CH), 6.82 (1H, d, J=8.8 Hz, Ar—H), 6.85 (1H, d, J=8.8 Hz,Ar—H), 7.02 (1H, d, J=8.5 Hz, Ar—H), 7.12 (1H, d, J=8.8 Hz, Ar—H),7.13-7.18 (3H, m, Ar—H), 7.22 (1H, d, J=8.5 Hz, Ar—H), 7.45-7.51 (3H, m,Ar—H), 7.70 (1H, t, J=6.6 Hz, Ar—H), 7.74 (1H, d, J=8.3 Hz, Ar—H), 7.86(1H, d, J=8.1 Hz, Ar—H), 8.16 (1H, d, J=8.1 Hz, Ar—H).

Example 121 Synthesis of K-2312

[0764] 4-Hydroxybenzaldehyde (490 mg, 4.01 mmol, 1.1 mol eq.) and4-methoxybenzylamine (0.476 ml, 3.64 mmol) were dissolved in methanoland MgSO₄ (525.8 mg, 4.37 mmol, 1.2 mol eq.) and AcOH (5 drops) wereadded thereto. Then the obtained mixture was stirred at room temperaturefor 45 minutes. After the completion of the reaction, sodium boronhydride (172 mg, 4.55 mmol, 1.25 mol eq.) was added to the reactionmixture. Then the obtained mixture was stirred at room temperature for10 minutes. After the completion of the reaction, the solvent wasdistilled off under reduced pressure. The obtained residue was extractedwith chloroform. The chloroform layer was washed with a saturatedaqueous solution of sodium hydrogencarbonate, water and a saturatedaqueous solution of sodium chloride and dried over sodium sulfate andthe solvent was distilled off under reduced pressure. The oil thusobtained was purified by column chromatography [silica gel,chloroform/methanol] to thereby give a colorless oil 255 (858.9 mg,97.1%).

[0765] MS m/z: 243, ¹H-NMR 5: 3.69 (2H, s, CH₂), 3.77 (2H, s, CH₂), 3.79(3H, s, OCH₃), 6.64 (2H, d, J=8.5 Hz, Ar—H), 6.86 (2H, d, J=8.8 Hz,Ar—H), 7.09 (2H, d, J=8.5 Hz, Ar—H), 7.26 (2H, d, J=8.5 Hz, Ar—H).

[0766] The dibenzylamine compound 255 (521.4 mg, 2.15 mmol) andtriethylamine (0.359 ml, 2.57 mmol, 1.2 mol eq.) were dissolved inchloroform and acryloyl chloride (214 mg, 2.36 mmol, 1.1 mol eq.)dissolved in chloroform was added thereto under ice-cooling. Thereaction mixture was stirred at room temperature for 1 hour. After thecompletion of the reaction, the reaction mixture was poured into waterand extracted with chloroform. The chloroform layer was washed withwater and a saturated aqueous solution of sodium chloride and dried oversodium sulfate. After distilling off the solvent, the oil thus obtainedwas purified by column chromatography [silica gel, chloroform] tothereby give a colorless oil 256 (375.5 mg, 58.8%).

[0767] MS m/z: 297, ¹H-NMR δ: 3.80 (3H, d, J=6.8 Hz, OCH₃), 4.44 (2H, d,J=16.1 Hz, CH₂), 4.56 (2H, d, J=9.0 Hz, CH₂), 5.76 (1H, dd, J=2.2, 10.2Hz, CH═CH₂), 6.48 (1H, ddd, J=2.2, 7.1, 16.6 Hz, CH═CH₂), 6.64 (1H, ddd,J=3.2, 10.2, 16.6 Hz, CH═CH₂), 6.79 (1H, d, J=8.5 Hz, Ar—H), 6.83 (1H,d, J=8.5 Hz, Ar—H), 6.85 (1H, d, J=8.5 Hz, Ar—H), 6.89 (1H, d, J=8.5 Hz,Ar—H), 6.98 (1H, d, J=8.3 Hz, Ar—H), 7.08 (1H, d, J=6.8 Hz, Ar—H), 710(1H, d, J=6.8 Hz, Ar—H), 7.19 (1H, d, J=8.5 Hz, Ar—H).

[0768] The conjugated ketone compound 256 (260.2 mg, 0.88 mmol) and(R)-(+)-1-(1-naphthyl)ethylamine (180 mg, 1.05 mmol, 1.2 mol eq.) weredissolved in chloroform/methanol (4:1) and allowed to stand at roomtemperature for 13 days. After the completion of the reaction, thesolvent was distilled off under reduced pressure and the oil thusobtained was purified by column chromatography [silica gel,chloroform/methanol] to thereby give a colorless oil K-2312 (177.4 mg,43.3%).

[0769] MS m/z: 468, ¹H-NMR δ: 1.61 (3H, d, J=6.8 Hz, CH₃), 2.63-2.71(1H, m, CH₂), 2.81-2.88 (2H, m, CH₂), 2.95 (1H, d, J=5.4 Hz, CH₂), 3.78(3H, d, J=5.4 Hz, OCH₃), 4.22 (2H, d, J=18.3 Hz, CH₂), 4.27 (2H, d,J=30.5 Hz, CH₂), 4.81-4.86 (1H, m, CH), 6.72 (1H, d, J=8.5 Hz, Ar—H),6.74 (1H, d, J=8.5 Hz, Ar—H), 6.82 (1H, d, J=8.8 Hz, Ar—H), 6.83 (1H, d,J=8.5 Hz, Ar—H), 6.85 (1H, d, J=8.5 Hz, Ar—H), 6.98 (1H, d, J=8.8 Hz,Ar—H), 7.02 (1H, d, J=8.5 Hz, Ar—H), 7.10 (1H, d, J=8.5 Hz, Ar—H),7.45-7.54 (3H, m, Ar-H), 7.77 (2H, d, J=7.6 Hz, Ar—H), 7.88 (1H, d,J=8.1 Hz, Ar—H), 8.11 (1H, d, J=8.1 Hz, Ar—H).

Example 122 Synthesis of K-2280(N-{5-[(4-methoxyphenyl)thio]pentyl-N-[(1R)-1-(1-naphthyl) ethyl]amine)

[0770] 4-Methoxythiophenol (753 mg, 5.37 mmol) was dissolved inacetonitrile (10 ml). To the obtained solution were successively addedat room temperature potassium carbonate (754 mg, 5.46 mmol) and1,5-dibromopentane (0.73 ml, 5.35 mmol) and the reaction mixture wasstirred at room temperature for 3 hours. After confirming the completionof the reaction by TLC, potassium carbonate (931 mg, 6.75 mmol) and(R)-(+)-1-(1-naphthyl)ethylamine (0.52 ml, 3.22 mmol) were added at thesame temperature to the reaction system. Further, the reaction mixturewas stirred at 85° C. for 12 hours. After the completion of thereaction, the mixture was cooled by allowing to stand at roomtemperature and water was added thereto. Next, the reaction mixture wassubjected to separatory extraction with chloroform and a saturatedaqueous solution of sodium chloride and washed. The organic layer thusobtained was dried over anhydrous sodium sulfate and concentrated underreduced pressure. The organic residue was purified by silica gel columnchromatography (chloroform:methanol=200:1) to thereby give a paleyellow, syrupy compound K-2280 as a free compound. Subsequently, 5 ml of10% hydrochloric acid/methanol was poured into the K-2280 obtained aboveand allowed to stand for 3 minutes followed by concentration. The paleyellow crystals thus obtained were subjected to Kiriyama's filtrationand the precipitate was washed with diethyl ether. Thus 210 mg (0.55mmol, yield: 20.6%) of K-2280 hydrochloride was obtained as whitecrystals.

[0771] 400 MHz-NMR 10.49 (1H, bs), 9.98 (1H, bs), 8.24 (1H, d, J=7.32Hz), 7.98 (1H, d, J=8.56 Hz), 7.94 (1H, dd, J=8.04 Hz, J=1.48 Hz), 7.90(1H, d, J=8.28 Hz), 7.52-7.68 (3H, m), 7.19-7.23 (2H, m), 6.73-6.77 (2H,m), 5.14-5.24 (1H, m), 3.73 (3H, s), 2.67-2.75 (2H, m), 2.65 (2H, t,J=7.20 Hz), 2.02 (3H, d, J=6.84 Hz), 1.91-1.99 (2H, m), 1.38-1.46 (2H,m), 1.21-1.35 (2H, m), m/z=379.

Example 123 Synthesis of K-2281(N-[(1R)-1-(1-naphthyl)ethyl]-N-{4-[(2,4,5-trichlorophenyl)thio]butyl}amine)

[0772] 2,4,5-Trichlorothiophenol (770 mg, 3.61 mmol) was dissolved inacetonitrile (10 ml). To the obtained solution were successively addedat room temperature potassium carbonate (560 mg, 4.05 mmol) and1,4-dibromobutane (0.43 ml, 3.60 mmol) and the reaction mixture wasstirred at room temperature for 3 hours. After confirming the completionof the reaction by TLC, potassium carbonate (545 mg, 3.94 mmol) and(R)-(+)-1-(1-naphthyl)ethylamine (0.41 ml, 3.94 mmol) were added at thesame temperature to the reaction system. Further, the reaction mixturewas stirred at 85° C. for 12 hours. After the completion of thereaction, the mixture was cooled by allowing to stand at roomtemperature and water was added thereto. Next, the reaction mixture wassubjected to separatory extraction with chloroform and a saturatedaqueous solution of sodium chloride and washed. The organic layer thusobtained was dried over anhydrous sodium sulfate and concentrated underreduced pressure. The organic residue was purified by silica gel columnchromatography (chloroform:methanol=200:1) to thereby give a paleyellow, syrupy compound K-2281 as a free compound. Subsequently, 10 mlof 10% hydrochloric acid/methanol was poured into the K-2281 obtainedabove and allowed to stand for 5 minutes followed by concentration. Thepale yellow crystals thus obtained were subjected to Kiriyama'sfiltration and the precipitate was washed with diethyl ether. Thus 280mg (0.59 mmol, yield: 15.0%) of K-2281 hydrochloride was obtained aswhite crystals.

[0773] 400 MHz-NMR 10.64 (1H, bs), 10.07 (1H, bs), 8.26 (1H, dd, J=7.3Hz, J=0.7 Hz), 8.01 (1H, d=8.3 Hz), 7.90-7.95 (2H, m), 7.52-7.68 (3H,m), 7.36 (1H, s), 7.11 (1H, s), 5.20-5.26 (1H, m), 2.76 (2H, t, J=7.0Hz), 2.76-2.82 (2H, m), 2.87 (3H, d, J=6.8 Hz), 1.53-1.63 (2H, m),m/z=437, 439.

Example 124 Synthesis of K-2282(N-[(1R)-1-(1-naphthyl)ethyl]-N-{5-[(2,4,5-trichlorophenyl)thio]pentyl}amine)

[0774] 2,4,5-Trichlorothiophenol (1.53 g, 7.15 mmol) was dissolved inacetonitrile (15 ml). To the obtained solution were successively addedat room temperature potassium carbonate (1.083 g, 7.84 mmol) and1,5-dibromopentane (0.98 ml, 7.19 mmol) and the reaction mixture wasstirred at room temperature for 2.5 hours. After confirming thecompletion of the reaction by TLC, potassium carbonate (1.00 g, 7.25mmol) and (R)-(+)-1-(1-naphthyl)ethylamine (0.69 ml, 4.27 mmol) wereadded at the same temperature to the reaction system. Further, thereaction mixture was stirred at 85° C. for 12 hours. After thecompletion of the reaction, the mixture was cooled by allowing to standat room temperature arid water was added thereto. Next, the reactionmixture was subjected to separatory extraction with chloroform and asaturated aqueous solution of sodium chloride and washed. The organiclayer thus obtained was dried over anhydrous sodium sulfate andconcentrated under reduced pressure. The organic residue was purified bysilica gel column chromatography (chloroform:methanol=200:1) to therebygive a pale yellow, syrupy compound K-2282 as a free compound.Subsequently, 15 ml of 10% hydrochloric acid/methanol was poured intothe K-2282 obtained above and allowed to stand for 5 minutes followed byconcentration. The pale yellow crystals thus obtained were subjected toKiriyama's filtration and the precipitate was washed with diethyl ether.Thus 283 mg (0.58 mmol, yield: 13.5%) of K-2282 hydrochloride wasobtained as white crystals.

[0775] 400 MHz-NMR 10.55 (1H, bs), 10.03 (1H, bs), 8.25 (1H, d, J=7.3Hz), 8.00 (1H, d, J=8.5 Hz), 7.90-7.95 (2H, m), 7.54-7.68 (3H, m), 7.37(1H, s), 7.16 (1H, s), 5.17-5.26 (1H, m), 2.73-2.82 (4H, m), 1.97-2.05(2H, m), 2.05 (3H, d, J=6.6 Hz), 1.52-1.60 (2H, m), 1.31-1.45 (2H, m),m/z=451, 453.

Example 125 Synthesis of K-2287(N-[(1R)-1-(1-naphthyl)ethyl]-N-(4-{[4-(trifluoromethoxy)phenyl)thio]butyl)amine)

[0776] 4-Trifluoromethoxythiophenol (908 mg, 4.68 mmol) was dissolved inacetonitrile (10 ml). To the obtained solution were successively addedat room temperature potassium carbonate (679 mg, 4.91 mmol) and1,4-dibromobutane (0.568 ml, 4.69 mmol) and the reaction mixture wasstirred at room temperature for 5 hours. After confirming the completionof the reaction by TLC, potassium carbonate (710 mg, 5.14 mmol) and(R)-(+)-1-(1-naphthyl)ethylamine (0.53 ml, 3.28 mmol) were added at thesame temperature to the reaction system. Further, the reaction mixturewas stirred at 90° C. for 1 2 hours. After the completion of thereaction, the mixture was cooled by allowing to stand at roomtemperature and water was added thereto. Next, the reaction mixture wassubjected to separatory extraction with chloroform and a saturatedaqueous solution of sodium chloride and washed. The organic layer thusobtained was dried over anhydrous sodium sulfate and concentrated underreduced pressure. The organic residue was purified by silica gel columnchromatography (chloroform:methanol=200:1) to thereby give a paleyellow, syrupy compound K-2287 as a free compound. Subsequently, 10 mlof 10% hydrochloric acid/methanol was poured into the K-2287 obtainedabove and allowed to stand for 5 minutes followed by concentration. Thepale yellow crystals thus obtained were subjected to Kiriyama'sfiltration and the precipitate was washed with hexane. Thus 245 mg (0.54mmol, yield: 16.5%) of K-2287 hydrochloride was obtained as whitecrystals.

[0777] 400 MHz-NMR 10.58 (1H, bs), 10.07 (1H, bs), 8.25 (1H, d, J=6.8Hz), 8.00 (1H, d, J=8.5 Hz), 7.90-7.96 (2H, m), 7.52-7.67 (3H, m),7.15-7.19 (3H, m), 7.02-7.04 (2H, m), 5.19-5.24 (1H, m), 2.73-2.76 (4H,m), 2.06-2.17 (2H, m), 2.06 (3H, d, J=6.8 Hz), 1.41-1.59 (2H, m),m/z=419.

Example 126 Synthesis of K-2288(N-[(1R)-1-(1-naphthyl)ethyl]-N-(5-{[4-(trifluoromethoxy)phenyl)thio]pentyl)amine)

[0778] 4-Trifluoromethoxythiophenol (995 mg, 5.12 mmol) was dissolved inacetonitrile (10 ml). To the obtained solution were successively addedat room temperature potassium carbonate (715 mg, 5.17 mmol) and1,5-dibromopentane (0.70 ml, 5.14 mmol) and the reaction mixture wasstirred at room temperature for 5 hours. After confirming the completionof the reaction by TLC, potassium carbonate (770 mg, 5.57 mmol) and(R)-(+)-1-(1-naphthyl)ethylamine (0.58 ml, 3.59 mmol) were added at thesame temperature to the reaction system. Further, the reaction mixturewas stirred at 85° C. for 12 hours. After the completion of thereaction, the mixture was cooled by allowing to stand at roomtemperature and water was added thereto. Next, the reaction mixture wassubjected to separatory extraction with chloroform and a saturatedaqueous solution of sodium chloride and washed. The organic layer thusobtained was dried over anhydrous sodium sulfate and concentrated underreduced pressure. The organic residue was purified by silica gel columnchromatography (chloroform:methanol=200:1) to thereby give a paleyellow, syrupy compound K-2288 as a free compound. Subsequently, 10 mlof 10% hydrochloric acid/methanol was poured into the K-2288 obtainedabove and allowed to stand for 5 minutes followed by concentration. Thepale yellow crystals thus obtained were subjected to Kiriyama'sfiltration and the precipitate was washed with hexane. Thus 313 mg (0.67mmol, yield: 18.7%) of K-2288 hydrochloride was obtained as whitecrystals.

[0779] 400 MHz-NMR 10.53 (1H, m), 10.03 (1 H, bs), 8.24-8.26 (1H, m),7.99 (1H, d, J=8.3 Hz), 7.52-7.67 (3H, m), 7.19-7.23 (2H, m),7.04-7.07.(2H, m), 5.15-5.25 (1H, m), 2.76 (2H, t, J=7.2 Hz), 2.69-2.78(2H, m), 2.03 (3H, d, J=6.8 Hz), 1.92-2.04 (2H, m), 1.49 (2H, tt, J=7.4Hz, J=7.4 Hz), 1.27-1.38 (2H, m), m/z=433.

Example 127 Synthesis of K-2293(N-{4-[(4-chlorophenyl)thio]butyl}-N-[(1R)-1-(1-naphthyl)ethyl]amine)

[0780] 4-Chlorothiophenol (782 mg, 5.41 mmol) was dissolved inacetonitrile (10 ml). To the obtained solution were successively addedat room temperature potassium carbonate (850 mg, 6.15 mmol) and1,4-dibromobutane (0.65 ml, 5.44 mmol) and the reaction mixture wasstirred at room temperature for 5 hours. After confirming the completionof the reaction by TLC, potassium carbonate (775 mg, 5.61 mmol) and(R)-(+)-1-(1-naphthyl)ethylamine (0.62 ml, 3.84 mmol) were added at thesame temperature to the reaction system. Further, the reaction mixturewas stirred at 85° C. for 24 hours. After the completion of thereaction, the mixture was cooled by allowing to stand at roomtemperature and water was added thereto. Next, the reaction mixture wassubjected to separatory extraction with chloroform and a saturatedaqueous solution of sodium chloride and washed. The organic layer thusobtained was dried over anhydrous sodium sulfate and concentrated underreduced pressure. The organic residue was purified by silica gel columnchromatography (chloroform:methanol=200:1) to thereby give a paleyellow, syrupy compound K-2293 as a free compound. Subsequently, 10 mlof 10% hydrochloric acid/methanol was poured into the K-2293 obtainedabove and allowed to stand for 5 minutes followed by concentration. Thepale yellow crystals thus obtained were subjected to Kiriyama'sfiltration and the precipitate was washed with diethyl ether. Thus 420mg (1.03 mmol, yield: 26.9%) of K-2293 hydrochloride was obtained aswhite crystals.

[0781] 400 MHz-NMR 10.58 (1H, bs), 10.05 (1H, bs), 8.25 (1H, d, J=6.8Hz), 7.99 (1H, d, J=8.3 Hz), 7.94 (1H, dd, J=8.0 Hz, J=1.2 Hz), 7.91(1H, d, J=8.04 Hz), 7.52-7.67 (3H, m), 7.12-7.16 (2H, m), 7.06-7.10 (2H,m), 5.16-5.25 (1H, m), 2.70-2.74 (4H, m), 2.06-2.15 (2H, m), 2.05 (3H,d, J=6.6 Hz), 1.40-1.57 (2H, m), m/z=369.

Example 128 Synthesis of K-2240(N-[(1R)-1-(1-naphthyl)ethyl]-N-(3-{[4-(trifluoromethyl)phenyl]thio}propyl)amine)

[0782] K-2240 hydrochloride was obtained as white crystals by the samemethod as the one employed for the synthesis of K-2293 but replacing the4-chlorothiophenol and 1,4-dibromobutane respectively by4-trifluoromethylthiophenol and 1,3-dibromopropane. m/z=339.

Example 129 Synthesis of K-2263(N-{4-[(4-fluorophenyl)thio]butyl}-N-[(1R)-1-(1-naphthyl)ethyl]amine)

[0783] K-2263 hydrochloride was obtained as white crystals by the samemethod as the one employed for the synthesis of K-2293 but replacing the4-chlorothiophenol by 4-fluorothiophenol.

[0784] 400 MHz-NMR 10.57 (1H, bs), 10.04 (1H, bs), 8.24 (1H, d, J=7.3Hz), 7.99 (1H, d, J=8.52 Hz), 7.90-7.96 (2H, m), 7.52-7.67 (3H, m),7.15-7.20 (2H, m), 6.86-6.92 (2H, m), 5.19-5.22 (1H, m), 2.67-2.77 (2H,m), 2.69 (2H, t, J=7.1 Hz), 2.05-2.15 (2H, m), 2.05 (3H, d, J=6.8 Hz),1.36-1.54 (2H, m), m/z=353.

Example 130 Synthesis of K-2269(N-{4-[(3-methoxyphenyl)thio]butyl}-N-[(1R)-1-(1-naphthyl)ethyl]amine)

[0785] K-2269 hydrochloride was obtained as white crystals by the samemethod as the one employed for the synthesis of K-2.293 but replacingthe 4-chlorothiophenol by 3-methoxythiophenol.

[0786] 400 MHz-NMR 10.58 (1H, bs), 10.06 (1H, bs), 8.24-8.26 (1H, m),7.99 (1H, d, J=8.3 Hz), 7.88-7.94 (3H, m), 7.53-7.67 (3H, m), 7.08 (1H,dd, J=8.3 Hz, J=8.3 Hz), 6.71-6.74 (2H, m), 6.64 (1H, ddd, J=8.3 Hz,J=2.4 Hz, J=1.0 Hz), 5.15-5.25 (1H, m), 2.70-2.79 (2H, m), 2.75 (2H, t,J=7.2 Hz), 2.07-2.16 (2H, m), 2.05 (3H, d, J=6.8 Hz), 1.43-1.60 (2H, m),m/z=365.

Example 131 Synthesis of K-2271(N-{[4-(5-ethoxy-1,3-benzothiazol-2-yl)thio]butyl-N-[(1R)-1-(1-naphthyl)ethyl]amine)

[0787] K-2271 hydrochloride was obtained as white crystals by the samemethod as the one employed for the synthesis of K-2293 but replacing the4-chlorothiophenol by 6-ethoxy-2-mercaptobenzothiazole.

[0788] 400 MHz-NMR 10.56 (1H, bs), 10.04 (1H, bs), 8.29 (1H, d, J=7.0Hz), 8.02 (1H, d, J=8.5 Hz), 7.87-7.92 (2H, m), 7.52-7.70 (4H, m), 7.13(1H, d, J=2.2 Hz), 6.96 (1H, dd, J=8.8 Hz, J=2.2 Hz), 5.20-5.28 (1H, m),4.02 (2H, dd, J=13.9 Hz, J=7.1 Hz), 3.27 (2H, dd, J=7.1Hz, J=7.1 Hz),2.20-2.60 (4H, m), 2.12-2.23 (2H, m), 2.06 (3H, d, J=6.6 Hz), 1.76-1.87(2H, m), 1.42 (3H, t, J=6.8 Hz), m/z=436.

Example 132 Synthesis of K-2279(N-{[5-(3-methoxyphenyl)thio]pentyl}N-[(1R)-1-(1-naphthyl)ethyl]amine)

[0789] K-2279 hydrochloride was obtained as white crystals by the samemethod as the one employed for the synthesis of K-2293 but replacing the4-chlorothiophenol and 1,4-dibromobutane respectively by3-methoxythiophenol and 1,5-dibromopentane.

[0790] 400 MHz-NMR 10.51 (1H, bs), 9.99 (1H, bs), 8.24 (1H, d, J=7.1Hz), 7.89-7.99 (3H, m), 7.54-7.67 (3H, m), 7.10 (1H, dd, J=7.9 Hz, J=7.9Hz), 6.75-6.79 (2H, m), 6.61-6.65 (1H, ddd, J=8.OHz, J=2.4 Hz, J=0.7Hz), 5.14-5.24 (1H, m), 3.72 (3H, s), 2.68-2.79 (4H, m), 2.03 (3H, d,J=6.8 Hz), 1.93-1.99 (2H, m), 1.47-1.54 (2H, m), 1.24-1.38 (2H, m),m/z=379.

Example 133 Synthesis of K-2284(N-[(1R)-1-(1-naphthyl)ethyl]-N-(5-{[2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl]thio}pentyl)amine)

[0791] K-2284 hydrochloride was obtained as white crystals by the samemethod as the one employed for the:synthesis of K-2293 but replacing the4-chlorothiophenol and 1,4-dibromobutane respectively by2,3,5,6-tetrafluoro-4-trifluoromethylthiophenol and 1,5-dibromopentane.

[0792] 400 MHz-NMR 10.54 (1H, bs), 10.43 (1H, bs), 8.24 (1H, d, J=6.6Hz), 7.99 (1H, d, J=8.3 Hz), 7.90-7.96 (2H, m), 7.55-7.67 (3H, m),5.15-5.25 (1H, bs), 2.91 (2H, t, J=7.2 Hz), 2.70-2.80 (2H, m), 2.04 (3H,d, J=6.6 Hz), 1.93-2.02 (2H, m), 1.48 (2H, tt, J=7.4 Hz, J=7.4 Hz),1.26-1.41 (2H, m), m/z=489.

Example 134 Synthesis of K-2286(N-{6-[(4-chiorophenyl)thio]hexyl}N-[(1R)-1-(1-naphthyl)ethyl]amine)

[0793] K-2286 hydrochloride was obtained as white crystals by the samemethod as the one employed for the synthesis of K-2293 but replacing the1,4-dibromobutane by 1,6-dibromohexane, m/z=397.

Example 135 Synthesis of K-2292(N-[(1R)-1-(1-naphthyl)ethyl]-N-(7-{[2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl]thio}heptyl)amine)

[0794] K-2292 hydrochloride was obtained as white crystals by the samemethod as the one employed for the synthesis of K-2293 but replacing the4-chlorothiophenol and 1,4-dibromobutane respectively by2,3,5,6-tetrafluoro-4-trifluorometylthiophenol and 1,7-dibromopentane.

[0795] 400 MHz-NMR 10.48 (1H, bs), 9.98 (1H, bs), 8.26 (1H, d, J=6.8Hz), 8.00 (1H, d, J=8.3 Hz), 7.94 (1H, d, J=7.3 Hz), 7.91 (1H, d, J=8.0Hz), 7.54-7.68 (3H, m), 5.21 (1H, bs), 2.92 (2H, t, J=7.3 Hz), 2.74 (2H,bs), 2.05 (3H, d, J=5.1 Hz), 1.97 (2H, bs), 1.42-1.50 (2H, m), 1.23-1.38(2H, m), 1.17 (4H, bs), m/z=517.

Example 136 Synthesis of K-2295

[0796] K-2295 hydrochloride was obtained as white crystals by the samemethod as the one employed for the synthesis of K-2293 but replacing the4-chlorothiophenol and 1,4-dibromobutane respectively by2,4,5-trichlorothiophenol and 1-bromo-2-chloroethane.

[0797] 400 MHz-NMR 10.94 (1H, bs), 10.31 (1H, bs), 8.17 (1H, d, J=6.6Hz), 7.88-7.96 (3H, m), 7.55-7.65 (3H, m), 7.42 (1 H, s), 7.29 (1H, s),5.20-5.28 (1H, m), 3.47-3.59 (2H, m), 2.92-3.07 (2H, m), 2.03 (3H, d,J=6.6 Hz), m/z=409.

Example 137 Synthesis of K-2296(N-{[5-(2,5-dichlorophenyl)thio]pentyl}N-[(1R)-1-(1-naphthyl)ethyl]amine)

[0798] K-2296 hydrochloride was obtained as white crystals by the samemethod as the one employed for the synthesis of K-2293 but replacing the4-chlorothiophenol and 1,4-dibromobutane respectively by2,5-dichlorothiophenol and 1,5-dibromopentane.

[0799] 400 MHz-NMR 10.63 (1H, bs), 10.08 (1H, bs), 8.26 (1H, d, J=6.8Hz), 8.01 (1H, d, =8.5 Hz), 7.90-7.94 (2H, m), 7.52-7.68 (3H, m), 7.18(1H, d, J=8.3 Hz), 6.98-7.02 (2H, m), 5.18-5.28 (1H, m), 2.75-2.84 (2H,m), 2.77 (2H, t, J=7.2 Hz), 2.12-2.20 (2H, m), 2.07 (3H, d, J=6.6 Hz),1.56-1.67 (4H, m), m/z=417.

Example 138 Synthesis of K-2297(N-[(1R)-1-(1-naphthyl)ethyl]-N-(4-{[2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl]thio}butyl)amine)

[0800] K-2297 hydrochloride was obtained as white crystals by the samemethod as the one employed for the synthesis of K-2293 but replacing the4-chlorothiophenol by 2,3,5,6-tetrafluoro-4-trifluoromethylthiophenol.

[0801] 400 MHz-NMR 10.59 (1H, bs), 10.08 (1H, b), 8.23 (1H, d, J=6.6Hz), 8.00 (1H, d, J=8.3 Hz), 7.94 (1H, dd, J=8.0 Hz, J=1.2 Hz),7.55-7.67 (3H, m), 5.18-5.23 (1H, m), 2.89 (2H, t, J=7.3 Hz), 2.70-2.82(2H, m), 2.04-2.13 (2H, m), 2.05 (3H, d, J=6.6 Hz), 1.47-1.60 (2H, m),m/z=475.

Example 139 Synthesis of K-2298(N-{4-[(2,5-dichlorophenyl)thio]butyl}N-[(1R)-1-(1-naphthyl)ethyl]amine)

[0802] K-2298 hydrochloride was obtained as white crystals by the samemethod as the one employed for the synthesis of K-2293 but replacing the4-chlorothiophenol by 2,5-dichlorothiophenol.

[0803] 400 MHz-NMR 10.64 (1H, bs), 10.09 (1H, bs), 8.26 (1H, d, J=6.6Hz), 8.01 (1H, d, J=8.3 Hz), 7.89-7.94 (2H, m), 7.52-7.68 (3H, m), 7.18(1H, d, J=8.3 Hz), 7.01 (1H, dd, J=6.6 Hz, J=2.4 Hz), 5.18-5.28 (1H, m),2.73-2.85 (2H, m), 2.76 (2H, t, J=7.2 Hz), 2.16 (2H, tt, J=7.2 Hz, J=7.2Hz), 2.07 (3H, d, J=6.8 Hz), 1.52-1.68 (2H, m), m/z=403.

Example 140 Synthesis of K-2301(N-[(1R)-1-((1-naphthyl)ethyl]-N-(6-{[4-(trifluoromethoxy)phenyl]thio}hexyl)amine)

[0804] K-2301 hydrochloride was obtained as white crystals by the samemethod as the one employed for the synthesis of K-2293 but replacingthe- 4-chlorothiophenol and 1,4-dibromobutane respectively by4-trifluoromethoxythiophenol and 1,6-dibromohexane.

[0805] 400 MHz-NMR 10.53 (1H, bs), 10.00 (1H, bs), 8.27 (1H, d, J=7.3Hz), 8.00 (1H, d, J=8.3 Hz), 7.89-7.95 (2H, m), 7.52-7.68 (3H, m),7.21-7.24 (2H, m), 7.05-7.08 (2H, m), 5.21 (1H, bs), 2.70-2.78 (2H, m),2.76 (2H, t, J=7.3 Hz), 2.06 (3H, d, J=6.6 Hz), 1.92-2.02 (2H, m),1.46-1.54 (2H, m), 1.17-1.35 (4H, m), m/z=447.

Example 141 Synthesis of K-2302(N-{4-[(2,4-dimethylphenyl)thio]butyl}-N-[(1R)-1-(1-naphthyl)ethyl]amine)

[0806] K-2302 hydrochloride was obtained as white crystals by the samemethod as the one employed for the synthesis of K-2293 but replacing the4-chlorothiophenol by 2,4-dimethylthiophenol.

[0807] 400 MHz-NMR 10.60 (1H, bs), 10.05 (1H, bs), 8.25 (1H, d, J=7.3Hz), 7.99 (1H, d, J=8.6 Hz), 7.93 (1H, d, J=7.84 Hz), 7.89 (1H, d, J=8.3Hz), 7.51-7.66 (3H, m), 7.00 (1H, d, J=7.8 Hz), 6.90 (1H, s), 6.83 (1H,d, J=7.8 Hz), 5.15-5.24 (1H, m), 2.70-2.78 (2H, m), 2.66 (2H, t, J=7.2Hz), 2.22 (6H, s), 2.07-2.13 (2H, m), 2.05 (3H, d, J=6.8 Hz), 1.40-1.55(2H, m), m/z=363.

Example 142 Synthesis of K-2303(N-{5-[(2,4-dimethylphenyl)thio]pentyl}N-[(1R)-1-((1-naphthyl)ethyl]amine)

[0808] K-2303 hydrochloride was obtained as white crystals by the samemethod as the one employed for the synthesis of K-2293 but replacing the4-chlorothiophenol and 1,4-dibromobutane respectively by2,4-dimethylthiophenol and 1,5-dibromohexane.

[0809] 400 MHz-NMR 10.51 (1H, bs), 10.00 (1H, bs), 8.25 (1H, d, J=7.1Hz), 7.98 (1H, d, J=8.3 Hz), 7.94 (1H, dd, J=7.8 Hz, J=1.2 Hz), 7.90(1H, d, J=8.3 Hz), 7.53-7.67 (3H, m), 7.05 (1H, d, J=7.8 Hz), 6.90 (1 H,s), 6.85 (1H, d, J=7.8 Hz), 5.14-5.23 (1H, m), 2.67-2.78 (2H, m), 2.67(2H, t, J=7.3 Hz), 2.24 (3H, s), 2.21 (3H s), 2.02 (3H, d, J=6.6 Hz),1.92-2.01 (2H, m), 1.43-1.51 (2H, m), 1.27-1.34 (2H, m), m/z=377.

Example 143 Synthesis of K-2304(N-{4-[(4-methylphenyl)thio]butyl}-N-[(1R)-1-(1-naphthyl)ethyl]amine)

[0810] K-2304 hydrochloride was obtained as white crystals by the samemethod as the one employed for the synthesis of K-2293 but replacing.the 4-chlorothiophenol by 4-methylthiophenol.

[0811] 400 MHz-NMR 10.55 (1H, bs), 10.03 (1H, bs), 8.25 (1H, d, J=7.1Hz), 7.99 (1H, d, J=8.5 Hz), 7.93-7.95 (1H, m), 7.89 (1H, d, J=8.0 Hz),7.06-7.86 (5H, m), 6.96-6.99 (2H, m), 5.18-5.22 (1H, m), 2.68-2.77 (2H,m), 2.69 (2H, t, J=7.2 Hz), 2.25 (3H, s), 2.04-2.14 (2H, m), 2.04 (3H,d, J=6.6 Hz), 1.37-1.55 (2H, m), m/z=349.

Example 144 Synthesis of K-2305(N-{5-[(4-methylphenyl)thio]pentyl}-N-[(1R)-1-((1-naphthyl)ethyl]amine)

[0812] K-2305 hydrochloride was obtained as white crystals by the samemethod as the one employed for the synthesis of K-2293 but replacing the4-chlorothiophencl and 1,4-dibromobutane respectively by4-methylthiophenol and 1,5-dibromopentane.

[0813] 400 MHz-NMR 10.50 (1H, bs), 9.99 (1H, bs), 8.25 (1H, d, J=7.1Hz), 7.98 (1H, d, J=8.3 Hz), 7.94 (1H, dd, J=7.8 Hz, J=1.2 Hz), 7.89(1H, d, J=8.3 Hz), 7.52-7.66 (3H, m), 7.11-7.13 (2H, m), 6.98-7.00 (2H,m), 5.1 8 (1H, bs), 2.68-2.73 (2H, m), 2.71 (2H, t, J=7.2 Hz), 2.24 (3H,s), 2.02 (3H, d, J=6.6 Hz), 1.91-1.99 (2H, m), 1.42-1.50 (2H, m),1.26-1.34 (2H, m), m/z=363.

Example 145 Synthesis of K-2275

[0814] K-2305 hydrochloride was obtained as white crystals by the samemethod as the one employed for the synthesis of K-2293 but replacing the4-chlorothiophenol and 1,4-dibromobutane respectively by3-trifluoromethylthiophenol and 1-bromo-2-chloroethane.

[0815] 400 MHz-NMR 10.88 (1H, bs), 10.25 (1H, bs), 8.16 (1H, d, J=6.6Hz), 7.87-7.95 (3H, m), 7.52-7.65 (3H, m), 7.40 (1H, bs), 7.31 -7.34(2H, m), 7.21-7.26 (1H, m), 5.18-5.28 (1H, m), 3.53 (2H, t, J=7.7 Hz),2.91 -3.06 (2H, m), 2.01 (3H, d, J=6.84 Hz), m/z=375.

Example 146 Synthesis of K-2314

[0816] K-2314 hydrochloride was obtained as white crystals by the samemethod as the one employed for the synthesis of K-2293 but replacing the4-chlorothiophenol by 4-methoxythiophenol.

[0817] 400 MHz-NMR 10.55 (1H, bs), 10.03 (1H, bs), 8.25 (1H, d, J=7.4Hz), 7.99 (1H, d, J=8.5 Hz), 7.89-7.95 (2H, m), 7.52-7.68 (3H, m),7.15-7.18 (2H, m), 6.71-6.75 (2H, m), 5.18-5.22 (1H, m), 3.74 (3H, s),2.67-2.76 (2H, m), 2.64 (2H, t, J=7.1 Hz), 2.03-2.15 (2H, m), 2.05 (2H,d, J=6.8 Hz), 1.32-1.50 (2H, m), m/z=365.

Example 147 Synthesis of K-2008

[0818] K-2008 hydrochloride was obtained as white crystals by the samemethod as the one employed for the synthesis of K-2293 but replacing the4-chlorothiophenol, 1,4-dibromobutane and(R)-(+)-1-(1-naphthyl)ethylamine respectively by3-trifluoromethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-methylbenzylamine. m/z=355.

Example 148 Synthesis of S-1

[0819] 2,5-Dimethylthiophenol (580 mg, 4.20 mmol) was dissolved inacetonitrile (6 ml). To the obtained solution were successively added atroom temperature potassium carbonate (785 mg, 5.68 mmol) and1-bromo-2-chloroethane (0.35 ml, 4.21 mmol) and the reaction mixture wasstirred at room temperature for 2.5 hours. After confirming thecompletion of the reaction by TLC, potassium carbonate (730 mg, 5.28mmol) and (R)-(+)-3-methoxy-α-benzylmethylamine (500 mg, 3.30 mmol) wereadded at the same temperature to the reaction system. Further, thereaction mixture was stirred at 90° C. for 24 hours. After thecompletion of the reaction, the mixture was cooled by allowing to standat room temperature and water was added thereto. Next, the reactionmixture was subjected to separatory extraction with chloroform and asaturated aqueous solution of sodium chloride and washed. The organiclayer thus obtained was dried over anhydrous sodium sulfate andconcentrated under reduced pressure. The organic residue was purified bysilica gel column chromatography (chloroform:methanol=200:1) to therebygive a pale yellow, syrupy compound S-1 (332 mg, 1.05 mmol, yield:31.8%).

[0820] 500 MHz-¹H-NMR 7.30 (1H, d, J=8.0 Hz), 7.21 (1H, dd, J=8.0 Hz,J=8.0 Hz), 7.06 (1H, s), 6.86-6.90 (3H, m), 6.75-6.78 (1H, m), 3.80 (3H,s), 3.74 (1H, q, J=6.5 Hz), 2.95-3.03 (2H, m), 2.68-2.77 (2H, m), 2.32(3H, s), 2.27 (3H, s), 1.34 (3H, d, J=6.5 Hz), m/z=315.

Example 149 Synthesis of S-2

[0821] S-2 was synthesized by almost the same method as the one employedfor the synthesis of S-1 but replacing the 1-bromo-2-chloroethane by1,3-dibromopropane.

[0822] 500 MHz-¹H-NMR 7.22 (1H, dd, J=8.0 Hz, J=8.0 Hz), 7.06 (1H, s),7.02 (1H, d, J=7.5 Hz), 6.86-6.88 (3H, m), 6.76-6.78 (1H, m), 3.80 (3H,s), 3.72 (1H, q, J=6.5 Hz), 2.85-2.96 (2H, m), 2.53-2.66 (2H, m), 2.29(3H, s), 2.28 (3H, s), 1.74-1.82 (2H, m), 1.33 (3H, d, J=6.5 Hz),m/z=329.

Example 150 Synthesis of S-3

[0823] S-3 was synthesized by almost the same method as the one employedfor the synthesis of S-1 but replacing the 1-bromo-2-chloroethane by1,4-dibromobutane.

[0824] 500 MHz-¹H-NMR 7.22 (1H, dd, J=8.3 Hz, J=8.3 Hz), 7.04 (1H, s),7.03 (1H, d, J=8.0 Hz), 6.85-6.89 (3H, m), 6.75-6.78 (1H, m), 3.80 (3H,s), 3.71 (1H, q, J=6.8 Hz), 2.85 (2H, t, J=7.3 Hz), 2.42-2.55 (2H, m),2.30 (3H, s), 2.29 (3H, s), 1.56-1.70 (4H, m), 1.33 (3H, d, J=6.8 Hz),m/z=343.

Example 151 Synthesis of S-4

[0825] S-4 was synthesized by almost the same method as the one employedfor the synthesis of S-1 but replacing the 1-bromo-2-chloroethane by1,5-dibromopentane.

[0826] 500 MHz-¹H-NMR 7.23 (1H, dd, J=8.3 Hz, J=8.3 Hz), 7.05 (1H, s),7.03 (1H, d, J=7.5 Hz), 6.87-6.88 (3H, m), 6.76-6.78 (1H, m), 3.81 (3H,s), 3.72 (1H, q, J=6.5 Hz), 2.85 (1H, t, J=7.5 Hz), 2.40-2.51 (2H, m),2.31 (3H, s), 2.30 (3H, s), 1.61-1.67 (2H, m), 1.42-1.51 (4H, m), 1.34(3H, d, J=6.5 Hz), m/z=357.

Example 152 Synthesis of S-5

[0827] S-5 was synthesized by almost the same method as the one employedfor the synthesis of S-1 but replacing the 1-bromo-2-chloroethane by1,6-dibromohexane.

[0828] 500 MHz-¹H-NMR 7.23 (1H, dd, J=8.0 Hz, J=8.0 Hz), 7.05 (1H, s),7.03 (1H, d, J=8.0 Hz), 6.86-6.89 (3H, m), 6.76-6.78 (3H, m), 3.81 (3H,s), 3.72 (1H, q, J=7.0 Hz), 2.85 (2H, t, J=7.3 Hz), 2.39-2.52 (2H, m),2.31 (3H, s), 2.30 (3H, s), 1.61-1.67 (2H, m), 1.39-1.50 (4H), 1.34 (3H,d, J=7.0 Hz), 1.29-1.34 (2H, m), m/z=371.

Example 153 Synthesis of S-6

[0829] S-6 was synthesized by almost the same method as the one employedfor the synthesis of S-1 but replacing the 1-bromo-2-chloroethane by1,7-dibromoheptane.

[0830] 500 MHz-¹H-NMR 7.22 (1H, dd, J=8.0 Hz, J=8.0 Hz), 7.05 (1H, s),7.03 (1H, d, J=7.5 Hz), 6.80-6.86 (3H, m), 6.75-6.78 (1H, m), 3.81 (3H,s), 3.72 (1H, q, J=6.8 Hz), 2.85 (2H, t, J=7.5 Hz), 2.38-2.51 (2H, m),2.31 (3H, s), 2.29 (3H, s), 1.60-1.66 (2H, m), 1.37-1.48 (4H, m), 1.34(3H, d, J=6.8 Hz), 1.27-1.30 (4H, m), m/z=385.

Example 154 Synthesis of S-7

[0831] S-7 was synthesized by almost the same method as the one employedfor the synthesis of S-1 but replacing the 1-bromo-2-chloroethane by1,8-dibromooctane.

[0832] 500 MHz-¹H-NMR 7.23 (1H, dd, J=8.3 Hz, J=8.3 Hz), 7.06 (1H, S),7.03 (1H, d, J=8.0 Hz), 6.87-6.89 (3H, m), 6.75-6.78 (1H, m), 3.81 (3H,s), 3.72 (1H, q, J=6.5 Hz), 2.86 (2H, t, J=7.5 Hz), 2.39-2.51 (2H, m),2.31 (3H, s), 2.30 (3H, s), 1.61-1.67 (2H, m), 1.38-1.47 (4H, m), 1.34(3H, d, J=6.5 Hz),1.23-1.31 (6H, m), m/z=399.

Example 155 Synthesis of S-8

[0833] S-8 was synthesized by almost the same method as the one employedfor the synthesis of S-1 but replacing the(R)-(+)-3-methoxy-α-benzylmethylamine by(R)-(+)-1-(1-naphthyl)ethylamine.

[0834] 500 MHz-¹H-NMR 8.16 (1H, d, J=8.8 Hz), 7.83-7.87 (1H, m), 7.74(1H, d, J=8.0 Hz), 7.64 (1H, d, J=7.1 Hz), 7.42-7.51 (3H, m), 7.05 (1H,s), 7.03 (1H, d, J=8.0 Hz), 6.88 (1H, d, J=7.8 Hz), 4.63 (1 H, q, J=6.6Hz), 3.05 (2H, t, J=6.6 Hz), 2.77-2.87 (2H, m), 2.32 (3H, S), 2.24 (3H,s), 1.49 (3H, d, J=6.6 Hz), m/z=335.

Example 156 Synthesis of S-9

[0835] S-9 was synthesized by almost the same method as the one employedfor the synthesis of S-1 but replacing the 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by 1,3-dibromopropaneand (R)-(+)-1-(1-naphthyl)ethylamine.

[0836] 500 MHz-¹H-NMR 8.18 (1H, d, J=8.3 Hz), 7.83-7.88 (1H, m), 7.74(1H, d, J=8.3 Hz), 7.64 (1H, d, J=6.8 Hz), 7.44-7.52 (3H, m), 7.25 (1H,s), 7.06 (1H, s), 7.02 (1H, d, J=7.7 Hz), 6.87 (1H, d, J=7.7 Hz), 4.62(1H, q, J=6.6 Hz), 2.87-3.00 (2H, m), 2.64-2.77 (2H, m), 2.28 (3H, s),2.27 (3H, s), 1.81-1.88 (2H, m), 1.49 (3H, d, J=6.6 Hz), m/z=349.

Example 157 Synthesis of S-10

[0837] S-10 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the1-bromo-2-chloroethane and (R)-(+)-3-methoxy-α-benzylmethylaminerespectively by 1,4-dibromobutane and (R)-(+)-1-(1-naphthyl)ethylamine.

[0838] 500 MHz-¹H-NMR 8.17 (1H, d, J=8.3 Hz), 7.85-7.88 (1H, m), 7.74(1H, d, J=8.0 Hz), 7.66 (1H, d, J=6.8 Hz), 7.03 (1H, s), 7.01 (1H, d,J=7.8 Hz), 6.86-6.89 (1H, m), 4.64 (1H, q, J=6.2 Hz), 2.85 (2H, t J=6.8Hz), 2.55-2.65 (2H, m), 2.30 (3H, s), 2.28 (3H, s),1.65-1.70 (4H, m),1.50 (3H, d, J=6.2 Hz), m/z=363.

Example 158 Synthesis of S-11

[0839] S-11 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the1-bromo-2-chloroethane and (R)-(+)-3-methoxy-α-benzylmethylaminerespectively by 1,5-dibromopentane and (R)-(+)-1-(1-naphthyl)ethylamine.

[0840] 500 MHz-¹H-NMR 8.45 (1H, d, J=8.0 Hz), 8.17 (1H, d, J=8.3 Hz),7.85-7.88 (1H, m), 7.74 (2H, d, J=8.3 Hz), 7.64 (1H, d, J=7.1 Hz),7.42-7.52 (3H, m), 7.01-7.04 (2H, m), 6.87 (1H, q, J=7.6 Hz), 4.62 (1H,q, J=6.5 Hz), 2.85 (2H, t, J=7.3 Hz), 2.51-2.63 (2H, m), 3.00 (3H,s),2.29 (3H, s), 1.61-1.68 (2H, m), 1.44-1.57 (4H, m), 1.49 (3H, d,J=6.5 Hz), m/z=377.

Example 159 Synthesis of S-12

[0841] S-12 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the1-bromo-2-chloroethane and (R)-(+)-3-methoxy-α-benzylmethylaminerespectively by 1,6-dibromohexane and (R)-(+)-1-(1-naphthyl)ethylamine.

[0842] 500 MHz-¹H-NMR 8.17 (1H, d, J=8.3 Hz), 7.73 (1H, d, J=8.0 Hz),7.64 (1H, d, J=7.1 Hz), 7.40-7.52 (3H, m), 6.06-6.98 (2H, m), 6.87 (1H,d, J=7.6 Hz), 4.62 (1H, q, J=6.6 Hz), 2.84 (2H, t, J=7.3 Hz), 2.49-2.63(2H, m), 2.30 (3H, s), 2.29 (3H, s), 1.59-1.67 (2H, m), 1.46-1.55 (2H,m), 1.49 (3H, d, J=6.6 Hz), 1.27-1.46 (4H, m), m/z=391.

Example 160 Synthesis of S-13

[0843] S-13 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the1-bromo-2-chloroethane and (R)-(+)-3-methoxy-α-benzylmethylaminerespectively by 1,7-dibromoheptane and (R)-(+)-1-(1-naphthyl)ethylamine.

[0844] 500 MHz-¹H-NMR 8.17 (1H, d, J=8.3 Hz), 7.85-7.88 (1H, m), 7.74(1H, d, J=8.3 Hz), 7.68 (1H, d, J=7.1 Hz), 7.41-7.53 (3H, m), 7.04 (1H,s), 7.02 (1H, d, J=7.6 Hz), 6.87 (1H, d, J=7.6 Hz), 4.66 (1H, q, J=6.5Hz), 2.84 (2H, t, J=7.3 Hz), 2.30 (3H, s), 2.29 (3H, s), 1.58-1.66 (2H,m), 1.53 (3H, d, J=6.5 Hz), 1.34-1.44 (2H, m), 1.26-1.30 (4H, m),m/z=405.

Example 161 Synthesis of S-14

[0845] S-14 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the1-bromo-2-chloroethane and (R)-(+)-3-methoxy-α-benzylmethylaminerespectively by 1,8-dibromooctane and (R)-(+)-1-(1-naphthyl)ethylamine.m/z =419.

Example 162 Synthesis of S-15

[0846] S-15 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the1-bromo-2-chloroethane and (R)-(+)-3-methoxy-α-benzylmethylaminerespectively by 1,10-dibromodecane and (R)-(+)-1-(1-naphthyl)ethylamine.

[0847] 400 MHz-¹H-NMR 8.18 (1H, d, J=8.6 Hz), 7.83-7.88 (1H, m), 7.73(1H, d, J=8.3 Hz), 7.65 (1H, d, J=6.8 Hz), 7.40-7.52 (3H, m), 7.06 (1H,s), 7.03 (1H, d, J=7.6 Hz), 6.87 (1H, d, J=7.6 Hz), 4.63 (1H, q, J=6.5Hz), 2.86 (2H, t, J=7.3 Hz), 2.50-2.62 (2H, m), 2.31 (3H, s), 2.30 (3H,s), 1.60-1.70 (2H, m), 1.49 (3H, d, J=6.5 Hz), 1.20-1.50 (14H, m),m/z=447.

Example 163 Synthesis of S-16

[0848] S-16 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the1-bromo-2-chloroethane and (R)-(+)-3-methoxy-α-benzylmethylaminerespectively by 1,12-dibromododecane and(R)-(+)-1-(1-naphthyl)ethylamine.

[0849] 400 MHz-¹H-NMR 8.17 (1H, d, J=8.3 Hz), 7.85-7.88 (1H, m), 7.74(1H, d, J=8.0 Hz), 7.65 (1H, d, J=7.1 Hz), 7.46-7.53 (3H, m), 7.06 (1H,s), 7.03 (1H, d, J=7.8 Hz), 6.87 (1H, d, J=7.8 Hz), 4.63 (1H, q, J=6.6Hz), 2.87 (2H, t, J=7.4 Hz), 2.50-2.63 (2H, m), 2.31.(3H, s), 2.30 (3H,s), 1.61-1.69 (2H, m), 1.15-1.55 (18H, m), 1.50 (3H, d, J=6.6 Hz),m/z=475.

Example 164 Synthesis of S-17

[0850] S-17 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol by 2,4-dimethylthiophenol.

[0851] 400 MHz-¹H-NMR 7.21 (1H, dd, J=8.0 Hz, J=8.0 Hz), 7.14 (1H, d,J=8.0 Hz), 6.98 (1H, s), 6.90-6.92 (1H, m), 6.85-6.88 (2H, m), 6.75-6.81(1H, m), 3.80 (3H, s), 3.72 (1H, q, J=6.6 Hz), 2.93-2.97 (2H, m),2.62-2.74 (2H, m), 2.34 (3H, s), 2.27 (3H, s), 1.33 (3H, d, J=6.6 Hz),m/z=315.

Example 165 Synthesis of S-18

[0852] S-18 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by2,4-dimethylthiophenol and 1,3-dibromopropane.

[0853] 400 MHz-¹H-NMR 7.22 (1H, dd, J=8.1 Hz, J=8.1 Hz), 7.16 (1H, d,J=7.8 Hz), 6.98 (1H, s), 6.92-6.95 (1H, m), 6.86-6.88.(2H, m), 6.75-6.79(1H, m), 3.80 (3H, s), 3.71 (1H, q, J=6.6 Hz), 2.80-2.93 (2H, m),2.51-2.65 (2H, m), 2.32 (3H, s), 2.28 (3H, s), 1.70-1.81 (2H, m), 1.32(3H, d, J=6.6 Hz), m/z=329.

Example 166 Synthesis of S-19

[0854] S-19 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by2,4-dimethylthiophenol and 1,4-dibromobutane.

[0855] 400 MHz-¹H-NMR 7.23 (1H, dd, J=8.3 Hz, J=8.3 Hz), 7.16 (1H, d,J=7.8 Hz), 6.98 (1H, slike), 6.93-6.95 (1H, m), 6.86-6.88 (2H, m),6.75-6.79 (1H, m), 3.80 (3H, s), 3.71 (1H, q, J=6.6 Hz), 2.81 (2H, t,J=6.9 Hz), 2.40-2.54 (2H, m), 2.33 (3H, s), 2.28 (3H, s), 1.53-1.66 (4H,m), 1.33 (3H, d, J=6.6 Hz), m/z=343.

Example 167 Synthesis of S-20

[0856] S-20 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by2,4-dimethylthiophenol and 1,5-dibromopentane.

[0857] 400 MHz-¹H-NMR 7.23 (1H, dd, J=8.0 Hz, J=8.0 Hz), 7.16 (1H, d,J=7.8 Hz), 6.98 (1H, s), 6.95 (1H, d, J=8.0 Hz), 6.66-6.89 (2H, m).,6.70-6.79 (1H, m), 3.81 (3H, s), 3.71 (1H, q, J=6.6 Hz), 2.81 (2H, t,J=7.3 Hz), 2.38-2.52 (2H, m), 2.33 (3H, s), 2.28 (3H, s), 1.56-1.64 (2H,m), 1.35-1.50 (4H, m), 1.34 (3H, d, J=6.6 Hz), m/z=357.

Example 168 Synthesis of S-21

[0858] S-21 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by2,4-dimethylthiophenol and 1,6-dibromohexane.

[0859] 400 MHz-¹H-NMR 7.23 (1H, dd, J=8.0 Hz, J=8.0 Hz), 7.16 (1H, d,J=7.8 Hz), 6.98 (1H, s), 6.93-6.96 (1H, m), 6.87-6.90 (2H, m), 6.75-6.79(1H, m), 3.81 (3H, s), 3.72 (1H, q, J=6.6 Hz), 2.81 (2H, t, J=7.3 Hz),2.38-2.51 (2H, m), 2.34 (3H, s), 2.28 (3H, s), 1.56-1.64 (2H, m),1.24-1.50 (6H, m), 1.34 (2H, d, J=6.6 Hz), m/z=371.

Example 169 Synthesis of S-22

[0860] S-22 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by2,4-dimethylthiophenol and 1,7-dibromoheptane.

[0861] 400 MHz-¹H-NMR 7.23 (1H, dd, J=8.0 Hz, J=8.0 Hz), 7.16 (1H, d,J=7.8 Hz), 6.99 (1H, s), 6.93-6.96 (1H, m), 6.87-6.90 (2H, m), 6.73-6.79(1H, m), 3.81 (3H, s), 3.72 (1H, q, J=6.6 Hz), 2.81 (2H, t, J=7.4 Hz),2.37-2.51 (2H, m), 2.34 (3H, s), 2.28 (3H, s), 1.56-1.64 (2H, m),1.24-1.46 (8H, m), 1.34 (3H, d, J=6.6 Hz), m/z=385.

Example 170 Synthesis of S-23

[0862] S-23 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by2,4-dimethylthiophenol and 1,8-dibromooctane.

[0863] 400 MHz-¹H-NMR 7.23 (1H, dd, J=8.3 Hz, J=8.3 Hz), 7.17 (1H, d,J=8.0 Hz), 6.99 (1H, s), 6.95 (1H, d, J=8.0 Hz), 6.87-6.89 (1 H, m),6.75-6.79 (1H, m), 3.81 (3H, s),3.72 (1H, q, J=6.6 Hz), 2.82 (2H, t,J=7.4 Hz), 2.38-2.52 (2H, m), 2.34 (3H, s), 2.28 (3H, s), 1.55-1.64 (2H,m), 1.20-1.50 (10H, m), 1.34 (3H, d, J=6.6 Hz), m/z=399.

Example 171 Synthesis of S-24

[0864] S-24 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and (R)-(+)-3-methoxy-α-benzylmethylaminerespectively by 2,4-dimethylthiophenol and(R)-(+)-1-(1-naphthyl)ethylamine.

[0865] 400 MHz-¹H-NMR 8.15 (1H, d, J=8.16 Hz), 7.83-7.90 (1 H, m), 7.72(1H, d, J=8.0 Hz), 7.63 (1H, d, J=7.3 Hz), 7.42-7.52 (3H, m), 7.14 (1H,d, J=7.8 Hz), 6.98 (1H, s), 6.87-6.90 (1H, m), 4.61 (1H, q, J=6.5 Hz),3.02 (2H, t, J=8.7 Hz), 2.73-2.81 (2H, m), 2.34 (3H, s), 2.27 (3H, s),1.48 (3H, d, J=6.5 Hz), m/z=335.

Example 172 Synthesis of S-25

[0866] S-25 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by2,4-dimethylthiophenol, 1,3-dibromopropane and(R)-(+)-1-(1-naphthyl)ethylamine. m/z=349.

Example 173 Synthesis of S-26

[0867] S-26 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by2,4-dimethylthiophenol, 1,6-dibromohexane and(R)-(+)-1-(1-naphthyl)ethylamine.

[0868] 400 MHz-¹H-NMR 8.15 (1H, d, J=8.31 Hz), 7.85-7.87 (1H, m), 7.23(1H, d, J=8.3 Hz), 7.64 (1H, d, J=7.1 Hz), 7.15 (1H, d, J=7.8 Hz), 6.98(1H, s), 6.93-6.95 (1H, m), 4.62 (1H, q, J=6.6 Hz), 2.80 (2H, t, J=7.3Hz), 2.48-2.62 (2H, m), 2.35 (3H, s), 2.27 (3H, s), 1.57-1.63 (2H, m),1.43-1.53 (2H, m), 1.25-1.44 (4H, m), 1.49 (3H, d, J=6.6 Hz), m/z=391.

Example 174 Synthesis of S-27

[0869] S-27 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by2,4-dimethylthiophenol, 1,7-dibromoheptane and(R)-(+)-1-(1-naphthyl)ethylamine.

[0870] 400 MHz-¹H-NMR 8.15 (1H, d, J=8.3 Hz), 7.87 (1H, d, J=6.0 Hz),7.68-7.78 (2H, m), 7.45-7.55 (3H, m), 7.15 (1H, d, J=7.8 Hz), 6.98 (1H,s), 6.94 (1H, d, J=7.8 Hz), 4.69 (1H, q, J=6.6 Hz), 2.79 (2H, t, J=7.3Hz), 2.50-2.63 (2H, m), 2.33 (3H, s), 2.27 (3H, s), 1.14-1.62 (13H, m),m/z=405.

Example 175 Synthesis of S-28

[0871] S-28 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by2,4-dimethylthiophenol, 1,8-dibromooctane and (R)-(+)-1-(1-naphthyl)ethylamine.

[0872] 400 MHz-¹H-NMR 8.15 (1H, d, J=8.0 Hz), 7.86-7.90 (1H, m),7.70-7.80 (2H, m), 7.45-7.55 (3H, m), 7.16 (1H, d, J=7.8 Hz), 6.98 (1H,s), 6.94 (1H, d, J=7.8 Hz), 4.72 (1H, q, J=6.4 Hz), 2.80 (2H, t, J=7.4Hz), 2.50-2.65 (2H, m), 2.33 (3H, s), 2.27 (3H, s), 1.17-1.63 (15H, m),m/z=419.

Example 176 Synthesis of S-29

[0873] S-29 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol by 2,6-dimethylthiophenol.

[0874] 400 MHz-¹H-NMR 7.21 (1H, dd, J=8.1 Hz, J=8.1 Hz), 7.05-7.12 (3H,m), 6.83-6.86 (2H, m), 6.73-6.78 (1H, m), 3.80 (3H, s), 3.69 (1H, q,J=6.6 Hz), 2.72-2.82 (2H, m), 2.57-2.64 (2H, m), 2.51 (6H, s), 1.32 (3H,d, J=6.6 Hz), m/z=315.

Example 177 Synthesis of S-30

[0875] S-30 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by2,6-dimethylthiophenol and 1,3-dibromopropane.

[0876] 400 MHz-¹H-NMR 7.22 (1H, dd, J=8.1 Hz, J=8.1 Hz), 7.05-7.09 (3H,m), 6.84-6.86 (2H, m), 6.74-6.78 (1H, m), 3.80 (3H, s), 3.69 (1H, q,J=6.6 Hz), 2.62-2.70 (2H, m), 2.51-2.60 (2H, m), 2.50 (6H, s), 1.61-1.70(2H, m),1.32 (3H, d, J=6.6 Hz), m/z=329.

Example 178 Synthesis of S-31

[0877] S-31 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by2,6-dimethylthiophenol and 1,4-dibromobutane.

[0878] 400 MHz-¹H-NMR 7.22 (1H, dd, J=8.0 Hz, J=8.0 Hz), 7.04-7.09 (3H,m), 6.85-6.88 (2H, m), 6.77 (1 H, ddd, J=8.OHz, J=2.4 Hz, J=1.0 Hz),3.80 (3H, s), 3.70 (1H, q, J=6.6 Hz), 2.61 (2H, t, J=6.7 Hz), 2.51 (6H,s), 2.39-2.48 (2H, m), 1.48-1.58 (4H, m), 1.32 (3H, d, J=6.6 Hz),m/z=343.

Example 179 Synthesis of S-32

[0879] S-32 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by2,6-dimethylthiophenol and 1,5-dibromopentane.

[0880] 400 MHz-¹H-NMR 7.23 (1H, dd, J=8.0 Hz, J=8.0 Hz), 7.06-7.11 (1H,m), 6.86-6.88 (2H, m), 6.75-6.79 (1H, m), 3.81 (3H, s), 3.71 (1H, q,J=6.6 Hz), 2.61 (2H, t, J=7.3 Hz), 2.52 (6H, s), 2.38-2.49 (2H, m),1.34-1.54 (6H, m), 1.33 (3H, d, J=6.6 Hz), m/z=357.

Example 180 Synthesis of S-33

[0881] S-33 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by2,6-dimethylthiophenol and 1,6-dibromohexane.

[0882] 400 MHz-¹H-NMR 7.23 (1H, dd, J=8.0 Hz, J=8.0 Hz), 7.07-7.11 (3H,m), 6.86-6.88 (2H, m), 6.75-6.79 (1H, m), 3.81 (3H, s), 3.71 (1H, q,J=6.6 Hz), 2.61 (2H, t, J=7.3 Hz), 2.52 (6H, s), 2.36-2.50 (2H, m),1.21-1.54 (8H, m), 1.33 (3H, d, J=6.6 Hz), m/z=371.

Example 181 Synthesis of S-34

[0883] S-34 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by2,6-dimethylthiophenol and 1,7-dibromoheptane.

[0884] 400 MHz-¹H-NMR 7.20-7.25 (1H, m), 7.07-7.09 (3H, m), 6.86-6.90(2H, m), 6.75-6.78 (1H, m), 3.81 (3H, s), 3.72 (1 H, q, J=6.6 Hz), 2.61(2H, t, J=7.32 Hz), 2.53 (6H, s), 2.36-2.50 (2H, m), 1.20-1.54 (10H, m),1.34 (3H, d, J=6.6 Hz), m/z=385.

Example 182 Synthesis of S-35

[0885] S-35 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by2,6-dimethylthiophenol and 1,8-dibromooctane.

[0886] 400 MHz-¹H-NMR 7.20-7.25 (1H, m), 7.05-7.10 (3H, m), 6.88-6.89(2H, m), 6.76-6.79 (1H, m), 3.81 (3H, s), 3.73 (1H, q, J=6.5 Hz), 2.61(2H, t, J=7.3 Hz), 2.53 (6H, s), 2.37-2.49 (2H, m), 1.20-1.55 (12H, m),1.35 (3H, d, J=6.5 Hz), m/z=399.

Example 183 Synthesis of S-36

[0887] S-36 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and (R)-(+)-3-methoxy-α-benzylmethylaminerespectively by 2,6-dimethylthiophenol and(R)-(+)-1-(1-naphthyl)ethylamine.

[0888] 400 MHz-¹H-NMR 8.15 (1H, d, J=8.0 Hz), 7.83-7.90 (1H, m), 7.73(1H, d, J=8.3 Hz), 7.63 (1H, d, J=7.1 Hz), 7.43-7.52 (3H, m), 7.04-7.12(3H, m), 4.59 (1H, q, J=6.6 Hz), 2.77-2.86 (2H, m), 2.70 (2H, t, J=6.6Hz), 2.50 (6H, s), 1.47 (3H, d, J=6.6 Hz), m/z=335.

Example 184 Synthesis of S-37

[0889] S-37 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by2,6-dimethylthiophenol, 1,3-dibromopropane and (R)-(+)-1-(1-naphthyl)ethylamine.

[0890] 400 MHz-¹H-NMR 8.15 (1H, d, J=8.0 Hz), 7.84-7.87 (1H, m), 7.73(1H, d, J=8.3 Hz), 7.62 (1H, d, J=7.1 Hz), 7.44-7.51 (3H, m), 7.04-7.11(3H, m), 4.58 (1H, q, J=6.5 Hz), 2.58-2.73 (4H, m), 2.50 (6H, s),1.68-1.75 (2H, m), 1.47 (3H, d, J=6.5 Hz), m/z=349.

Example 185 Synthesis of S-38

[0891] S-38 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by2,6-dimethylthiophenol, 1,4-dibromobutane and(R)-(+)-1-(1-naphthyl)ethylamine.

[0892] 400 MHz-¹H-NMR 8.16 (1H, d, J=8.3 Hz), 7.85-7.88 (1H, m), 7.73(1H, d, J=8.3 Hz), 7.63 (1H, d, J=7.1 Hz), 7.44-7.52 (3H, m), 7.05-7.11(3H, m), 4.61 (1H, q, J=6.5 Hz), 2.61 (2H, t, J=7.3 Hz), 2.50-2.59 (2H,m), 2.50 (6H, s), 1.50-1.64 (4H, m), 1.48 (3H, d, J=6.5 Hz), m/z=363.

Example 186 Synthesis of S-39

[0893] S-39 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by2,6-dimethylthiophenol, 1,5-dibromopentane and(R)-(+)-1-(1-naphthyl)ethylamine.

[0894] 400 MHz-¹H-NMR 8.17 (1H, d, J=8.0 Hz), 7.85-7.88 (1H, m), 7.74(1H, d, J=8.3 Hz), 7.63 (1H, d, J=7.1 Hz), 7.44-7.52 (3H, m), 7.06-7.08(3H, m), 4.61 (1H, q, J=6.6 Hz), 2.61 (2H, t, J=7.1 Hz), 2.50-2.58 (2H,m), 2.51 (6H, s), 1.35-1.55 (6H, m), 1.48 (3H, d, J=6.6 Hz), m/z=377.

Example 187 Synthesis of S-40

[0895] S-40 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by2,6-dimethylthiophenol, 1,6-dibromohexane and(R)-(+)-1-(1-naphthyl)ethylamine.

[0896] 400 MHz-¹H-NMR 8.17 (1H, d, J=8.0 Hz), 7.85-7.87 (1H, m), 7.74(1H, d, J=8.0 Hz), 7.64 (1H, d, J=5.9 Hz), 7.44-7.52 (3H, m), 7.05-7.09(3H, m), 4.62 (1H, q, J=6.5 Hz), 2.50-2.62 (4H, m), 2.52 (6H, s),1.23-1.53 (8H, m), 1.49 (3H, d, J=6.5 Hz), m/z=391.

Example 188 Synthesis of S-41

[0897] S-41 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by2,6-dimethylthiophenol, 1,7-dibromoheptane and(R)-(+)-1-(1-naphthyl)ethylamine.

[0898] 400 MHz-¹H-NMR 8.17 (1H, d, J=8.3 Hz), 7.85-7.88 (1H, m), 7.74(1H, d, J=8.3 Hz), 7.64 (1H, d, J=7.1 Hz), 7.44-7.53 (3H, m), 7.07-7.09(3H, m), 4.62 (1H, q, J=6.6 Hz), 2.50-2.62 (4H, m), 2.52 (6H, s),1.20-1.53 (10H, m), 1.49 (3H, d, J=6.6 Hz), m/z=405.

Example 189 Synthesis of S-42

[0899] S-42 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by2,6-dimethylthiophenol, 1,8-dibromooctane and(R)-(+)-1-(1-naphthyl)ethylamine.

[0900] 400 MHz-¹H-NMR 8.15 (1H, d, J=8.6 Hz), 7.86-7.89 (1H, m),7.74-7.78 (2H, m), 7.46-7.54 (3H, m), 6.99-7.10 (3H, m) 4.70-4.78 (1H,m), 2.51-2.62 (4H, m), 2.52 (6H, s), 1.07-1.84 (12H, m), 1.59 (3H, d,J=6.1 Hz), m/z=419.

Example 190 Synthesis of S-43

[0901] S-43 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol by 3,4-dimethylthiophenol.

[0902] 400 MHz-¹H-NMR 7.21 (1H, dd, J=8.0 Hz, J=8.0 Hz), 7.11 (1H, s),7.00-7.07 (2H, m), 6.80-6.87 (2H, m), 6.75-6.87 (2H, m), 6.75-6.78 (1H,m), 3.79 (3H, s), 3.72 (1H, q, J=6.5 Hz), 2.95-2.99 (2H, m), 2.63-2.70(2H, m), 2.21 (3H, s), 2.20 (3H, s),1.33 (3H, d, J=6.5 Hz), m/z=315.

Example 191 Synthesis of S-44

[0903] S-44 was synthesized by almost the sarne method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by3,4-dimethylthiophenol and 1,3-dibromopropane.

[0904] 400 MHz-¹H-NMR 7.20-7.25 (1H, m), 7.12 (1H, s), 7.01-7.08 (2H,m), 6.84-6.88 (2H, m), 6.75-6.78 (1H, m), 3.80 (3H, s), 3.70 (1H, q,J=7.0 Hz), 2.83-2.95 (2H, m), 2.50-2.63 (2H, m), 2.22 (3H, s), 2.21 (3H,s), 1.72-1.77 (2H, m), 1.32 (3H, d, J=7.0 Hz), m/z=329.

Example 192 Synthesis of S-45

[0905] S-45 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by3,4-dimethylthiophenol and 1,4-dibromobutane.

[0906] 400 MHz-¹H-NMR 7.22 (1H, dd, J=8.0 Hz, J=8.0 Hz), 7.11 (1H, s),7.01 -7.07 (2H, m), 6.85-6.87 (2H, m), 6.75-6.78 (1 H, m), 3.80 (3H, s),3.70 (1H, q, J=7.0 Hz), 2.84 (2H, t, J=7.5 Hz), 2.40-2.52 (2H, m), 2.22(3H, s), 2.21 (3H, s), 1.54-1.65 (4H, m), 1.32 (3H, d, J=7.0 Hz),m/z=343.

Example 193 Synthesis of S-46

[0907] S-46 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by3,4-dimethylthiophenol and 1,5-dibromopentane. m/z=357.

Example 194 Synthesis of S-47

[0908] S-47 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by3,4-dimethylthiophenol and 1,6-dibromohexane.

[0909] 400 MHz-¹H-NMR 7.23 (1H, dd, J=8.0 Hz, J=8.0 Hz), 7.12 (1H,s),7.02-7.08 (2H, m), 6.86-6.89 (2H, m), 6.75-6.78 (1H, m), 3.81 (3H,s), 3.71 (1H, q, J=7.0 Hz), 2.84 (2H, t, J=7.3 Hz), 2.38-2.50 (2H, m),2.23 (3H, s), 2.22 (3H, s),1.56-1.62 (2H, m), 1.24-1.48 (6H, m), 1.33(3H, d, J=7.0 Hz), m/z=377.

Example 195 Synthesis of S-48

[0910] S-48 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by3,4-dimethylthiophenol and 1,7-dibromoheptane.

[0911] 400 MHz-¹H-NMR 7.22 (1H, dd, J=8.0 Hz, J=8.0 Hz), 7.11 (1H, s),7.01-7.08 (2H, m), 6.86-6.88 (2H, m), 6.75-6.78 (1H, m), 3.80 (3H, s),3.71 (1H, q, J=6.5 Hz), 2.80 (2H, t, J=7.5 Hz), 2.38-2.50 (2H, m), 2.22(3H, s), 2.21 (3H, s), 1.56-1.62 (2H, m), 1.33-1.45 (4H, m), 1.33 (3H,d, J=6.5Hz), 1.24-1.28 (4H, m), m/z=385.

Example 196 Synthesis of S-49

[0912] S-49 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by3,4-dimethylthiophenol and 1,8-dibromooctane.

[0913] 400 MHz-¹H-NMR 7.21-7.25 (1H, m), 7.12 (1 H, s), 7.02-7.08 (2H,m), 6.87-6.89 (1H, d, J=8.0 Hz), 6.87 (1H, s), 6.76-6.78 (1 H, m), 3.80(3H, s), 3.70-3.74 (1H, m), 2.85 (2H, t, J=7.8 Hz), 2.38-2.50 (2H, m),2.22 (3H, s), 2.21 (3H, s), 1.56-1.62 (2H, m), 1.33-1.46 (4H, m), 1.34(3H, d, J=7.0 Hz), 1.25 (6H, bs), m/z=399.

Example 197 Synthesis of S-50

[0914] S-50 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and (R)-(+)-3-methoxy-α-benzylmethylaminerespectively by 3,4-dimethylthiophenol and(R)-(+)-1-(1-naphthyl)ethylamine.

Example 198 Synthesis of S-51

[0915] S-51 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by3,4-dimethylthiophenol, 1,3-dibromopropane and(R)-(+)-1-(1-naphthyl)ethylamine.

[0916] 400 MHz-¹H-NMR 8.16 (1H, d, J=8.5 Hz), 8.85 (1H, d, J=9.0 Hz),7.72 (1H, d, J=8.0 Hz), 7.61 (1H, d, J=7.5 Hz), 7.43-7.49 (3H, m), 7.11(1H, s), 6.97-7.07 (2H, m), 4.58 (1H, q, J=6.5 Hz), 2.85-2.97 (2H, m),2.61-2.73 (2H, m), 2.22 (6H, s), 1.76-1.82 (2H, m), 1.46 (3H, d, J=6.5Hz), m/z=349.

Example 199 Synthesis of S-52

[0917] S-52 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by3,4-dimethylthiophenol, 1,4-dibromobutane and(R)-(+)-1-(1-naphthyl)ethylamine.

[0918] 400 MHz-¹H-NMR 8.86 (1H, d, J=9.0 Hz), 8.18 (1H, d, J=8.5 Hz),7.73 (1H, d, J=8.0 Hz), 7.62 (1H, d, J=7.0 Hz), 7.44-7.51 (3H, m), 7.11(1H, s), 7.01-7.07 (2H, m), 4.60 (1H, q, J=6.5 Hz), 2.84 (2H, t, J=6.8Hz), 2.50-2.62 (2H, m), 1.60-1.68 (4H, m), 1.47 (3H, d, J=6.5 Hz),m/z=363.

Example 200 Synthesis of S-53

[0919] S-53 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by3,4-dimethylthiophenol, 1,5-dibromopentane and(R)-(+)-1-(1-naphthyl)ethylamine.

[0920] 400 MHz-¹H-NMR 8.17 (1H, d, J=8.5 Hz), 7.86 (1H, dd, J=8.0 Hz,J=1.5 Hz), 7.73 (1H, d, J=8.0 Hz), 7.62 (1H, d, J=7.0 Hz), 7.44-7.51(3H, m), 7.11 (1 H s), 7.01-7.09 (2H, m), 4.60 (1H, q, J=6.5 Hz), 2.84(2H, t, J=7.3 Hz), 2.50-2.61 (2H, m), 2.22 (3H, s), 2.24 (3H, s),1.57-1.63 (2H, m), 1.41-1.53 (4H, m), 1.48 (3H, d, J=6.5 Hz), m/z=377.

Example 201 Synthesis of S-54

[0921] S-54 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by3,4-dimethylthiophenol, 1,6-dibromohexane and(R)-(+)-1-(1-naphthyl)ethylamine. m/z=391.

Example 202 Synthesis of S-55

[0922] S-55 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by3,4-dimethylthiophenol, 1,7-dibromoheptane and(R)-(+)-1-(1-naphthyl)ethylamine.

[0923] 400 MHz-¹H-NMR 8.18 (1H, d, J=8.0 Hz), 7.86 (1H, d, J=8.0 Hz),7.73 (1H, d, J=8.0 Hz), 7.63 (1H, d, J=7.5 Hz), 7.39-7.51 (3H, m), 7.11(1H, s), 7.01-7.07 (2H, m), 4.60 (1H, q, J=6.5 Hz), 2.83 (2H, t, J=7.3Hz), 2.49-2.59 (2H, m), 2.22 (3H, s), 2.20 (3H, s), 1.28-1.62 (10H, m),1.48 (3H, d, J=6.5 Hz), m/z=405.

Example 203 Synthesis of S-56

[0924] S-56 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by3,4-dimethylthiophenol, 1,8-dibromooctane and(R)-(+)-1-(1-naphthyl)ethylamine.

[0925] 400 MHz-¹H-NMR 8.18 (1H, d, J=8.0 Hz), 7.87 (1H, d, J=8.0 Hz),7.74 (1H, d, J=8.0 Hz), 7.65 (1H, d, J=7.5 Hz), 7.45-7.52 (3H, m), 7.12(1H, s), 7.02-7.08 (2H, m), 4.63 (1H, q, J=7.0 Hz), 2.84 (2H, t, J=7.3Hz), 2.51-2.62 (2H, m), 2.22 (3H, s), 2.21 (3H, s), 1.56-1.62 (2H, m),1.50 (3H, d, J=7.0 Hz), 1.45-1.55 (2H, m), 1.33-1.42 (2H, m),1.25-1.28(6H, m), m/z=419.

Example 204 Synthesis of S-57

[0926] S-57 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol by 3,5-dimethylthiophenol.

[0927] 400 MHz-¹H-NMR 7.24 (1H, dd, J=8.0 Hz, J=8.0 Hz), 6.96 (2H, s),6.88-6.91 (2H, m), 6.82 (1H, s), 6.78-6.80 (1H, m), 3.82 (3H, s), 3.76(1H, q, J=6.5 Hz), 3.01-3.06 (2H, m), 2.69-2.78 (2H, m), 2.28 (6H, s),1.36 (3H, d, J=6.5 Hz), m/z=315.

Example 205 Synthesis of S-58

[0928] S-58 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by3,5-dimethylthiophenol and 1,3-dibromopropane.

[0929] 400 MHz-¹H-NMR 7.22 (1H, dd, J=8.0 Hz, J=8.0 Hz), 6.93 (2H, s),6.86-6.88 (2H, m), 6.76-6.78 (2H, m), 3.80 (3H, s), 3.71 (1H, q, J=6.5Hz), 2.86-2.98 (2H, m), 2.51-2.65 (2H, m), 2.27 (6H, s), 1.74-1.81 (2H,m), 1.32 (3H, d, J=6.5 Hz), m/z=329.

Example 206 Synthesis of S-59

[0930] S-59 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by3,5-dimethylthiophenol and 1,4-dibromobutane.

[0931] 400 MHz-¹H-NMR 7.22 (1H, dd, J=7.5 Hz, J=7.5 Hz), 6.92 (2H, s),6.86-6.88 (2H, m), 6.75-6.78 (2H, m), 3.80 (3H, s), 3.71 (1H, q, J=7.0Hz), 2.86 (2H, t, J=7.0 Hz), 2.39-2.54 (2H, m), 2.27 (6H, s), 1.55-1.68(4H, m), 1.33 (3H, d, J=7.0 Hz), m/z=343.

Example 207 Synthesis of S-60

[0932] S-60 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by3,5-dimethylthiophenol and 1,5-dibromopentane.

[0933] 400 MHz-¹H-NMR 7.22 (1H, dd, J=8.0 Hz, J=8.0 Hz), 6.92 (2H, s),6.86-6.88 (2H, m), 6.75-6.78 (2H, m), 3.81 (3H, m), 3.71 (1H, q, J=7.0Hz), 2.87 (2H, t, J=7.3 Hz), 2.39-2.51 (2H, m), 2.27 (6H, s), 1.58-1.65(2H, m), 1.40-1.49 (4H, m), 1.33 (3H, d, J=7.0 Hz), m/z=357.

Example 208 Synthesis of S-61

[0934] S-61 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by3,5-dimethylthiophenol and 1,6-dibromohexane.

[0935] 400 MHz-¹H-NMR 7.23 (1H, dd, J=8.0 Hz, J=8.0 Hz), 6.93 (2H, s),6.86-6.89 (2H, m), 6.76-6.78 (2H, m), 3.81 (3H, s), 3.71 (1H, q, J=6.5Hz), 2.87 (2H, t, J=7.3 Hz), 2.39-2.88 (2H, m), 2.27 (6H, s),1.58-1.65(2H, m), 1.36-1.49 (4H, m), 1.33 (3H, d, J=6.5 Hz), 1.25-1.31 (2H, m),m/z=371.

Example 209 Synthesis of S-62

[0936] S-62 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by3,5-dimethylthiophenol and 1,7-dibromoheptane.

[0937] 400 MHz-¹H-NMR 7.23 (1H, dd, J=8.0 Hz, J=8.0 Hz), 6.93 (2H, s),6.86-6.89 (2H, m), 6.75-6.78 (2H, m), 3.81 (3H, s), 3.72 (1 H, q, =7.0Hz), 2.87 (2H, t, J=7.5 Hz), 2.38-2.51 (2H, m), 2.72 (6H, s), 1.58-1.64(2H, m), 1.35-1.47 (4H, m), 1.33 (3H, d, J=7.0 Hz), 1.25-1.30 (4H, m),m/z=385.

Example 210 Synthesis of S-63

[0938] S-63 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by3,5-dimethylthiophenol and 1,8-dibromooctane.

[0939] 400 MHz-¹H-NMR 7.21 (1H, dd, J=8.0 Hz, J=8.0 Hz), 6.91 (2H, s),6.85-6.88 (2H, m), 6.77 (1H, s), 6.74-6.75 (1H, m), 3.79 (3H, s), 3.71(1H, q, J=6.5 Hz), 2.86 (2H, t, J=7.5 Hz), 2.37-2.49 (2H, m), 2.26 (6H,s), 1.57-1.63 (2H, m), 1.34-1.43 (4H, m), 1.32 (3H, d, J=6.5 Hz),1.20-1.30 (6H, m), m/z=399.

Example 211 Synthesis of S-64

[0940] S-64 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and (R)-(+)-3-methoxy-α-benzylmethylaminerespectively by 3,5-dimethylthiophenol and(R)-(+)-1-(1-naphthyl)ethylamine.

[0941] 400 MHz-¹H-NMR 8.15 (1H, d, J=8.0 Hz), 7.85-7.87 (1H, m), 7.72(1H, d, J=8.0 Hz), 7.63 (1H, d, J=6.5 Hz), 7.42-7.52 (3H, m), 6.93 (2H,s), 6.79 (1H, s), 4.62 (1H, q, J=6.5 Hz), 3.05 (2H, t, J=6.5 Hz),2.76-2.84 (2H, m), 2.24 (6H, s,), 1.48 (3H, d, J=6.5 Hz), m/z=335.

Example 212 Synthesis of S-65

[0942] S-65 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and (R)-(+)-3-methoxy-α-benzylmethylamine respectively by 3,5-dimethylthiophenol,1,3-dibromopropane and (R)-(+)-1-(1-naphthyl)ethylamine.

[0943] 400 MHz-¹H-NMR 8.18 (1H, d, J=8.5 Hz), 7.86 (1H, d, J=7.0 Hz),7.24 (1H, d, J=8.5 Hz), 7.63 (1H, d, J=6.5 Hz), 7.45-7.51 (3H, m), 6.93(2H, s), 6.78 (1H, s), 4.60 (1H, q, J=6.5 Hz), 2.89-3.01 (2H, m),2.63-2.75 (2H, m), 2.26 (6H, s), 1.79-1.85 (2H, m), 1.48 (3H, d, J=6.5Hz), m/z=349.

Example 213 Synthesis of S-66

[0944] S-66 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by3,5-dimethylthiophenol, 1,4-dibromobutane and(R)-(+)-1-(1-naphthyl)ethylamine.

[0945] 400 MHz-¹H-NMR 8.86 (1H, d, J=8.5 Hz), 8.18 (1H, d, J=8.0 Hz),7.63 (1H, d, J=7.5 Hz), 7.23 (1H, d, J=8.0 Hz), 7.44-7.51 (3H, m), 6.92(2H, s), 6.78 (1H, s), 4.61 (1H, q, J=7.0 Hz), 2.86-2.88 (2H, m),2.53-2.64 (2H, m), 2.26 (6H, s), 1.60-1.70 (4H, m), 1.48 (3H, d, J=7.0Hz), m/z=363.

Example 214 Synthesis of S-67

[0946] S-67 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by3,5-dimethylthiophenol, 1,5-dibromopentane and(R)-(+)-1-(1-naphthyl)ethylamine.

[0947] 400 MHz-¹H-NMR 8.85 (1H, d, J=7.5 Hz), 8.16 (1H, d, J=8.5 Hz),7.72 (1H, d, J=8.0 Hz), 7.61 (1H, d, J=7.5 Hz), 7.43-7.50 (3H, m), 6.91(2H, s), 6.77 (1H, s), 4.60 (1H, q, J=6.5 Hz), 2.85 (2H, t, J=7.5 Hz),2.49-2.60 (2H, m), 2.25 (6H, s), 1.58-1.64 (2H, m), 1.41-1.53 (4H, m),1.47 (3H, d, J=6.5 Hz), m/z=377.

Example 215 Synthesis of S-68

[0948] S-68 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by3,5-dimethylthiophenol, 1,6-dibromohexane and(R)-(+)-1-(1-naphthyl)ethylamine.

[0949] 400 MHz-¹H-NMR 8.18 (1H, d, J=8.5 Hz), 7.86 (1H, d, J=7.5 Hz),7.73 (1H, d, J=8.0 Hz), 7.63 (1H, d, J=7.5 Hz), 7.46-7.50 (3H, m), 6.92(2H, s), 6.77 (1H, s), 4.61 (1H, q, J=6.5 Hz), 2.86 (2H, t, J=7.3 Hz),2.52-2.61 (2H, m), 2.26 (6H, s), 1.57-1.64 (2H, m), 1.45-1.57 (2H, m),1.48 (3H, d, J=6.5 Hz), 1.35-1.44 (2H, m), 1.29-1.36 (2H, m), m/z=391.

Example 216 Synthesis of S-69

[0950] S-69 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by3,5-dimethylthiophenol, 1,7-dibromoheptane and(R)-(+)-1-(1-naphthyl)ethylamine.

[0951] 400 MHz-¹H-NMR 8.18 (1H, d, J=8.0 Hz), 7.86 (1H, d, J=8.0 Hz),7.73 (1H, d, J=8.0 Hz), 7.64 (1H, d, J=7.5 Hz), 7.45-7.52 (3H, m), 6.92(2H, s), 6.78 (1H, s), 4.62 (1H, q, J=7.0 Hz), 2.86 (2H, t, J=7.3 Hz),2.51-2.60 (2H, m), 2.27 (6H, s), 1.79-1.85 (2H, m), 1.57-1.63 (2H, m),1.49 (3H, d, J=7.0 Hz), 1.39 (2H, bs), 1.29 (4H, bs), m/z=405.

Example 217 Synthesis of S-70

[0952] S-70 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by3,5-dimethylthiophenol, 1,8-dibromooctane and(R)-(+)-1-(1-naphthyl)ethylamine.

[0953] 400 MHz-¹ H-NMR 8.18 (1H, d, J=8.5 Hz), 7.86 (1H, d, J=8.0 Hz),7.73 (1H, d, J=8.0 Hz), 7.64 (1H, d, J=7.5 Hz), 7.44-7.52 (3H, m), 6.93(2H, s), 6.78 (1H, s), 4.62 (1H, q, J=6.5 Hz), 2.87 (2H, t, J=7.5 Hz),2.50-2.61 (2H, m), 2.27 (6H, s), 1.58-1.64 (2H, m), 1.47-1.52 (2H, m),1.49 (3H, d, J=6.5 Hz), 1.35-1.42 (2H, m), 1.24-1.30 (6H, m), m/z=419.

Example 218 Synthesis of S-71

[0954] S-71 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol by 4-bromothiophenol.

[0955] 400 MHz-¹H-NMR 7.33-7.37 (2H, m), 7.22 (1H, dd, J=8.0 Hz, J=8.0Hz), 7.13-7.16 (2H, m), 6.83-6.87 (2H, m), 6.76-6.79 (1 H, m), 3.80 (3H,s), 3.72 (1H, q, J=6.5 Hz), 2.99 (2H, t, J=6.5 Hz), 2.59-2.75 (2H, m),1.34 (3H, d, J=6.5 Hz), m/z=365, 367.

Example 219 Synthesis of S-72

[0956] S-72 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by4-bromothiophenol and 1,3-dibromopropane.

[0957] 400 MHz-¹H-NMR 7.37 (2H, d, J=8.8 Hz), 7.23 (1 H, dd, J=8.1 Hz,J=8.1 Hz), 7.15 (2H, d, J=8.8 Hz), 6.85-6.88 (2H, m), 6.78 (1H, ddd,J=8.1 Hz, J=2.4 Hz, J=1.0 Hz), 3.80 (3H, s), 3.71 (1 H, q, J=8.2 Hz),2.85-2.98 (2H, m), 2.50-2.65 (2H, m), 1.71-1.81 (2H, m), 1.33 (3H, d,J=6.6 Hz), m/z=379, 381.

Example 220 Synthesis of S-73

[0958] S-73 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by4-bromothiophenol and 1,4-dibromobutane.

[0959] 400 MHz-¹H-NMR 7.37 (2H, d, J=8.5 Hz), 7.23 (1H, dd, J=8.1 Hz,J=8.1 Hz), 7.15 (2H, d, J=8.5 Hz), 6.85-6.88 (2H, m), 6.75-6.79 (1H, m),3.80 (3H, s), 3.71 (1H, q. J=6.6 Hz), 2.85 (2H, t, J=7.1 Hz), 2.39-2.54(2H, m), 1.51-1.69 (4H, m), 1.33 (3H, d, J=6.6 Hz), m/z=393, 395.

Example 221 Synthesis of S-74

[0960] S-74 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by4-bromothiophenol and 1,5-dibromopentane.

[0961] 400 MHz-¹H-NMR 7.37 (2H, d, J=8.8 Hz), 7.23 (1H, dd, J=8.2 Hz,J=8.2 Hz), 7.15 (2H, d, J=8.8 Hz), 6.86-6.88 (2H, m), 6.76-6.79 (1H, m),3.81 (3H, s), 3.72 (1H, q, J=6.6 Hz), 2.86 (2H, t, J=7.3 Hz), 2.38-2.52(2H, m), 1.60 (2H, tt, J=7.3 Hz, J=7.3 Hz), 1.36-1.51 (4H, m), 1.34 (3H,d, J=6.6 Hz), m/z=407, 409.

Example 222 Synthesis of S-75

[0962] S-75 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by4-bromothiophenol and 1,6-dibromohexane.

[0963] 400 MHz-¹H-NMR 7.37 (2H, d, J=8.6 Hz), 7.23 (1H, dd, J=8.1 Hz,J=8.1 Hz), 7.15 (2H, d, J=8.6 Hz), 6.87-6.89 (2H, m), 6.76-6.79 (1H, m),3.81 (3H, s), 3.72 (1H, q, J=6.6 Hz), 2.86 (2H, t, J=7.3 Hz), 2.38-2.52(2H, m), 1.60 (2H, tt, J=7.3 Hz, J=7.3 Hz), 1.23-1.50 (6H, m), 1.35 (3H,d, J=6.6 Hz), m/z=421, 423.

Example 223 Synthesis of S-76

[0964] S-76 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by4-bromothiophenol and 1,7-dibromoheptane.

[0965] 400 MHz-¹H-NMR 7.38 (2H, d, J=8.5 Hz), 7.23 (1H, dd, J=8.1 Hz,J=8.1 Hz), 6.87-6.89 (2H, m), 6.78 (1H, ddd, J=8.3 Hz, J=2.4 Hz, J=1.0Hz), 3.81 (3H, s), 3.73 (1H, q, J=6.6 Hz), 2.86 (2H, t, J=7.3 Hz),2.38-2.52 (2H, m), 1.60 (2H, tt, J=7.3 Hz, J=7.3 Hz), 1.08-1.50 (8H, m),1.36 (3H, d, J=6.6 Hz), m/z=435, 437.

Example 224 Synthesis of S-77

[0966] S-77 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chlorcethane respectively by4-bromothiophenol and 1,8-dibromooctane.

[0967] 400 MHz-¹H-NMR 7.35-7.40 (2H, m), 7.23 (1H, d, J=8.0 Hz),7.14-7.18 (2H, m), 6.88-6.92 (2H, m), 6.74-6.80 (1 H, m), 3.81 (3H, s),3.75 (1H, q, J=6.7 Hz), 2.86 (2H, t, J=7.6 Hz), 2.39-2.53 (2H, m),1.54-1.64 (2H, m), 1.20-1.50 (10H, m), 1.38 (3H, d, J=6.7 Hz), m/z=449,451.

Example 225 Synthesis of S-78

[0968] S-78 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and (R)-(+)-3-methoxy-α-benzylmethylaminerespectively by 4-bromothiophenol and (R)-(+)-1-(1-naphthyl)ethylamine.

Example 226 Synthesis of S-79

[0969] S-79 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by 4-bromothiophenol,1,3-dibromopropane and (R)-(+)-1-(1-naphthyl)ethylamine.

[0970] 400 MHZ-¹H-NMR 8.16 (1H, d, J=7.8 Hz), 7.85-7.88 (1H, m), 7.74(1H, d, J=8.3 Hz), 7.62 (1H, d, J=6.8 Hz), 7.44-7.52 (3H, m), 7.32-7.42(2H, m), 7.10-7.15 (2H, m), 4.60 (1H, q, J=6.6 Hz), 2.83-3.05 (2H, m),2.60-2.77 (2H, m), 1.76-1.87 (2H, m), 1.49 (3H, d, J=6.6 Hz), m/z=399,401.

Example 227 Synthesis of S-80

[0971] S-80 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by 4-bromothiophenol,1,4-dibromobutane and (R)-(+)-1-(1-naphthyl)ethylamine.

[0972] 400 MHz-¹H-NMR 8.17 (1H, d, J=7.8 Hz), 7.84-7.88 (1H, m), 7.74(1H, d, J=8.28 Hz), 7.62 (1H, d, J=6.6 Hz), 7.43-7.52 (3H, m), 7.33-7.37(2H, m), 7.11-7.16 (2H, m), 4.61 (1H, q, J=6.5 Hz), 2.85 (2H, d, J=7.0Hz), 2.50-2.64 (2H, m), 1.58-1.68 (4H, m), 1.48 (3H, d, J=6.5 Hz),m/z=413, 415.

Example 228 Synthesis of S-81

[0973] S-81 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by 4-bromothiophenol,1,5-dibromopentane and (R)-(+)-1-(1-naphthyl)ethylamine.

[0974] 400 MHz-¹H-NMR 8.17 (1H, d, J=8.3 Hz), 7.85-7.88 (1H, m), 7.74(1H, d, J=8.2 Hz), 7.64 (1H, d, J=7.3 Hz), 7.45-7.53 (3H, m), 7.34-7.37(2H, m), 7.11-7.16 (2H, m), 4.62 (1H, q, J=6.6 Hz), 2.85 (2H, t, J=7.3Hz), 2.49-2.62 (2H, m), 1.40-1.65 (6H, m), 1.49 (3H, d, J=6.6 Hz),m/z=427, 429.

Example 229 Synthesis of S-82

[0975] S-82 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by 4-bromothiophenol,1,6-dibromohexane and (R)-(+)-1-(1-naphthyl)ethylamine.

Example 230 Synthesis of S-83

[0976] S-83 was synthesized by almost the same method as the oneemployed. for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by 4-bromothiophenol,1,7-dibromoheptane and (R)-(+)-1-(1-naphthyl)ethylamine.

[0977] 400 MHz-¹H-NMR 8.30 (1H, bs), 8.10 (1H, d, J=8.0 Hz), 7.90 (1H,d, J=8.1 Hz), 7.82 (1H, d, J=8.1 Hz),7.49-7.59 (3H, m),7.33-7.38 (2H,m),7.11-7.15 (2H, m), 4.96 (1H, bs), 2.80 (2H, t, J=7.3 Hz), 2.54-2.74(2H, m), 0.95-1.88 (13H, m), m/z=455, 457.

Example 231 Synthesis of S-84

[0978] S-84 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by 4-bromothiophenol,1,8-dibromooctane and (R)-(+)-1-(1-naphthyl)ethylamine.

[0979] 400 MHz-¹H-NMR 8.35 (1H, bs), 8.13 (1H, d, J=8.0 Hz), 7.88 (1H,d, J=8.2 Hz), 7.79 (1H, d, J=8.3 Hz), 7.45-7.56 (3H, m), 7.33-7.39 (2H,m), 7.12-7.18 (2H, m), 4.82 (1H, bs), 2.84 (2H, t, J=7.3 Hz), 2.58-2.64(2H, m), 1.00-1.74 (15H, m), m/z=469, 471.

Example 232 Synthesis of S-85

[0980] S-85 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by4-iodophenol and 1,3-dibromopropane.

[0981] 400 MHz-¹H-NMR 7.50-7.54 (2H, m), 7.21 (1H, dd, J=8.0 Hz, J=8.0Hz), 6.86-6.88 (2H, m), 6.76 (1H, dd, J=8.0 Hz, J=2.5 Hz), 6.61-6.65(2H, m), 3.93-4.00 (1H, m), 3.78 (3H, s), 3.72-3.76 (1H, m), 2.58-2.70(2H, m), 1.86-1.94 (2H, m), 1.34 (3H, d, J=7.0 Hz), m/z=411.

Example 233 Synthesis of S-86

[0982] S-86 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by4-iodophenol and 1,4-dibromobutane.

[0983] 400 MHz-¹H-NMR 7.50-7.53 (2H, m), 7.22 (1H, dd, J=3.0 Hz, J=3.0Hz), 6.87-6.89 (2H, m), 6.76-6.78 (1H, m), 6.61-6.64 (2H, m), 3.88 (1H,t, J=6.8 Hz), 3.80 (3H, s), 3.73 (1H, q, J=6.8 Hz), 2.46-2.58 (2H, m),1.72-1.82 (2H, m), 1.55-1.67 (2H, m), 1.34 (3H, d, J=6.8 Hz), m/z=425.

Example 234 Synthesis of S-87

[0984] S-87 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by4-iodophenol and 1,5-dibromopentane.

[0985] 400 MHz-¹H-NMR 7.52 (2H, d, J=8.5 Hz), 7.20-7.25 (1H, m), 6.87(2H, s), 6.74-6.80 (1H, m), 6.64 (2H, d, J=8.0 Hz), 3.88 (2H, t, J=6.5Hz), 3.80 (3H, s), 3.72 (1H, q, J=6.3 Hz),.2.40-2.55 (2H, m), 1.71-1.77(2H, m), 1.40-1.45 (4H, m), 1.34 (3H, d, J=6.3 Hz), m/z=439.

Example 235 Synthesis of S-88

[0986] S-88 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chioroethane respectively by4-iodophenol and 1,6-dibromohexane.

[0987] 400 MHz-¹H-NMR 7.52 (2H, d, J=9.0 Hz), 7.23 (1H, dd, J=8.0 Hz,J=8.0 Hz), 6.87-6.89 (2H, m), 6.77 (1H, dd, J=8.0 Hz, J=2.0 Hz), 6.64(2H, d, J=9.0 Hz), 3.88 (3H, t, J=6.5 Hz), 3.81 (3H, s), 3.72 (1H, q,J=7.0 Hz), 2.41-2.53 (2H, m), 1.71-1.76 (2H, m), 1.46-1.45 (2H, m),1.39-1.45 (2H, m), 1.31-1.38 (2H, m), 1.34 (3H, d, J=6.5 Hz), m/z=453.

Example 236 Synthesis of S-89

[0988] S-89 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by4-iodophenol and 1,7-dibromoheptane.

[0989] 400 MHz-¹H-NMR 7.52 (2H, d, J=9.0 Hz), 7.22 (1H, dd, J=8.0 Hz,J=8.0 Hz), 6.87-6.89 (2H, m), 6.76-6.78 (1H, m), 6.65 (2H, d, J=8.5 Hz),3.88 (2H, t, J=6.5 Hz), 3.81 (3H, s),3.72 (1H, q, J=6.5 Hz), 2.39-2.51(2H, m), 1.70-1.76 (2H, m), 1.37-1.49 (4H, m), 1.34 (3H, d, J=6.5 Hz),1.25-1.35 (6H, m), m/z=467.

Example 237 Synthesis of S-90

[0990] S-90 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by4-iodophenol and 1,8-dibromooctane.

[0991] 400 MHz-¹ H-NMR 7.53 (2H, d, J=8.5 Hz), 7.23 (1H, dd, J=8.0 Hz,J=8.0 Hz), 6.87-6.89 (2H, m), 6.75-6.78 (1H, m), 6.65 (2H, d, J=8.5 Hz),3.89 (2H, t, J=6.8 Hz), 3.81 (3H, s), 3.72 (1H, q, J=6.5 Hz), 2.39-2.51(2H, m), 1.71-1.76 (2H, m), 1.38-1.47 (4H, m), 1.34 (3H, d, J=6.5 Hz),1.25-1.35 (6H, m), m/z=481.

Example 238 Synthesis of S-91

[0992] S-91 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by 4-iodophenol,1,3-dibromopropane and (R)-(+)-1-(1-naphthyl)ethylamine.

[0993] 400 MHz-¹H-NMR 8.17-8.19 (1H, m), 7.84-7.87 (1H, m), 7.73 (1H, d,J=8.0 Hz), 7.61 (1H, d, J=7.0 Hz), 7.50-7.53 (2H, m), 7.34-7.49 (3H, m),6.61 (2H, d, J=9.0 Hz), 4.63 (1H, q, J=6.5 Hz), 3.95-4.01 (2H, m),2.69-2.80 (2H, m), 1.91-1.97 (2H, m), 1.49 (3H, d, J=6.5 Hz), m/z=431.

Example 239 Synthesis of S-92

[0994] S-92 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by 4-iodophenol,1,4-dibromobutane and (R)-(+)-1-(1-naphthyl)ethylamine.

[0995] 400 MHz-¹H-NMR 8.19 (1H, d, J=7.5 Hz), 7.86 (1H, d, J=8.0 Hz),7.73 (1H, d, J=8.0 Hz), 7.64 (1H, d, J=8.0 Hz), 7.45-7.52 (5H, m), 6.61(2H, d, J=7.5 Hz), 4.63 (1H, q, J=6.5 Hz), 3.88 (2H, t, J=6.5 Hz),2.56-2.69 (2H, m), 1.74-1.84 (2H, m), 1.62-1.68 (2H, m), 1.49 (3H, d,J=6.5 Hz), m/z=445.

Example 240 Synthesis of S-93

[0996] S-93 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by 4-iodophenol,1,5-dibromopentane and (R)-(+)-1-(1-naphthyl)ethylamine.

[0997] 400 MHz-¹H-NMR 8.18 (1H, d, J=8.0 Hz), 7.86 (1H, d, J=8.5 Hz),7.73 (1H, d, J=8.0 Hz), 7.64 (1H, d, J=7.0 Hz), 7.45-7.53 (5H, m), 6.63(2H, d, J=8.5 Hz), 4.58-4.64 (1H, m), 3.85-3.88 (2H, m), 2.50-2.65 (2H,m), 1.70-1.76 (2H, m), 1.40-1.55 (4H, m), 1.49 (3H, d, J=6.5 Hz),m/z=459.

Example 241 Synthesis of S-94

[0998] S-94 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by 4-iodophenol,1,6-dibromohexane and (R)-(+)-1-(1-naphthyl)ethylamine.

[0999] 400 MHz-¹H-NMR 8.18 (1H, d, J=8.5 Hz), 7.83 (1H, d, J=7.0 Hz),7.72 (1H, d, J=7.5 Hz), 7.64 (1H, d, J=7.5 Hz), 7.40-7.53 (5H, m), 6.63(2H, d, J=9.5 Hz), 4.62 (1H, q, J=6.5 Hz), 3.87 (2H, t, J=6.5 Hz),2.50-2.62 (2H, m), 1.70-1.75 (2H, m), 1.35-1.60 (6H, m), 1.49 (3H, d,J=6.5 Hz), m/z=473.

Example 242 Synthesis of S-95

[1000] S-95 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by 4-iodophenol,1,7-dibromoheptane and (R)-(+)-1-(1-naphthyl)ethylamine.

[1001] 400 MHz-¹H-NMR 8.17 (1H, d, J=8.5 Hz), 7.87 (1H, d, J=8.0 Hz),7.74 (1H, d, J=7.5 Hz), 7.67 (1H, d, J=7.0 Hz), 7.45-7.53 (5H, m), 6.64(2H, d, J=8.5 Hz), 4.65 (1H, q, J=7.0 Hz), 3.87 (2H, t, J=6.8 Hz),2.51-2.63 (2H, m), 1.78-1.84 (2H, m), 1.69-1.75 (2H, m), 1.52 (3H, d,J=7.0 Hz), 1.25-1.45 (6H, m), m/z=487.

Example 243 Synthesis of S-96

[1002] S-96 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by 4-iodophenol,1,8-dibromooctane and (R)-(+)-1-(1-naphthyl)ethylamine.

[1003] 400 MHz-¹H-NMR 8.86 (1H, d, J=7.5 Hz), 8.18 (1H, d, J=8.5 Hz),7.74 (1H, d, J=8.0 Hz), 7.66 (1H, d, J=7.5 Hz), 7.45-7.54 (5H, m), 6.65(2H, d, J=8.5 Hz), 4.64 (1H, q, J=6.5 Hz), 3.88 (2H, t, J=6.8 Hz),2.51-2.63 (2H, m), 1.79-1.85 (2H, m), 1.70-1.75 (2H, m),1.51 (3H, d,J=6.5 Hz), 1.24-1.43 (8H, m), m/z=501.

Example 244 Synthesis of S-97

[1004] S-97 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol by 2-napthalenethiol. m/z=337.

Example 245 Synthesis of S-98

[1005] S-98 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by2-naphthalenethiol and 1,3-dibromopropane.

[1006] 400 MHz-¹H-NMR 7.75-7.77 (1H, m), 7.69-7.73 (3H, m), 7.37-7.48(3H, m), 7.21 (1H, dd, J=8.2 Hz, J=8.2 Hz), 6.85-6.88 (2H, m), 6.75-6.79(1H, m), 3.79 (3H, s), 3.71 (1H, q, J=6.6 Hz), 2.98-3.11 (2H, m),2.54-2.68 (2H, m), 1.78-1.87 (2H, m), 1.32 (3H, d, J=6.6 Hz), m/z=351.

Example 246 Synthesis of S-99

[1007] S-99 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by2-naphthalenethiol and 1,4-dibromobutane.

[1008] 400 MHz-¹H-NMR 7.69-7.78 (4H, m), 7.38-7.51 (3H, m), 7.21 (1H,dd, J=8.0 Hz, J=8.0 Hz), 6.85-6.88 (2H, m), 6.76 (1 H, ddd, J=8.3 Hz,J=2.4 Hz, J=1.0 Hz), 3.79 (3H, s), 3.71 (1H, q, J=6.6 Hz), 2.99 (2H, t,J=7.1 Hz), 2.41-2.55 (2H, m), 1.56-1.74 (4H, m), 1.33 (3H, d, J=6.6 Hz),m/z=365.

Example 247 Synthesis of S-100

[1009] S-100 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by2-naphthalenethiol and 1,5-dibromopentane.

[1010] 400 MHz-¹H-NMR 7.69-778 (4H, m), 7.37-7.51 (3H, m), 7.22 (1H, dd,J=8.0 Hz, J=8.0 Hz), 6.86-6.88 (2H, m), 6.77 (1H, ddd, J=8.0 Hz, J=2.4Hz, J=1.0 Hz), 3.80 (3H, s), 3.71 (1H, q, J=6.6 Hz), 2.99 (2H, t, J=7.3Hz), 2.39-2.52 (2H, m), 1.67 (2H, tt, J=7.3 Hz, J=7.3 Hz), 1.41-1.53(4H, m), 1.33 (3H, d, J=6.6 Hz), m/z=379.

Example 248 Synthesis of S-101

[1011] S-101 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by2-naphthalenethiol and 1,6-dibromohexane.

[1012] 400 MHz-¹H-NMR 7.70-7.78 (4H, m); 7.38-7.47 (3H, m), 7.23 (1H,dd, J=8.3 Hz, J=8.3 Hz), 6.86-6.88 (2H, m), 6.77 (1 H, ddd, J=8.3 Hz,J=2.4 Hz, J=1.0 Hz), 3.80 (3H, s), 3.71 (1H, q, J=6.6 Hz), 2.99 (2H, t,J=7.3 Hz), 2.37-2.51 (2H, m), 1.67 (2H, tt, J=7.3 Hz, J=7.3 Hz),1.39-1.50 (4H, m), 1.25-1.35 (2H, m), 1.33 (3H, d, J=6.6 Hz), m/z=393.

Example 249 Synthesis of S-102

[1013] S-102 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by2-naphthalenethiol and 1,7-dibromoheptane.

[1014] 400 MHz-¹H-NMR 7.70-7.78 (4H, m), 7.38-7.47 (3H, m), 7.24 (1H,dd, J=8.1 Hz, J=8.1 Hz), 6.90-6.95 (2H, m), 6.78-6.81 (1 H, m), 3.81(3H, s), 3.79-3.82 (1H, m), 2.99 (2H, t, J=7.4 Hz), 2.41-2.54 (2H, m),1.66 (2H, tt, J=7.4 Hz, J=7.4 Hz), 1.15-1.55 (8H, m), 1.43 (3H, d, J=6.6Hz), m/z=407.

Example 250 Synthesis of S-103

[1015] S-103 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by2-naphthalenethiol and 1,8-dibromooctane.

[1016] 400 MHz-¹H-NMR 7.70-7.78 (4H, m), 7.38-7.47 (3H, m), 7.23 (1H, d,J=7.8 Hz), 6.88-6.92 (2H, m), 6.78 (1H, ddd, J=8.3 Hz, J=2.7 Hz, J=1.0Hz), 3.81 (3H, s), 3.76 (1H, q, J=6.4 Hz), 2.99 (2H, t, J=7.3 Hz),2.39-2.52 (2H, m), 1.66 (2H, tt, J=7.3 Hz, J=7.3 Hz), 1.15-1.55 (10H,m), m/z=421.

Example 251 Synthesis of S-104

[1017] S-104 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and (R)-(+)-3-methoxy-α-benzylrnethylaminerespectively by 2-naphthalenethiophenol and(R)-(+)-1-(1-naphthyl)ethylamine. m/z 357.

Example 252 Synthesis of S-105

[1018] S-105 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by2-naphthalenethiol, 1,3-dibromopropane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1019] 400 MHz-¹H-NMR 8.14-8.16 (1H, m), 7.84-7.88 (1H, m), 7.75-7.77(2H, m), 7.68-7.76 (3H, m), 7.64 (1H, d, J=6.6 Hz), 7.36-7.48 (6H, m),4.61 (1H, q, J=6.6 Hz), 3.00-3.14 (2H, m), 2.66-279 (2H, m), 1.88 (2H,m), 1.49 (3H, d, J=6.6 Hz), m/z=371.

Example 253 Synthesis of S-106

[1020] S-106 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by2-naphthalenethiol, 1,4-dibromobutane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1021] 400 MHz-¹H-NMR 8.16 (1H, d, J=8.1 Hz), 7.84-7.87 (1H, m),7.74-7.77 (2H, m), 7.68-7.72 (3H, m), 7.63 (1H, d, J=7.1 Hz), 7.36-7.51(6H, m), 4.62 (1H, q, J=6.6 Hz), 2.98 (2H, t, J=7.0 Hz), 2.52-2.65 (2H,m), 1.63-1.76 (4H, m), 1.48 (3H, d, J=6.6 Hz), m/z=385.

Example 254 Synthesis of S-107

[1022] S-107 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by2-naphthalenethiol, 1,5-dibromopentane and(R)-(+)-1-(1-naphthyl)ethylamine.

Example 255 Synthesis of S-108

[1023] S-108 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by2-naphthalenethiol, 1,6-dibromohexane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1024] 400 MHz-¹H-NMR 8.16 (1H, d, J=8.3 Hz), 7.85-7.88 (1H, m),7.74-7.77 (2H, m), 7.69-7.73 (3H, m), 7.64 (1H, d, J=7.1 Hz), 7.38-7.52(6H, m), 4.62 (1H, q, J=6.5 Hz), 2.98 (2H, t, J=7.4 Hz), 2.49-2.62 (2H,m), 1.66 (2H, tt, J=7.4 Hz, J=7.4 Hz), 1.27-1.54 (6H, m), 1.49 (3H, d,J=6.5 Hz), m/z=413.

Example 256 Synthesis of S-109

[1025] S-109 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by2-naphthalenethiol, 1,7-dibromoheptane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1026] 400 MHz-¹H-NMR 8.16 (1H, m), 7.84-7.87 (1 H, m), 7.69-7.77 (5H,m), 7.64 (1H, d, J=6.8 Hz), 7.37-7.53 (6H, m), 4.62 (1H, q, J=6.6 Hz),2.98 (2H, t, J=7.4 Hz), 2.48-2.62 (2H, m), 1.65 (2H, tt, J=7.4 Hz, J=7.4Hz), 1.25-1.52 (8H, m), 1.49 (3H, d, J=6.6 Hz), m/z=427.

Example 257 Synthesis of S-110

[1027] S-110 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by2-naphthalenethiol, 1,8-dibromooctane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1028] 400 MHz-¹H-NMR 8.14 (1H, d, J=8.3 Hz), 7.85-7.88 (1 H, m),7.67-7.79 (6H, m), 7.37-7.53 (6H, m), 4.70 (1 H, q, J=6.6 Hz), 2.98 (2H,t, J=7.3 Hz), 2.50-2.65 (2H, m), 1.65 (2H, tt, J=7.3 Hz, J=7.3 Hz),1.05-1.60 (10H, m), 1.57 (3H, d, J=6.6 Hz), m/z=441.

Example 258 Synthesis of S-111

[1029] S-111 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but repiacing the2,5-dimethylthiophenol by 2-methoxythiophenol.

[1030] 400 MHz-¹H-NMR 7.14-7.22 (3H, m), 6.81-6.89 (4H, m), 6.73-6.76(1H, m), 3.85 (3H, s), 3.78 (3H, s), 3.71 (1H, q, J=6.6 Hz), 2.98 (2H,t, J=6.5 Hz), 2.61-2.73 (2H, m), 1.32 (3H, d, J=6.6 Hz), m/z=317.

Example 259 Synthesis of S-112

[1031] S-112 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by2-methoxythiophenol and 1,3-dibromopropane.

[1032] 400 MHz-¹H-NMR 7.21-7.25 (2H, m), 7.14-7.19 (1H, m), 6.82-6.92(4H, m), 6.77 (1H, ddd, J=8.3 Hz, J=2.4 Hz, J=1.0 Hz), 3.87 (3H, s),3.80 (3H, s), 3.73 (1H, q, J=6.6 Hz), 2.85-2.98 (2H, m), 2.52-2.67 (2H,m), 1.73-1.86 (2H, m), 1.33 (3H, d, J=6.6 Hz), m/z=331.

Example 260 Synthesis of S-113

[1033] S-113 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by2-methoxythiophenol and 1,4-dibromobutane.

[1034] 400 MHz-¹H-NMR 7.21-7.25 (2H, m), 7.14-7.19 (1H, m), 6.82-6.93(4H, m), 6.75-6.79 (1H, ddd, J=8.0 HZ, J=2.4 Hz, J=1.0 Hz), 3.88 (3H,s), 3.80 (3H, s), 3.72 (1H, q, J=6.6 Hz), 2.86 (2H, t, J=7.0 Hz),2.41-2.55 (2H, m), 1.58-1.71 (4H, m), 1.34 (3H, d, J=6.6 Hz), m/z=345.

Example 261 Synthesis of S-114

[1035] S-114 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by2-methoxythiophenol and 1,5-dibromopentane.

[1036] 400 MHz-¹H-NMR 7.21-7.26 (2H, m), 7.13-7.18 (1H, m), 6.82-6.93(4H, m), 6.76-6.79 (1H, m), 3.88 (3H, s), 3.81 (3H, s), 3.72 (1H, q,J=6.6 Hz), 2.86 (2H, t, J=7.4 Hz), 2.38-2.52 (2H, m), 1.56-1.67 (2H, m),1 .38-1.53 (4H, m), 1.34 (3H, d, J=6.6 Hz), m/z=359.

Example 262 Synthesis of S-115

[1037] S-115 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by2-methoxythiophenol and 1,6-dibromohexane.

[1038] 400 MHz-¹H-NMR 7.19-7.24 (2H, m), 7.12-7.16 (1H, m), 6.81-6.91(4H, m), 6.74-6.77 (1H, m), 3.86 (3H, s), 3.79 (3H, s),3.70 (1H, q,J=6.6 Hz), 2.84 (2H, t, J=7.5 Hz), 2.36-2.50 (2H, m), 1.57-1.65 (2H, m),1.23-1.48 (6H, m), 1.32 (3H, d, J=6.6 Hz), m/z=373.

Example 263 Synthesis of S-116

[1039] S-116 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by2-methoxythiophenol and 1,7-dibromoheptane.

[1040] 400 MHz-¹H-NMR 7.21-7.27 (2H, m), 7.13-7.18 (1H, m), 6.89-6.97(4H, m), 6.80-6.85 (1H, m), 3.88 (3H, s), 3.83 (3H, s), 3.80-3.83 (2H,t, J=7.3 Hz), 2.85 (1H, m), 2.43-2.56 (2H, m), 1.36-1.66 (6H, m), 1.47(3H, d, J=6.2 Hz), 1.18-1.30 (4H, m), m/z=387.

Example 264 Synthesis of S-117

[1041] S-117 was synthesized by almost the same method as the oneemployed for the synthesis of 3-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by2-methoxythiophenol and 1,8-dibromooctane.

[1042] 400 MHz-¹H-NMR 7.21-7.25 (2H, m), 7.13-7.18 (1H, m), 6.82-6.94(4H, m), 6.76-6.79 (1H, m), 3.88 (3H, s), 3.81 (3H, s), 3.73 (2H, t,J=7.3 Hz), 2.86 (1H, q, J=6.5 Hz), 2.38-2.52 (2H, m), 1.60-1.70 (2H, m),1.20-1.60 (10H, m), 1.35 (3H, d, J=6.5 Hz), m/z=401.

Example 265 Synthesis of S-118

[1043] S-118 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and (R)-(+)-3-methoxy-α-benzylmethylaminerespectively by 2-methoxythiophenol and(R)-(+)-1-(1-naphthyl)ethylamine.

[1044] 4000 MHz-¹H-NMR 8.15 (1H, d, J=7.6 Hz), 7.84-7.87 (1H, m), 7.73(1H, d, J=8.0 Hz), 7.64 (1H, d, J=6.4 Hz), 7.40-7.51 (3H, m), 7.24 (1H,dd, J=7.6 Hz, J=1.7 Hz), 7.18 (1H, ddd, J=7.8 Hz, J=7.8 Hz, J=1.7 Hz),6.81-6.88 (2H, m), 4.62 (1H, q, J=6.6 Hz), 3.84 (3H, s), 3.05 (2H, t,J=6.4Hz), 2.73-2.82 (2H, m), 1.48 (3H, d, J=6.6 Hz), m/z=337.

Example 266 Synthesis of S-119

[1045] S-119 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by2-methoxythiophenol, 1,3-dibromopropane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1046] 400 MHz-²H-NMR 8.15 (1H, d, J=7.6 Hz), 7.82-7.86 (1H, m), 7.72(1H, d, J=8.3 Hz), 7.63 (1H, d, J=6.8 Hz), 7.43-7.50 (3H, m), 7.21 (1H,dd, J=7.6 Hz, J=1.5 Hz), 7.14 (1H, ddd, J=8.0 HZ, J=8.0 Hz, J=1.SHz),6.87 (1H, dd, J=7.6 Hz, J=1.2 Hz), 6.81 (1H, dd, J=8.0 Hz, J=1.1 Hz),4.61 (1H, q, J=6.6 Hz), 3.84 (3H, s), 2.85-2.99 (2H, m), 2.61-2.77 (2H,m), 1.78-1.86 (2H, m), 1.47 (3H, d, J=6.6 Hz), m/z=351.

Example 267 Synthesis of S-120

[1047] S-120 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by2-methoxythiophenol, 1,4-dibromobutane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1048] 400 MHz-¹H-NMR 8.17 (1H, d, J=8.0 Hz), 7.85-7.88 (1H, m), 7.73(1H, d, J=8.3 Hz), 7.64 (1H, d, J=7.1 Hz), 7.44-7.52 (3H, m), 7.21 (1H,dd, J=7.8 Hz, J=1.6 Hz), 7.13-7.18 (1H, m), 6.89 (ddd, J=7.61 Hz, J=7.6Hz, J=1.2 Hz), 6.82 (1H, dd, J=8.3 Hz, J=1.2 Hz), 4.62 (1H, q, J=6.5Hz), 3.86 (3H, s), 2.83-2.88 (2H, m), 2.52-2.65 (2H, m), 1.64-1.70 (4H,m), 1.49 (3H, d, J=6.5 Hz), m/z=365.

Example 268 Synthesis of S-121

[1049] S-121 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by2-methoxythiophenol, 1,5-dibromopentane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1050] 400 MHz-¹H-NMR 8.17 (1H, d, J=8.0 Hz), 7.83-7.88 (1H, m),7.71-7.75 (1H, m), 7.63 (1H, d, J=7.0 Hz), 7.41-7.52 (3H, m), 7.21 (1H,dd, J=7.6 Hz, J=1.7 Hz), 7.15 (1H, ddd, J=7.6 Hz, J=7.6 Hz, J=1.7 Hz),6.90 (1H, ddd, J=7.6 Hz, J=7.6 Hz, J=1.2 Hz), 6.82 (1H, dd, J=8.2 Hz,J=1.1 Hz), 4.61 (1H, q, J=6.6 Hz), 3.87 (3H, s), 2.85 (2H, t, J=7.3 Hz),2.50-2.62 (2H, m), 1.40-1.48 (6H, m), 1.49 (3H, d, J=6.6 Hz), m/z=379.

Example 269 Synthesis of S-122

[1051] S-122 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by2-methoxythiophenol, 1,6-dibromohexane and(R)-(+)-1-(1-naphthyl)ethylamine. m/z=393.

Example 270 Synthesis of S-123

[1052] S-123 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by2-methoxythiophenol, 1,7-dibromoheptane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1053] 400 MHz-¹H-NMR 8.15 (1H, d, J=8.3 Hz), 7.87 (1H, d, J=7.1 Hz),7.70-7.78 (2H, m), 7.41-7.51 (3H, m), 7.21 (1H, dd, J=7.6 Hz, J=1.5 Hz),7.12-7.17 (1H, m), 6.90 (1H, ddd, J=7.6 Hz, J=7.6 Hz, J=1.2 Hz),6.80-6.83 (1H, m), 4.67-4.75 (1H, m), 3.87 (3H, s), 2.84 (2H, t, J=7.3Hz), 2.51-2.64 (2H, m), 1.05-1.64 (13H, m), m/z=407.

Example 271 Synthesis of S-124

[1054] S-124 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by2-methoxythiophenol, 1,8-dibromooctane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1055] 400 MHz-¹H-NMR 8.16 (1H, d, J=8.3 Hz), 7.86-7.89 (1H, m),7.70-7.78 (2H, m), 7.46-7.55 (3H, m), 7.22 (1H, dd, J=7.6 Hz, J=1.7 Hz),7.13-7.17 (1H, m), 6.87-6.92 (1H, m), 4.70 (1H, bs), 3.88 (3H, s), 2.85(2H, t, J=7.4 Hz), 2.52-2.64 (2H, m),1.05-1.65 (15H, m), m/z=421.

Example 272 Synthesis of S-125

[1056] S-125 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the 2,5-dimethylthiol by3-methoxythiophenol.

[1057] 400 MHz-¹H-NMR 7.22 (1H, d, J=8.0 Hz), 7.16 (1H, dd, J=8.0 Hz,J=8.0 Hz), 6.83-6.89 (4H, m), 6.77 (1H, ddd, J=8.0 Hz, J=2.6 Hz, J=1.0Hz), 6.71 (1H, ddd, J=7.5 Hz, J=2.6 Hz, J=1.0 Hz), 3.80 (3H, s), 3.78(3H, s), 3.74 (1H, q, J=6.5 Hz), 3.02-3.06 (2H, m), 2.67-2.78 (2H, m),1.35 (3H, d, J=6.5 Hz), m/z=317.

Example 273 Synthesis of S-126

[1058] S-126 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chlorcethane respectively by3-methoxythiophenol and 1,3-dibromopropane.

[1059] 400 MHz-¹H-NMR 7.23 (1H, dd, J=8.0 Hz, J=8.0 Hz), 7.18 (1H, dd,J=8.0 Hz, J=8.0 Hz), 6.86-6.89 (3H, m), 6.85 (1H, dd, J=2.1 Hz, J=2.1Hz), 6.78 (1H, ddd, J=8.0 Hz, J=2.4 Hz, J=1.2 Hz), 6.70 (1 H, ddd, J=8.4Hz, J=2.7 Hz, J=1.0 Hz), 3.81 (3H, s), 3.78 (3H, s), 3.72 (1H, q, J=6.6Hz), 2.88-3.02 (2H, m), 2.51-2.66 (2H, m), 1.74-1.87 (2H, m), 1.33 (3H,d, J=6.6 Hz), m/z=331.

Example 274 Synthesis of S-127

[1060] S-127 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by3-methoxythiophenol and 1,4-dibromobutane.

[1061] 400 MHz-¹H-NMR 7.23 (1H, dd, J=8.0 Hz, J=8.0 Hz), 7.18 (1H, dd,J=8.0 Hz, J=8.0 Hz), 6.86-6.89 (3H, m), 6.83-6.84 (1 H, m), 6.76-6.79(1H, m), 6.69 (1H, ddd, J=8.0 Hz, J=2.4 Hz, J=1.0 Hz), 3.81 (3H, s),3.79 (3H, s), 3.72 (1H, q, J=6.6 Hz), 2.89 (2H, t, J=7.1 Hz), 2.40-2.55(2H, m),1.53-1.72 (4H, m), 1.34 (4H, m), m/z=345.

Example 275 Synthesis of S-128

[1062] S-128 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by3-methoxythiophenol and 1,5-dibromopentane.

[1063] 400 MHz-¹H-NMR 7.23 (1H, dd, J=8.0 Hz, J=8.0 Hz), 7.18 (1H, dd,J=8.0 Hz, J=8.0 Hz), 6.86-6.89 (3H, m), 6.84 (1H, dd, J=4.1 Hz, J=4.1Hz), 6.76-6.79 (1H, m), 6.70 (1H, ddd, J=8.0 Hz, J=2.4 Hz, J=1.0 Hz),3.81 (3H, s), 3.79 (3H, s), 3.72 (1H, q, J=6.5 Hz), 2.89 (2H, t, J=7.3Hz), 2.38-2.52 (2H, m), 1.59-1.67 (2H, m), 1.37-1.52 (4H, m), 1.34 (3H,d, J=6.5 Hz), m/z=359.

Example 276 Synthesis of S-129

[1064] S-129 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by3-methoxythiophenol and 1,6-dibromohexane.

[1065] 400 MHz-¹H-NMR 7.24 (1H, dd, J=8.0 Hz, J=8.0 Hz), 7.18 (1H, dd,J=8.0 Hz, J=8.0 Hz), 6.86-6.90 (3H, m), 6.83-6.85 (1 H, m), 6.76-6.79(1H, m), 6.69 (1H, ddd, J=8.3 Hz, J=2.6 Hz, J=1.0 Hz), 3.81 (3H, s),3.79 (3H, s), 3.72 (1H, q, J=6.6 Hz), 2.89 (2H, t, J=7.3 Hz), 2.37-2.51(2H, m), 1.59-1.67 (2H, m), 1.24-1.52 (6H, m), 1.35 (3H, d, J=6.6 Hz),m/z=373.

Example 277 Synthesis of S-130

[1066] S-130 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by3-methoxythiophenol and 1,7-dibromoheptane.

[1067] 400 MHz-¹H-NMR 7.24 (1H, dd, J=8.0 Hz, J=8.0 Hz), 7.18 (1H, dd,J=8.0 Hz, J=8.0 Hz), 6.86-6.90 (3H, m), 6.76-6.80 (1H, m), 6.69 (1H,ddd, J=8.0 Hz, J=2.4 Hz, J=1.0 Hz), 3.81 (3H, s), 3.79 (3H, s), 3.74(1H, q, J=6.6 Hz), 2.89 (2H, t, J=7.3 Hz), 2.38-2.52 (2H, m), 1.58-1.66(2H, m), 1.19-1.49 (8H, m), 1.37 (3H, d, J=6.6 Hz), m/z=387.

Example 278 Synthesis of S-131

[1068] S-131 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by3-methoxythiophenol and 1,8-dibromooctane.

[1069] 400 MHz-¹H-NMR 7.23 (1H, dd, J=8.0 Hz, =8.0 Hz), 7.18 (1H, dd,J=8.0 Hz, J=8.0 Hz), 6.87-6.91 (3H, m), 6.84-6.85 (1H, m), 6.78 (1H,ddd, J=8.0 Hz, J=2.4 Hz, J=0.8 Hz), 6.69 (1H, ddd, J=8.0 Hz, J=2.4 Hz,J=0.8 Hz), 3.81 (3H, s), 3.79 (3H, s), 3.73 (1H, q, J=6.5 Hz), 2.89 (2H,t, J=7.4 Hz), 2.38-2.52 (2H, m), 1.59-1.70 (2H, m), 1.20-1.50 (10H, m),1.35 (3H, d, J=6.5 Hz), m/z=401.

Example 279 Synthesis of S-132

[1070] S-132 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and (R)-(+)-3-methoxy-α-benzylmethylaminerespectively by 3-methoxythiophenol and(R)-(+)-1-(1-naphthyl)ethylamine.

[1071] 400 MHz-¹H-NMR 8.15 (1H, d, J=7.8 Hz), 7.85-7.87 (1H, m), 7.73(1H, d, J=8.3 Hz), 7.63 (1H, d, J=6.6 Hz), 7.42-7.55 (3H, m), 7.1 2-7.16 (1 H, m), 6.85-6.89 (2H, m), 6.69-6.72 (1H, m), 4.63 (1 H, q,J=6.5Hz), 3.76 (1H, s), 3.08 (2H, t, J=6.4 Hz), 2.76-2.87 (2H, m), 1.49(3H, d, J=6.5 Hz), m/z=337.

Example 280 Synthesis of S-133

[1072] S-133 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by3-methoxythiophenol, 1,3-dibromopropane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1073] 400 MHz-¹H-NMR 8.18 (1H, d, J=9.4 Hz), 7.85-7.88 (1H, m), 7.74(1H, d, J=8.0 Hz), 7.63 (1H, d, J=6.6 Hz), 7.44-7.52 (3H, m), 7.16 (1H,dd, J=7.8 Hz, J=7.8 Hz), 6.84-6.89 (2H, m), 6.68-6.71 (1H, m), 4.61 (1H,q, J=6.6 Hz), 3.77 (3H, s), 2.91-3.04 (2H, m), 2.62-2.76 (2H, m),1.80-1.90 (2H, m), 1.48 (3H, d, J=6.6 Hz), m/z=351.

Example 281 Synthesis of S-134

[1074] S-134 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by3-methoxythiophenol, 1,4-dibromobutane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1075] 400 MHz-¹H-NMR 8.17 (1H, d, J=8.0 Hz), 7.85-7.88 (1H, m), 7.73(1H, d, J=8.0 Hz), 7.63 (1H, d, J=6.84 Hz), 7.44-7.52 (3H, m), 7.16 (1H,dd, J=7.8 Hz, J=7.8 Hz), 6.83-6.88 (2H, m), 6.67-6.70 (1H, m), 4.62 (1H,q, J=6.6 Hz), 3.77 (3H, s), 2.89 (2H, t, J=7.1 Hz), 2.51-2.65 (2H, m),1.59-1.73 (4H, m), 1.49 (3H, d, J=6.6 Hz), m/z=365.

Example 282 Synthesis of S-135

[1076] S-135 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by3-methoxythiophenol, 1,5-dibromopentane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1077] 400 MHz-¹H-NMR 8.17 (1H, d, J=8.0 Hz), 7.85-7.88 (1H, m), 7.74(1H, d, J=8.1 Hz), 7.63 (1H, d, J=6.6 Hz), 7.43-7.52 (3H, m), 7.17 (1H,dd, J=8.0 Hz, J=8.0 Hz), 6.85-6.88 (1H, m), 6.84 (1H, dd, J=2.1 Hz,J=2.1 Hz), 6.69 (1H, ddd, J=6.7 Hz, J=2.4 Hz, J=0.7 Hz), 4.62 (1H, q,J=6.6Hz), 3.78 (3H, s), 2.88 (2H, t, J=7.3 Hz), 2.50-2.63 (2H, m),1.59-1.67 (2H, m), 1.40-1.55 (4H, m), 1.49 (3H, d, J=6.6 Hz), m/z=379.

Example 283 Synthesis of S-136

[1078] S-136 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by3-methoxythiophenol, 1,6-dibromohexane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1079] 400 MHz-¹H-NMR 8.16 (1H, d, J=8.3 Hz), 7.80-7.88 (2H, m),7.73-7.76 (1H, m), 7.41-7.53 (3H, m), 6.85-6.88 (1H, m), 6.83 (1H, dd,J=2.1 Hz, J=2.1 Hz), 6.68 (1H, ddd, J=8.4 Hz, J=2.4 Hz, J=0.9 Hz), 4.67(1H, q, J=6.6 Hz), 2.87 (2H, t, J=7.3 Hz), 2.51-2.63 (2H, m), 1.25-1.66(11H, m), m/z=393.

Example 284 Synthesis of S-137

[1080] S-137 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by3-methoxythiophenol, 1,7-dibromoheptane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1081] 400 MHz-¹H-NMR 8.15 (1H, d, J=8.3 Hz), 7.86-7.89 (1H, m),7.75-7.80 (2H, m), 7.45-7.55 (3H, m), 7.16 (1H, dd, J=8.1 Hz, J=8.1 Hz),6.82-6.88 (2H, m), 6.68 (1H, ddd, J=8.3 Hz, J=2.4 Hz, J=0.7 Hz),4.70-4.78 (1H, m), 3.78 (3H, s), 2.86 (2H, t, J=7.3 Hz), 2.52-2.65 (2H,m), 1.05-1.65 (13H, m), m/z=407.

Example 285 Synthesis of S-138

[1082] S-138 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by3-methoxythiophenol, 1,8-dibromooctane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1083] 400 MHz-¹H-NMR 8.14 (1H, d, J=8.0 Hz), 7.87-7.89 (1H, m), 7.77(1H, d, J=8.0 Hz), 7.47-7.55 (3H, m), 7.17 (1H, dd, J=8.1 Hz, J=8.1 Hz),6.83-6.89 (2H, m), 6.68 (1H, ddd, J=8.3 Hz, J=2.4 Hz, J=1.0 Hz), 4.75(1H, bs), 3.78 (3H, s), 2.88 (2H, t, J=7.3 Hz), 2.53-2.66 (2H, m),1.00-1.75 (15H, m), m/z=421.

Example 286 Synthesis of S-139

[1084] S-139 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the 2,5-dimethylthiol by4-methoxythiophenol.

[1085] 400 MHz-¹H-NMR 7.28 (2H, d, J=8.0 Hz), 7.21 (1H, dd, J=8.0 Hz,J=8.0 Hz), 6.75-6.88 (5H, m), 3.80 (3H, s), 3.78 (3H, s), 3.70 (1H, q,J=6.6 Hz), 2.88-2.93 (2H, m), 2.57-2.70 (2H, m), 1.34 (3H, d, J=6.6 Hz),m/z=317.

Example 287 Synthesis of S-140

[1086] S-140 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by4-methoxythiophenol and 1,3-dibromopropane.

[1087] 400 MHz-¹H-NMR 7.31 (2H, d, J=8.8 Hz), 7.23 (1H, dd, J=8.1 Hz,J=8.1 Hz), 6.85-6.88 (2H, m), 6.82 (2H, d, J=8.8 Hz), 6.77 (1H, ddd,J=8.2 Hz, J=2.7 Hz, J=1.0 Hz), 3.80 (3H, s), 3.79 (3H, s), 3.70 (1H, q,J=6.6 Hz), 2.77-2.89 (2H, m), 2.49-2.64 (2H, m), 1.64-1.80 (2H, m), 1.32(3H, d, J=6.6 Hz), m/z=331.

Example 288 Synthesis of S-141

[1088] S-141 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by4-methoxythiophenol and 1,4-dibromobutane.

[1089] 400 MHz-¹H-NMR 7.31 (2H, d, J=8.8 Hz), 7.23 (1H, dd, J=8.0 Hz,J=8.0 Hz), 6.85-6.89 (2H, m), 6.82 (2H, d, J=8.8 Hz), 6.76-6.79 (1H, m),3.81 (3H, s), 3.79 (3H, s), 3.71 (1H, q, J=6.6 Hz), 2.75-2.80 (2H, m),2.33-2.53 (2H, m), 1.53-1.62 (4H, m), 1.33 (3H, d, J=6.6 Hz), m/z=345.

Example 289 Synthesis of S-142

[1090] S-142 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by4-methoxythiophenol and 1,5-dibromopentane.

[1091] 400 MHz-¹H-NMR 7.31 (2H, d, J=8.8 Hz), 7.23 (1H, dd, J=8.0 Hz,J=8.0 Hz), 6.86-6.89 (2H, m), 6.83 (2H, d, J=8.8 Hz), 6.76-6.80 (1H, m),3.81 (3H, s), 3.79 (3H, s),3.71 (1H, q, J=6.6 Hz), 2.78 (2H, t, J=7.3Hz), 2.38-2.52 (2H, m),1.50-1.60 (2H, m), 1.36-1.50 (4H, m), 1.34 (3H,d, J=6.6 Hz), m/z=359.

Example 290 Synthesis of S-143

[1092] S-143 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by4-methoxythiophenol and 1,6-dibromohexane.

[1093] 400 MHz-¹H-NMR 7.31 (2H, d, J=8.8 Hz), 7.23 (1H, dd, J=8.0 Hz,J=8.0 Hz), 6.87-6.90 (2H, m), 6.81-6.85 (2H, m), 6.76-6.80 (1H, m), 3.81(3H, s), 3.79 (3H, s), 3.73 (1H, q, J=6.6 Hz), 2.78 (2H, t, J=7.3 Hz),2.38-2.51 (2H, m), 1.21-1.59 (8H, m), 1.35 (3H, d, J=6.6 Hz), m/z=373.

Example 291 Synthesis of S-144

[1094] S-144 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by4-methoxythiophenol and 1,7-dibromoheptane.

[1095] 400 MHz-¹H-NMR 7.32 (2H, d, J=8.8 Hz), 7.24 (1H, dd, J=8.0 Hz,J=8.0 Hz), 6.88-6.91 (2H, m), 6.83 (2H, d, J=8.8 Hz), 6.76-6.80 (1H, m),3.81 (3H, s), 3.79 (3H, s), 3.75 (1H, q, J=6.6 Hz), 2.78 (2H, t, J=7.4Hz), 2.38-2.52 (2H, m), 1.40-1.60 (4H, m),1.20-1.30 (4H, m), 1.32-1.40(2H, m), 1.37 (3H, d, J=6.6 Hz), m/z=387.

Example 292 Synthesis of S-145

[1096] S-145 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by4-methoxythiophenol and 1,8-dibromooctane.

[1097] 400 MHz-¹H-NMR 7.29-7.33 (2H, m), 7.25 (1H, dd, J=8.0 Hz, J=8.0Hz), 6.92-6.99 (2H, m), 6.79-6.85 (2H, m), 3.83 (3H, s), 3.79 (3H, s),3.81-3.84 (1H, m), 2.78 (2H, t, J=7.4 Hz),2.43-2.56 (2H, m), 1.43-1.60(4H, m), 1.19-1.40 (8H, m), 1.48 (3H, d, J=5.9 Hz), m/z=401.

Example 293 Synthesis of S-146

[1098] S-146 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and (R)-(+)-3-methoxy-α-benzylmethylaminerespectively by 4-methoxythiophenol and(R)-(+)-1-(1-naphthyl)ethylamine.

[1099] 400 MHz-¹H-NMR 8.15 (1H, d, J=7.6 Hz), 7.85-7.89 (1H, m), 7.73(1H, d, J=8.2 Hz), 7.62 (1H, d, J=6.6 Hz), 7.42-7.52 (3H, m), 7.27-7.30(2H, m), 6.75-6.80 (2H, m), 4.61 (1H, q, J=6.5 Hz), 3.78 (3H, s), 2.97(2H, t, J=6.2 Hz), 2.68-2.78 (2H, m), 1.48 (3H, d, J=6.5 Hz), m/z=337.

Example 294 Synthesis of S-147

[1100] S-147 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by4-methoxythiophenol, 1,3-dibromopropane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1101] 400 MHz-¹H-NMR 8.15 (1H, d, J=7.8 Hz), 7.85-7.88 (1H, m), 7.74(1H, d, J=8.3 Hz), 7.64 (1H, d, J=7.1 Hz), 7.46-7.52 (3H, m), 7.27-7.31(2H, m), 6.77-6.82 (2H, m), 4.61 (1H, q, J=6.5 Hz), 3.78 (3H, s),2.79-2.92 (2H, m), 2.61-2.75 (2H, m), 1.73-1.81, (2H, m), 1.49 (3H, d,J=6.5 Hz), m/z=351.

Example 295 Synthesis of S-148

[1102] S-148 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by4-methoxythiophenol, 1,4-dibromobutane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1103] 400 MHz-¹H-NMR 8.16 (1H, d, J=8.0 Hz), 7.85-7.88 (1H, m), 7.74(1H, d, J=8.3 Hz), 7.64 (1H, d, J=6.4 Hz), 7.45-7.53 (3H, m), 7.28-7.31(2H, m), 6.78-6.82 (2H, m), 4.62 (1H, q, J=6.4 Hz), 3.78 (3H, s), 2.78(2H, t, J=6.7 Hz), 2.49-2.63 (2H, m), 1.46-1.68 (4H, m), 1.49 (3H, d,J=6.4 Hz), m/z=365.

Example 296 Synthesis of S-149

[1104] S-149 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by4-methoxythiophenol, 1,5-dibromopentane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1105] 400 MHz-¹H-NMR 8.17 (1H, d, J=8.3 Hz), 7.83-7.88 (1H, m), 7.74(1H, d, J=8.0 Hz), 7.63 (1H, d, J=7.1 Hz), 7.46-7.53 (3H, m), 7.28-7.32(2H, m), 6.79-6.83 (2H, m), 4.62 (1H, q, J=6.6 Hz), 3.78 (3H, s), 2.78(2H, t, J=7.3 Hz), 2.48-2.61 (2H, m), 1.46-1.60 (4H, m), 1.49 (3H, d,J=6.6 Hz), 1.36-1.44 (2H, m), m/z=379.

Example 297 Synthesis of S-150

[1106] S-150 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by4-methoxythiophenol, 1,6-dibromohexane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1107] 400 MHz-¹H-NMR 8.17 (1H, d, J=8.0 Hz), 7.82-7.88 (1H, m), 7.74(1H, d, J=8.3 Hz), 7.65 (1H, d, J=7.1 Hz), 7.41-7.54 (3H, m), 7.28-7.33(2H, m), 6.80-6.84 (2H, m), 4.63 (1H, q, J=6.4 Hz), 3.78 (3H, s),2.75-2.79 (2H, m), 2.49-2.61 (2H, m), 1.24-1.58 (8H, m), m/z=393.

Example 298 Synthesis of S-151

[1108] S-151 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chlorbethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by4-methoxythiophenol, 1,7-dibromoheptane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1109] 400 MHz-¹H-NMR 8.15 (1H, d, J=8.0 Hz), 7.86-7.88 (1H, m),7.71-7.77 (2H, m), 7.46-7.54 (3H, m), 7.29-7.32 (2H, m), 6.80-6.84 (2H,m), 4.69 (1 H, bs), 3.80 (3H, s), 2.77 (2H, t, J=7.5 Hz), 2.51-2.64 (2H,m), 1.00-1.64 (13H, m), m/z=407.

Example 299 Synthesis of S-152

[1110] S-152 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by4-methoxythiophenol, 1,8-dibromooctane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1111] 400 MHz-¹H-NMR 8.15 (1H, d, J=8.0 Hz), 7.86-7.89 (1H, m),7.71-7.77 (2H, m), 7.45-7.54 (3H, m), 7.29-7.33 (2H, m), 6.80-6.85 (2H,m), 4.66-4.76 (1H, m), 3.78 (3H, s), 2.78 (2H, t, J=7.3 Hz), 2.51-2.64(2H, m),1.05-1.56 (15H, m), m/z=421.

Example 300 Synthesis of S-153

[1112] S-153 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the 2,5-dimethylthiol by2,3,5,6-tetrafluorothiophenol.

[1113] 400 MHz-¹H-NMR 7.21 (1H, dd, J=8.0 Hz, J=8.0 Hz), 6.96-7.06 (1H,m), 6.82-6.86 (2H, m), 6.74-6.77 (1H, m), 3.80 (3H, s), 3.70 (1H, q,J=6.6 Hz), 3.03 (2H, t, J=6.0 Hz), 2.55-2.67 (2H, m), 1.34 (3H, d, J=6.6Hz), m/z=359.

Example 301 Synthesis of S-154

[1114] S-154 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by2,3,5,6-tetrafluorothiophenol and 1,3-dibromopropane.

[1115] 400 MHz-¹H-NMR 7.23 (1H, dd, J=8.3 Hz, J=8.3 Hz), 6.97-7.06 (1H,m), 6.84-6.87 (2H, m), 6.74-6.79 (1H, m), 3.81 (3H, s), 3.70 (1H, q,J=6.6 Hz), 2.90-3.03 (2H, m), 2.49-2.65 (2H, m), 1.66-1.75 (2H, m), 1.33(3H, d, J=6.6 Hz), m/z=373.

Example 302 Synthesis of S-155

[1116] S-155 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by2,3,5,6-tetrafluorothiophenol and 1,4-dibromobutane.

[1117] 400 MHz-¹H-NMR 7.23 (1H, dd, J=8.1 Hz.J=8.1 Hz), 6.97-7.06 (1H,m), 6.84-6.88 (2H, m), 6.76-6.78 (1H, m), 3;81 (3H, s), 3.70 (1H, q,J=6.6 Hz), 2.91 (2H, t, J=6.6 Hz), 2.37-2.53 (2H, m), 1.53-1.63 (4H, m),1.32 (3H, d, J=6.6 Hz), m/z=387.

Example 303 Synthesis of S-156

[1118] S-156 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by2,3,5,6-tetrafluorothiophenol and 1,5-dibromopentane.

[1119] 400 MHz-¹H-NMR 7.23 (1H, dd, J=8.0 Hz, J=8.0 Hz), 6.96-7.05 (1H,m), 6.85-6.89 (2H, m), 6.75-6.79 (1H, m), 3.81 (3H, s), 3.71 (1H, q,J=6.5 Hz), 2.91 (2H, t, J=7.3 Hz), 2.37-2.51 (2H, m), 1.50-1.59 (2H, m),1.36-1.46 (4H, m), 1.33 (3H, d, J=6.6 Hz), m/z=401.

Example 304 Synthesis of S-157

[1120] S-157 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by2,3,5,6-tetrafluorothiophenol and 1,6-dibromohexane.

[1121] 400 MHz-¹H-NMR 7.23 (1H, dd, J=8.1 Hz, J=8.1 Hz), 6.97-7.06 (1H,m), 6.86-6.89 (2H, m), 6.78-6.79 (1H, m), 3.81 (3H, s), 3.72 (1H, q,J=6.6 Hz), 2.91 (2H, t, J=7.3 Hz), 2.37-2.51 (2H, m), 1.51-1.58 (2H, m),1.23-1.49 (6H, m), 1.34 (3H, d, J=6.6 Hz), m/z=415.

Example 305 Synthesis of S-158

[1122] S-158 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by2,3,5,6-tetrafluorothiophenol and 1,7-dibromoheptane.

[1123] 400mHz-¹H-NMR 7.24 (1H, dd, J=8.0 Hz, J=8.0 Hz), 6.97-7.05 (1H,m), 6.88-6.90 (2H, m), 6.78 (1H, m), 3.81 (3H, s), 3.74 (1H, q, J=6.7Hz), 2.91 (2H, t, J=7.3 Hz), 2.38-2.51 (2H, m), 1.20-1.58 (8H, m), 1.36(3H, d, J=6.7 Hz), m/z=429.

Example 306 Synthesis of S-159

[1124] S-159 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by2,3,5,6-tetrafluorothiophenol and 1,8-dibromooctane.

[1125] 400 MHz-¹H-NMR 7.22-7.26 (1H, m), 6.97-7.05 (1H, m), 6.89-6.92(2H, m), 6.78-6.81 (1H, m), 3.81 (3H, s), 3.77 (1H, q, J=6.6 Hz), 2.91(2H, t, J=7.4 Hz), 2.40-2.54 (2H, m), 1.17-1.57 (12H, m), 1.40 (3H, d,J=6.6 Hz), m/z=443.

Example 307 Synthesis of S-160

[1126] S-160 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and (R)-(+)-3-methoxy-α-benzylmethylaminerespectively by 2,3,5,6-tetrafluorothiophenol and(R)-(+)-1-(1-naphthyl)ethylamine.

[1127] 400 MHz-¹H-NMR 8.15 (1H, d, J=8.3 Hz), 7.84-7.89 (1H, m), 7.72(1H, d, J=8.3 Hz), 7.61 (1H, d, J=7.1 Hz), 7.48 (1H, d, J=7.1 Hz),7.43-7.52 (3H, m), 6.95-7.03 (1H, m), 4.61 (1H, q, J=6.6 Hz), 3.06 (2H,t, J=6.1 Hz), 2.65-2.75 (2H, m), 1.48 (3H, d, J=6.6 Hz), m/z=379.

Example 308 Synthesis of S-161

[1128] S-161 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by2,3,5,6-tetrafluorothiophenol, 1,3-dibromopropane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1129] 400 MHz-¹H-NMR 8.16 (1H, d, J=8.0 Hz), 7.85-7.88 (1H, m), 7.74(1H, d, J=8.3 Hz), 7.61 (1H, d, J=6.6 Hz), 7.44-7.52 (3H, m), 6.95-7.04(1H, m), 4.60 (1H, q, J=6.5 Hz), 2.93-3.05 (2H, m), 2.61-2.75 (2H, m),1.68-1.78 (2H, m), 1.48 (3H, d, J=6.5 Hz), m/z=393.

Example 309 Synthesis of S-162

[1130] S-162 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by2,3,5,6-tetrafluorothiophenol, 1,4-dibromobutane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1131] 400 MHz-¹H-NMR 8.17 (1H, d, J=8.3 Hz), 7.85-7.87 (1H, m), 7.73(1H, d, J=8.3 Hz), 7.62 (1H, d, J=7.1 Hz), 7.44-7.52 (3H, m), 6.95-7.04(1H, m), 4.61 (1H, q, J=6.6 Hz), 2.90 (2H, t, J=6.7 Hz), 2.48-2.62 (2H,m), 1.57-1.63 (4H, m), 1.48 (3H, d, J=6.6 Hz), m/z=407.

Example 310 Synthesis of S-163

[1132] S-163 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by2,3,5,6-tetrafluorothiophenol, 1,5-dibromopentane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1133] 400 MHz-¹H-NMR 8.17 (1H, d, J=8.3 Hz), 7.85-7.88 (1H, m), 7.74(1H, d, J=8.3 Hz), 7.63 (1H, d, J=6.8 Hz), 7.44-7.52 (3H, m), 6.95-7.04(1 H, m), 4.61 (1H, q, J=6.6 Hz), 2.90 (2H, t, J=7.2 Hz), 2.48-2.62 (2H,m), 1.38-1.58 (6H, m), 1.49 (3H, d, J=6.6 Hz), m/z=421.

Example 311 Synthesis of S-164

[1134] S-164 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by2,3,5,6-tetrafluorothiophenol, 1,6-dibromohexane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1135] 400 MHz-¹H-NMR 8.17 (1H, d, J=8.3 Hz), 7.85-7.88 (1H, m), 7.74(1H, d, J=8.1 Hz), 7.65 (1H, d, J=7.1 Hz), 7.45-7.53 (3H, m), 6.98-7.02(1H, m), 4.63 (1H, q, J=6.6 Hz), 2.89 (2H, t, J=7.3 Hz), 2.47-2.62 (2H,m), 1.23-1.57 (8H, m), 1.50 (3H, d, J=6.6 Hz), m/z=435.

Example 312 Synthesis of S-165

[1136] S-165 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by2,3,5,6-tetrafluorothiophenol, 1,7-dibromoheptane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1137] 400 MHz-¹H-NMR 8.13 (1H, d, J=8.3 Hz), 7.87-7.89 (1H, m), 7.78(1H, d, J=8.0 Hz), 7.47-7.56 (3H, m), 6.95-7.04 (1H, m), 4.79 (1H, q,J=6.4 Hz), 2.87 (2H, t, J=7.3 Hz), 2.52-2.68 (2H, m), 1.02-1.70 (10H,m), 1.65 (3H, d, J=6.4 Hz), m/z=449.

Example 313 Synthesis of S-166

[1138] S-166 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by2,3,5,6-tetrafluorothiophenol, 1,8-dibromooctane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1139] 400 MHz-¹H-NMR 8.11 (1H, d, J=8.5 Hz), 7.88-7.91 (1H, m), 7.80(1H, d, J=8.3 Hz), 7.44-7.57 (3H, m), 6.95-7.03 (1H, m), 4.89 (1H, bs),2.88 (2H, t, J=7.3 Hz), 2.54-2.72 (2H, m), 1.00-1.80 (15H, m), m/z=463.

Example 314 Synthesis of S-167

[1140] S-167 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the 2,5-dimethylthiol by5-chloro-2-mercaptobenzothiazole.

[1141] 400 MHz-¹H-NMR 7.80 (1H, d, J=1.7 Hz), 7.63 (1H, dd, J=8.6 Hz,J=1.2 Hz), 7.18-7.28 (2H, m), 6.86-6.90 (2H, m), 6.74-6.78 (1H, m), 3.80(3H, s), 3.77-3.82 (1H, m), 3.43-3.47 (2H, m), 2.85-3.00 (2H, m), 1.35(3H, d, J=6.6 Hz), m/z=378.

Example 315 Synthesis of S-168

[1142] S-168 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by5-chloro-2-mercaptobenzothiazole and 1,3-dibromopropane.

[1143] 400 MHz-1H-NMR 7.79 (1H, d, J=2.0 Hz), 7.63 (1H, d, J=8.2 Hz),7.19-7.27 (2H, m), 6.87-6.89 (2H, m), 6.77-6.79 (1H, m), 3.80 (3H, s),3.74 (1H, q, J=6.6 Hz), 3.33-3.47 (2H, m), 2.55-2.72 (2H, m), 1.93-2.00(2H, m), 1.35 (3H, d, J=6.6 Hz), m/z=392.

Example 316 Synthesis of S-169

[1144] S-169 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by5-chloro-2-mercaptobenzothiazole and 1,4-dibromobutane.

[1145] 400 MHz-¹H-NMR 7.82 (1H, d, J=2.0 Hz), 7.63 (1H, d, J=8.5 Hz),7.21-7.27 (2H, m), 6.87-6.90 (2H, m), 6.76-6.79 (1H, m), 3.80 (3H, s),3.73 (1H, q, J=6.6 Hz), 3.32 (2H, t, J=7.3 Hz), 2.45-2.60 (2H, m),1.78-1.90 (2H, m), 1.59-1.65 (2H, m), 1.34 (3H, d, J=6.6 Hz), m/z=406.

Example 317 Synthesis of S-170

[1146] S-170 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by5-chloro-2-mercaptobenzothiazole and 1,5-dibromopentane.

[1147] 400 MHz-¹H-NMR 7.83 (1H, d, J=2.0 Hz), 7.63 (1H, d, J=7.6 Hz),7.20-7.27 (2H, m), 6.86-6.87 (2H, m), 6.75-6.78 (1H, m), 3.81 (3H, s),3.72 (3H, s), 3.72 (1H, q, J=6.6 Hz), 3.31 (2H, t, J=7.3 Hz), 2.41-2.55(2H, m), 1.80 (2H, tt, J=7.3 Hz, J=7.3 Hz), 1.43-1.57 (4H, m), 1.34 (3H,d, J=6.6 Hz), m/z=420.

Example 318 Synthesis of S-171

[1148] S-171 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by5-chloro-2-mercaptobenzothiazole and 1,6-dibromohexane.

[1149] 400 MHz-¹H-NMR 7.82-7.83 (1H, m), 7.63 (1H, dd, J=8.6 Hz, J=1.7Hz), 7.19-7.26 (2H, m), 6.88-6.93 (2H, m), 6.75-6.81 (1 H, m), 3.82 (3H,s), 3.75-3.83 (1H, m), 3.30 (2H, t, J=7.3 Hz), 2.42-2.56 (2H, m), 1.79(2H, tt, J=7.3 Hz, J=7.3 Hz), 1.30-1.56 (6H, m), 1.40 (3H, d, J=6.4 Hz),m/z=434.

Example 319 Synthesis of S-172

[1150] S-172 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by5-chloro-2-mercaptobenzothiazole and 1,7-dibromoheptane.

[1151] 400 MHz-¹H-NMR 7.83 (1H, d, J=2.2 Hz), 7.63 (1H, d, J=8.3 Hz),7.24-7.27 (2H, m), 6.89-6.92 (2H, m), 6.77-6.80 (1H, m), 3.81 (3H, s),3.77 (1H, q, J=6.6 Hz), 3.31 (2H, t, J=7.3 Hz), 2.41-2.45 (2H, m), 1.79(2H, tt, J=7.3 Hz, =7.3 Hz), 1.21-1.55 (8H, m), 1.40 (3H, d, J=6.6 Hz),m/z=448.

Example 320 Synthesis of S-173

[1152] S-173 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by5-chloro-2-mercaptobenzothiazole and 1,8-dibromooctane.

[1153] 400 MHz-¹H-NMR 8.83 (1H, d, J=1.6 Hz), 7.63 (1H, d, J=8.5 Hz),7.22-7.27 (2H, m), 6.91-6.94 (2H, m), 6.80 (1H, dd, J=8.3 Hz, J=2.7 Hz),3.82 (3H, s), 3.78-3.85 (1H, m), 3.31 (2H, t, J=8.8 Hz), 2.42-2.53 (2H,m), 1.79 (2H, tt, J=8.8 Hz, J=8.8 Hz), 1.20-1.57 (10H, m), 1.43 (3H, d,J=6.3 Hz), m/z=462.

Example 321 Synthesis of S-174

[1154] S-174 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and (R)-(+)-3-methoxy-α-benzylmethylaminerespectively by 5-chloro-2-mercaptobenzothiazole and(R)-(+)-1-(1-naphthyl)ethylamine. m/z=398.

Example 322 Synthesis of S-175

[1155] S-175 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by5-chloro-2-mercaptobenzothiazole, 1,3-dibromopropane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1156] 400 MHz-¹H-NMR 8.18 (1H, d, J=7.3 Hz), 7.84-7.88 (1H, m),7.73-7.76 (2H, m), 7.64 (1H, d, J=7.8 Hz), 7.62 (1H, d, J=8.3 Hz),7.43-7.48 (3H, m), 7.23-7.26 (1H, m), 4.63 (1H, q, J=6.6 Hz), 3.35-3.50(2H, m), 2.67-2.82 (2H, m), 2.01 (2H, tt, J=6.9 Hz, J=6.9 Hz), 1.50 (3H,d, J=6.6 Hz), m/z=412.

Example 323 Synthesis of S-176

[1157] S-176 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by5-chloro-2-mercaptobenzothiazole, 1,4-dibromobutane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1158] 400 MHz-¹H-NMR 8.18 (1H, d, J=8.1 Hz), 7.84-7.87 (1H, m), 8.80(1H, d, J=1.9 Hz), 7.73 (1H, d, J=8.3 Hz), 7.65 (1 H, d, J=6.8 Hz), 7.62(1H, d, J=8.3 Hz), 7.43-7.52 (3H, m), 7.23-7.26 (1H, m), 4.63 (1H, q,J=6.6 Hz), 3.31 (2H, t, J=7.2 Hz), 2.56-2.70 (2H, m), 1.82-1.90 (2H, m),1.68 (2H, tt, J=7.2 Hz, J=7.2 Hz), 1.49 (3H, d, J=6.6 Hz), m/z=426.

Example 324 Synthesis of S-177

[1159] S-177 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by5-chloro-2-mercaptobenzothiazole, 1,5-dibromopentane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1160] 400 MHz-¹H-NMR 8.17 (1H, d, J=8.3 Hz), 7.82-7.87 (2H, m), 7.71-7.42 (1H, m), 7.58-7.64 (2H, m), 7.41-7.52 (3H, m), 7.23-7.26 (1H, m),4.62 (1H, q, J=6.6 Hz), 3.30 (2H, t, J=7.3 Hz), 2.51-2.65 (2H, m), 1.79(2H, tt, J=7.3 Hz, J=7.3 Hz), 1.58-1.60 (4H, m), 1.49 (3H, d, J=6.6 Hz),m/z=440.

Example 325 Synthesis of S-178

[1161] S-178 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by5-chloro-2-mercaptobenzothiazole, 1,6-dibromohexane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1162] 400 MHz-¹H-NMR 8.17 (1H, d, J=8.5 Hz), 7.82-7.88 (2H, m),7.71-7.75 (1H, m), 7.65 (1H, d, J=7.1 Hz), 7.62 (1H, d, J=8.5 Hz),7.42-7.52 (3H, m), 7.23-7.26 (1H, m), 4.63 (1H, q, J=6.6 Hz), 3.29 (2H,t, J=7.3Hz), 2.51-2.64 (2H, m), 1.78 (2H, tt, J=7.3 Hz, J=7.3Hz),1.32-1.56 (6H, m), 1.50 (3H, d, J=6.6 Hz), m/z=454.

Example 326 Synthesis of S-179

[1163] S-179 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by5-chloro-2-mercaptobenzothiazole, 1,7-dibromoheptane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1164] 400 MHz-¹H-NMR 8.15 (1H, d, J=8.3 Hz), 7.86-7.88 (1H, m),7.82-7.83 (1H, m), 7.72-7.78 (2H, m), 7.62 (1H, dd, J=8.6 Hz, J=0.5 Hz),7.45-7.55 (3H, m), 7.23-7.26 (1H, m), 4.71 (1H, q, J=6.6 Hz), 3.29 (1H,t, J=7.3 Hz), 2.50-2.66 (2H, m), 1.71-1.80 (2H, m), 1.58 (3H, d, J=6.6Hz), 1.06-1.64 (8H, m), m/z=468.

Example 327 Synthesis of S-180

[1165] S-180 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by5-chloro-2-mercaptobenzothiazole, 1,8-dibromooctane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1166] 400 MHz-¹H-NMR 8.15 (1H, d, J=8.3 Hz), 7.85-7.88 (1H, m), 7.83(1H, d, J=2.4 Hz), 7.45 (1H, d, J=8.0 Hz), 7.71 (1H, d, J=6.8 Hz), 7.62(1H, d, J=8.6 Hz), 7.45-7.54 (1H, m), 7.23-7.24 (1H, m), 4.70 (1H, q,J=6.6 Hz), 3.30 (2H, t, J=7.3 Hz), 2.52-2.65 (2H, m), 1.68-1.84 (2H, m),1.56 (3H, d, J=6.6 Hz), 1.06-1.59 (10O, m), m/z=482.

Example 328 Synthesis of S-181

[1167] S-181 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the 2,5-dimethylthiol by2,3,5,6-tetrachloro-4-mercaptopyridine.

[1168] 400 MHz-¹H-NMR 7.23 (1H, d, J=8.0 Hz), 6.84-6.87 (2H, m),6.76-6.79 (1H, m), 3.81 (3H s), 3.69 (1H, q, J=6.6 Hz), 3.06-3.19 (2H,m), 2.50-2.66 (2H, m), 1.69 (2H, tt, J=7.0 Hz, J=7.0 Hz), 1.33 (3H, d,J=6.6 Hz), m/z=424, 426.

Example 329 Synthesis of S-182

[1169] S-182 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by2,3,5,6-tetrachloro-4-mercaptopyridine and 1,3-dibromopropane. m/z=438,440.

Example 330 Synthesis of S-183

[1170] S-183 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by2,3,5,6-tetrachloro-4-mercaptopyridine and 1,4-dibromobutane. m/z=452,454.

Example 331 Synthesis of S-184

[1171] S-184 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by2,3,5,6-tetrachloro-4-mercaptopyridine and 1,5-dibromopentane.

[1172] 400 MHz-¹H-NMR 7.24 (1H, dd, J=8.0 Hz, J=8.0 Hz), 6.86-6.88 (2H,m), 6.76-6.79 (1H, m), 3.05 (2H, t, J=7.3 Hz), 3.81 (3H, s), 3.71 (1H,q, J=6.5 Hz), 2.38-2.52 (2H, m),,1.55 (2H, tt, J=7.1 Hz, J=7.1 Hz),1.36-1.50 (4H, m), 1.34 (3H, d, J=6.5 Hz), m/z=466, 468.

Example 332 Synthesis of S-185

[1173] S-185 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by2,3,5,6-tetrachloro-4-mercaptopyridine and 1,6-dibromohexane.

[1174] 400 MHz-¹H-NMR 7.23 (1H, dd, J=8.0 Hz, J=8.0 Hz), 6.86-6.89 (2H,m), 6.76-6.81 (1H, m), 3.81 (3H, s), 3.72 (1H, q, J=6.6 Hz), 3.05 (2H,t, J=7.3 Hz), 2.37-2.52 (2H, m), 1.55 (2H, tt, J=7.2 Hz, J=7.2 Hz),1.23-1.49 (6H, m), 1.34 (3H, d, J=6.6 Hz), m/z=480, 482.

Example 333 Synthesis of S-186

[1175] S-186 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by2,3,5,6-tetrachloro-4-mercaptopyridine and 1,7-dibromoheptane.

[1176] 400 MHz-¹H-NMR 7.24 (1H, dd, J=8.2 Hz, J=8.2 Hz), 6.87-6.90 (2H,m), 6.76-6.81 (1H, m), 3.81 (3H, s), 3.72 (1H, q, J=6.6 Hz), 3.05 (2H,t, J=7.3 Hz), 2.38-2.51 (2H, m), 1.55 (2H, tt, J=7.3 Hz, J=7.3 Hz),1.20-1.49 (8H, m), 1.35 (3H, d, J=6.6 Hz), m/z=494, 496.

Example 334 Synthesis of S-187

[1177] S-187 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by2,3,5,6-tetrachloro-4-mercaptopyridine and 1,8-dibromooctane.

[1178] 400 MHz-¹H-NMR 7.24 (1H, dd, J=8.0 Hz, J=8.0 Hz), 6.88-6.90 (2H,m), 6.76-6.79 (1H, m), 3.81 (3H, s), 3.73 (1H, q, J=6.6 Hz), 3.06 (2H,t, J=7.3 Hz), 2.39-2.53 (2H, m), 1.55 (2H, tt, J=7.3 Hz, J=7.3 Hz),1.20-1.50 (10H, m), 1.35 (3H, d, J=6.6 Hz), m/z=508, 510.

Example 335 Synthesis of S-188

[1179] S-188 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and (R)-(+)-3-methoxy-α-benzylmethylaminerespectively by 2,3,5,6-tetrachloro-4-mercaptopyridine and(R)-(+)-1-(1-naphthyl)ethylamine. m/z=444, 446.

Example 336 Synthesis of S-189

[1180] S-189 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethyiamine respectively by2,3,5,6-tetrachloro-4-mercaptopyridine, 1,3-dibromopropane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1181] 400 MHz-¹H-NMR 8.17 (1H, d, J=7.8 Hz), 7.85-7.88 (1H, m), 7.74(1H, d, J=8.0 Hz), 7.30 (1H, d, J=6.8 Hz), 7.44-7.52 (3H, m), 4.60 (1H,q, J=6.5 Hz), 3.08-3.21 (2H, m), 2.61-2.75 (2H, m), 1.69-1.76 (2H, m),1.49 (3H, d, J=6.5 Hz), m/z=458, 460.

Example 337 Synthesis of S-190

[1182] S-190 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by2,3,5,6-tetrachloro-4-mercaptopyridine, 1,4-dibromobutane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1183] 400 MHz-¹H-NMR 8.40 (1H, d, J=8.0 Hz), 7.82-7.88 (1H, m),7.69-7.75 (2H, m), 7.43-7.51 (3H, m), 4.04 (1H, q, J=6.6 Hz), 2.47-2.70(4H, m), 1.78-1.82 (4H, m), 1.53 (3H., d, J=6.6 Hz), m/z=472, 474.

Example 338 Synthesis of S-191

[1184] S-191 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by2,3,5,6-tetrachloro-4-mercaptopyridine, 1,5-dibromopentane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1185] 400 MHz-¹H-NMR 8.17 (1H, d, J=8.3 Hz), 7.85-7.88 (1H, m), 7.75(1H, d, J=8.0 Hz), 7.66 (1H, d, J=6.8 Hz), 7.45-7.53 (3H, m), 4.64 (1H,q, J=6.6 Hz), 3.03 (2H, t, J=7.2 Hz), 2.49-2.63 (2H, m), 1.35-1.60 (9H,m), m/z=486, 488.

Example 339 Synthesis of S-192

[1186] S-192 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by2,3,5,6-tetrachloro-4-mercaptopyridine, 1,6-dibromohexane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1187] 400 MHz-¹H-NMR 8.16 (1H, d, J=8.0 Hz), 7.86-7.89 (1H, m), 7.76(1H, d, J=8.3 Hz), 7.70 (1H, bs), 7.46-7.54 (3H, m), 4.69 (1H, bs), 3.02(2H, t, J=7.2 Hz), 2.51-2.64 (2H, m), 1.25-1.60 (11H, m), m/z=500, 502.

Example 340 Synthesis of S-193

[1188] S-193 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by2,3,5,6-tetrachloro-4-mercaptopyridine, 1,7-dibromoheptane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1189] 400 MHz-¹H-NMR 8.15 (1H, d, J=8.3 Hz), 7.86-7.89 (1H, m),7.70-7.78 (1H, m), 7.46-7.55 (3H, m), 4.74 (1H, bs), 3.03 (2H, t, J=7.2Hz), 2.50-2.66 (2H, m), 1.05-1.65 (13H, m), m/z=514, 516.

Example 341 Synthesis of S-194

[1190] S-194 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by2,3,5,6-tetrachloro-4-mercaptopyridine, 1,8-dibromooctane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1191] 400 MHz-¹H-NMR 8.15 (1H, d, J=8.3 Hz), 7.86-7.89 (1H, m)7.72-7.78 (2H, m), 7.46-7.54 (3H, m), 4.72 (1H, q, J=7.2 Hz), 3.04 (2H,t, J=7.2 Hz), 2.52-2.57 (2H, m), 1.00-1.56 (12H, m), 1.58.(3H, d, J=6.2Hz), m/z=528, 530.

Example 342 Synthesis of S-195

[1192] S-195 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and (R)-(+)-3-methoxy-α-benzylmethylaminerespectively by 2,3,5,6-tetrafluoro-4-trifluoromethylthiophenol and(R)-(+)-1-(1-naphthyl)ethylamine. m/z=447.

Example 343 Synthesis of S-196

[1193] S-196 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by2,3,5,6-tetrafluoro-4-trifluoromethylthiophenol, 1,3-dibromopropane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1194] 400 MHz-¹H-NMR 8.16 (1H, d, J=8.0 Hz), 7.84-7.86 (1H, m), 7.73(1H, d, J=8.0 Hz), 7.60 (1H, d, J=6.8 Hz), 7.43-7.51 (3H, m), 4.59 (1H,q, J=6.2 Hz), 3.02-3.15 (2H, m), 2.60-2.74 (2H, m), 1.67-1.77 (2H, m),1.48 (3H, d, J=6.2 Hz), m/z=461.

Example 344 Synthesis of S-197

[1195] S-197 was synthesized by aimost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by2,3,5,6-tetrafluoro-4-trifluoromethylthiophenol, 1,6-dibromohexane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1196] 400 MHz-¹H-NMR 8.17 (1H, d, J=8.2 Hz), 7.85-7.88 (1H, m), 7.75(1H, d, J=8.3 Hz), 7.66 (1H, d, J=6.8 Hz), 7.45-7.53 (3H, m), 4.64 (1H,q, J=6.4 Hz), 2.99 (2H, t, J=7.3 Hz), 2.50-2.63 (2H, m), 1.48-1.60 (4H,m), 1.52 (3H, d, J=6.4 Hz), 1.26-1.42 (4H, m), m/z=503.

Example 345 Synthesis of S-198

[1197] S-198 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by2,3,5,6-tetrafluoro-4-trifluoromethylthiophenol, 1,7-dibromoheptane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1198] 400 MHz-¹H-NMR 8.17 (1H, d, J=8.3 Hz), 7.85-7.88 (1H, m), 7.74(1H, d, J=8.3 Hz), 7.66 (1H, d, J=6.8 Hz), 7.45-7.52 (3H, m), 4.65 (1H,q, J=6.4 Hz), 3.00 (2H, t, J=7.4 Hz), 2.50-2.63 (2H, m), 1.47-1.60 (4H,m), 1.52 (3H, d, J=6.4 Hz), 1.23-1.41 (6H, m), m/z=517.

Example 346 Synthesis of S-199

[1199] S-199 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by2,3,5,6-tetrafluoro-4-trifluoromethylthiophenol, 1,8-dibromooctane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1200] 400 MHz-¹H-NMR 8.16 (1H, d, J=8.3 Hz), 7.86-7.88 (1H, m), 7.75(1H, d, J=8.3 Hz), 7.69 (1H, d, J=6.1 Hz), 7.45-7.53 (3H, m), 4.67 (1H,q, J=6.4 Hz), 3.01 (2H, t, J=7.3 Hz), 2.51-2.64 (2H, m), 1.20-1.70 (15H,m), m/z=531.

Example 347 Synthesis of S-200

[1201] S-200 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by2,3,5,6-tetrafluoro-4-trifluoromethylthiophenol, 1,10-dibromodecane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1202] 400 MHz-¹H-NMR 8.17 (1H, d, J=8.3 Hz), 7.51-7.88 (1H, m), 7.74(1H, d, J=8.3 Hz), 7.64 (1H, d, J=7.1 Hz), 7.44-7.52 (3H, m), 4.62 (1H,q, J=6.6 Hz), 3.02 (2H, t, J=7.4 Hz), 2.50-2.62 (2H, m), 1.54-1.62 (2H,m), 1.49 (3H, d, J=6.6 Hz), 1.00-1.54 (14H, m), m/z=559.

Example 348 Synthesis of S-201

[1203] S-201 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by2,3,5,6-tetrafluoro-4-trifluoromethylthiophenol, 1,12-dibromododecaneand (R)-(+)-1-(1-naphthyl)ethylamine.

[1204] 400 MHz-¹H-NMR 8.17 (1H, d, J=8.3 Hz), 7.85-7.88:(1H, m), 7.74(1H, d, J=8.0 Hz), 7.66 (1H, d, J=7.1 Hz), 7.45-7.53 (3H, m), 4.64 (1H,q, J=6.6 Hz), 3.03 (2H, t, J=7.4 Hz), 2.50-2.63 (2H, m),1.20-1.63 (18H,m), 1.51 (3H, d, J=6.6 Hz), m/z=587.

Example 349 Synthesis of S-202

[1205] S-202 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and (R)-(+)-3-methoxy-α-benzylmethylaminerespectively by 2-isopropylthiophenol and(R)-(+)-1-(1-naphthyl)ethylamine.

[1206] 400 MHz-¹H-NMR 8.16 (1H, d, J=7.8 Hz), 7.84-7.87 (1H, m), 7.72(1H, d, J=8.0 Hz), 7.63 (1H, d, J=7.1 Hz), 7.41-7.54 (3H, m), 7.23-7.27(2H, m), 7.13-7.16 (1H, m), 7.03-7.07 (1H, m), 4.63 (1 H, q, J=6.5Hz),3.45-3.54 (1H, m), 3.04 (2H, t, J=6.2 Hz), 2.81 (2H, t, J=6.8 Hz), 1.48(2H, d, J=6.5 Hz), 1.19-1.22 (6H, m), m/z=349.

Example 350 Synthesis of S-203

[1207] S-203 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by2-isopropylthiophenol, 1,3-dibromopropane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1208] 400 MHz-¹H-NMR 8.17 (1H, d, J=7.8 Hz), 7.86 (1H, d, J=7.8 Hz),7.73 (1H, d, J=8.0 Hz), 7.63 (1H, d, J=7.3 Hz), 7.43-7.51 (3H, m),7.22-7.29 (2H, m), 7.08-7.17 (2H, m), 4.60 (1H, q, J=6.4 Hz), 3.42-3.50(1H, m), 2.87-3.00 (2H, m), 2.62-2.76 (2H, m), 1.79-1.86 (2H, m), 1.48(3H, d, J=6.4 Hz), 1.18-1.22 (6H, m), m/z=363.

Example 351 Synthesis of S-204

[1209] S-204 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by2-isopropylthiophenol, 1,4-dibromobutane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1210] 400 MHz-¹H-NMR 8.17 (1H, d, J=8.0 Hz), 7.85-7.87 (1H, m), 7.73(1H, d, J=8.3 Hz), 7.63 (1H, d, J=6.8 Hz), 7.44-7.51 (3H, m), 7.22-7.27(2H, m), 7.07-7.18 (2H, m), 4.61 (1H, q, J=6.5 Hz), 3.44-3.53 (1 H, m),2.85 (2H, t, J=6.8 Hz), 2.51-2.65 (2H, m), 1.63-1.70 (4H, m), 1.48 (3H,d, J=6.5 Hz), 1.21 (6H, d, J=6.8 Hz), m/z=377.

Example 352 Synthesis of S-205

[1211] S-205 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by2-isopropylthiophenol, 1,5-dibromopentane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1212] 400 MHz-¹H-NMR 8.17 (1H, d, J=8.0 Hz), 7.85-7.88 (1H, m), 7.73(1H, d, J=8.3 Hz), 7.63 (1H, d, J=7.1 Hz), 7.44-7.52 (3H, m), 7.22-7.28(2H, m), 7.08-7.18 (2H, m), 4.61 (1H, q, J=6.5 Hz), 3.42-3.53 (1H, m),2.85 (2H, t, J=7.3 Hz), 2.49-2.62 (2H, m), 1.59-1.67 (2H, m), 1.40-1.56(4H, m), 1.48 (3H, d, J=6.5 Hz), 1.21 (6H, d, J=6.8 Hz), m/z=391.

Example 353 Synthesis of S-206

[1213] S-206 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by2-isopropylthiophenol, 1,6-dibromohexane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1214] 400 MHz-¹H-NMR 8.17 (1H, d, J=8.0 Hz), 7.85-7.88 (1H, m), 7.73(1H, d, J=8.3 Hz), 7.64 (1H, d, J=6.8 Hz), 7.41-7.52 (3H, m), 7.21-7.29(2H, m), 7.09-7.17 (2H, m), 4.62 (1H, q, J=6.5 Hz), 3.43-3.53 (1H, m),2.84 (2H, t, J=7.3 Hz), 2.49-2.62 (2H, m), 1.58-1.66 (2H, m), 1.45-1.55(2H, m), 1.25-1.45 (4H, m), 1.49 (3H, m), 1.21-1.23 (6H, m), m/z=405.

Example 354 Synthesis of S-207

[1215] S-207 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by2-isopropylthiophenol, 1,7-dibromoheptane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1216] 400 MHz-¹H-NMR 8.17 (1H, d, J=8.3 Hz), 7.85-7.88 (1H, m), 7.74(1H, d, J=8.0 Hz), 7.65 (1H, d, J=7.1 Hz), 7.44-7.52 (3H, m), 7.22-7.29(2H, m), 7.09-7.17 (2H, m), 4.63 (1H, q, J=6.6 Hz), 3.43-3.54 (1H, m),2.85 (2H, t, J=7.4 Hz), 2.49-2.62 (2H, m), 1.57-1.65 (2H, m), 1.36-1.55(4H, m), 1.49 (3H, d, J=6.6 Hz), 1.25-1.30 (4H, m), 1.20-1.25 (6H, m),m/z=419.

Example 355 Synthesis of S-208

[1217] S-208 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by2-isopropylthiophenol, 1,8-dibromooctane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1218] 400 MHz-¹H-NMR 8.18 (1H, d, J=8.5 Hz), 7.85-7.88 (1H, m), 7.74(1H, d, J=8.0 Hz), 7.65 (1H, d, J=7.1 Hz), 7.44-7.53 (3H, m), 7.23-7.29(2H, m), 7.09-7.17 (2H, m), 4.63 (1H, q, J=6.6 Hz), 3.43-3.54 (1H, m),2.85 (2H, t, J=7.4 Hz), 2.50-2.62 (2H, m), 1.58-1.67 (2H, m), 1.24-1.52(10H, m), 1.50 (3H, d, J=6.6 Hz), 1.22 (6H, d, J=6.8 Hz), m/z=433.

Example 356 Synthesis of S-209

[1219] S-209 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the 2,5-dimethylthiol by2,4,5-trichlorothiophenol.

[1220] 400 MHz-¹H-NMR 7.44 (1H, s), 7.29 (1H, s), 7.23 (1H, dd, J=8.3Hz, J=8.3 Hz), 6.87-6.89 (2H, m), 6.76-6.79 (1H, m), 3.80 (3H, s), 3.76(1H, q, J=6.6 Hz), 3.03 (2H, t, J=6.5 Hz), 2.70-2.85 (2H, m), 1.36 (3H,d, J=6.6 Hz), m/z=389, 391.

Example 357 Synthesis of S-210

[1221] S-210 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by2,4,5-trichlorothiophenol and 1,3-dibromopropane.

[1222] 400 MHz-¹H-NMR 7.44 (1H, s), 7.30 (1H, s), 7.22-7.25 (1H, m),6.87-6.90 (2H, m), 6.77-6.80 (1H, m), 3.81 (3H, s), 3.74 (1H, q, J=6.5Hz), 2.89-3.03 (2H, m), 2.54-2.70 (2H, m), 1.77-1.85 (2H, m), 1.36 (3H,d, J=6.5 Hz), m/z=403, 405.

Example 358 Synthesis of S-211

[1223] S-211 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by2,4,5-trichlorothiophenol and 1,4-dibromobutane.

[1224] 400 MHz-¹H-NMR 7.44 (1H, s),7.21-7.27 (2H, m), 6.86-6.90 (2H, m),6.76-6.79 (1H, m), 3.81 (3H, s), 3.72 (1H, q, J=6.6 Hz), 2.86-2.91 (2H,m), 2.43-2.58 (2H, m), 1.58-1.76 (4H, m), 1.34 (3H, d, J=6.6 Hz),m/z=419, 421.

Example 359 Synthesis of S-212

[1225] S-212 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by2,4,5-trichlorothiophenol and 1,5-dibromopentane.

[1226] 400 MHz-¹H-NMR 7.44 (1H, s), 7.21-7.26 (2H, m), 6.87-6.90 (2H,m), 6.76-6.79 (1H, m), 3.81 (3H, s), 3.72 (1H, q, J=6.6 Hz), 2.89 (2H,t, J=7.3 Hz), 2.41-2.55 (2H, m), 1.64-1.71 (2H, m),1.43-1.56 (4H, m),1.35 (3H, d, J=6.6 Hz), m/z=431, 433.

Example 360 Synthesis of S-213

[1227] S-213 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by2,4,5-trichlorothiophenol and 1,6-dibromohexane.

[1228] 400 MHz-¹H-NMR 7.44 (1H, s), 7.21-7.26 (2H, m), 6.87-6.90 (2H,m), 6.76-6.79 (1H, m), 3.81 (3H, s), 3.72 (1H, q, J=6.6 Hz), 2.88 (2H,t, J=7.3 Hz), 2.39-2.53 (2H, m), 1.63-1.71 (2H, m), 1.28-1.52 (6H, m),1.34 (3H, d, J=6.6 Hz), m/z=445, 447.

Example 361 Synthesis of S-214

[1229] S-214 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by2,4,5-trichlorothiophenol and 1,7-dibromoheptane.

[1230] 400 MHz-¹H-NMR 7.44 (1H, s), 7.21-7.26 (2H, m), 6.87-6.91 (2H,m), 6.76-6.80 (2H, m), 3.81 (3H, s), 3.73 (1H, q, J=6.6 Hz), 2.89 (2H,t, J=7.3 Hz), 2.39-2.53 (2H, m), 1.64-1.71 (2H, m), 1.39-1.48 (4H, m),1.25-1.37 (6H, m), 1.35 (3H, d, J=6.6 Hz), m/z=459, 461.

Example 362 Synthesis of S-215

[1231] S-215 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethyithiophenol and 1-bromo-2-chloroethane respectively by2,4,5-trichlorothiophenol and 1,8-dibromooctane.

[1232] 400 MHz-¹H-NMR 7.44 (1H, s), 7.25 (1H, s), 7.24 (1H, dd, J=8.0Hz, J=8.0 Hz), 6.87-6.90 (2H, m), 6.76-6.79 (1H, m), 3.81 (3H, s), 3.73(1H, q, J=6.6 Hz), 2.89 (1H, t, J=7.3 Hz), 2.38-2.52 (2H, m), 1.64-1.71(2H, m), 1.40-1.50 (4H, m), 1.35 (3H, d, J=6.6 Hz),1.25-1.35 (6H, m),m/z=473, 735.

Example 363 Synthesis of S-216

[1233] S-216 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by2,4,5-trichlorothiophenol, 1,3-dibromopropane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1234] 400 MHz-¹H-NMR 8.20 (1H, d, J=8.0 Hz), 7.85-7.88 (1H, m), 7.75(1H, d, J=8.0 Hz), 7.64 (1H, d, J=7.1 Hz), 7.45-7.52 (3H, m), 7.43 (1H,s), 7.29 (1H, s), 4.63 (1H, q, J=6.5 Hz), 2.90-3.05 (2H, m), 2.64-2.⁸⁰(2H, m),1.81-1.89 (2H, m), 1.52 (3H, d, J=6.5 Hz), m/z=423, 425.

Example 364 Synthesis of S-217

[1235] S-217 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by2,4,5-trichlorothiophenol, 1,6-dibromohexane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1236] 400 MHz-¹H-NMR 8.17 (1H, d, J=8.3 Hz), 7.86-7.88 (1H, m), 7.75(1H, d, J=8.3 Hz), 7.66 (1H, d, J=6.8 Hz), 7.45-7.53 (3H, m), 7.44 (1H,s), 7.23 (1H, s), 4.65 (1H, q, J=6.6 Hz), 2.86 (2H, t, J=7.3 Hz),2.51-2.66 (2H, m), 1.30-1.73 (8H, m), 1.52 (3H, d, J=6.6 Hz), m/z=465,467.

Example 365 Synthesis of S-218

[1237] S-218 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by2,4,5-trichlorothiophenol, 1,7-dibromoheptane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1238] 400 MHz-¹H-NMR 8.17 (1H, d, J=8.3 Hz), 7.86-7.88 (1H, m), 7.75(1H, d, J=8.3 Hz), 7.68 (1H, d, J=6.6 Hz), 7.45-7.53 (3H, m), 7.43 (1H,s), 7.24 (1H, s), 4.66 (1H, q, J=6.4 Hz), 2.87 (2H, t, J=7.3 Hz),2.51-2.64 (2H, m), 1.25-1.70 (10H, m), 1.53 (3H, d, J=6.4 Hz), m/z=423,425.

Example 366 Synthesis of S-219

[1239] S-219 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by2,4,5-trichlorothiophenol, 1,8-dibromooctane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1240] 400 MHz-¹H-NMR 8.17 (1H, d, J=8.3 Hz), 7.86-7.89 (1H, m), 7.75(1H, d, J=8.3 Hz), 7.68 (1H, bs), 7.45-7.53 (3H, m), 7.44 (1H, s), 7.24(1H, s), 4.67 (1H, bs), 2.88 (2H, t, J=7.3 Hz), 2.51-2.64 (2H, m),1.23-1.71 (15H, m), m/z=493, 495.

Example 367 Synthesis of S-220

[1241] S-220 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by6-ethoxy-2-mercaptobenzothiazole and 1,3-dibromopropane. m/z=402.

Example 368 Synthesis of S-221

[1242] S-221 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by6-ethoxy-2-mercaptobenzothiazole and 1,4-dibromobutane.

[1243] 400 MHz-¹H-NMR 7.71 (1H, d, J=8.8 Hz), 7.20-7.24 (2H, m), 6.98(1H, dd, J=9.0 Hz, J=2.4 Hz), 6.87-6.89 (2H, m), 6.77 (1H, ddd, J=8.0Hz, J=2.4 Hz, J=1.0 Hz), 4.06 (2H, q, J=6.9 Hz), 3.80 (3H, s), 3.28 (2H,t, J=7.5 Hz), 2.45-2.61 (2H, m), 1.75-1.88 (2H, m), 1.58-1.70 (2H, m),1.44 (3H, t, J=7.5 Hz), 1.35 (3H, d, J=6.9 Hz), m/z=416.

Example 369 Synthesis of S-222

[1244] S-222 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by6-ethoxy-2-mercaptobenzothiazole and 1,5-dibromopentane.

[1245] 400 MHz-¹H-NMR 7.23 (1H, d, J=8.8 Hz), 7.20-7.25 (2H, m), 6.99(1H, dd, J=8.8 Hz, J=2.4 Hz), 6.87-6.90 (2H, m), 6.76-6.77 (1H, m),4.03-4.11 (2H, m), 3.81 (3H, s), 3.72 (1H, q, J=6.6 Hz), 3.27 (2H, t,J=7.6 Hz), 2.41-2.54 (2H, m), 1.74-1.82 (2H, m), 1.41-1.56 (4H, m), 1.44(3H, t, J=6.8 Hz), 1.34 (3H, d, J=6.6 Hz), m/z=430.

Example 370 Synthesis of S-223

[1246] S-223 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by6-ethoxy-2-mercaptobenzothiazole and 1,6-dibromohexane.

[1247] 400 MHz-¹H-NMR 7.73 (1H, d, J=9.0 Hz), 7.20-7.25 (2H, m), 6.99(1H, dd, J=8.8 Hz, J=2.4 Hz), 6.88-6.90 (2H, m), 6.77 (1H, ddd, J=8.3Hz, J=2.4 Hz, J=1.0 Hz), 4.06 (2H, q, J=7.0 Hz), 3.81 (3H, s), 3.73 (1H,q, J=6.0 Hz), 3.27 (2H, t, J=7.3 Hz), 2.40-2.53 (2H, m), 1.74-1.81 (2H,m), 1.25-1.53 (6H, m), 1.44 (3H, t, J=7.0 Hz), 1.35 (3H, d, J=6.0 Hz),m/z=444.

Example 371 Synthesis of S-224

[1248] S-224 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by6-ethoxy-2-mercaptobenzothiazole and 1,7-dibromoheptane.

[1249] 400 MHz-¹H-NMR 7.72 (1H, d, J=9.0 Hz), 7.25 (1H, dd, J=6.9 Hz,J=6.9 Hz), 7.21 (1H, d, J=2.4 Hz), 6.98 (1H, dd, J=9.0 Hz, J=2.4 Hz),6.78-6.82 (1H, m), 4.06 (3H, q, J=7.0 Hz), 3.82 (3H, s), 3.79-3.85 (1 H,m), 3.27 (2H, t, J=7.3 Hz), 2.43-2.56 (2H, m), 1.73-1.80 (2H, m),1.18-1.57 (11 H, m), 1.44 (3H, t, J=7.0 Hz), m/z=458.

Example 372 Synthesis of S-225

[1250] S-225 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by6-ethoxy-2-mercaptobenzothiazole and 1,8-dibromooctane.

[1251] 400 MHz-¹H-NMR 7.23 (1H, d, J=8.8 Hz), 7.21-7.24 (2H, m), 6.99(1H, dd, J=8.8 Hz, J=2.7 Hz), 6.87-6.91 (2H, m), 6.76-6.80 (1H, m), 4.06(2H, q, J=7.0 Hz), 3.81 (3H, s), 3.75 (1H, q, J=6.6 Hz), 3.28 (2H, t,J=7.3 Hz), 1.99-2.53 (2H, m), 1.74-1.81 (2H, m), 1.24-1.48 (1 OH, m),1.44 (3H, t, J=7.0 Hz), 1.37 (3H, d, J=6.6 Hz), m/z=472.

Example 373 Synthesis of S-226

[1252] S-226 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and (R)-(+)-3-methoxy-α-benzylmethylaminerespectively by 6-ethoxy-2-mercaptobenzothiazole and(R)-(+)-1-(1-naphthyl)ethylamine. m/z=408.

Example 374 Synthesis of S-227

[1253] S-227 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by6-ethoxy-2-mercaptobenzothiazole, 1,3-dibromopropane and(R)-(+)-1-(1-naphthyl)ethylamine. m/z=422.

Example 375 Synthesis of S-228

[1254] S-228 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by6-ethoxy-2-mercaptobenzothiazole, 1,4-dibromobutane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1255] 400 MHz-¹H-NMR 8.18 (1H, d, J=8.3 Hz), 7.84-7.88 (1H, m), 7.73(1H, d, J=8.3 Hz), 7.70 (1H, d, J=9.0 Hz), 7.65 (1 H, d, J=7.1 Hz),7.44-7.52 (3H, m), 7.20 (1H, d, J=2.4 Hz), 6.97 (1H, dd, J=9.0 Hz,J=2.4Hz), 4.63 (1H, q, J=6.6 Hz), 4.05 (2H, q, J=7.0 Hz), 3.28 (2H, dt,J=9.2 Hz, J=1.2Hz), 2.55-2.69 (2H, m), 1.81-1.90 (2H, m), 1.63-1.72 (2H,m), 1.50 (3H, d, J=6.6 Hz), 1.43 (3H, t, J=7.0 Hz), m/z=436.

Example 376 Synthesis of S-229

[1256] S-229 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by6-ethoxy-2-mercaptobenzothiazole, 1,5-dibromopentane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1257] 400 MHz-¹H-NMR 8.17 (1H, d, J=8.3 Hz), 7.83-7.88 (1H, m), 7.73(1H, d, J=8.0 Hz), 7.72 (1H. d, J=8.8 Hz), 7.64 (1 H, d, J=7.3 Hz),7.44-7.52 (3H, m), 7.20 (1H, d, J=2.4 Hz), 6.98 (1H, dd, J=9.0 Hz,J=2.7Hz), 4.62 (1H, q, J=6.5 Hz), 4.06 (2H, q, J=7.0 Hz), 3.27 (2H, t,J=7.3 Hz), 2.52-2.65 (2H, m), 1.70-1.82 (2H, m), 1.49 (3H, d, J=6.5 Hz),1.44 (3H, t, J=7.0 Hz), 1.41-1.60 (4H, m), m/z=450.

Example 377 Synthesis of S-230

[1258] S-230 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by6-ethoxy-2-mercaptobenzothiazole, 1,6-dibromohexane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1259] 400 MHz-¹H-NMR 8.17 (1H, d, J=8.5 Hz), 7.82-7.88 (1H, m),7.71-7.75 (2H, m), 7.66 (1H, d, J=7.0 Hz), 7.41-7.53 (3H, m), 7.20 (1H,d, J=2.7 Hz), 6.98 (1H, dd, J=8.8 Hz, J=2.7 Hz), 4.64 (1H, q, J=6.4 Hz),4.05 (2H, q, J=7.0 Hz), 3.26 (2H, t, J=7.3 Hz), 2.50-2.64 (2H, m),1.73-1.81 (2H, m), 1.30-1.55 (6H, m), 1.51 (3H, d, J=6.4 Hz), 1.43 (3H,t, J=7.0 Hz), m/z=464.

Example 378 Synthesis of S-231

[1260] S-231 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by6-ethoxy-2-mercaptobenzothiazole, 1,7-dibromoheptane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1261] 400 MHz-¹H-NMR 8.15 (1H, d, J=8.3 Hz), 7.86-7.88 (1H, m),7.72-7.73 (2H, m), 7.72 (1H, d, J=9.1 Hz), 7.45-7.55 (3H, m), 6.98 (1H,dd, J=8.8 Hz, J=2.4 Hz), 4.72 (1H, q, J=6.4 Hz), 4.05 (2H, q, J=7.0 Hz),3.25 (2H, t, J=7.3 Hz), 2.52-2.66 (2H, m), 1.64-1.82 (2H, m), 1.59 (3H,d, J=6.4 Hz), 1.43 (3H, t, J=7.0 Hz), 1.03-1.68 (8H, m), m/z=478.

Example 379 Synthesis of S-232

[1262] S-232 was synthesized by almost the same method as.the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by6-ethoxy-2-mercaptobenzothiazole, 1,8-dibromooctane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1263] 400 MHz-¹H-NMR 8.16 (1H, d, J=8.5 Hz), 7.86-7.88 (1H, m),7.68-7.76 (3H, m), 7.45-7.53 (3H, m), 7.21 (1H, d, J=2.4 Hz), 6.98 (1H,dd, J=8.8 Hz, J=2.4 Hz), 4.67 (1H, q, J=6.4 Hz), 4.06 (2H, q, J=7.0Hz),3.27 (2H, t, J=7.4 Hz), 2.51-2.64 (2H, m), 1.69-1.80 (2H, m), 1.54 (3H,d, J=6.4 Hz), 1.43 (3H, t, J=7.0 Hz), 1.20-1.60 (10O, m), m/z=492.

Example 380 Synthesis of S-233

[1264] S-233 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and (R)-(+)-3-methoxy-α-benzylmethylaminerespectively by 2,4-dichlorothiophenol and(R)-(+)-1-(1-naphthyl)ethylamine. m/z=375.

Example 381 Synthesis of S-234

[1265] S-234 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by2,4-dichlorothiophenol, 1,3-dibromopropane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1266] 400 MHz-¹H-NMR 8.18 (1H, d, J=7.6 Hz), 7.84-7.89 (1H, m), 7.74(1H, d, J=8.3 Hz), 7.63 (1H, d, J=7.1 Hz), 7.45-7.56 (3H, m), 7.34-7.56(1H, m), 7.33-7.34 (2H, m), 4.62 (1H, q, J=6.6 Hz), 2.88-3.04 (2H, m),2.63-2.78 (2H, m), 1.79-1.87 (2H, m), 1.50 (3H, d, J=6.6 Hz), m/z=389.

Example 382 Synthesis of S-235

[1267] S-235 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by2,4-dichlorothiophenol, 1,4-dibromobutane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1268] 400 MHz-¹H-NMR 8.18 (1H, d, J=8.0 Hz), 7.86-7.88 (1H, m), 7.75(1H, bs), 7.67 (1H, bs), 7.45-7.53 (3H, m), 7.35-7.36 (1H, m), 7.13-7.14(2H, m), 4.61-4.69 (1H, m), 2.84-2.89 (2H, m), 2.52-2.68 (2H, m),1.48-1.73 (7H, m), m/z=403.

Example 383 Synthesis of S-236

[1269] S-236 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by2,4-dichlorothiophenol, 1,5-dibromopentane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1270] 400 MHz-¹H-NMR 8.18 (1H, d, J=8.0 Hz), 7.86-7.88 (1H, m), 7.75(1H, d, J=8.3 Hz), 7.65 (1H, d, J=7.1 Hz), 7.45-7.53 (3H, m), 7.35-7.37(1H, m), 7.14-7.16 (2H, m), 4.64 (1H, q, J=6.4 Hz), 2.87 (2H, t, J=7.3Hz), 2.51-2.64 (2H, m), 1.60-1.68 (2H, m), 1.42-1.58 (4H, m), 1.51 (3H,d, J=6.4 Hz), m/z=417.

Example 384 Synthesis of S-237

[1271] S-237 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by2,5-dichlorothiophenol, 1,3-dibromopropane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1272] 400 MHz-¹H-NMR 8.20 (1H, d, J=8.0 Hz), 7.84-7.87 (1H, m), 7.74(1H, d, J=8.0 Hz), 7.66 (1H, d, J=7.1 Hz), 7.44-7.52 (3H, m), 7.19-7.25(2H, m), 7.03 (1H, dd, J=3.5 Hz, J=2.4 Hz), 4.62 (1H, q, J=6.6 Hz),2.90-3.06 (2H, m), 2.62-2.80 (2H, m), 1.86 (2H, tt, J=7.0 Hz, J=7.0 Hz),1.50 (3H, d, J=6.6 Hz), m/z=389.

Example 385 Synthesis of S-238

[1273] S-238 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by2,5-dichlorothiophenol, 1,6-dibromohexane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1274] 400 MHz-¹H-NMR 8.18 (1H, d, J=8.3 Hz), 7.85-7.88 (1H, m), 7.73(1H, d, J=8.0 Hz), 7.64 (1H, d, J=6.8 Hz), 7.44-7.53 (3H, m), 7.23-7.26(1H, m), 7.14 (1H, d, J=2.4 Hz), 7.03 (1H, dd, J=8.6 Hz, J=2.4 Hz), 4.63(1H, q, J=6.5 Hz), 2.87 (2H, t, J=7.3 Hz), 2.51-2.64 (2H, m), 1.68 (1 H,tt, J=7.3 Hz, J=7.3 Hz), 1.30-1.56 (6H, m), 1.50 (3H, d, J=6.5 Hz),m/z=431.

Example 386 Synthesis of S-239

[1275] S-239 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by2,5-dichlorothiophenol, 1,7-dibromoheptane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1276] 400 MHz-¹H-NMR 8.16 (1H, d, J=8.3 Hz), 7.86-7.88 (1H, m), 7.75(1H, d, J=8.0 Hz), 7.70 (1H, d, J=7.1 Hz), 7.45-7.53 (3H, m), 7.23 (1H,s), 7.14 (1H, d, J=2.4 Hz), 7.03 (1H, d, J=2.4 Hz, J=6.3 Hz), 4.68 (1H,q, J=6.4 Hz), 2.87 (2H, t, J=7.3 Hz), 2.50-2.65 (2H, m), 1.66 (2H, tt,J=7.3 Hz, 7.3 Hz), 1.55 (3H, d, J=6.4 Hz), 1.05-1.60 (8H, m), m/z=445.

Example 387 Synthesis of S-240

[1277] S-240 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by2,5-dichlorothiophenol, 1,8-dibromooctane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1278] 400 MHz-¹H-NMR 8.16 (1H, d, J=8.3 Hz), 8.85-8.88 (2H, m), 7.75(1H, d, J=8.3 Hz), 7.70 (1H, d, J=7.1 Hz), 7.45-7.54 (3H, m), 7.24 (1H,s), 7.14 (1H, d, J=2.4 Hz), 7.02 (1H, dd, j=8.5 Hz, J=2.4 Hz), 4.69 (1H,q, J=6.5 Hz), 2.86 (2H, t, J=6.8 Hz), 2.51-2.65 (2H, m), 1.66 (2H, tt,J=6.8 Hz, J=6.8 Hz), 1.55 (3H, d, J=6.5 Hz), 1.03-1.55 (10H, m),m/z=459.

Example 388 Synthesis of S-241

[1279] S-241 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and (R)-(+)-3-methoxy-α-benzylmethylaminerespectively by 4-trifluoromethoxythiophenol and(R)-(+)-1-(1-naphthyl)ethylamine. m/z=391.

Example 389 Synthesis of S-242

[1280] S-242 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by4-trifluoromethoxythiophenol, 1,3-dibromopropane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1281] 400 MHz-¹H-NMR 8.16-8.20 (1H, m), 7.82-7.89 (1H, m), 7.74 (1H, d,J=8.0 Hz), 7.62 (1H, d, J=6.6 Hz), 7.44-7.52 (3H, m), 7.27-2.30 (2H, m),7.08-7.11 (2H, m), 4.61 (1H, q, J=6.6 Hz), 2.88-3.05 (2H, m), 2.61-2.76(2H, m), 1.77-1.85 (2H, m), 1.49 (3H, d, J=6.6 Hz), m/z=405.

Example 390 Synthesis of S-243

[1282] S-243 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by4-trifluoromethoxythiophenol, 1,7-dibromoheptane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1283] 400 MHz-¹H-NMR 8.10 (1H, d, J=8.3 Hz), 7.78-7.81 (1H, m), 7.66(1H, d, J=8.3 Hz), 7.57 (1H, d, J=6.8 Hz), 7.37-7.45 (3H, m), 7.21-7.24(2H, m), 7.03-7.05 (2H, m), 4.55 (1H, q, J=6.6 Hz), 2.80 (2H, t, J=7.3Hz), 2.41 -2.55 (2H, m), 1.49-1.57 (2H, m), 1.18-1.45 (8H, m), 1.42 (3H,d, J=6.6 Hz), m/z=461.

Example 391 Synthesis of S-244

[1284] S-244 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by4-trifluoromethoxythiophenol, 1,8-dibromooctane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1285] 400 MHz-¹H-NMR 8.17 (1H, d, J=8.3 Hz), 7.85-7.88 (1H, m), 7.74(1H, d, J=8.0 Hz), 7.65 (1H, d, J=7.1 Hz), 7.44-7.53 (3H, m), 7.28-7.33(2H, m), 7.10-7.13 (2H, m)-, 4.64 (1H, q, J=6.6 Hz), 2.87 (2H, t, J=7.4Hz), 2.49-2.62 (2H, m), 1.56-1.65 (2H, m), 1.46-1.55 (2H, m), 1.50 (3H,d, J=6.6 Hz), 1.33-1.42 (2H, m), 1.23-1.30 (6H, m), m/z=475.

Example 392 Synthesis of S-245

[1286] S-245 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol by 2-chlorobenzylmercaptan.

[1287] 400 MHz-¹H-NMR 7.33-7.38 (1H, m), 7.28-7.31 (1H, m), 7.47-7.26(3H, m), 6.87-6.88 (2H, m), 6.78 (1H, ddd, J=8.1 Hz, J=2.4 Hz, J=1.0Hz), 3.81 (3H, s), 3.77 (2H, s), 3.70 (1H, q, J=6.5 Hz), 2.57-2.73 (4H,m), 1.33 (3H, d, J=6.5 Hz), m/z=335.

Example 393 Synthesis of S-246

[1288] S-246 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by2-chlorobenzylmercaptan and 1,3-dibromopropane.

[1289] 400 MHz-¹H-NMR 7.32-7.37 (2H, m), 7.14-7.25 (3H, m), 6.86-6.88(2H, m), 6.77 (1H, ddd, J=8.3 Hz, J=2.7 Hz, J=1.0 Hz), 3.80 (5H, s),3.71 (1H, q, J=6.6 Hz), 2.44-2.61 (4H, m), 1.70-1.78 (2H, m), 1.32 (3H,d, J=6.6 Hz), m/z=349.

Example 394 Synthesis of S-247

[1290] S-247 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by2-chlorobenzylmercaptan and 1,5-dibromopentane.

[1291] 400 MHz-¹H-NMR 7.32-7.36 (2H, m), 7.14-7.27 (3H, m), 6.88-6.89(2H, m), 6.76-6.79 (1H, m), 3.81 (3H, s), 3.80 (2H, s), 3.73 (1H, q,J=6.6 Hz), 2.38-2.51 (4H, m), 1.30-1.60 (6H, m), 1.35 (3H, d, J=6.6 Hz),m/z=377.

Example 395 Synthesis of S-248

[1292] S-248 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by2-chlorobenzylmercaptan and 1,6-dibromohexane.

[1293] 400 MHz-¹H-NMR 7.33-7.36 (2H, m), 7.14-7.27 (3H, m), 6.87-6.90(2H, m), 6.74-6.79 (1H, m), 3.81 (5H, s), 3.72 (1H, q, J=6.6 Hz),2.37-2.51 (4H, m), 1.56 (2H, tt, J=7.3 Hz, J=7.3 Hz), 1.40-1.49 (2H, m),1.20-1.38 (4H, m), 1.34 (3H, d, J=6.6 Hz), m/z=391.

Example 396 Synthesis of S-249

[1294] S-249 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and (R)-(+)-3-methoxy-α-benzylmethylaminerespectively by 2-chlorobenzylmercaptan and(R)-(+)-1-(1-naphthyl)ethylamine.

[1295] 400 MHz-¹H-NMR 8.16 (1H, d, J=8.0 Hz), 7.85-7.87 (1H, m), 7.74(1H, d, J=8.3 Hz), 7.65 (1H, d, J=6.8 Hz), 7.44-7.53 (3H, m), 7.24-7.34(2H, m), 7.13-7.18 (2H, m), 4.60 (1H, q, J=6.6 Hz), 3.77 (2H, s),2.63-2.78 (4H, m), 1.48 (3H, d, J=6.6 Hz), m/z=355.

Example 397 Synthesis of S-250

[1296] S-250 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by2-chlorobenzylmercaptan, 1,3-dibromopropane and (R)-(+)-1-(1-naphthyl)ethylamine.

[1297] 400 MHz-¹H-NMR 8.16 (1H, d, J=8.3 Hz), 7.84-7.88 (1H, m), 7.74(1H, d, J=8.3 Hz), 7.63 (1H, d, J=6.8 Hz), 7.44-7.52 (3H, m), 7.28-7.34(2H, m), 7.12-7.18 (2H, m), 4.62 (1H, q, J=6.6 Hz), 3.79 (2H, s),2.45-2.72 (4H, m), 1.75-1.81 (2H, m), 1.49 (3H, d, J=6.6 Hz), m/z=369.

Example 398 Synthesis of S-251

[1298] S-251 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol by 4-chlorobenzylmercaptan.

[1299] 400 MHz-¹H-NMR 7.21-7.26 (3H, m), 7.15-7.19 (2H, m), 6.85-6.87(2H, m), 6.76-6.80 (1H, m), 3.81 (3H, s), 3.68 (1H, q, J=6.6 Hz), 3.58(2H, d, J=2.0 Hz), 2.49-2.67 (4H, m), 1.33 (3H, d, J=6.6 Hz), m/z=335.

Example 399 Synthesis of S-252

[1300] S-252 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by4-chlorobenzylmercaptan and 1,3-dibromopropane.

[1301] 400 MHz-¹H-NMR 7.19-7.27 (5H, m), 6.85-6.87 (2H, m), 6.76-6.79(1H, m), 3.80 (3H, s), 3.69 (1H, q, J=6.6 Hz), 3.63 (2H, s), 2.35-2.59(4H, m), 1.63-1.73 (2H, m), 1.32 (3H, d, J=6.6 Hz), m/z=349.

Example 400 Synthesis of S-253

[1302] S-253 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and (R)-(+)-3-methoxy-α-benzylmethylaminerespectively by 4-chlorobenzylmercaptan and(R)-(+)-1-(1-naphthyl)ethylamine. m/z=355.

Example 401 Synthesis of S-254

[1303] S-254 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chlorcethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by4-chlorobenzylmercaptan, 1,3-dibromopropane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1304] 400 MHz-¹H-NMR 8.17 (1H, d, J=2.1 Hz), 7.85-7.88 (1H, m),7.73-7.75 (1H, d, J=8.1 Hz), 7.62 (1H, d, J=7.4 Hz), 7.45-7.53 (3H, m),7.17-7.25 (4H, m), 4.60 (1H, q, J=6.6 Hz), 3.61 (2H, s), 2.55-2.71 (2H,m), 2.37-2.48 (2H, m), 1.70-1.78 (2H, m), 1.48 (3H, d, J=6.6 Hz),m/z=369.

Example 402 Synthesis of S-255

[1305] S-255 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by2-quinolinethiol and 1,4-dibromobutane.

[1306] 400 MHz-¹H-NMR 7.83-7.88 (2H, m), 7.69 (1H, d, J=8.0 Hz),7.59-7.63 (1H, m), 7.37-7.41 (1H, m), 7.15-7.24 (2H, m), 6.86-6.90 (2H,m), 6.73-6.78 (1H, m), 3.78 (3H, s), 3.73 (1H, q, J=6.8 Hz), 3.30 (2H,t, J=6.8 Hz), 2.47-2.61 (2H, m), 1.58-1.84 (4H, m), 1.33 (3H, d, J=6.8Hz), m/z=366.

Example 403 Synthesis of S-256

[1307] S-256 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by2-quinolinethiol and 1,5-dibromopentane.

[1308] 400 MHz-¹H-NMR 7.90 (1H, d, J=8.4 Hz), 7.85 (1H, d, J=8.4 Hz),7.67-6.70 (1H, m), 7.60-7.64 (1H, m), 7.38-7.42 (1H, m), 7.22 (1H, dd,J=6.2 Hz, J=6.2 Hz), 7.18 (1H, d, J=8.4 Hz), 6.86-6.90 (2H, m),6.75-6.78 (1H, m), 3.80 (3H, s), 3.74 (1H, q, J=6.4 Hz), 3.32 (2H, t,J=7.4 Hz), 2.40-2.55 (2H, m), 1.76 (2H, tt, J=7.4 Hz, J=7.4 Hz),1.44-1.59 (4H, m), 1.34 (3H, d, J=6.4 Hz), m/z=380.

Example 404 Synthesis of S-257

[1309] S-257 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and 1-bromo-2-chloroethane respectively by2-quinolinethiol and 1,6-dibromohexane.

[1310] 400 MHz-¹H-NMR 7.91 (1H, d, J=8.2 Hz), 7.85 (1H, d, J=8.8 Hz),7.70 (1H, dd, J=8.0 Hz, J=1.2 Hz), 7.61-7.64 (1H, m), 7.38-7.43 (1H, m),7.23 (1H, dd, J=8.0 Hz, J=8.0 Hz), 7.18 (1H, d, J=8.4 Hz), 6.88-6.90(2H, m), 6.76-6.79 (1H, m), 3.80 (3H, s), 3.74 (1H, q, J=6.4 Hz), 3.34(2H, t, J=7.2 Hz), 2.41-2.54 (2H, m), 1.78 (2H, tt, J=7.2 Hz, J=7.2 Hz),1.41-1.54 (4H, m), 1.35 (3H, d, J=6.4 Hz), m/z=394.

Example 405 Synthesis of S-258

[1311] S-258 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by 2-quinolinethiol,1,4-dibromobutane and (R)-(+)-1-(1-naphthyl)ethylamine.

[1312] 400 MHz-¹H-NMR 8.18 (1H, d, J=8.0 Hz), 7.83-7.87 (3H, m), 7.73(1H, d, J=8.0 Hz), 7.65-7.70 (2H, m), 7.56-7.60 (1 H, m), 7.43-7.52 (3H,m), 7.37-7.42 (1H, m), 7.17 (1H, d, J=8.8 Hz), 4.65 (1H, q, J=6.4 Hz),3.32 (2H, t, J=7.2 Hz), 2.59-2.75 (2H, m), 1.67-1.87 (4H, m), 1.49 (3H,d, J=6.4 Hz), m/z=386.

Example 406 Synthesis of S-259

[1313] S-259 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by 2-quinolinethiol,1,5-dibromopentane and (R)-(+)-1-(1-naphthyl)ethylamine.

[1314] 400 MHz-¹H-NMR 8.16 (1H, d, J=8.0 Hz), 7.83-7.92 (3H, m),7.58-7.74 (4H, m), 7.37-7.52 (4H, m), 7.18 (1H, d, J=8.4 Hz), 4.63 (1H,q, J=6.4 Hz), 3.32 (2H, t, J=7.4 Hz), 2.54-2.66 (2H, m), 1.40-1.82 (6H,m), 1.49 (3H, d, J=6.4 Hz), m/z=400.

Example 407 Synthesis of S-260

[1315] S-260 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by 2-quinolinethiol,1,6-dibromohexane and (R)-(+)-1-(1-naphthyl)ethylamine.

[1316] 400 MHz-¹H-NMR 8.17 (1H, d, J=8.4 Hz), 7.37-7.82 (11H, m), 7.18(1H, d, J=8.8 Hz), 4.60-4.70 (1H, m), 3.30 (2H, t, J=7.4 Hz), 2.46-2.83(4H, m), 1.20-1.77 (9H, m), m/z=414.

Example 408 Synthesis of S-261

[1317] S-261 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and (R)-(+)-3-methoxy-α-benzylmethylaminerespectively by 4-methylthiophenol and (R)-(+)-1-(1-naphthyl)ethylamine.

[1318] 400 MHz-¹H-NMR 8.13-8.16 (1H, m), 7.83-7.89 (1H, m), 7.72 (1H, d,J=8.4 Hz), 7.62 (1H, d, J=6.8 Hz), 7.41-7.52 (3H, m), 7.21 (2H, d, J=8.0Hz), 7.02-7.05 (2H, m), 4.61 (1H, q, J=6.8 Hz), 3.02 (2H, t, J=6.2 Hz),2.71-2.82 (2H, m), 2.29 (3H, s), 1.48 (3H, d, J=6.8 Hz), m/z=321.

Example 409 Synthesis of S-262

[1319] S-262 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylam ine respectively by4-methylthiopheol, 1,3-dibromopropane and(R)-(+)-1-(1-naphthyl)ethylamine.

[1320] 400 MHz-¹H-NMR 8.16 (1H, d, J=7.6 Hz), 7.83-7.88 (1H, m), 7.73(1H, d, J=8.4 Hz), 7.63 (1H, d, J=7.2 Hz), 7.44-7.51 (3H, m), 7.21 (2H,d, J=8.0 Hz), 7.04-7.07 (2H, m), 4.59 (1H, q, J=6.8 Hz), 2.85-2.96 (2H,m), 2.61-2.74 (2H, m), 2.30 (3H, s),1.79 (2H, tt, J=7.1 Hz, J=7.1 Hz),1.47 (3H, d, J=6.8 Hz), m/z=335.

Example 410 Synthesis of S-263

[1321] S-263 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chioroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by5-fluoro-2-mercaptobenzothiazole, 1,5-dibromopentane and(R)-(+)-1-(1-naphthyl)ethylamine. m/z=424.

Example 411 Synthesis of S-264

[1322] S-264 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzyimethylamine respectively by5-fluoro-2-mercaptobenzothiazole, 1,6-dibromohexane and(R)-(+)-1-(1-naphthyl)ethylamine. m/z=438.

Example 412 Synthesis of S-265

[1323] K-2117 (hydrochloride) (110 mg, 0.267 mmol) was dissolved in 2.2ml of toluene (reagent grade). Next, m-chloroperbenzoic acid (56.0 mg,0.325 mmol) was added thereto at room temperature and the obtainedmixture was stirred at the same temperature for 1 hour.

[1324] After confirming the completion of the reaction by TLC, asaturated aqueous solution of sodium hydrogencarbonate and a saturatedaqueous solution of sodium thiosulfate were added thereto at roomtemperature and the reaction mixture was subjected to separatoryextraction with chloroform and a saturated aqueous solution of sodiumchloride and washed. The organic layer thus obtained was dried overanhydrous sodium sulfate. The obtained organic layer was furtherconcentrated under reduced pressure and the residue was purified bycolumn chromatography [silica gel, 5 g, chloroform/methanol 150/1] tothereby give a pale yellow, syrupy compound S-265 (82 mg, 0.214 mmol,yield: 78.3%). m/z=391.

Example 413 Synthesis of S-266

[1325] K-2117 (hydrochloride) (500 mg, 0.121 mmol) was dissolved in 20ml of toluene (reagent grade). Next, m-chloroperbenzoic acid (58.0 mg,0.336 mmol) was added thereto at room temperature and the obtainedmixture was stirred at the same temperature for 8 hours. Afterconfirming the completion of the reaction by TLC, a saturated aqueoussolution of sodium hydrogencarbonate and a saturated aqueous solution ofsodium thiosulfate were added thereto at room temperature and thereaction mixture was subjected to separatory extraction with chloroformand a saturated aqueous solution of sodium chloride and washed. Theorganic layer thus obtained was dried over anhydrous sodium sulfate. Theobtained organic layer was further concentrated under reduced pressureand the residue was purified by column chromatography [silica gel, 5 g,chloroform/methanol=150/1] to thereby give a pale yellow, syrupycompound S-266 (28 mg, 0.0686 mmol, yield: 56.7). m/z=408.

Example 414 Synthesis of F-3

[1326] 2,5-Dichlorothiophenol (5 g) was dissolved in acetonitrile (100ml). Then N-(2-bromoethylphthalimide) (7.8 g) was added thereto whilestirring at 0° C. Further, potassium carbonate (4.04 g) was addedthereto. After 1 hour, water was added and the resulting mixture wasextracted with ethyl acetate. The organic layer was washed with asaturated aqueous solution of sodium chloride, dried over sodiumsulfate, filtered and concentrated. The crystals thus obtained werewashed with chloroform to thereby giveN-(2-(2′,5′-dichlorophenylthio)ethyl)phthalimide (F-8) (8.28 g). MSm/z:351 (M⁺).

Example 415 Synthesis of F-37

[1327] N-(2-(2′,5′-Dichlorophenylthio)ethyl)phthalimide (F-8) (7.06 g)was added to ethanol (120 ml). After further adding hydrazinemonchydrate (6.9 ml), the obtained mixture was heated under reflux for1.5 hours. Then it was brought to room temperature and water was addedthereto followed by extraction with chloroform. The organic layer waswashed with a saturated aqueous solution of sodium chloride, dried oversodium sulfate, filtered and concentrated. The crude product thusobtained was purified by column chromatography (silica gel,chloroform/methanol=20:1) to thereby give2-(2′,5′-dichlorophenylthio)ethylamine (F-37) (4.29 g). MS m/z: 221(M⁺).

Example 416 Synthesis of F-12

[1328] 2-(2′,5′-Dichlorophenylthio)ethylamine (F-37) (250 mg) was mixedwith 3′-methoxyacetophenone (0.15 ml). After adding titaniumtetraisopropoxide (0.4 ml), the mixture was stirred for 3 hours. Afteradding ethanol (3 ml), sodium boron hydride (43 mg) was further added tothe reaction mixture under ice-cooling. Then the mixture was brought toroom temperature and stirred for 15 hours. The reaction mixture wasconcentrated and ethyl acetate and water were added thereto. Theinsoluble matters were filtered off and the organic layer was washedwith a saturated aqueous solution of sodium chloride, dried over sodiumsulfate, filtered and concentrated. The crude product thus obtained waspurified by column chromatography (silica gel, chloroform/methanol=50:1)to thereby give(±)-N-(1-(3-methoxyphenyl)ethyl)-2-(2′,5′-dichlorophenylthio)ethylamine(F-12) (146 mg). MS m/z: 355 (M⁺).

Example 417 Synthesis of F-13

[1329] The procedure employed for the synthesis of F-12 was repeated butreplacing the 3′-methoxyacetophenone by 3′,4′-dimehtoxyacetophenone tothereby give(±)-N-(1-(3,4-dimethoxyphenyl)ethyl)-2-(2′,5′-dichlorophenylthio)ethylamine(F-13). MS m/z: 385 (M⁺).

Example 418 Synthesis of F-14

[1330] The procedure employed for the synthesis of F-12 was repeated butreplacing the 3′-methoxyacetophenone by 3′-methylacetophenone to therebygive(±)-N-(1-(3-methylphenyl)ethyl)-2-(2′,5′-dichlorophenylthio)ethylamine(F-14). MS m/z: 339 (M⁺).

Example 419 Synthesis of F-15

[1331] The procedure employed for the synthesis of F-12 was repeated butreplacing the 3′-methoxyacetophenone by 4′-methylacetophenone to therebygive(±)-N-(1-(4-methylphenyl)ethyl)-2-(2′,5′-dichlorophenylthio)ethylamine(F-13). MS m/z: 339 (M⁺).

Example 420 Synthesis of F-16

[1332] The procedure employed for the synthesis of F-12 was repeated butreplacing the 3′-methoxyacetophenone by 3′,4′,5′-trimethoxyacetophenoneto thereby give(±)-N-(1-(3,4,5-trimethoxyphenyl)ethyl)-2-(2′,5′-dichlorophenylthio)ethylamine(F-16). MS m/z: 415 (M⁺).

Example 421 Synthesis of F-17

[1333] The procedure employed for the synthesis of F-12 was repeated butreplacing the 3′-methoxyacetophenone by 4′-hydroxyacetophenone tothereby give(±)-N-(1-(4-hydroxyphenyl)ethyl)-2-(2′,5′-dichlorophenylthio)ethylamine(F-17). MS m/z: 341 (M⁺).

Example 422 Synthesis of F-18

[1334] The procedure employed for the synthesis of F-12 was repeated butreplacing the 3′-methoxyacetophenone by 3′-(trifluoromethyl)acetophenoneto thereby give(±)-N-(1-(3-trifluoromethylphenyl)ethyl)-2-(2′,5′-dichlorophenylthio)ethylamine(F-18). MS m/z: 393 (M⁺).

Example 423 Synthesis of F-21

[1335] The procedure employed for the synthesis of F-12 was repeated butreplacing the 3′-methoxyacetophenone by4′-hydroxy-3′-methoxyacetophenone to thereby give(±)-N-(1-(4-hydroxy-3-methoxyphenyl)ethyl)-2-(2′,5′-dichlorophenylthio)ethylamine(F-21). MS m/z: 371 (M⁺).

Example 424 Synthesis of F-22

[1336] The procedure employed for the synthesis of F-12 was repeated butreplacing the 3′-methoxyacetophenone by 4′-bromoacetophenone to therebygive(±)-N-(1-(4-bromophenyl)ethyl)-2-(2′,5′-dichlorophenylthio)ethylamine(F-22). MS m/z: 405 (M⁺).

Example 425 Synthesis of F-23

[1337] The procedure employed for the synthesis of F-12 was repeated butreplacing the 3′-methoxyacetophenone by 3′-bromoacetophenone to therebygive(±)-N-(1-(3-bromophenyl)ethyl)-2-(2′,5′-dichlorophenylthio)ethylamine(F-23). MS m/z: 405 (M⁺).

Example 426 Synthesis of F-24

[1338] The procedure employed for the synthesis of F-12 was repeated butreplacing the 3′-methoxyacetophenone by 2′-bromoacetophenone to therebygive(±)-N-(1-(2-bromophenyl)ethyl)-2-(2′,5′-dichlorophenylthio)ethylamine(F-24). MS m/z: 405 (M⁺).

Example 427 Synthesis of F-29

[1339] The procedure employed for the synthesis of F-12 was repeated butreplacing the 3′-methoxyacetophenone by 3′,4′-dihydroxyacetophenone tothereby give(±)-N-(1-(3,4-dihydroxyphenyl)ethyl)-2-(2′,5′-dichlorophenylthio)ethylamine(F-29). MS m/z: 357 (M⁺).

Example 428 Synthesis of F-30

[1340] The procedure employed for the synthesis of F-12 was repeated butreplacing the 3′-methoxyacetophenone by 2′,5′-dichloroacetophenone tothereby give(±)-N-(1-(2,5-chlorophenyl)ethyl)-2-(2′,5′-dichlorophenylthio)ethylamine(F-30). MS m/z: 395 (M⁺).

Example 429 Synthesis of F-31

[1341] The procedure employed for the synthesis of F-12 was repeated butreplacing the 3′-methoxyacetophenone by 3′-fluoro-4′-methoxyacetophenoneto thereby give(±)-N-(1-(3-fluoro-4-methoxyphenyl)ethyl)-2-(2′,5′-dichlorophenylthio)ethylamine(F-31). MS m/z: 373 (M⁺).

Example 430 Synthesis of F-35

[1342] The procedure employed for the synthesis of F-12 was repeated butreplacing the 3′-methoxyacetophenone by3′-(trifluoromethoxy)acetophenone to thereby give(±)-N-(1-(3-trifluoromethoxyphenyl)ethyl)-2-(2′,5′-dichlorophenylthio)ethylamine(F-35). MS m/z: 409 (M⁺).

Example 431 Synthesis of F-48

[1343] The procedure employed for the synthesis of F-12 was repeated butreplacing the 3′-methoxyacetophenone by 3′,4′-dimethylacetophenone tothereby give (±)-N-(1-(3,4-dimethylphenyl)ethyl)-2-(2′,5′-dichlorophenylthio)ethylamine (F-48). MS m/z: 353 (M⁺).

Example 432 Synthesis of F-49

[1344] The procedure employed for the synthesis of F-12 was repeated butreplacing the 3′-methoxyacetophenone by 2′-chloroacetophenone to therebygive(±)-N-(1-(2-chlorophenyl)ethyl)-2-(2′,5′-dichlorophenylthio)ethylamine(F-49). MS m/z: 359 (M⁺).

Example 433 Synthesis of F-50

[1345] The procedure employed for the synthesis of F-12 was repeated butreplacing the 3′-methoxyacetophenone by 3′-chloroacetophenone to therebygive (±)-N-(1-(3-chlorophenyl)ethyl)-2-(2′,5′-dichlorophenylthioethylamine (F-50). MS m/z: 359 (M⁺).

Example 434 Synthesis of F-51

[1346] The procedure employed for the synthesis of F-12 was repeated butreplacing the 3′-methoxyacetophenone by 4′-chloroacetophenone to therebygive(±)-N-(1-(4-chlorophenyl)ethyl)-2-(2′,5′-dichlorophenylthio)ethylamine(F-51). MS m/z: 359 (M⁺).

Example 435 Synthesis of F-52

[1347] The procedure employed for the synthesis of F-12 was repeated butreplacing the 3′-methoxyacetophenone by 3′-fluoroacetophenone to therebygive(±)-N-(1-(3-fluorophenyl)ethyl)-2-(2′,5′-dichlorophenylthio)ethylamine(F-52). MS m/z: 343 (M⁺).

Example 436 Synthesis of F-53

[1348] The procedure employed for the synthesis of F-12 was repeated butreplacing the 3′-methoxyacetophenone by 4′-fluoroacetophenone to therebygive(±)-N-(1-(4-fluorophenyl)ethyl)-2-(2′,5′-dichlorophenylthio)ethylamine(F-53). MS m/z: 343 (M⁺).

Example 437 Synthesis of F-54

[1349] The procedure employed for the synthesis of F-12 was repeated butreplacing the 3′-methoxyacetophenone by 2′,5′-dimethylacetophenone tothereby give(±)-N-(1-(2,5-dimethylphenyl)ethyl)-2-(2′,5′-dichlorophenylthio)ethylamine(F-54). MS m/z: 353 (M⁺).

Example 438 Synthesis of F-55

[1350] The procedure employed for the synthesis of F-12 was repeated butreplacing the 3′-methoxyacetophenohe by 2′,4′-dimethylacetophenone tothereby give(±)-N-(1-(2,4-dimethylphenyl)ethyl)-2-(2′,5′-dichloraphenylthio)ethylamine(F-55). MS m/z: 353 (M⁺).

Example 439 Synthesis of F-57

[1351] The procedure employed for the synthesis of F-12 was repeated butreplacing the 3′-methoxyacetophenone by 2′,4′-dichloroacetophenone tothereby give(±)-N-(1-(2,4-dichlorophenyl)ethyl)-2-(2′,5′-dichlorophenylthio)ethylamine(F-57). MS m/z: 395 (M⁺).

Example 440 Synthesis of F-58

[1352] The procedure employed for the synthesis of F-12 was repeated butreplacing the 3′-methoxyacetophenone by 3′,4′-dichlcroacetophenone tothereby give(±)-N-(1-(3,4-dichlorophenyl)ethyl)-2-(2′,5′-dichlorophenylthio)ethylamine(F-58). MS m/z: 395 (M⁺).

Example 441 Synthesis of F-63

[1353] 3′-Hydroxyacetophenone (200 mg) was dissolved in acetonitrile (4ml). After adding ethyl iodide (0.2 ml) and potassium carbonate (347mg), the mixture was stirred at 70° C. for 9 hours. After 9 hours, waterand ethyl acetate were added to the reaction mixture followed byseparation. The organic layer was washed with a saturated aqueoussolution of sodium chloride, dried over sodium sulfate, filtered andconcentrated. The crude product thus obtained was purified by silica gelchromatography (n-hexane:ethyl acetate=8:1) to thereby give 204 mg of3′-ethoxyacetophenone. The procedure employed for the synthesis of F-12was repeated, but replacing the 3′-methoxyacetophenone by3′-ethoxyacetophenone to thereby give(±)-N-(1-(3-ethoxyphenyl)ethyl)-2-(2′,5′-dichlorophenylthio)ethylamine(F-63). MS m/z : 369 (M⁺).

Example 442 Synthesis of F-64

[1354] The procedure employed for the synthesis of 3′-ethoxyacetophenonewas repeated but replacing the ethyl iodide by n-propyl iodide tothereby give 3′-n-propoxyacetophenone. The procedure employed for thesynthesis of F-12 was repeated but replacing the 3′-methoxyacetophenoneby 3′-n-propoxyacetophenone to thereby give(±)-N-(1-(3-n-propoxyphenyl)ethyl)-2-(2′,5′-dichlorophenylthio)ethylamine(F-64). MS m/z: 383 (M⁺).

Example 443 Synthesis of F-65

[1355] The procedure employed for the synthesis of 3′-ethoxyacetophenonewas repeated but replacing the ethyl iodide by n-butyl iodide to therebygive 3′-n-butoxyacetophenone. The procedure employed for the synthesisof F-12 was repeated but replacing the 3′-methoxyacetophenone by3′-n-butoxyacetophenone to thereby give(±)-N-(1-(3-n-butoxyphenyl)ethyl)-2-(2′,5′-dichlorophenylthio)ethylamine(F-65). MS m/z : 397 (M⁺).

Example 444 Synthesis of K-2255

[1356] The procedure employed for the synthesis of 3′-ethoxyacetophenonewas repeated but replacing the ethyl iodide by n-hexyl bromide tothereby give 3′-n-hexyloxyacetophenone. The procedure employed for thesynthesis of F-12 was repeated but replacing the 3′-methoxyacetophenoneby 3′-n-hexyloxyacetophenone to thereby give(±)-N-(1-(3-n-hexyloxyphenyl)ethyl)-2-(2′,5′-dichlorophenylthio)ethylamine (K-2255). MS m/z: 425(M⁺).

Example 445 Synthesis of F-67

[1357] The procedure employed for the synthesis of 3′-ethoxyacetophenonewas repeated but replacing the ethyl iodide by isopropyl iodide tothereby give 3′-isopropoxyacetophenone. The procedure employed for thesynthesis of F-12 was repeated but replacing the 3′-methoxyacetophenoneby 3′-isopropoxyacetophenone to thereby give(±)-N-(1-(3-isopropoxyphenyl)ethyl)-2-(2′,5′-dichlorophenylthio)ethylamine(F-67). MS m/z: 383 (M⁺).

Example 446 Synthesis of F-68

[1358] The procedure employed for the synthesis of 3′-ethoxyacetophenonewas repeated but replacing the ethyl iodide by dodecane iodide tothereby give 3′-dodecyl,xyacetophenone. The procedure employed for thesynthesis of F-12 was repeated but replacing the 3′-methoxyacetophenoneby 3′-n-dodecyloxyacetophenone to thereby give(±)-N-(1-(3-n-dodecyloxyphenyl)ethyl)-2-(2′,5′-dichlorophenylthio)ethylamine(F-68). MS m/z: 509 (M⁺).

Example 447 Synthesis of F-69

[1359] The procedure employed for the synthesis of 3′-ethoxyacetophenonewas repeated but replacing the ethyl iodide by isobutyl iodide tothereby give 3′-isobutoxyacetophenone. The procedure employed for thesynthesis of F-12 was repeated but replacing the 3′-methoxyacetophenoneby 3′-isobutoxyacetophenone to thereby give(±)-N-(1-(3-isobutoxyphenyl)ethyl)-2-(2′,5′-dichlorophenylthio)ethylamine(F-69). MS m/z: 397 (M⁺).

Example 448 Synthesis of K-2258

[1360] The procedure employed for the synthesis of 3′-ethoxyacetophenonewas repeated but replacing the ethyl iodide by 4-chrolobenzyl bromide tothereby give 3′-(4-chlorobenzyloxy)acetophenone. The procedure employedfor the synthesis of F-12 was repeated but replacing the3′-methoxyacetophenne by 3′-(4-chlorobenzyloxy)acetophenone to therebygive(±)-N-(1-(3-(4-chlorobenzyloxy)phenyl)ethyl)-2-(2′,5′-dichlorophenylthio)ethylamine(K-2258). MS m/z: 465 (M⁺).

Example 449 Synthesis of F-71

[1361] The procedure employed for the synthesis of 3′-ethoxyacetophenonewas repeated but replacing the ethyl iodide by 2-chlorobenzyl bromide tothereby give 3′-(2-chlorobenzyloxy)acetophenone. The procedure employedfor the synthesis of F-12 was repeated but replacing the3′-methbxyacetophenone by 3′-(2-chlorobenzyloxy)acetophenone to therebygive(±)-N-(1-(3-(2-chlorobenzyloxy)phenyl)ethyl)-2-(2′,5′-dichlorophenylthio)ethylamine(F-71). MS m/z: 465 (M⁺).

Example 450 Synthesis of F-72

[1362] The procedure employed for the synthesis of 3′-ethoxyacetophenonewas repeated but replacing the ethyl iodide by benzyl bromide to therebygive 3′-benzyloxyacetophenone. The procedure employed for the synthesisof F-12 was repeated but replacing the 3′-methoxyacetophenone by3′-benzyloxyacetophenone to thereby give(±)-N-(1-(3-benzyloxyphenyl)ethyl)-2-(2′,5′-dichlorophenylthio)ethylamine(F-72). MS m/z: 431 (M⁺).

Example 451 Synthesis of F-73

[1363] The procedure employed for the synthesis of 3′-ethoxyacetophenonewas repeated but replacing the ethyl iodide by 2,6-dichlorobenzylbromide to thereby give 3′-(2,6-dichlorobenzyloxy)acetophenone. Theprocedure employed for the synthesis of F-12 was repeated but replacingthe 3′-methoxyacetophenone by 3′-(2,6-dichlorobenzyloxy)acetophenone tothereby give(±)-N-(1-(3-(2,6-dichlorobenzyloxy)phenyl)ethyl)-2-(2′,5′-dichlorophenylthio)ethylamine(F-73). MS m/z :501 (M⁺).

Example 452 Synthesis of K-2260

[1364] The procedure employed for the synthesis of 3′-ethoxyacetophenonewas repeated but replacing the ethyl iodide by 1-bromo-6-chlorohexane tothereby give 3′-(6-chlorohexyloxy)acetophenone. The procedure employedfor the synthesis of F-12 was repeated but replacing the3′-methoxyacetophenone by 3′-(6-chlorohexyloxy)acetophenone to therebygive(±)-N-(1-(3-(6-chlorohexyloxy)phenyl)ethyl)-2-(2′,5′-dichlorophenylthio)ethylamine(K-2260). MS m/z: 459 (M⁺).

Example 453 Synthesis of F-75

[1365] The procedure employed for the synthesis of 3′-ethoxyacetophenonewas repeated but replacing the ethyl iodide by 1-bromo-6-chlorohexane tothereby give 3′-(2-chloroethoxy)acetophenone. The procedure employed forthe synthesis of F-12 was repeated but replacing the3′-methoxyacetophenone by 3′-(2-chloroethoxy)acetophenone to therebygive(±)-N-(1-(3-(2-chloroethoxy)phenyl)ethyl)-2-(2′,5′-dichlorophenylthio)ethylamine(F-75). MS m/z: 403 (M⁺).

Example 454 Synthesis of F-76

[1366] The procedure employed for the synthesis of 3′-ethoxyacetophenonewas repeated but replacing the ethyl iodide by 2-methylbenzyl bromide tothereby give 3′-(2-methylbenzyl)acetophenone. The procedure employed forthe synthesis of F-12 was repeated but replacing the3′-methoxyacetophenone by 3′-(2-methylbenzyl)acetophenone to therebygive(±)-N-(1-(3-(2-methylbenzyl)phenyl)ethyl)-2-(2′,5′-dichlorophenylthio)ethylamine(F-76). MS m/z: 445 (M⁺).

Example 455 Synthesis of K-2268

[1367] The procedure employed for the synthesis of 3′-ethoxyacetophenonewas repeated but replacing the ethyl iodide by 4-methylbenzyl bromide tothereby give 3′-(4-methylbenzyloxy)acetophenone. The procedure employedfor the synthesis of F-12 was repeated but replacing the3′-methoxyacetophenone by 3′-(4-methylbenzyioxy)acetophenone to therebygive (±)-N-(1-(3-(4-methylbenzyloxy)phenyi)ethyl)-2-(2′,5′-dichlorophenylthio)ethylamine (K-2268). MS m/z:445 (M⁺).

Example 456 Synthesis of F-78

[1368] The procedure employed for the synthesis of F-12 was repeated butreplacing the 3′-methoxyacetophenone by 2-acetyl-5-methylfuran tothereby give(±)-N-(1-(2-(5-methyl)furanyi)ethyl)-2-(2′,5′-dichlorophenylthio)ethylamine(F-78). MS m/z: 329 (M⁺).

Example 457 Synthesis of F-79

[1369] The procedure employed for the synthesis of F-12 was repeated butreplacing the 3′-methoxyacetophenone by 2-acetylfuran to thereby give(±)-N-(1-(2-furanyl)ethyl)-2-(2′,5′-dichlorophenylthio)ethylamine(F-79). MS m/z: 315 (M⁺).

Example 458 Synthesis of F-80

[1370] The procedure employed for the synthesis of F-12 was repeated butreplacing the 3′-methoxyacetophenone by 2-acetyl-1-methylpyrrole tothereby give (±)-N-(1-(2-(1-methyl)yrrolyl)ethyl)-2-(2′,5′-dichlorophenylthio)ethylamine (F-80). MS m/z:328 (M⁺).

Example 459 Synthesis of F-81

[1371] The procedure employed for the synthesis of F-12 was repeated butreplacing the 3′-methoxyacetophenone by 2-acetylthiophene to therebygive (±)-N-(1-(2-thienyl) ethyl)-2-(2′,5′-dichlorophenylthio)ethylamine(F-81). MS m/z: 331 (M⁺).

Example 460 Synthesis of F-82

[1372] The procedure employed for the synthesis of F-12 was repeated butreplacing the 3′-methoxyacetophenone by 3-acetyl-2,5-dimethylfuran tothereby give(±)-N-(1-(3-(2,5-dimethyl)furanyl)ethyl)-2-(2′,5′-dichlorophenylthio)ethylamine(F-82). MS m/z: 343 (M⁺).

Example 461 Synthesis of F-83

[1373] The procedure employed for the synthesis of F-12 was repeated butreplacing the 3′-methoxyacetophenone by 3-acetylthiophene to therebygive (±)-N-(1-(3-thienyl)ethyl)-2-(2′,5′-dichlorophenylthio)ethylamine(F-83). MS m/z: 331 (M⁺).

Example 462 Synthesis of F-84

[1374] The procedure employed for the synthesis of F-12 was repeated butreplacing the 3′-methoxyacetophenone by 2-acetyl-5-methylthiophene tothereby give(±)-N-(1-(2-(5-methyl)thienyl)ethyl)-2-(2′,5′-dichlorophenylthio)ethylamine(F-84). MS m/z: 345 (M⁺).

Example 463 Synthesis of F-85

[1375] The procedure employed for the synthesis of F-12 was repeated butreplacing the 3′-methoxyacetophenone by 3-acetyl-1-methylpyrrole tothereby give(±)-N-(1-(3-(1-methyl)pyrrolyl)ethyl)-2-(2′,5′-dichlorophenylthio)ethylamine(F-85). MS m/z: 329 (M⁺).

Example 464 Synthesis of F-86

[1376] The procedure employed for the synthesis of F-12 was repeated butreplacing the 3′-methoxyacetophenone by 5-acetyl-2,4-dimethylthiazle tothereby give(±)-N-(1-(5-(2,4-dimethyl)thiazolyl)ethyl)-2-(2′,5′-dichlorophenylthio)ethylamine(F-86). MS m/z: 360 (M⁺).

Example 465 Synthesis of F-90

[1377] The procedure employed for the synthesis of 3′-ethoxyacetophenonewas repeated but replacing the ethyl iodide by cyclohexylmethyl bromideto thereby give 3′-(cyclohexylmethoxybenzyloxy)acetophenone. Theprocedure employed for the synthesis of F-12 was repeated but replacingthe 3′-methoxyacetophenone by3′-(cyclohexylmethoxybenzyloxy)-acetophenone to thereby give(±)-N-(1-(3-(cyclohexylmethoxybenzyloxy) phenyl)ethyl)-2-(2′,5′-dichlorophenylthio)ethylamine (F-90). MS m/z: 437 (M⁺).

Example 466 Synthesis of F-91

[1378] The procedure employed for the synthesis of F-12 was repeated butreplacing the 3′-methoxyacetophenone by 2-acetylpyridine to thereby give(±)-N-(1-(2-pyridyl)ethyl)-2-(2′,5′-dichlorophenylthio)ethylamine(F-91). MS m/z: 327 (M⁺).

Example 467 Synthesis of F-92

[1379] The procedure employed for the synthesis of F-12 was repeated butreplacing the 3′-methoxyacetophenone by 3-acetylpyridine to thereby give(±)-N-(1-(3-pyridyl) ethyl)-2-(2′,5′-dichlorophenylthio) ethylamine(F-92). MS m/z: 326 (M⁺).

Example 468 Synthesis of F-93

[1380] The procedure employed for the synthesis of F-12 was repeated butreplacing the 3′-methoxyacetophenone by 4-acetylpyridine to thereby give(±)-N-(1-(4-pyridyl)ethyl)-2-(2′,5′-dichlorophenylthio)ethylamine(F-93). MS m/z: 326 (M⁺).

Example 469 Synthesis of F-94

[1381] The procedure employed for the synthesis of F-12 was repeated butreplacing the 3′-methoxyacetophenone by 2-acetylpyrazine to thereby give(±)-N-(1-(2-pyrazyl)ethyl)-2-(2′,5′-dichlorophenylthio)ethylamine(F-94). MS m/z: 327 (M⁺).

Example 470 Synthesis of F-95

[1382] The procedure employed for the synthesis of F-12 was repeated butreplacing the 3′-methoxyacetophenone by3-acetyl-2-(methylaminesulfonyl)thiophene to thereby give(±)-N-(1-(3-(2-methylaminosulfonyl)thienyl)ethyl)-2-(2′,5′-dichlorophenylthio)ethylamine(F-95). MS m/z: 425 (M⁺).

Example 471 Synthesis of F-96

[1383] The procedure employed for the synthesis of F-12 was repeated butreplacing the 3′-methoxyacetophenone by 3-acetylindole to thereby give(±)-N-(1-(3-indolyl)ethyl)-2-(2′,5′-dichlorophenylthio)ethylamine(F-96). MS m/z: 364 (M⁺).

Example 472 Synthesis of F-97

[1384] Di(4-trifluoromethyl)benzylamine (450 mg) was dissolved inmethylene chloride (10 ml) and bromoacetic acid (186 mg) was addedthereto. After further adding WSC. HCl (390 mg), the reaction mixturewas heated under reflux for 30 minutes. Then it was brought back to roomtemperature and separated into aqueous and ethyl acetate layers. Theorganic layer was washed with a saturated aqueous solution of sodiumchloride, dried over sodium sulfate, filtered and concentrated. Thecrude product thus obtained was purified by silica gel chromatography(n-hexane:ethyl acetate=3:1) to thereby give 510 mg of a bromo compound.This bromo compound (500 mg) was dissolved in acetonitrile (10 ml) andpotassium carbonate (763 mg) and (R)-(+)-1-(1-naphthyl)ethylamine (0.18ml) was added thereto. After further adding tetrabutylammonium iodide(41 mg), the mixture was heated under reflux. After 2 hours, it wasbrought back to room temperature and separated into aqueous andchloroform layers. The organic layer washed with a saturated aqueoussolution of sodium chloride, dried over sodium sulfate, filtered andconcentrated. The crude product thus obtained was purified by silica gelchromatography (n-hexane:ethyl acetate=2:1) to thereby give 280 mg of aF-97. MS m/z: 544 (M+1⁺).

Example 473 Synthesis of F-98

[1385] The procedure employed for the synthesis of F-97 was repeated butreplacing the di(4-trifluoromethyl)benzylamine by(4-trifluoromethoxy)benzylamine to thereby give F-98. MS m/z: 576(M+1⁺).

Example 474 Synthesis of F-99

[1386] The procedure employed for the synthesis of F-97 was repeated butreplacing the bromoacetic acid by 5-bromopentanoic acid to thereby giveF-99. MS m/z: 586 (M⁺).

Example 475 Synthesis of F-100

[1387] The procedure employed for the synthesis of F-97 was repeated butreplacing the di(4-trifluoromethyl)benzylamine by (4-chloro)benzylamineto thereby give F-100. MS m/z: 476 (M⁺).

Example 476 Synthesis of F-101

[1388] The procedure employed for the synthesis of F-99 was repeated butreplacing the di(4-trifluoromethyl)benzylamine bydi(4-trifluoromethoxy)benzylamine to thereby give F-101. MS m/z: 618(M⁺).

Example 477 Synthesis of F-102

[1389] The procedure employed for the synthesis of F-98 was repeated butreplacing the bromoacetic acid by 4-bromobutyric acid to thereby giveF-102. MS m/z: 604 (M⁺).

Example 478 Synthesis of F-103

[1390] The procedure employed for the synthesis of F-98 was repeated butreplacing the bromoacetic acid by 6-bromohexanoic acid to thereby giveF-103. MS m/z: 632 (M⁺).

Example 479 Synthesis of F-104

[1391] The procedure employed for the synthesis of F-103 was repeatedbut replacing the di(4-trifluoromethoxy)benzylamine bydi(4-trifluoromethyl)benzylamine to thereby give F-104. MS m/z: 600(M⁺).

Example 480 Synthesis of F-105

[1392] The procedure employed for the synthesis of F-101 was repeatedbut replacing the di(4-trifluoromethyl)benzylamine bydi(4-chloro)benzylamine to thereby give F-105. MS m/z: 533 (M+1⁺).

Example 481 Synthesis of F-106

[1393] The procedure employed for the synthesis of F-102 was repeatedbut replacing the di(4-trifluoromethoxy)benzylamine bydi(4-chloro)benzylamine to thereby give F-106. MS m/z: 505 (M+1⁺).

Example 482 Synthesis of F-107

[1394] The procedure employed for the synthesis of F-99 was repeated butreplacing the di(4-trifluoromethyl)benzylamine bydi(4-chloro)benzylamine to thereby give F-107. MS m/z: 519 (M+1⁺).

Example 483 Synthesis of F-108

[1395] The procedure employed for the synthesis of F-98 was repeated butreplacing the bromoacetic acid by 8-bromooctanoic acid to thereby giveF-108. MS m/z: 660 (M⁺).

Example 484 Synthesis of F-109

[1396] The procedure employed for the synthesis of F-108 was repeatedbut replacing the di(4-trifluoromethoxy)benzylamine bydi(4-trifluoromethyl)benzylamine to thereby give F-109. MS m/z: 628(M⁺).

Example 485 Synthesis of F-110

[1397] The procedure employed for the synthesis of F-108 was repeatedbut replacing the di(4-trifluoromethyl)benzylamine bydi(4-chloro)benzylamine to thereby give F-110. MS m/z: 561 (M+1⁺).

Example 486 Synthesis of F-111

[1398] The procedure employed for the synthesis of F-99 was repeated butreplacing the di(4-trifluoromethyl)benzylamine byN-(4-trifluoromethylbenzyl)-N-(3,4-dichlorobenzyl)amine to thereby giveF-111. MS m/z: 587 (M+1⁺).

Example 487 Synthesis of F-112

[1399] The procedure employed for the synthesis of F-103 was repeatedbut replacing the di(4-trifluoromethoxy)benzylamine byN-(4-trifluoromethylbenzyl)-N-(3,4-dichlorobenzyl)amine to thereby giveF-112. MS m/z: 601 (M+1⁺).

Example 488 Synthesis of F-113

[1400] The procedure employed for the synthesis of F-97 was repeated butreplacing the di(4-trifluoromethyl)benzylamine byN-(4-trifluoromethylbenzyl)-N-(3,4-dichlorobenzyl)amine to thereby giveF-113. MS m/z: 544 (M⁺).

Example 489 Synthesis of F-114

[1401] The procedure employed for the synthesis of F-108 was repeatedbut replacing the di(4-trifluoromethoxy)benzylamine byN-(4-trifluorbmethylbenzyl)-N-(3,4-dichlorobenzyl)amine to thereby giveF-114. MS m/z: 628 (M⁺).

Example 490 Synthesis of F-115

[1402] The procedure employed for the synthesis of F-102 was repeatedbut replacing the di(4-trifluoromethoxy)benzylamine byN-(4-trifluoromethylbenzyl)-N-(3,4-dichlorobenzyl)amine to thereby giveF-115. MS m/z: 572 (M⁺).

Example 491 Synthesis of F-116

[1403] The procedure employed for the synthesis of F-115 was repeatedbut replacing the 4-bromobutyric acid by 12-bromododecanoic acid tothereby give F-116. MS m/z: 684 (M⁺).

Example 492 Synthesis of F-117

[1404] The procedure employed for the synthesis of F-102 was repeatedbut replacing the di(4-trifluoromethoxy)benzylamine by dibenzylamine tothereby give F-117. MS m/z: 450 (M⁺).

Example 493 Synthesis of F-118

[1405] The procedure employed for the synthesis of F-103 was repeatedbut replacing the di(4-trifluoromethoxy)benzylamine by dibenzylamine tothereby give F-118. MS m/z: 464 (M⁺).

Example 494 Synthesis of F-119

[1406] The procedure employed for the synthesis of F-108 was repeatedbut replacing the di(4-trifluoromethoxy)benzylamine by dibenzylamine tothereby give F-119. MS m/z: 492 (M⁺).

Example 495 Synthesis of F-120

[1407] The procedure employed for the synthesis of F-97 was repeated butreplacing the di(4-trifluorornethoxy)benzylamine by dibenzylamine tothereby give F-120. MS m/z: 408 (M⁺).

Example 496 Synthesis of S-267

[1408] S-267 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol and (R)-(+)-3-methoxy-a-benzylmethylaminerespectively by 4-tert-butylthiophenol and(R)-(+)-1-(1-naphthyl)ethylamine. m/z=363.

Example 497 Synthesis of S-268

[1409] S-268 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by4-tert-butylthiophenol, 1,3-dibromopropane and(R)-(+)-1-(1-naphthyl)ethylamine. m/z=377.

Example 498 Synthesis of S-269

[1410] S-269 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by4-tert-butylthiophenol, 1,4-dibromobutane and(R)-(+)-1-(1-naphthyl)ethylamine. m/z=391.

Example 499 Synthesis of S-270

[1411] S-270 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by4-tert-butylthiophenol, 1,5-dibromopentane and(R)-(+)-1-(1-naphthyl)ethylamine. m/z=405.

Example 500 Synthesis of S-271

[1412] S-271 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by4-tert-butylthiophenol, 1,6-dibromohexane and(R)-(+)-1-(1-naphthyl)ethylamine. m/z=419.

Example 501 Synthesis of S-272

[1413] S-272 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by4-tert-butylthiophenol, 1,7-dibromoheptane and(R)-(+)-1-(1-naphthyl)ethylamine. m/z=433.

Example 502 Synthesis of S-273

[1414] S-273 was synthesized by almost the same method as the oneemployed for the synthesis of S-1 but replacing the2,5-dimethylthiophenol, 1-bromo-2-chloroethane and(R)-(+)-3-methoxy-α-benzylmethylamine respectively by4-tert-butylthiophenol, 1,8-dibromooctane and(R)-(+)-1-(1-naphthyl)ethylamine. m/z=447.

Example 503 Synthesis of S-274

[1415] S-274 was synthesized by almost the same method as the oneemployed for the synthesis of S-265 but replacing the K-2117 by K-2027.m/z=399.

Example 504 Synthesis of S-275

[1416] S-275 was synthesized by almost the same method as the oneemployed for the synthesis of S-265 but replacing the K-2117 by K-2076.m/z=433.

Example 505 Synthesis of S-276

[1417] S-276 was synthesized by almost the same method as the oneemployed for the synthesis of K-2310 but replacing the4-(trifluoromethoxy)benzaldehyde by 4-dimethylaminobenzaldehyde.

Example 506 Synthesis of S-277

[1418] S-277 can be synthesized by almost the same method as the oneemployed for the synthesis of K-2310 but replacing the4-methylbenzylamine and 4-(trifluoromethoxy)benzaldehyde respectively by4-tert-butylbenzylamine and 3,4-dichlorobenzaldehyde.

Example 507 Synthesis of S-278

[1419] S-278 can be synthesized by almost the same method as the oneemployed for the synthesis of K-2310 but replacing the4-methylbenzylamine and 4-(trifluoromethoxy)benzaldehyde respectively by4-nitrobenzylamine and 3,4-dichlorobenzaldehyde.

Example 508 Synthesis of S-279

[1420] S-279 can be synthesized by almost the same method as the oneemployed for the synthesis of K-2310 but replacing the4-methylbenzylamine and 4-(trifluoromethoxy)benzaldehyde respectively by3,4-dichlorobenzylamine and 4-dimethylaminobenzaldehyde.

Example 509 Synthesis of S-280

[1421] S-280 was synthesized by almost the same method as the oneemployed for the synthesis of K-2310 but replacing the4-(trifluoromethoxy) benzaldehyde by 3,4-dimethoxybenzaidehyde.

Example 510 Synthesis of S-281

[1422] S-281 was synthesized by almost the same method as the oneemployed for the synthesis of K-2310 but replacing the4-methylbenzylamine and 4-(trifluoromethoxy)benzaldehyde respectively by4-(trifluoromethyl) benzylamine and 3,4-dimethoxybenzaldehyde.

Example 511 Synthesis of S-282

[1423] S-282 was synthesized by almost the same method as the oneemployed for the synthesis of K-2310 but replacing the4-(trifluoromethoxy)benzaldehyde by 3,4-dimethylbenzaJdehyde.

Example 512 Synthesis of S-283

[1424] S-283 was synthesized by almost the same method as the oneemployed for the synthesis of K-2310 but replacing the4-methylbenzylamine and 4-(trifluoromethoxy)benzaldehyde respectively by4-(trifluoromethyl) benzylamine and 3,4-dimethylbenzaldehyde.

Example 513 Synthesis of S-284

[1425] S-284 was synthesized by almost the same method as the oneemployed for the synthesis of K-2310 but replacing the4-(trifluoromethoxy)benzaldehyde by 3,4-methylenedioxybenzaldehyde.

Example 514 Synthesis of S-285

[1426] S-285 was synthesized by almost the same method as the oneemployed for the synthesis of K-2310 but replacing the4-methylbenzylamine and 4-(trif)uoromethoxy)benzaldehyde respectively by4-tert-butylbenzylamine and 4-tert-butylbenzaldehyde.

Example 515 Synthesis of S-286

[1427] S-286 was synthesized by almost the same method as the oneemployed for the synthesis of K-2310 but replacing the4-(trifluoromethoxy)benzaldehyde by 4-chlorobenzaldehyde.

Example 516 Synthesis of S-287

[1428] S-287 was synthesized by almost the same method as the oneemployed for the synthesis of K-2310 but replacing the4-methylbenzylamine and 4-(trifluo romethoxy) benzaldehyde respectivelyby 4-chlorobenzylamine and 4-pyridinecarboxyaldehyde.

Example 517 Synthesis of S-288

[1429] S-288 was synthesized by almost the same method as the oneemployed for the synthesis of K-2310 but replacing the4-methylbenzylamine and 4-(trifluoromethoxy)benzaldehyde respectively by4-(trifluoromethyl)benzylamine and 4-pyridinecarboxyaldehyde.

Example 518 Synthesis of S-289

[1430] S-289 can be synthesized by almost the same method as the oneemployed for the synthesis of K-2310 but replacing the4-methylbenzylamine and 4-(trifluoromethoxy)benzaldehyde respectively by3,4-dichlorobenzylamine and 4-phenylbenzaldehyde.

Example 519 Synthesis of S-290

[1431] S-290 can be synthesized by almost the same method as the oneemployed for the synthesis of K-2310 but replacing the4-methylbenzylamine and 4-(trifluoromethoxy)benzaldehyde respectively by3,4-dimethylbenzylamine and 4-phenylbenzaldehyde.

Example 520 Synthesis of S-291

[1432] S-291 can be synthesized by almost the same method as the oneemployed for the synthesis of K-2310 but replacing the4-methylbenzylamine and 4-(trifluoromethoxy)benzaldehyde respectively by3,4-dimethoxybenzylamine and 4-phenylbenzaldehyde.

Example 521 Synthesis of S-292

[1433] S-292 can be synthesized by almost the same method as the oneemployed for the synthesis of K-2310 but replacing the4-methylbenzylamine and 4-(trifluoromethoxy)benzaldehyde respectively by3,4-dichlorobenzylamine and 4-methylthiobenzaldehyde.

Example 522 Synthesis of S-293

[1434] S-293 can be synthesized by almost the same method as the oneemployed for the synthesis of K-2310 but replacing the4-methylbenzylamine and 4-(trifluoromethoxy)benzaldehyde respectively by3,4-dimethylbenzylamine and 4-methylthiobenzaldehyde.

Example 523 Synthesis of S-294

[1435] S-294 can be synthesized by almost the same method as the oneemployed for the synthesis of K-2310 but replacing the4-methylbenzylamine and 4-(trifluoromethoxy)benzaldehyde respectively by3,4-dimethoxybenzylamine and 4-methylthiobenzaldehyde.

Example 524 Synthesis of S-295

[1436] S-295 can be synthesized by almost the same method as the oneemployed for the synthesis of K-2310 but replacing the4-methylbenzylamine and 4-(trifluoromethoxy)benzaldehyde respectively by4-(trifluoromethyl)benzylamine and 3-chloro-4-fluorobenzaldehyde.

Example 525 Synthesis of S-296

[1437] S-296 can be synthesized by almost the same method as the oneemployed for the synthesis of K-2310 but replacing the4-(trifluoromethoxy)benzaldehyde by 3-chloro-4-fluorobenzaldehyde.

Example 526 Synthesis of S-297

[1438] S-297 can be synthesized by almost the same method as the oneemployed for the synthesis of K-2310 but replacing the4-methylbenzylamine and 4-(trifluoromethoxy)benzaldehyde respectively by4-(trifluoromethyl)benzylamine and 4-chloro-3-nitrobenzaldehyde.

Example 527 Synthesis of S-298

[1439] S-298 can be synthesized by almost the same method as the oneemployed for the synthesis of K-2310 but replacing the4-(trifluoromethoxy)benzaldehyde by 4-chloro-3-nitrobenzaldehyde.

Example 528 Synthesis of S-299

[1440] S-299 was synthesized by almost the same method as the oneemployed for the synthesis of K-2310 but replacing the4-methylbenzylamine and 4-(trifluoromethoxy)benzaldehyde respectively by4-chlorobenzylamine and 5-methyl-2-thiophenecarboxyaldehyde.

Example 529 Synthesis of S-300

[1441] S-300 was synthesized by almost the same method as the oneemployed for the synthesis of K-2310 but replacing the4-methylbenzylamine and 4-(trifluoromethoxy)benzaldehyde respectively by4-(trifluoromethyl)benzylamine and 5-methyl-2-thiophenecarboxyaldehyde.

Example 530

[1442] The activities of the compounds of the present invention oncalcium receptors were measured. The measurement was performed inaccordance with the method described in Example 4 of Nemeth et al.,PCT/US95/13704 (International Publication No. WO96/12697). In brief,HEK293 cells were transfected with a plasmid pHuPCaR4.0 containing ahuman calcium receptor gene and loaded with fluo-3. The loading wascarried out by incubating the cells at 37° C. for 1 hour in Dulbecco'smodified Eagle's medium which contained about 5 μM of fluo-3/AM and hadbeen buffered with 20 mM HEPES. Next, the cells were rinsed with Hank'sbalanced salt solution which contained 1 mM CaCl₂ and 1 mM MgCl₂ and hadbeen buffered with 20 mM HEPES. Then each test compound was added to thecells and the fluorescence was measured with the use of an excitationwavelength of 485 nm and an emission wavelength of 540 nm. The resultsare shown in Table 1. TABLE 1 Compound EC₅₀ (μM) Compound EC₅₀ (μM) 2 13 46 0.93 6 7.6  52 0.48 8 1.9  53 1.6 10 1.0  56 0.28 12 1.2  59 1.02 142.9  62 0.509 16 0.55  65 0.524 18 0.75  68 0.65 20 3.2  71 0.27 22 0.31 74 7.2 24 0.44  77 1.0 26 1.8  80 0.464 28 1.6  83 1.0 30 0.071  88 3.232 0.051  93 0.11 34 0.71 103 0.3 36 0.21 106 0.064 38 0.98 109 0.27 405.1 112 0.078 42 0.14 117 0.2 44 0.15 123 0.1 K-2003 0.29 K-2048 0.73K-2004 0.42 K-2049 0.83 K-2005 0.43 K-2050 0.55 K-2006 0.77 K-2051 0.34K-2007 0.47 K-2052 5.7 K-2008 0.86 K-2055 0.057 K-2010 0.14 K-2056 0.039K-2011 0.21 K-2057 0.41 K-2012 0.87 K-2058 0.39 K-2015 0.49 K-2059 0.27K-2016 0.36 K-2061 0.15 K-2017 0.36 K-2066 0.26 K-2018 0.33 K-2075 0.14K-2027 0.39 K-2076 6.2 K-2030 0.049 K-2078 0.17 K-2033 0.35 K-2079 0.2K-2034 0.061 K-2080 0.77 K-2035 0.22 K-2082 2.81 K-2040 0.08 K-2084 0.12K-2041 0.1 K-2085 0.13 K-2045 0.87 K-2087 0.087 K-2046 0.14 K-2117 0.043K-2047 0.13 K-2177 0.075 K-2240 0.36 K-2267 0.014 K-2243 0.092 K-22680.089 K-2246 0.12 K-2269 0.071 K-2247 0.13 K-2270 0.14 K-2248 0.078K-2271 0.14 K-2249 0.082 K-2272 0.052 K-2250 0.076 K-2273 0.16 K-22510.051 K-2274 1.2 K-2252 0.018 K-2275 0.27 K-2253 0.19 K-2276 0.064K-2254 0.088 K-2277 0.93 K-2255 9.6 K-2278 2.50 K-2256 0.18 K-2279 0.63K-2257 0.039 K-2280 0.27 K-2258 0.38 K-2281 0.43 K-2259 0.0024 K-22820.34 K-2260 0.096 K-2283 0.093 K-2261 0.026 K-2284 0.36 K-2262 0.084K-2285 0.32 K-2263 0.11 K-2286 0.62 K-2264 0.016 K-2287 0.062 K-22650.061 K-2288 0.14 K-2266 0.036 K-2289 0.074 K-2290 0.1 K-2306 1.85K-2291 0.081 K-2309 0.066 K-2292 0.074 K-2310 0.059 K-2293 0.28 K-23110.053 K-2294 0.062 K-2312 0.08 K-2295 1.36 K-2314 0.29 K-2296 0.22 S-160.11 K-2297 0.23 S-52 0.16 K-2298 0.34 S-64 0.098 K-2299 0.15 S-69 0.31K-2300 0.14 S-80 0.1 K-2301 0.8 S-165 0.15 K-2302 0.5 S-193 0.066 K-23030.35 S-201 0.18 K-2304 0.098 S-202 0.15 K-2305 0.11 S-265 0.91

Example 531

[1443] The compound of the present invention was administered to rats soas to examine the effects of the compound on the plasma calcium ionlevel and serum PTH level. The test was performed by orallyadministering single dose of the compound of the invention or a controlcompound to normal male SD rats with six animals in each group.

[1444] To the group 1 was administered as a control a 10% cyclodextrinaqueous solution in a dose of 2.5 ml/kg. To the group 2 was administeredas a reference (R)-N-(3-(2-chlorophenyl)propyl)-1-(3-methoxyphenyl)ethylamine (KRN568) dissolved in a 10%cyclodextrin aqueous solution in a dose of 30 μmol/kg. To the group 3was administered the compound of the present invention dissolved in a10% cyclodextin aqueous solution in a dose of 30 μmol/kg, provided that1% sodium-CMC aqueous solution was used in place of 10% cyclodextrinaqueous solution for the compounds marked with ** in Table 2.

[1445] Blood of each rat was collected from the tail tip before theadministration and 30 minutes and 1, 2, 4, 8 and 24 hours thereafter (orat the time indicated in Table 2), and the plasma Ca²⁺ level and serumPTH level were measured. The data of the serum PTH level werestatistically processed by the multiple comparison analysis inaccordance with Steel's calibration by using the group 1 as the control.The results are shown in Table 2 and FIGS. 46-96. TABLE 2 PlasmaCa²⁺(mmol/l) Compound 0 hr 1 hr 2 hr 4 hr 8 hr 24 hr 48 hr K-2027 mean1.427 1.197 1.102 0.995 1.048 1.363 S.E. 0.010 0.053 0.027 0.027 0.0240.013 K-2052 mean 1.425 1.283 1.187 1.087 1.185 S.E. 0.015 0.012 0.0070.016 0.006 K-2087 mean 1.470 1.325 1.243 1.197 1.255 S.E. 0.008 0.0150.009 0.012 0.008 K-2240 mean 1.415 1.302 1.272 1.175 1.230 S.E. 0.0090.038 0.022 0.027 0.003 K-2247 mean 1.400 1.378 1.298 1.175 1.217 S.E.0.016 0.014 0.018 0.018 0.016 K-2250 mean 1.457 1.327 1.225 1.122 1.203S.E. 0.014 0.030 0.022 0.010 0.019 K-2255 mean 1.413 1.328 1.212 1.1771.232 S.E. 0.020 0.013 0.019 0.009 0.012 K-2258 mean 1.452 1.317 1.2271.133 1.207 S.E. 0.009 0.015 0.026 0.031 0.014 K-2262 mean 1.413 1.3901.260 1.138 1.142 S.E. 0.020 0.009 0.021 0.017 0.020 K-2263 mean 1.4231.273 1.237 1.212 1.308 S.E. 0.011 0.028 0.024 0.016 0.011 K-2264** mean1.403 1.335 1.203 1.013 0.998 1.182    1.240*^(a) S.E. 0.015 0.019 0.0190.019 0.021 0.027 0.017 K-2265 mean 1.425 1.430 1.363 1.260 1.218 S.E.0.019 0.012 0.010 0.023 0.008 K-2266 mean 1.417 1.368 1.222 1.065 1.0451.370 S.E. 0.020 0.021 0.036 0.023 0.017 0.009 K-2267 mean 1.417 1.3471.212 1.027 1.022 1.312 S.E. 0.015 0.018 0.019 0.016 0.018 0.023 K-2269mean 1.450 1.152 1.140 1.097 1.173 S.E. 0.016 0.057 0.029 0.017 0.017K-2270** mean 1.430 1.355 1.238 1.088 1.175 S.E. 0.012 0.014 0.019 0.0160.020 K-2271 mean 1.428 1.278 1.227 1.128 1.197 S.E. 0.012 0.017 0.0170.023 0.022 K-2272** mean 1.442 1.382 1.237 1.075 1.022 1.240 S.E. 0.0150.014 0.011 0.011 0.015 0.012 K-2279 mean 1.443 1.200 1.155 1.130 1.2101.445 S.E. 0.014 0.064 0.034 0.022 0.010 0.015 K-2280 mean 1.443 1.2331.167 1.077 1.142 1.405 S.E. 0.010 0.017 0.013 0.011 0.017 0.008 K-2281mean 1.437 1.380 1.245 1.103 0.993 1.230*^(b) S.E. 0.015 0.017 0.0310.011 0.011 0.014 K-2282** mean 1.435 1.425 1.298 1.168 1.078 1.230*^(b)S.E. 0.016 0.019 0.015 0.017 0.010 0.014 K-2283** mean 1.433 1.395 1.3051.210 1.253 S.E. 0.016 0.015 0.014 0.013 0.014 K-2284 mean 1.428 1.3771.267 1.152 1.102 S.E. 0.018 0.011 0.025 0.025 0.020 K-2286 mean 1.4051.318 1.218 1.088 1.098 1.390 1.412 S.E. 0.017 0.015 0.018 0.021 0.0180.008 0.014 K-2287 mean 1.403 1.180 1.042 0.955 0.950 1.200 1.392 S.E.0.0.13 0.019 0.017 0.019 0.006 0.041 0.012 K-2288 mean 1.405 1.190 1.0570.955 0.905 1.162 1.387 S.E. 0.012 0.018 0.020 0.018 0.009 0.020 0.015K-2289** mean 1.407 1.270 1.173 1.003 1.093 S.E. 0.013 0.018 0.022 0.0170.025 K-2290** mean 1.380 1.428 1.248 1.063 1.055 S.E. 0.007 0.014 0.0280.019 0.033 K-2291** mean 1.410 1.298 1.247 1.130 1.132 S.E. 0.017 0.0410.022 0.021 0.019 K-2292 mean 1.412 1.375 1.252 1.152 1.108 S.E. 0.0140.007 0.012 0.015 0.015 K-2293 mean 1.408 1.245 1.152 1.068 1.088 S.E.0.012 0.039 0.022 0.020 0.014 K-2294** mean 1.410 1.357 1.255 1.1171.022 S.E. 0.018 0.014 0.022 0.026 0.015 K-2296** mean 1.410 1.340 1.1951.1.13 1.083 S.E. 0.013 0.009 0.013 0.014 0.016 K-2297 mean 1.405 1.3931.305 1.172 1.082 S.E. 0.016 0.010 0.022 0.016 0.022 K-2298 mean 1.4051.348 1.265 1.187 1.100 S.E. 0.015 0.015 0.030 0.024 0.017 K-2299 mean1.395 1.287 1.192 0.998 0.983 1.382*^(c) S.E. 0.015 0.013 0.021 0.0190.014 0.013 K-2300** mean 1.395 1.293 1.158 0.958 1.022 1.397*^(c) S.E.0.014 0.015 0.019 0.022 0.014 0.020 K-2301 mean 1.397 1.237 1.165 1.0771.075 1.350*^(c) S.E. 0.009 0.030 0.017 0.024 0.019 0.010 K-2302** mean1.412 1.238 1.130 0.978 1.010 S.E. 0.014 0.019 0.013 0.016 0.016 K-2303mean 1.415 1.255 1.165 1.020 1.032 S.E. 0.018 0.021 0.018 0.010 0.023K-2304 mean 1.382 1.262 1.157 1.053 1.065 S.E. 0.014 0.029 0.023 0.0060.012 K-2305 mean 1.415 1.242 1.170 1.098 1.202 S.E. 0.015 0.018 0.0130.025 0.022 K-2309 mean 1.428 1.320 1.207 1.018 0.963 1.332*^(d) S.E.0.016 0.012 0.024 0.029 0.008 0.003 K-2310 mean 1.428 1.342 1.188 1.0080.943 1.330*^(d) S.E. 0.014 0.014 0.025 0.026 0.013 0.014 K-2311** mean1.447 1.375 1.232 1.075 1.110 S.E. 0.014 0.011 0.012 0.016 0.034 KRN568mean 1.378 1.305 1.237 1.290 1.340 S.E. 0.018 0.014 0.008 0.012 0.015

[1446] As these tables and figures clearly show, the compound of thepresent invention was able to lower the plasma Ca²⁺ level and serum PTHlevel in vivo.

1. A compound having the formula:Ar₅—[CHR¹⁶]_(t)—W—(CH₂)_(u)—CHR¹⁷)—NH—CH(R¹⁸)—AR₆ wherein: Ar₅ isphenyl, indole, carbazole, pyridine, dibenzofuran, or fluorene,optionally substituted with one or more groups independentlyselectedfrom the group consisting of unsubstituted lower alkyl, halogen,unsubstituted lower alkoxy, lower alkyl substituted with one or morehalogens, lower alkoxy substituted with one or more halogens, nitro,dimethylamino, and unsubstituted phenyl; Ar₆ is 3-methoxy phenyl oralpha-naphthyl; t is 0 or 1; u is an integer of from 0 to 11, inclusive;W is selected from the group consisting of oxygen, sulfur, sulfinyl,sulfonyl, carbonyl, and amino; R¹⁶ and R¹⁷ are H or unsubstituted loweralkyl; R¹⁸ is unsubstituted lower alkyl; or a pharmaceuticallyacceptable salt or hydrate of said compound.
 2. (New) The compound, saltor hydrate of claim 1 wherein: Ar₅ is pyridine substituted with one ormore halogens, or phenyl optionally substituted with one or more groupsindependently selected from the group consisting of halogen, or loweralkoxy; Ar₆ is unsubstituted naphthyl; R¹⁷ is H or methyl; R¹⁸ ismethyl; W is sulfur, sulfinyl, or sulfonyl; t is 0; u is
 1. 3. Thecompound, salt or hydrate of claim 1 wherein: Ar₅ is indole, fluorene,or dibenzofuran optionally substituted with one or more groupsindependently selected from the group consisting of halogen,unsubstituted lower alkoxy, and lower alkyl substituted with one or morehalogens; Ar₆ is phenyl optionally substituted with one or more loweralkoxy; W is oxygen; t is 0; u is 2; R¹⁷ is hydrogen; and R¹⁸ isunsubstituted lower alkyl.
 4. The compound, salt or hydrate of claim 1wherein: Ar₅ is phenyl, napthyl, or carbozole, optionally substitutedwith one or more groups independently selected from the group consistingof halogen, lower alkyl, unsubstituted lower alkoxy, and lower alkylsubstituted with one or more halogens; Ar₆ is napthyl or phenyloptionally substituted with one or more lower alkoxy; t is 1; R¹⁶ islower alkyl; R¹⁷ is hydrogen; R¹⁸ is lower alkyl; and W is N.
 5. (New) Acompound according to claim 2 selected from the group consisting of:

or a pharmaceutically acceptable salt or hydrate thereof.
 6. A compoundaccording to claim 3 selected from the group consisting of:

or a pharmaceutically acceptable salt or hydrate thereof.
 7. A compoundaccording to claim 4 selected from the group consisting of:


8. A pharmaceutical composition comprising a compound, or apharmaceutically acceptable salt or hydrate thereof, having the formula:Ar₅—[CHR¹⁶]—W—(CH₂)_(u)—CHR¹⁷)—NH—CH(R¹⁸)—Ar₆ wherein: Ar₅ is phenyl,indole, carbazole, pyridine, dibenzofuran, or fluorene, optionallysubstituted with one or more groups independentlyselected from the groupconsisting of unsubstituted lower alkyl, halogen, unsubstituted loweralkoxy, lower alkyl substituted with one or more halogens, lower alkoxysubstituted with one or more halogens, nitro, dimethylamino, andunsubstituted phenyl; Ar₆ is 3-methoxy phenyl or alpha-naphthyl; t is 0or 1; u is an integer of from 0 to 11, inclusive; W is selected from thegroup consisting of oxygen, sulfur, sulfinyl, sulfonyl, carbonyl, andamino; R¹⁶ and R¹⁷ are H or unsubstituted lower alkyl; R¹⁸ isunsubstituted lower alkyl; or a pharmaceutically acceptable salt orhydrate of said compound.
 9. (New) A method of treating a patientcomprising administering to said patient a therapeutically effectiveamount of one or more of compounds, or a pharmaceutically acceptablesalt or hydrate thereof, having the formula:Ar₅—[CHR¹⁶]_(t)—W—(CH₂)_(u)—CHR¹⁷)—NH—CH(R¹⁸)—Ar₆ wherein: Ar₅ isphenyl, indole, carbazole, pyridine, dibenzofuran, or fluorene,optionally substituted with one or more groups independentlyselectedfrom the group consisting of unsubstituted lower alkyl, halogen,unsubstituted lower alkoxy, lower alkyl substituted with one or morehalogens, lower alkoxy substituted with one or more halogens, nitro,dimethylamino, and unsubstituted phenyl; Ar₆ is 3-methoxy phenyl oralpha-naphthyl; t is 0 or 1; u is an integer of from 0 to 11, inclusive;W is selected from the group consisting of oxygen, sulfur, sulfinyl,sulfonyl, carbonyl, and amino; R¹⁶ and R¹⁷ are H or unsubstituted loweralkyl; R¹⁸ is unsubstituted lower alkyl; or a pharmaceuticallyacceptable salt or hydrate of said compound.
 10. (New) The method ofclaim 9 wherein said patient is suffering from a disease or disordercharacterized by either or both of (1) abnormal calcium homeostasis and,(2) an abnormal amount of an intracellular or extracellular messengerwhose production can be affected by calcium receptor activity.
 11. (New)A method for modulating the PTH level in a patient comprisingadministering to said patient an effective amount of a compound, or apharmaceutically acceptable salt or hydrate thereof, having the formula:Ar₅—[CHR¹⁶]_(t)—W—(CH₂)_(u)—CHR¹⁷)—NH—CH(R¹⁸)—Ar₆ wherein: Ar₅ isphenyl, indole, carbazole, pyridine, dibenzofuran, or fluorene,optionally substituted with one or more groups independentlyselectedfrom the group consisting of unsubstituted lower alkyl, halogen,unsubstituted lower alkoxy, lower alkyl substituted with one or morehalogens, lower alkoxy substituted with one or more halogens, nitro,dimethylamino, and unsubstituted phenyl; Ar₆ is 3-methoxy phenyl oralpha-naphthyl; t is 0 or 1; u is an integer of from 0 to 11, inclusive;W is selected from the group consisting of oxygen, sulfur, sulfinyl,sulfonyl, carbonyl, and amino; R¹⁶ and R¹⁷ are H or unsubstituted loweralkyl; R¹⁸ is unsubstituted lower alkyl; or a pharmaceuticallyacceptable salt or hydrate of said compound.
 12. (New) The method ofclaim 11 wherein said effective amount of said compound reduces said PTHlevel in a patient.
 13. (New) The method of claim 12 wherein saidpatient has an abnormally high PTH level and effective amount of saidcompound reduces said PTH level in said patient to a degree sufficientto cause a decrease in plasma Ca²⁺.
 14. (New) The method of claim 13,wherein administering said compound to said patient results in a PTHlevel in said patient equal to a level present in a normal individual.15. (New) A method for modulating one or more Ca²⁺ receptors activitiesin a cell comprising administration to said cell one or more compounds,or a pharmaceutically acceptable salt or hydrate thereof, having theformula: Ar₅—[CHR¹⁶]_(t)—W—(CH₂)_(u)—CHR¹⁷)—NH—CH(R¹⁸)—Ar₆ wherein: Ar₅is phenyl, indole, carbazole, pyridine, dibenzofuran, or fluorene,optionally substituted with one or more groups independentlyselectedfrom the group consisting of unsubstituted lower alkyl, halogen,unsubstituted lower alkoxy, lower alkyl substituted with one or morehalogens, lower alkoxy substituted with one or more halogens, nitro,dimethylamino, and unsubstituted phenyl; Ar₆ is 3-methoxy phenyl oralpha-naphthyl; t is 0 or 1; u is an integer of from 0 to 11, inclusive;W is selected from the group consisting of oxygen, sulfur, sulfinyl,sulfonyl, carbonyl, and amino; R¹⁶ and R¹⁷ are H or unsubstituted loweralkyl; R¹⁸ is unsubstituted lower alkyl; or a pharmaceuticallyacceptable salt or hydrate of said compound.
 16. (New) The method ofclaim 15 wherein said cell is a parathyroid cell, a juxtaglomerularkidney cell, a proximal tubule kidney cell, a parafollicular thyroidcell, a bone osteoclast, a keratinocyte or a placental trophoblast. 17.(New) The method of claim 15 wherein the modulating one or more Ca²⁺receptors activities in a cell treats or prevents a disorder selectedfrom the group consisting of hyperparathyroidism, renal osteodystrophy,hypercalcemia malignancy, osteoporosis, Paget's disease andhypertension.
 18. (New) The method of claim 17 wherein saidhyperparathyroidism is primary hyperparathyroidism.
 19. (New) The methodof claim 17 wherein said hyperparathyroidism is secondaryhyperparathyroidism.
 20. (New) A pharmaceutical composition fortreatment of primary and secondary hyperparathyroidism comprising acompound, or a pharmaceutically acceptable salt or hydrate thereof,having the formula: Ar₅—[CHR¹⁶]_(t)—W—(CH₂)_(u)—CHR¹⁷)—NH—CH(R¹⁸)—Ar₆wherein: Ar₅ is phenyl, indole, carbazole, pyridine, dibenzofuran, orfluorene, optionally substituted with one or more groupsindependentlyselected from the group consisting of unsubstituted loweralkyl, halogen, unsubstituted lower alkoxy, lower alkyl substituted withone or more halogens, lower alkoxy substituted with one or morehalogens, nitro, dimethylamino, and unsubstituted phenyl; Ar₆ is3-methoxy phenyl or alpha-naphthyl; t is 0 or 1; u is an integer of from0 to 11, inclusive; W is selected from the group consisting of oxygen,sulfur, sulfinyl, sulfonyl, carbonyl, and amino; R¹⁶ and R¹⁷ are H orunsubstituted lower alkyl; R¹⁸ is unsubstituted lower alkyl; or apharmaceutically acceptable salt or hydrate of said compound.
 21. (New)A pharmaceutical composition for treatment of renalosteodystrophycomprising a compound, or a pharmaceutically acceptable salt or hydratethereof, having the formula:Ar₅—[CHR¹⁶]_(t)—W—(CH₂)_(u)—CHR¹⁷)—NH—CH(R¹⁸)—Ar₆ wherein: Ar₅ isphenyl, indole, carbazole, pyridine, dibenzofuran, or fluorene,optionally substituted with one or more groups independentlyselectedfrom the group consisting of unsubstituted lower alkyl, halogen,unsubstituted lower alkoxy, lower alkyl substituted with one or morehalogens, lower alkoxy substituted with one or more halogens, nitro,dimethylamino, and unsubstituted phenyl; Ar₆ is 3-methoxy phenyl oralpha-naphthyl; t is 0 or 1; u is an integer of from 0 to 11, inclusive;W is selected from the group consisting of oxygen, sulfur, sulfinyl,sulfonyl, carbonyl, and amino; R¹⁶ and R¹⁷ are H or unsubstituted loweralkyl; R¹⁸ is unsubstituted lower alkyl; or a pharmaceuticallyacceptable salt or hydrate of said compound.
 22. (New) A pharmaceuticalcomposition for treatment of hypercalcemia comprising a compound, or apharmaceutically acceptable salt or hydrate thereof, having the formula:Ar₅—[CHR¹⁶]_(t)—W—(CH₂)_(u)—CHR¹⁷)—NH—CH(R¹⁸)—Ar₆ wherein: Ar₅ isphenyl, indole, carbazole, pyridine, dibenzofuran, or fluorene,optionally substituted with one or more groups independentlyselectedfrom the group consisting of unsubstituted lower alkyl, halogen,unsubstituted lower alkoxy, lower alkyl substituted with one or morehalogens, lower alkoxy substituted with one or more halogens, nitro,dimethylamino, and unsubstituted phenyl; Ar₆ is 3-methoxy phenyl oralpha-naphthyl; t is 0 or 1; u is an integer of from 0 to 11, inclusive;W is selected from the group consisting of oxygen, sulfur, sulfinyl,sulfonyl, carbonyl, and amino; R¹⁶ and R¹⁷ are H or unsubstituted loweralkyl; R¹⁸ is unsubstituted lower alkyl; or a pharmaceuticallyacceptable salt or hydrate of said compound.
 23. (New) A pharmaceuticalcomposition for treatment of hypercalcemia malignancy comprising acompound, or a pharmaceutically acceptable salt or hydrate thereof,having the formula: Ar₅—[CHR¹⁶]_(t)—W—(CH₂)_(u)—CHR¹⁷)—NH—CH(R¹⁸)—Ar₆wherein: Ar₅ is phenyl, indole, carbazole, pyridine, dibenzofuran, orfluorene, optionally substituted with one or more groupsindependentlyselected from the group consisting of unsubstituted loweralkyl, halogen, unsubstituted lower alkoxy, lower alkyl substituted withone or more halogens, lower alkoxy substituted with one or morehalogens, nitro, dimethylamino, and unsubstituted phenyl; Ar₆ is3-methoxy phenyl or alpha-naphthyl; t is 0 or 1; u is an integer of from0 to 11, inclusive; W is selected from the group consisting of oxygen,sulfur, sulfinyl, sulfonyl, carbonyl, and amino; R¹⁶and R¹⁷ are H orunsubstituted lower alkyl; R¹⁸ is unsubstituted lower alkyl; or apharmaceutically acceptable salt or hydrate of said compound.
 86. (New)A pharmaceutical composition for treatment of osteoporosis comprising acompound, or a pharmaceutically acceptable salt or hydrate thereof,having the formula: Ar₅—[CHR¹⁶]_(t)—W—(CH₂)_(u)—CHR¹⁷)—NH—CH(R¹⁸)—Arwherein: Ar₅ is phenyl, indole, carbazole, pyridine, dibenzofuran, orfluorene, optionally substituted with one or more groupsindependentlyselected from the group consisting of unsubstituted loweralkyl, halogen, unsubstituted lower alkoxy, lower alkyl substituted withone or more halogens, lower alkoxy substituted with one or morehalogens, nitro, dimethylamino, and unsubstituted phenyl; Ar₆ is3-methoxy phenyl or alpha-naphthyl; t is 0 or 1; u is an integer of from0 to 11, inclusive; W is selected from the group consisting of oxygen,sulfur, sulfinyl, sulfonyl, carbonyl, and amino; R¹⁶ and R¹⁷ are H orunsubstituted lower alkyl; R¹⁸ is unsubstituted lower alkyl; or apharmaceutically acceptable salt or hydrate of said compound.